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Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (Schmalspur protein)

 FOXH1_DANRE             Reviewed;         472 AA.
Q9I9E1; Q9I8K6;
14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 127.
RecName: Full=Forkhead box protein H1;
AltName: Full=Forkhead activin signal transducer 1;
Short=Fast-1;
AltName: Full=Schmalspur protein;
Name=foxh1; Synonyms=fast1, sur;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION,
DEVELOPMENTAL STAGE, MUTAGENESIS OF ARG-94 AND LYS-97, AND DISRUPTION
PHENOTYPE.
PubMed=10996071; DOI=10.1016/S0960-9822(00)00669-2;
Pogoda H.-M., Solnica-Krezel L., Driever W., Meyer D.;
"The zebrafish forkhead transcription factor FoxH1/Fast1 is a
modulator of nodal signaling required for organizer formation.";
Curr. Biol. 10:1041-1049(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND
MUTAGENESIS OF ARG-94.
TISSUE=Embryo;
PubMed=10996072; DOI=10.1016/S0960-9822(00)00679-5;
Sirotkin H.I., Gates M.A., Kelly P.D., Schier A.F., Talbot W.S.;
"Fast1 is required for the development of dorsal axial structures in
zebrafish.";
Curr. Biol. 10:1051-1054(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
TISSUE=Embryo;
PubMed=11091091; DOI=10.1016/S0925-4773(00)00485-8;
Boggetti B., Argenton F., Haffter P., Bianchi M.E., Cotelli F.,
Beltrame M.;
"Cloning and expression pattern of a zebrafish homolog of forkhead
activin signal transducer (FAST), a transcription factor mediating
Nodal-related signals.";
Mech. Dev. 99:187-190(2000).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=AB;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Transcriptional activator. Activates an activin response
element (ARE). Recognizes and binds to the DNA sequence 5'-
TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for
organizer formation. Also required for the development of dorsal
axial structures and left-right symmetry.
{ECO:0000269|PubMed:10996071, ECO:0000269|PubMed:10996072}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00089, ECO:0000269|PubMed:10996071}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Localized to the prospective animal pole during oogenesis.
Ubiquitous expression during the blastula stages. During early
gastrulation, levels are higher ventrally and in the presumptive
shield (organizer region). Later in gastrulation, expression is
restricted to midline and ventral cells. At the start of
somatogenesis, expression is restricted to notochord, lateral
plate mesoderm and a stripe of anterior dorsal neuroectoderm. By
the 19-somite stage, expression in the lateral plate and midline
diminishes but forebrain expression persists. All expression is
lost by 24 hours post-fertilization (hpf).
{ECO:0000269|PubMed:10996071, ECO:0000269|PubMed:10996072,
ECO:0000269|PubMed:11091091}.
-!- DOMAIN: The FM region is required for binding smad2/smad4
complexes. FM2 is more effective than FM1 and only interacts with
phosphorylated smad2 that is in an activated smad complex (By
similarity). {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Fishes exhibit ventral body curvature,
reduced spacing of the eyes, and absence or reduction of ventral
neuroectoderm, including the floor plate.
{ECO:0000269|PubMed:10996071}.
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EMBL; AF263000; AAF72712.1; -; mRNA.
EMBL; AF264751; AAF81247.1; -; mRNA.
EMBL; BC044340; AAH44340.1; -; mRNA.
RefSeq; NP_571577.1; NM_131502.1.
UniGene; Dr.7743; -.
ProteinModelPortal; Q9I9E1; -.
SMR; Q9I9E1; -.
STRING; 7955.ENSDARP00000072485; -.
PaxDb; Q9I9E1; -.
GeneID; 57930; -.
KEGG; dre:57930; -.
CTD; 8928; -.
ZFIN; ZDB-GENE-000616-15; foxh1.
eggNOG; KOG2294; Eukaryota.
eggNOG; COG5025; LUCA.
HOGENOM; HOG000169991; -.
HOVERGEN; HBG051646; -.
InParanoid; Q9I9E1; -.
KO; K09400; -.
PhylomeDB; Q9I9E1; -.
PRO; PR:Q9I9E1; -.
Proteomes; UP000000437; Unplaced.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IDA:ZFIN.
GO; GO:0043565; F:sequence-specific DNA binding; IMP:ZFIN.
GO; GO:0046332; F:SMAD binding; IMP:ZFIN.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IBA:GO_Central.
GO; GO:0048319; P:axial mesoderm morphogenesis; IMP:ZFIN.
GO; GO:0048327; P:axial mesodermal cell fate specification; IMP:ZFIN.
GO; GO:0001568; P:blood vessel development; IMP:ZFIN.
GO; GO:0048854; P:brain morphogenesis; IMP:ZFIN.
GO; GO:0060070; P:canonical Wnt signaling pathway; IMP:ZFIN.
GO; GO:0042074; P:cell migration involved in gastrulation; IMP:ZFIN.
GO; GO:0071345; P:cellular response to cytokine stimulus; ISS:UniProtKB.
GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0060971; P:embryonic heart tube left/right pattern formation; IMP:ZFIN.
GO; GO:0003143; P:embryonic heart tube morphogenesis; IMP:ZFIN.
GO; GO:0001706; P:endoderm formation; IMP:ZFIN.
GO; GO:0033504; P:floor plate development; IMP:ZFIN.
GO; GO:0021508; P:floor plate formation; IMP:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
GO; GO:0048382; P:mesendoderm development; IGI:ZFIN.
GO; GO:0001707; P:mesoderm formation; IMP:ZFIN.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:ZFIN.
GO; GO:0030903; P:notochord development; IMP:ZFIN.
GO; GO:0014028; P:notochord formation; IMP:ZFIN.
GO; GO:0046619; P:optic placode formation involved in camera-type eye formation; IMP:ZFIN.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0021501; P:prechordal plate formation; IMP:ZFIN.
GO; GO:2000223; P:regulation of BMP signaling pathway involved in heart jogging; IMP:ZFIN.
GO; GO:0010468; P:regulation of gene expression; IMP:ZFIN.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IGI:ZFIN.
GO; GO:0032525; P:somite rostral/caudal axis specification; IMP:ZFIN.
GO; GO:0010159; P:specification of animal organ position; IMP:ZFIN.
GO; GO:0060063; P:Spemann organizer formation at the embryonic shield; IMP:ZFIN.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00059; FH; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR001766; Fork_head_dom.
InterPro; IPR030456; TF_fork_head_CS_2.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00250; Forkhead; 1.
PRINTS; PR00053; FORKHEAD.
SMART; SM00339; FH; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00658; FORK_HEAD_2; 1.
PROSITE; PS50039; FORK_HEAD_3; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 472 Forkhead box protein H1.
/FTId=PRO_0000091844.
DNA_BIND 97 193 Fork-head. {ECO:0000255|PROSITE-
ProRule:PRU00089}.
REGION 339 465 SMAD-interaction domain (SID).
MOTIF 357 361 Fast/FoxH1 motif 1 (FM1).
MOTIF 367 373 Fast/FoxH1 motif 2 (FM2).
MOTIF 428 448 SMAD interaction motif (SIM).
MUTAGEN 94 94 R->H: In sur(m768); loss of function.
{ECO:0000269|PubMed:10996071,
ECO:0000269|PubMed:10996072}.
MUTAGEN 97 97 K->N: In sur(ty68b); loss of function.
{ECO:0000269|PubMed:10996071}.
CONFLICT 233 233 Q -> H (in Ref. 3; AAF81247).
{ECO:0000305}.
CONFLICT 318 318 G -> R (in Ref. 3; AAF81247).
{ECO:0000305}.
CONFLICT 395 395 G -> S (in Ref. 3; AAF81247).
{ECO:0000305}.
SEQUENCE 472 AA; 51620 MW; EC6285F1BFA970CA CRC64;
MTKHWGGPGL LAPPVITVGE GAQRDHHLDC RIGYSSSKRS CHRSSNPLLE LGGRLDKSTG
MAQDSCYRAK ATNQGPWELQ DGNSSGGKKK NYQRYPKPPY SYLAMIAMVI QNSPEKKLTL
SEILKEISTL FPFFKGNYKG WRDSVRHNLS SYDCFVKVLK DPGKPQGKGN FWTVEVNRIP
LELLKRQNTA VSRQDETIFA QDLAPYIFQG YSQPNKSKPL PPESSLPPVP TRQSPPPSED
PYRPKLDSTF AIDSLLHSLR PASSAGEGLR ERESWGVGPP PHTRSTTPPR PCNASYNGSS
SASSVSPASD FSDEDWRGVT VVGKRSGDRG ITSDAYSDSC PPPNKSSKRG NTPPWELPTS
YAKYTPPNAV APPSMRFNGN PFMPLGGIPF YGYGGAHVTT SHLIGHPYWP ILPSGPVSIQ
APPLLMDLDS MLQSVPPNKS VFDALGSNNQ TVHPSPNQYA LQNGPSLCKY SL


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