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Forkhead box protein L2

 FOXL2_CAPHI             Reviewed;         377 AA.
Q8MIP2;
25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
05-JUL-2017, entry version 73.
RecName: Full=Forkhead box protein L2;
Name=FOXL2;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=15885498; DOI=10.1016/j.ygeno.2005.02.011;
Pannetier M., Renault L., Jolivet G., Cotinot C., Pailhoux E.;
"Ovarian-specific expression of a new gene regulated by the goat PIS
region and transcribed by a FOXL2 bidirectional promoter.";
Genomics 85:715-726(2005).
[2]
FUNCTION AS TRANSCRIPTIONAL REGULATOR OF CYP19, AND TISSUE
SPECIFICITY.
PubMed=16720712; DOI=10.1677/jme.1.01947;
Pannetier M., Fabre S., Batista F., Kocer A., Renault L., Jolivet G.,
Mandon-Pepin B., Cotinot C., Veitia R., Pailhoux E.;
"FOXL2 activates P450 aromatase gene transcription: towards a better
characterization of the early steps of mammalian ovarian
development.";
J. Mol. Endocrinol. 36:399-413(2006).
-!- FUNCTION: Transcriptional regulator. Critical factor essential for
ovary differentiation and maintenance, and repression of the
genetic program for somatic testis determination (By similarity).
Prevents trans-differentiation of ovary to testis through
transcriptional repression of the Sertoli cell-promoting gene SOX9
(By similarity). Has apoptotic activity in ovarian cells (By
similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2
stimulated by tamoxifen (By similarity). Activates SIRT1
transcription under cellular stress conditions (By similarity).
Activates transcription of OSR2 (By similarity). Is a
transcriptional repressor of STAR (By similarity). Participates in
SMAD3-dependent transcription of FST via the intronic SMAD-binding
element (By similarity). Is a regulator of CYP19 expression.
{ECO:0000250, ECO:0000269|PubMed:16720712}.
-!- SUBUNIT: Interacts with ESR1. Interacts with UBE2I/UBC9. Interacts
with SMAD3. Interacts with DDX20. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00089}.
-!- TISSUE SPECIFICITY: Detected in the majority of somatic cells in
the developing ovary. {ECO:0000269|PubMed:16720712}.
-!- PTM: Sumoylated with SUMO1; sumoylation is required for
transcriptional repression activity. {ECO:0000250}.
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EMBL; AY112725; AAM52099.1; -; Genomic_DNA.
RefSeq; XP_017905386.1; XM_018049897.1.
ProteinModelPortal; Q8MIP2; -.
SMR; Q8MIP2; -.
GeneID; 102191377; -.
KEGG; chx:102191377; -.
CTD; 668; -.
HOVERGEN; HBG051651; -.
KO; K09405; -.
GO; GO:0005634; C:nucleus; ISS:AgBase.
GO; GO:0043028; F:cysteine-type endopeptidase regulator activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; ISS:AgBase.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0006309; P:apoptotic DNA fragmentation; ISS:UniProtKB.
GO; GO:0048048; P:embryonic eye morphogenesis; ISS:AgBase.
GO; GO:0008210; P:estrogen metabolic process; NAS:UniProtKB.
GO; GO:0002074; P:extraocular skeletal muscle development; ISS:UniProtKB.
GO; GO:0019101; P:female somatic sex determination; ISS:AgBase.
GO; GO:0060014; P:granulosa cell differentiation; ISS:AgBase.
GO; GO:0042703; P:menstruation; ISS:UniProtKB.
GO; GO:0001541; P:ovarian follicle development; IEP:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; IEA:InterPro.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR001766; Fork_head_dom.
InterPro; IPR033063; FoxL2.
InterPro; IPR018122; TF_fork_head_CS_1.
InterPro; IPR030456; TF_fork_head_CS_2.
InterPro; IPR011991; WHTH_DNA-bd_dom.
PANTHER; PTHR11829:SF240; PTHR11829:SF240; 1.
Pfam; PF00250; Forkhead; 1.
PRINTS; PR00053; FORKHEAD.
SMART; SM00339; FH; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00657; FORK_HEAD_1; 1.
PROSITE; PS00658; FORK_HEAD_2; 1.
PROSITE; PS50039; FORK_HEAD_3; 1.
1: Evidence at protein level;
Differentiation; DNA-binding; Isopeptide bond; Nucleus;
Phosphoprotein; Transcription; Transcription regulation;
Ubl conjugation.
CHAIN 1 377 Forkhead box protein L2.
/FTId=PRO_0000246178.
DNA_BIND 55 149 Fork-head. {ECO:0000255|PROSITE-
ProRule:PRU00089}.
COMPBIAS 222 235 Poly-Ala.
MOD_RES 34 34 Phosphoserine.
{ECO:0000250|UniProtKB:P58012}.
CROSSLNK 25 25 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
{ECO:0000250}.
SEQUENCE 377 AA; 38802 MW; D7BD295AFCDD9E52 CRC64;
MMASYPEPED ASGALLAPET GRAAKEPEAP APPSPGKGGG GGAGAAPEKP DPAQKPPYSY
VALIAMAIRE SAEKRLTLSG IYQYIIAKFP FYEKNKKGWQ NSIRHNLSLN ECFIKVPREG
GGERKGNYWT LDPACEDMFE KGNYRRRRRM KRPFRPPPAH FQPGKGLFGA GGAAGGCGVA
GAGADGYGYL APPKYLQSGF LNNSWPLPQP PSPMPYASCQ MAAAAAAAAA AAAAAGPGSP
GAAAVVKGLA GPAASYGPYS RVQSMALPPG VVNSYNGLGG PPAAPPPPPH PHSHPHAHHL
HAAAAPPPAP PHHGAAAPPP GQLSPASPAT AAPPAPAPTN APGLQFACAR QPELAMMHCS
YWDHDSKTGA LHSRLDL


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