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Formate-dependent phosphoribosylglycinamide formyltransferase (5'-phosphoribosylglycinamide transformylase 2) (Formate-dependent GAR transformylase) (EC 2.1.2.-) (GAR transformylase 2) (GART 2) (Non-folate glycinamide ribonucleotide transformylase) (Phosphoribosylglycinamide formyltransferase 2)

 PURT_FRATF              Reviewed;         386 AA.
A7N9C6;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
02-OCT-2007, sequence version 1.
22-NOV-2017, entry version 69.
RecName: Full=Formate-dependent phosphoribosylglycinamide formyltransferase {ECO:0000255|HAMAP-Rule:MF_01643};
AltName: Full=5'-phosphoribosylglycinamide transformylase 2 {ECO:0000255|HAMAP-Rule:MF_01643};
AltName: Full=Formate-dependent GAR transformylase {ECO:0000255|HAMAP-Rule:MF_01643};
EC=2.1.2.- {ECO:0000255|HAMAP-Rule:MF_01643};
AltName: Full=GAR transformylase 2 {ECO:0000255|HAMAP-Rule:MF_01643};
Short=GART 2 {ECO:0000255|HAMAP-Rule:MF_01643};
AltName: Full=Non-folate glycinamide ribonucleotide transformylase {ECO:0000255|HAMAP-Rule:MF_01643};
AltName: Full=Phosphoribosylglycinamide formyltransferase 2 {ECO:0000255|HAMAP-Rule:MF_01643};
Name=purT {ECO:0000255|HAMAP-Rule:MF_01643};
OrderedLocusNames=FTA_0101;
Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA).
Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
Francisellaceae; Francisella.
NCBI_TaxID=458234;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FTNF002-00 / FTA;
PubMed=19756146; DOI=10.1371/journal.pone.0007041;
Barabote R.D., Xie G., Brettin T.S., Hinrichs S.H., Fey P.D.,
Jay J.J., Engle J.L., Godbole S.D., Noronha J.M., Scheuermann R.H.,
Zhou L.W., Lion C., Dempsey M.P.;
"Complete genome sequence of Francisella tularensis subspecies
holarctica FTNF002-00.";
PLoS ONE 4:E7041-E7041(2009).
-!- FUNCTION: Involved in the de novo purine biosynthesis. Catalyzes
the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR),
producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is
provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
{ECO:0000255|HAMAP-Rule:MF_01643}.
-!- CATALYTIC ACTIVITY: Formate + ATP + 5'-phospho-ribosylglycinamide
= 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate.
{ECO:0000255|HAMAP-Rule:MF_01643}.
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-
phospho-D-ribosyl)glycinamide (formate route): step 1/1.
{ECO:0000255|HAMAP-Rule:MF_01643}.
-!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01643}.
-!- SIMILARITY: Belongs to the PurK/PurT family. {ECO:0000255|HAMAP-
Rule:MF_01643}.
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EMBL; CP000803; ABU60579.1; -; Genomic_DNA.
RefSeq; WP_003014073.1; NC_009749.1.
ProteinModelPortal; A7N9C6; -.
SMR; A7N9C6; -.
EnsemblBacteria; ABU60579; ABU60579; FTA_0101.
KEGG; fta:FTA_0101; -.
HOGENOM; HOG000072820; -.
KO; K08289; -.
OMA; GMVTMIT; -.
UniPathway; UPA00074; UER00127.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:InterPro.
GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
Gene3D; 3.30.1490.20; -; 1.
HAMAP; MF_01643; PurT; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR003135; ATP-grasp_carboxylate-amine.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR016185; PreATP-grasp_dom_sf.
InterPro; IPR005862; PurT.
InterPro; IPR011054; Rudment_hybrid_motif.
Pfam; PF02222; ATP-grasp; 1.
SUPFAM; SSF51246; SSF51246; 1.
SUPFAM; SSF52440; SSF52440; 1.
TIGRFAMs; TIGR01142; purT; 1.
PROSITE; PS50975; ATP_GRASP; 1.
3: Inferred from homology;
ATP-binding; Magnesium; Metal-binding; Nucleotide-binding;
Purine biosynthesis; Transferase.
CHAIN 1 386 Formate-dependent
phosphoribosylglycinamide
formyltransferase.
/FTId=PRO_0000319167.
DOMAIN 112 301 ATP-grasp. {ECO:0000255|HAMAP-
Rule:MF_01643}.
NP_BIND 153 158 ATP. {ECO:0000255|HAMAP-Rule:MF_01643}.
NP_BIND 188 191 ATP. {ECO:0000255|HAMAP-Rule:MF_01643}.
REGION 15 16 5'-phosphoribosylglycinamide binding.
{ECO:0000255|HAMAP-Rule:MF_01643}.
REGION 356 357 5'-phosphoribosylglycinamide binding.
{ECO:0000255|HAMAP-Rule:MF_01643}.
METAL 260 260 Magnesium. {ECO:0000255|HAMAP-
Rule:MF_01643}.
METAL 272 272 Magnesium. {ECO:0000255|HAMAP-
Rule:MF_01643}.
BINDING 75 75 5'-phosphoribosylglycinamide.
{ECO:0000255|HAMAP-Rule:MF_01643}.
BINDING 107 107 ATP. {ECO:0000255|HAMAP-Rule:MF_01643}.
BINDING 148 148 ATP. {ECO:0000255|HAMAP-Rule:MF_01643}.
BINDING 196 196 ATP. {ECO:0000255|HAMAP-Rule:MF_01643}.
BINDING 279 279 5'-phosphoribosylglycinamide.
{ECO:0000255|HAMAP-Rule:MF_01643}.
BINDING 349 349 5'-phosphoribosylglycinamide.
{ECO:0000255|HAMAP-Rule:MF_01643}.
SEQUENCE 386 AA; 42533 MW; 9D6A2E489F931F45 CRC64;
MNISNIKIML LGSGELGKEF IIAAQRLGIH TIAVDRYKNA PAMQVAHESY VIDMLNSDAL
EQLILAKNPT YIVPEIEAIN TDSLVKLEAH NFNIIPCAKA TKLTMDRQGI RALAVQQLNL
QTSKFAFANS EQEYLDVIQS IGLPFVIKPV MSSSGKGQSI VKEHNEIKKA WDYAQNGSRG
HAKGVIVEQF IDFDYEITLL TVRHKDGTSF CDPIGHIQKD GDYRFSWQPH TMPDTALAKS
QEIAKEITDA LGGYGVFGVE LFIKGDEVFF NEVSPRPHDT GMVTLISQNI NEFELHLRAI
VGLPIPDIQT LQPSASAAIL LEGDTANASI CGIDKALADA NVDIRIFSKK EIHGKRRMGV
VLAKAQNTHI ALETSKQALA HIHLTK


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