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Frequency clock protein

 FRQ_NEUCR               Reviewed;         989 AA.
P19970; Q01276; Q7RVB1; V5IKG2; V5IL36;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
07-JUN-2005, sequence version 3.
28-FEB-2018, entry version 111.
RecName: Full=Frequency clock protein;
Name=frq; ORFNames=B13D24.170, NCU02265;
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
1257 / FGSC 987).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
Neurospora.
NCBI_TaxID=367110;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS OF GLU-364; GLY-459;
GLY-482 AND ALA-895.
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=8052643; DOI=10.1073/pnas.91.16.7683;
Aronson B.D., Johnson K.A., Dunlap J.C.;
"Circadian clock locus frequency: protein encoded by a single open
reading frame defines period length and temperature compensation.";
Proc. Natl. Acad. Sci. U.S.A. 91:7683-7687(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=12655011; DOI=10.1093/nar/gkg293;
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V.,
Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J.,
Schulte U.;
"What's in the genome of a filamentous fungus? Analysis of the
Neurospora genome sequence.";
Nucleic Acids Res. 31:1944-1954(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=12712197; DOI=10.1038/nature01554;
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-989.
PubMed=2525233; DOI=10.1038/339558a0;
McClung C.R., Fox B.A., Dunlap J.C.;
"The Neurospora clock gene frequency shares a sequence element with
the Drosophila clock gene period.";
Nature 339:558-562(1989).
[5]
PHOSPHORYLATION AT THR-501; SER-513 AND SER-519, AND MUTAGENESIS OF
501-THR--SER-503; 513-SER-THR-514 AND SER-519.
PubMed=10618401; DOI=10.1073/pnas.97.1.234;
Liu Y., Loros J., Dunlap J.C.;
"Phosphorylation of the Neurospora clock protein frequency determines
its degradation rate and strongly influences the period length of the
circadian clock.";
Proc. Natl. Acad. Sci. U.S.A. 97:234-239(2000).
[6]
PHOSPHORYLATION BY CK2.
PubMed=11959847; DOI=10.1101/gad.965102;
Yang Y., Cheng P., Liu Y.;
"Regulation of the Neurospora circadian clock by casein kinase II.";
Genes Dev. 16:994-1006(2002).
-!- FUNCTION: Circadian clock component involved in the generation of
biological rhythms, in particular in rhythm stability, period
length, and temperature compensation. Oscillates in abundance with
a daily peak early in the morning. Behaves as a negative element
in circadian transcriptional loop. May bind to wc-2 protein. The
complex frq-wc-2 may turn off the expression of frq.
-!- INTERACTION:
Q873J5:B9B11.040 (xeno); NbExp=2; IntAct=EBI-6995022, EBI-15874858;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=2;
Name=Long;
IsoId=P19970-1; Sequence=Displayed;
Note=Maintains rhythms at high temperature (30 degrees
Celsius).;
Name=Short;
IsoId=P19970-2; Sequence=VSP_018781;
Note=Maintains rhythms at lower temperature (18 degrees
Celsius).;
-!- INDUCTION: By light; perhaps through white collar-1 (wc-1) and
white collar-2 (wc-2). Also activated directly by wc-1 and wc-2.
-!- PTM: Progressive phosphorylation during the late circadian day and
early night. Phosphorylation is also involved in regulating frq
degradation. Phosphorylation by CKII may have at least three
functions; it decreases the stability of frq, reduces the protein
complex formation between frq and the white collar proteins, and
is important for the closing of the Neurospora circadian negative
feedback loop. {ECO:0000269|PubMed:10618401,
ECO:0000269|PubMed:11959847}.
-!- SIMILARITY: Belongs to the FRQ family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=Ref.4; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; U17073; AAA57121.1; -; mRNA.
EMBL; BX908789; CAF05882.1; -; Genomic_DNA.
EMBL; CM002242; ESA42013.1; -; Genomic_DNA.
EMBL; CM002242; ESA42014.1; -; Genomic_DNA.
EMBL; CM002242; ESA42015.1; -; Genomic_DNA.
PIR; T46659; T46659.
RefSeq; XP_011395124.1; XM_011396822.1. [P19970-2]
RefSeq; XP_011395125.1; XM_011396823.1. [P19970-1]
RefSeq; XP_011395126.1; XM_011396824.1. [P19970-1]
DIP; DIP-41987N; -.
IntAct; P19970; 2.
MINT; P19970; -.
iPTMnet; P19970; -.
EnsemblFungi; ESA42013; ESA42013; NCU02265. [P19970-1]
EnsemblFungi; ESA42014; ESA42014; NCU02265. [P19970-1]
EnsemblFungi; ESA42015; ESA42015; NCU02265. [P19970-2]
GeneID; 3876095; -.
KEGG; ncr:NCU02265; -.
EuPathDB; FungiDB:NCU02265; -.
InParanoid; P19970; -.
OMA; MDYIRHL; -.
OrthoDB; EOG092C1TPI; -.
Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
GO; GO:0005737; C:cytoplasm; IEA:InterPro.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR018554; FRQ.
Pfam; PF09421; FRQ; 1.
1: Evidence at protein level;
Alternative initiation; Biological rhythms; Complete proteome;
Nucleus; Phosphoprotein; Reference proteome; Transcription;
Transcription regulation.
CHAIN 1 989 Frequency clock protein.
/FTId=PRO_0000021288.
MOTIF 564 568 Nuclear localization signal.
{ECO:0000255}.
COMPBIAS 244 250 Poly-Ser.
COMPBIAS 862 888 Asp/Glu-rich (acidic).
MOD_RES 501 501 Phosphothreonine.
{ECO:0000269|PubMed:10618401}.
MOD_RES 513 513 Phosphoserine.
{ECO:0000269|PubMed:10618401}.
MOD_RES 519 519 Phosphoserine.
{ECO:0000269|PubMed:10618401}.
VAR_SEQ 1 99 Missing (in isoform Short).
{ECO:0000305}.
/FTId=VSP_018781.
MUTAGEN 364 364 E->K: In FRQ3; lengthened period.
{ECO:0000269|PubMed:8052643}.
MUTAGEN 459 459 G->D: In FRQ7; lengthened period.
{ECO:0000269|PubMed:8052643}.
MUTAGEN 482 482 G->S: In FRQ1; shortened period.
{ECO:0000269|PubMed:8052643}.
MUTAGEN 501 503 TPS->APG: In FRQ10; no effect.
{ECO:0000269|PubMed:10618401}.
MUTAGEN 513 514 ST->RA: In FRQ10; strong reduction in the
degradation rate; lengthened period.
{ECO:0000269|PubMed:10618401}.
MUTAGEN 513 513 S->D: In FRQ10; reduces phosphorylation;
slight reduction in the degradation rate;
loss of rhythmicity.
MUTAGEN 513 513 S->I: In FRQ10; reduces phosphorylation;
strong reduction in the degradation rate;
lengthened period.
MUTAGEN 519 519 S->A: In FRQ10; no effect.
{ECO:0000269|PubMed:10618401}.
MUTAGEN 663 989 Missing: In FRQ9; loss of rhythmicity.
MUTAGEN 895 895 A->T: In FRQ2; shortened period.
{ECO:0000269|PubMed:8052643}.
CONFLICT 146 146 S -> T (in Ref. 1; AAA57121).
{ECO:0000305}.
CONFLICT 202 207 EATLRD -> MGGNRP (in Ref. 4).
{ECO:0000305}.
CONFLICT 207 207 D -> H (in Ref. 1; AAA57121).
{ECO:0000305}.
CONFLICT 233 233 H -> Y (in Ref. 1; AAA57121).
{ECO:0000305}.
CONFLICT 962 963 ML -> IV (in Ref. 1; AAA57121 and 4).
{ECO:0000305}.
SEQUENCE 989 AA; 108200 MW; EC4E984FAD39F095 CRC64;
MADSGDKSQG MRPPPFDSRG HPLPRRASPD KSITLENHRL ARDTSSRVTS SSALGVTESQ
PQLKSSPTRR NSSGESEPTN WFNQSNRNPA AAFHDESHIM EVDPPFYQKE TDSSNEESRY
PPGRNPVHPP GGVQLPGFRP VAAHSSAADD YRSVIDDLTV ENKRLKEELK RYKQFGSDVM
RKEKLFEIKV HGLPRRKKRE LEATLRDFAA SLGDSSESTS QRRKTGRHGT AVHSSGVSLS
KHDSSSSSRS RPVDSAYNSM STGRSSHAPH SSGPSLGRPS LTRAKSVGTQ KVENYLRDTP
DGLLPHHIVM TDKEKKKLVV RRLEQLFTGK ISGRNMQRNQ SMPSMDAPLA PEGTNMAPPR
PPPEGLREAC IQLQDGDNPR KNRSSKDNGS ASNSGGDQTE LGGTGTGSGD GSGSGGRTGN
NTSPPGAIAP DQRPTRPRDL DPDRVQIPSE NMDYIRHLGL VSPEFLQGSR TSYQDVAPDA
EGWVYLNLLC NLAQLHMVNV TPSFIRQAVS EKSTKFQLSA DGRKIRWRGG TDGTKFSSDS
SEDKSQQSPM TEDTEDGSDK NGRRKKRKTQ QASSEIGRFG PSRSPSDTFH YKPMFVHRNS
SSIETSLEES MSQGSEDAVD ESNMGNSKWD FSGSGTTQQR RKRRYDGAIV YYTGAPFCTD
LSGDPGDMSP TAQMTAGREV EGSGSGDEVE HVLQRTLSGS SLPIRPLSDD RARVAEVLDF
DPGNPPELVA DDGSSPNDED FVFPWCEDPA KVRIQPIAKE VMEPSGLGGV LPDDHFVMLV
TTRRVVRPIL QRQLSRSTTS EDTAEFIAER LAAIRTSSPL PPRSHRLTVA PLQVEYVSGQ
FRRLNPAPLP PPAIFYPPFS TDSSWDDGDD LASDDEEVEE VEEDSYSEGQ ISRRANPHFS
DNNTYMRKDD LAFDTETDVR MDSDDNRLSD SGHNMRAMMP RAEAVDGDDS PLAAVTGKEV
DMLHTGSSVA TAGGAESGYS SSMEDVSSS


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