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G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K( ) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6)

 KCNJ6_RAT               Reviewed;         425 AA.
P48550;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
10-MAY-2017, entry version 128.
RecName: Full=G protein-activated inward rectifier potassium channel 2;
Short=GIRK-2;
AltName: Full=BIR1;
AltName: Full=Inward rectifier K(+) channel Kir3.2;
AltName: Full=KATP-2;
AltName: Full=Potassium channel, inwardly rectifying subfamily J member 6;
Name=Kcnj6; Synonyms=Girk2, Kcnj7;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=7601286; DOI=10.1016/0014-5793(95)00497-W;
Bond C.T., Aemmaelae C., Ashfield R., Blair T.A., Gribble F.,
Khan R.N., Lee K., Proks P., Rowe I.C.M., Sakura H., Ashford M.J.,
Adelman J.P., Ashcroft F.M.;
"Cloning and functional expression of the cDNA encoding an inwardly-
rectifying potassium channel expressed in pancreatic beta-cells and in
the brain.";
FEBS Lett. 367:61-66(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7626127; DOI=10.1006/bbrc.1995.2053;
Stoffel M., Tokuyama Y., Trabb J.B., German M.S., Tsaar M.L.,
Jan L.Y., Polonsky K.S., Bell G.I.;
"Cloning of rat KATP-2 channel and decreased expression in pancreatic
islets of male Zucker diabetic fatty rats.";
Biochem. Biophys. Res. Commun. 212:894-899(1995).
[3]
INTERACTION WITH SNX27.
PubMed=17828261; DOI=10.1038/nn1953;
Lunn M.L., Nassirpour R., Arrabit C., Tan J., McLeod I., Arias C.M.,
Sawchenko P.E., Yates J.R. III, Slesinger P.A.;
"A unique sorting nexin regulates trafficking of potassium channels
via a PDZ domain interaction.";
Nat. Neurosci. 10:1249-1259(2007).
-!- FUNCTION: This potassium channel is controlled by G proteins. It
may be involved in the regulation of insulin secretion by glucose
and/or neurotransmitters. Inward rectifier potassium channels are
characterized by a greater tendency to allow potassium to flow
into the cell rather than out of it. Their voltage dependence is
regulated by the concentration of extracellular potassium; as
external potassium is raised, the voltage range of the channel
opening shifts to more positive voltages. The inward rectification
is mainly due to the blockage of outward current by internal
magnesium. Can be blocked by external barium or cesium.
-!- SUBUNIT: Associates with GIRK1 or GIRK4 to form a G-protein-
activated heteromultimer pore-forming unit. The resulting inward
current is much larger (By similarity). Interacts (via PDZ-binding
motif) with SNX27 (via PDZ domain); the interaction is required
for recycling to the plasma membrane when endocytosed and prevent
degradation in lysosomes. {ECO:0000250,
ECO:0000269|PubMed:17828261}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Pancreatic beta cells and brain.
-!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
(TC 1.A.2.1) family. KCNJ6 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X83583; CAA58566.1; -; mRNA.
EMBL; U21087; AAA87002.1; -; mRNA.
PIR; S66266; S52852.
RefSeq; NP_037324.1; NM_013192.2.
UniGene; Rn.10185; -.
ProteinModelPortal; P48550; -.
SMR; P48550; -.
STRING; 10116.ENSRNOP00000059308; -.
iPTMnet; P48550; -.
PhosphoSitePlus; P48550; -.
PaxDb; P48550; -.
PRIDE; P48550; -.
GeneID; 25743; -.
KEGG; rno:25743; -.
UCSC; RGD:2959; rat.
CTD; 3763; -.
RGD; 2959; Kcnj6.
eggNOG; KOG3827; Eukaryota.
eggNOG; ENOG410XQ62; LUCA.
HOGENOM; HOG000237325; -.
HOVERGEN; HBG006178; -.
InParanoid; P48550; -.
KO; K05000; -.
PhylomeDB; P48550; -.
PRO; PR:P48550; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0009986; C:cell surface; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0032809; C:neuronal cell body membrane; IDA:RGD.
GO; GO:0015467; F:G-protein activated inward rectifier potassium channel activity; IEA:InterPro.
GO; GO:0001965; F:G-protein alpha-subunit binding; IDA:RGD.
GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
GO; GO:0071315; P:cellular response to morphine; IEP:RGD.
GO; GO:0010107; P:potassium ion import; IBA:GO_Central.
GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
Gene3D; 2.60.40.1400; -; 1.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR016449; K_chnl_inward-rec_Kir.
InterPro; IPR003275; K_chnl_inward-rec_Kir3.2.
InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
PANTHER; PTHR11767; PTHR11767; 1.
PANTHER; PTHR11767:SF88; PTHR11767:SF88; 1.
Pfam; PF01007; IRK; 1.
PIRSF; PIRSF005465; GIRK_kir; 1.
PRINTS; PR01328; KIR32CHANNEL.
PRINTS; PR01320; KIRCHANNEL.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
Complete proteome; Ion channel; Ion transport; Membrane;
Phosphoprotein; Potassium; Potassium transport; Reference proteome;
Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
CHAIN 1 425 G protein-activated inward rectifier
potassium channel 2.
/FTId=PRO_0000154946.
TOPO_DOM 1 91 Cytoplasmic. {ECO:0000250}.
TRANSMEM 92 116 Helical; Name=M1. {ECO:0000250}.
TOPO_DOM 117 140 Extracellular. {ECO:0000250}.
INTRAMEM 141 152 Helical; Pore-forming; Name=H5.
{ECO:0000250}.
INTRAMEM 153 159 Pore-forming. {ECO:0000250}.
TOPO_DOM 160 168 Extracellular. {ECO:0000250}.
TRANSMEM 169 190 Helical; Name=M2. {ECO:0000250}.
TOPO_DOM 191 425 Cytoplasmic. {ECO:0000250}.
MOTIF 154 159 Selectivity filter. {ECO:0000250}.
MOTIF 422 425 PDZ-binding.
SITE 184 184 Role in the control of polyamine-mediated
channel gating and in the blocking by
intracellular magnesium. {ECO:0000250}.
MOD_RES 18 18 Phosphoserine.
{ECO:0000250|UniProtKB:P48542}.
MOD_RES 25 25 Phosphoserine.
{ECO:0000250|UniProtKB:P48542}.
CONFLICT 328 328 V -> I (in Ref. 2; AAA87002).
{ECO:0000305}.
CONFLICT 360 360 H -> Y (in Ref. 2; AAA87002).
{ECO:0000305}.
SEQUENCE 425 AA; 48640 MW; 66CE9599A4AE38D3 CRC64;
MTMAKLTESM TNVLEGDSMD QDVESPVAIH QPKLPKQARD DLPRHISRDR TKRKIQRYVR
KDGKCNVHHG NVRETYRYLT DIFTTLVDLK WRFNLLIFVM VYTVTWLFFG MIWWLIAYIR
GDMDHIEDPS WTPCVTNLNG FVSAFLFSIE TETTIGYGYR VITDKCPEGI ILLLIQSVLG
SIVNAFMVGC MFVKISQPKK RAETLVFSTH AVISMRDGKL CLMFRVGDLR NSHIVEASIR
AKLIKSKQTS EGEFIPLNQT DINVGYYTGD DRLFLVSPLI ISHEINQQSP FWEISKAQLP
KEELEIVVIL EGMVEATGMT CQARSSYVTS EILWGYRFTP VLTLEDGFYE VDYNSFHETH
ETSTPSLSAK ELAELANRAE LPLSWSVSSK LNQHAELETE EEEKNPEELT ERNGDVANLE
NESKV


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