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G protein-coupled receptor kinase (EC 2.7.11.-)

 Q3TST4_MOUSE            Unreviewed;       590 AA.
Q3TST4;
11-OCT-2005, integrated into UniProtKB/TrEMBL.
11-OCT-2005, sequence version 1.
28-MAR-2018, entry version 129.
RecName: Full=G protein-coupled receptor kinase {ECO:0000256|RuleBase:RU000308};
EC=2.7.11.- {ECO:0000256|RuleBase:RU000308};
Name=Grk5 {ECO:0000313|MGI:MGI:109161};
Synonyms=Gprk5 {ECO:0000313|MGI:MGI:109161};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE36591.1};
[1] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1}, and
Testis {ECO:0000313|EMBL:BAE36591.1};
PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
Carninci P., Hayashizaki Y.;
"High-efficiency full-length cDNA cloning.";
Methods Enzymol. 303:19-44(1999).
[2] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1}, and
Testis {ECO:0000313|EMBL:BAE36591.1};
PubMed=11042159; DOI=10.1101/gr.145100;
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
"Normalization and subtraction of cap-trapper-selected cDNAs to
prepare full-length cDNA libraries for rapid discovery of new genes.";
Genome Res. 10:1617-1630(2000).
[3] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1}, and
Testis {ECO:0000313|EMBL:BAE36591.1};
PubMed=11076861; DOI=10.1101/gr.152600;
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
"RIKEN integrated sequence analysis (RISA) system--384-format
sequencing pipeline with 384 multicapillary sequencer.";
Genome Res. 10:1757-1771(2000).
[4] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1}, and
Testis {ECO:0000313|EMBL:BAE36591.1};
PubMed=11217851; DOI=10.1038/35055500;
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
"Functional annotation of a full-length mouse cDNA collection.";
Nature 409:685-690(2001).
[5] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1}, and
Testis {ECO:0000313|EMBL:BAE36591.1};
PubMed=12466851; DOI=10.1038/nature01266;
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
"Analysis of the mouse transcriptome based on functional annotation of
60,770 full-length cDNAs.";
Nature 420:563-573(2002).
[6] {ECO:0000313|EMBL:BAE22411.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE22411.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
Muramatsu M., Hayashizaki Y.;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Testis {ECO:0000313|EMBL:BAE36591.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
Muramatsu M., Hayashizaki Y.;
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1}, and
Testis {ECO:0000313|EMBL:BAE36591.1};
The FANTOM Consortium;
Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
"The Transcriptional Landscape of the Mammalian Genome.";
Science 309:1559-1563(2005).
[9] {ECO:0000313|EMBL:BAE36591.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36591.1};
TISSUE=Olfactory brain {ECO:0000313|EMBL:BAE22411.1}, and
Testis {ECO:0000313|EMBL:BAE36591.1};
PubMed=16141073; DOI=10.1126/science.1112009;
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
"Antisense Transcription in the Mammalian Transcriptome.";
Science 309:1564-1566(2005).
[10] {ECO:0000213|PubMed:17242355}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[11] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
protein kinase family. GPRK subfamily.
{ECO:0000256|RuleBase:RU000308}.
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EMBL; AK135076; BAE22411.1; -; mRNA.
EMBL; AK161821; BAE36591.1; -; mRNA.
RefSeq; NP_061357.3; NM_018869.3.
UniGene; Mm.279400; -.
UniGene; Mm.482751; -.
GeneID; 14773; -.
KEGG; mmu:14773; -.
CTD; 2869; -.
MGI; MGI:109161; Grk5.
eggNOG; KOG0986; Eukaryota.
eggNOG; ENOG410YRQZ; LUCA.
HOVERGEN; HBG004532; -.
KO; K08291; -.
OMA; GCFPFRR; -.
OrthoDB; EOG091G062G; -.
Bgee; ENSMUSG00000003228; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0047696; F:beta-adrenergic receptor kinase activity; IEA:Ensembl.
GO; GO:0004703; F:G-protein coupled receptor kinase activity; IEA:InterPro.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
GO; GO:0007217; P:tachykinin receptor signaling pathway; IEA:Ensembl.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR000239; GPCR_kinase.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR016137; RGS.
InterPro; IPR036305; RGS_sf.
Pfam; PF00069; Pkinase; 1.
Pfam; PF00615; RGS; 1.
PRINTS; PR00717; GPCRKINASE.
SMART; SM00315; RGS; 1.
SMART; SM00133; S_TK_X; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF48097; SSF48097; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS50132; RGS; 1.
1: Evidence at protein level;
ATP-binding {ECO:0000256|RuleBase:RU000308,
ECO:0000256|SAAS:SAAS00593399};
Kinase {ECO:0000256|RuleBase:RU000308, ECO:0000256|SAAS:SAAS00593706};
Nucleotide-binding {ECO:0000256|RuleBase:RU000308,
ECO:0000256|SAAS:SAAS00593399};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000308,
ECO:0000256|SAAS:SAAS00593706};
Transferase {ECO:0000256|RuleBase:RU000308,
ECO:0000256|SAAS:SAAS00593706}.
DOMAIN 59 171 RGS. {ECO:0000259|PROSITE:PS50132}.
DOMAIN 186 448 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 449 514 AGC-kinase C-terminal.
{ECO:0000259|PROSITE:PS51285}.
ACT_SITE 311 311 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR600239-51}.
SEQUENCE 590 AA; 67732 MW; F47D87397B1A2399 CRC64;
MELENIVANT VLLKAREGGG GKRKGKSKKW KEILKFPHIS QCEDLRRTID RDYYSLCDKQ
PIGRLLFRQF CETRPGLECY IQFLDLVAEY EITPDENLGA KGKEIMTKYL TPKSPVFIAQ
VGQDLVSQTE KKLLQSPCKE LFSACAQSVH DYLKGDPFHE YLDSMYFDRF LQWKWLERQP
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKRLEKK RIKKRKGESM ALNEKQILEK
VNSQFVVNLA YAYETKDALC LVLTIMNGGD LKFHIYNMGN PGFEEERALF YAAEILCGLE
DLHRENTVYR DLKPENILLD DYGHIRISDL GLAVKIPEGD LIRGRVGTVG YMAPEVLNNQ
RYGLSPDYWG LGCLIYEMIE GQSPFRGRKE KVKREEVDRR VLETEEVYSS KFSEEAKSIC
NMLLTKDSKQ RLGCQEEGAA EVKRHPFFRN MNFKRLEAGM LDPPFVPDPR AVYCKDVLDI
EQFSTVKGVN LDHTDDDFYS KFSTGSVPIP WQNEMIETEC FKELNVFGPN GTLSPDLNRS
QPPEPPKKGL FHRLFRRQHQ SNSKSSPTPK TSCNHRINSN HINSNSTGSS


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