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G-protein coupled estrogen receptor 1 (G protein-coupled estrogen receptor 1) (G-protein coupled receptor 30)

 GPER1_MICUN             Reviewed;         354 AA.
B0F9W3;
11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
26-FEB-2008, sequence version 1.
18-JUL-2018, entry version 41.
RecName: Full=G-protein coupled estrogen receptor 1;
AltName: Full=G protein-coupled estrogen receptor 1;
AltName: Full=G-protein coupled receptor 30;
Name=gper1;
Micropogonias undulatus (Atlantic croaker).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Eupercaria; Sciaenidae; Micropogonias.
NCBI_TaxID=29154;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ESTROGEN-BINDING,
BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=18420744; DOI=10.1210/en.2007-1663;
Pang Y., Dong J., Thomas P.;
"Estrogen signaling characteristics of Atlantic croaker G protein-
coupled receptor 30 (GPR30) and evidence it is involved in maintenance
of oocyte meiotic arrest.";
Endocrinology 149:3410-3426(2008).
[2]
FUNCTION, ESTROGEN-BINDING, AND BIOPHYSICOCHEMICAL PROPERTIES.
PubMed=19931550; DOI=10.1016/j.steroids.2009.11.005;
Thomas P., Alyea R., Pang Y., Peyton C., Dong J., Berg A.H.;
"Conserved estrogen binding and signaling functions of the G protein-
coupled estrogen receptor 1 (GPER) in mammals and fish.";
Steroids 75:595-602(2010).
-!- FUNCTION: Membrane G-protein coupled estrogen receptor that binds
to 17-beta-estradiol (E2) with high affinity, leading to rapid and
transient activation of numerous intracellular signaling pathways.
Plays a role in the embryonic development of sensory and motor
neurons. May induce apoptosis and reduce proliferation of brain
cells. Involved in maintenance of meiotic arrest in oocytes.
{ECO:0000269|PubMed:18420744, ECO:0000269|PubMed:19931550}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
Note=Binds 17-beta-estradiol (E2) in plasma membranes with high
affinity and displays rapid kinetics of association and
dissociation. {ECO:0000269|PubMed:18420744,
ECO:0000269|PubMed:19931550};
-!- SUBUNIT: Homodimer. Heterodimer (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm,
perinuclear region {ECO:0000250}. Cytoplasm {ECO:0000250}.
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle
membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Cell membrane {ECO:0000269|PubMed:18420744}; Multi-pass membrane
protein {ECO:0000269|PubMed:18420744}. Basolateral cell membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane
protein {ECO:0000250}. Early endosome {ECO:0000250}. Recycling
endosome {ECO:0000250}. Golgi apparatus, trans-Golgi network
{ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Cell projection, dendrite
{ECO:0000250}. Cell projection, dendritic spine membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell
projection, axon {ECO:0000250}. Cell junction, synapse,
postsynaptic cell membrane, postsynaptic density {ECO:0000250}.
Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein
{ECO:0000250}. Note=Colocalized with cadherin at the plasma
membrane.
-!- TISSUE SPECIFICITY: Expressed in oocytes (at protein level).
Highly expressed in brain, heart, testis and ovary. Weakly
expressed in muscle and intestine. {ECO:0000269|PubMed:18420744}.
-!- DEVELOPMENTAL STAGE: Expressed during oocyte development.
{ECO:0000269|PubMed:18420744}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
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EMBL; EU274298; ABY51613.1; -; mRNA.
ProteinModelPortal; B0F9W3; -.
PRIDE; B0F9W3; -.
HOVERGEN; HBG005351; -.
GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0005496; F:steroid binding; IDA:UniProtKB.
GO; GO:1990239; F:steroid hormone binding; IDA:UniProtKB.
GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0071392; P:cellular response to estradiol stimulus; IDA:UniProtKB.
GO; GO:0071371; P:cellular response to gonadotropin stimulus; IDA:UniProtKB.
GO; GO:0051447; P:negative regulation of meiotic cell cycle; IDA:UniProtKB.
GO; GO:1900194; P:negative regulation of oocyte maturation; IDA:UniProtKB.
GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO; GO:0043401; P:steroid hormone mediated signaling pathway; IDA:UniProtKB.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Apoptosis; Cell cycle; Cell junction; Cell membrane; Cell projection;
Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Developmental protein;
Differentiation; Disulfide bond; Endoplasmic reticulum; Endosome;
G-protein coupled receptor; Golgi apparatus; Membrane; Mitochondrion;
Neurogenesis; Nucleus; Postsynaptic cell membrane; Receptor; Synapse;
Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 354 G-protein coupled estrogen receptor 1.
/FTId=PRO_0000424545.
TOPO_DOM 1 40 Extracellular. {ECO:0000255}.
TRANSMEM 41 61 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 62 81 Cytoplasmic. {ECO:0000255}.
TRANSMEM 82 102 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 103 112 Extracellular. {ECO:0000255}.
TRANSMEM 113 133 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 134 160 Cytoplasmic. {ECO:0000255}.
TRANSMEM 161 181 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 182 202 Extracellular. {ECO:0000255}.
TRANSMEM 203 223 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 224 245 Cytoplasmic. {ECO:0000255}.
TRANSMEM 246 266 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 267 292 Extracellular. {ECO:0000255}.
TRANSMEM 293 313 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 314 353 Cytoplasmic. {ECO:0000255}.
DISULFID 115 192 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 354 AA; 40771 MW; FBDBCDA55E965D8E CRC64;
MEEQTTSLVW IYVNSTEQLN TSYEYNTTYL IEDSDKYQSY VIGLFLSCLY TILLFPIGFI
GNILILVVNL NHRGKMAIPD LYFVNLAVAD LILVADSLIE VFNLNEKYYD YAVLCTFMSL
FLQVNMYSSI FFLTWMSFDR YIALANSMSS SPLRTMQHAK LSCGLIWMAS ILATLLPFTI
VQTQHRGEVH FCFANVFEIQ WLEVTIGFLV PFSIIGLCYS LIGRILMRSQ KHRGLWPRRQ
KALRMIVVVV LVFFICWLPE NVFISIQLLQ GTADPSQRTA TTLRHDYPLT GHIVNLAAFS
NSCLNPIIYS FLGETFRDKL RLFIKQKASW SVVNRFCHHG LDLHLPVRSE VSEV


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