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G2/mitotic-specific cyclin-B1

 CCNB1_RAT               Reviewed;         423 AA.
P30277;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
18-JUL-2018, entry version 153.
RecName: Full=G2/mitotic-specific cyclin-B1;
Name=Ccnb1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Kanaoka Y., Nojima H., Okayama H.;
"Nucleotide sequences of cDNAs encoding rat cdc2 + and cyclin 2.";
Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Fibroblast;
PubMed=8270434;
Markiewicz D.A., McKenna W.G., Flick M.B., Maity A., Muschel R.J.;
"The effects of radiation on the expression of a newly cloned and
characterized rat cyclin B mRNA.";
Int. J. Radiat. Oncol. Biol. Phys. 28:135-144(1994).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Testis;
PubMed=8123599;
Trembley J.H., Kren B.T., Steer C.J.;
"Posttranscriptional regulation of cyclin B messenger RNA expression
in the regenerating rat liver.";
Cell Growth Differ. 5:99-108(1994).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pituitary;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Essential for the control of the cell cycle at the G2/M
(mitosis) transition.
-!- SUBUNIT: Interacts with the CDC2 protein kinase to form a
serine/threonine kinase holoenzyme complex also known as
maturation promoting factor (MPF). The cyclin subunit imparts
substrate specificity to the complex. Binds HEI10. Interacts with
catalytically active RALBP1 and CDC2 during mitosis to form an
endocytotic complex during interphase. Interacts with CCNF;
interaction is required for nuclear localization. Interacts with
CDK5RAP3. Interacts with RFPL4A and UBE2A.
{ECO:0000250|UniProtKB:P14635, ECO:0000250|UniProtKB:P24860}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome {ECO:0000250}.
-!- DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is
abruptly destroyed at mitosis.
-!- PTM: Ubiquitinated by the SCF(NIPA) complex during interphase,
leading to its destruction. Not ubiquitinated during G2/M phases
(By similarity). {ECO:0000250}.
-!- PTM: Phosphorylated by PLK1 at Ser-123 on centrosomes during
prophase: phosphorylation by PLK1 does not cause nuclear import.
Phosphorylation at Ser-137 was also reported to be mediated by
PLK1 but Ser-123 seems to be the primary phosphorylation site (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X60768; CAA43178.1; -; mRNA.
EMBL; X64589; CAA45877.1; -; mRNA.
EMBL; L11995; AAC00032.1; -; mRNA.
EMBL; BC059113; AAH59113.1; -; mRNA.
PIR; S34226; S34226.
RefSeq; NP_741988.1; NM_171991.3.
UniGene; Rn.9232; -.
ProteinModelPortal; P30277; -.
SMR; P30277; -.
ComplexPortal; CPX-2072; Cyclin B1-CDK1 complex.
CORUM; P30277; -.
IntAct; P30277; 1.
STRING; 10116.ENSRNOP00000025297; -.
BindingDB; P30277; -.
ChEMBL; CHEMBL2093; -.
iPTMnet; P30277; -.
PhosphoSitePlus; P30277; -.
PaxDb; P30277; -.
PRIDE; P30277; -.
Ensembl; ENSRNOT00000082846; ENSRNOP00000075114; ENSRNOG00000058539.
GeneID; 25203; -.
KEGG; rno:25203; -.
UCSC; RGD:2291; rat.
CTD; 891; -.
RGD; 2291; Ccnb1.
eggNOG; KOG0653; Eukaryota.
eggNOG; COG5024; LUCA.
GeneTree; ENSGT00760000118939; -.
HOGENOM; HOG000167672; -.
HOVERGEN; HBG061650; -.
InParanoid; P30277; -.
KO; K05868; -.
OMA; HMTVKNK; -.
OrthoDB; EOG091G0E9B; -.
PhylomeDB; P30277; -.
TreeFam; TF101001; -.
Reactome; R-RNO-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
Reactome; R-RNO-176408; Regulation of APC/C activators between G1/S and early anaphase.
Reactome; R-RNO-176412; Phosphorylation of the APC/C.
Reactome; R-RNO-176417; Phosphorylation of Emi1.
Reactome; R-RNO-2299718; Condensation of Prophase Chromosomes.
Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
Reactome; R-RNO-2565942; Regulation of PLK1 Activity at G2/M Transition.
Reactome; R-RNO-2980767; Activation of NIMA Kinases NEK9, NEK6, NEK7.
Reactome; R-RNO-3301854; Nuclear Pore Complex (NPC) Disassembly.
Reactome; R-RNO-4419969; Depolymerisation of the Nuclear Lamina.
Reactome; R-RNO-6804114; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.
Reactome; R-RNO-68875; Mitotic Prophase.
Reactome; R-RNO-69273; Cyclin A/B1/B2 associated events during G2/M transition.
Reactome; R-RNO-69478; G2/M DNA replication checkpoint.
Reactome; R-RNO-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
Reactome; R-RNO-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint.
Reactome; R-RNO-8878166; Transcriptional regulation by RUNX2.
PRO; PR:P30277; -.
Proteomes; UP000002494; Chromosome 2.
Bgee; ENSRNOG00000058539; -.
Genevisible; P30277; RN.
GO; GO:0005813; C:centrosome; ISS:UniProtKB.
GO; GO:0000942; C:condensed nuclear chromosome outer kinetochore; IEA:Ensembl.
GO; GO:0097125; C:cyclin B1-CDK1 complex; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0016020; C:membrane; IEA:Ensembl.
GO; GO:0005759; C:mitochondrial matrix; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0000922; C:spindle pole; IEA:Ensembl.
GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:Ensembl.
GO; GO:0016301; F:kinase activity; IEA:Ensembl.
GO; GO:0005113; F:patched binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IPI:RGD.
GO; GO:0044389; F:ubiquitin-like protein ligase binding; IEA:Ensembl.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0071398; P:cellular response to fatty acid; IEP:RGD.
GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
GO; GO:0071283; P:cellular response to iron(III) ion; IEP:RGD.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
GO; GO:0048565; P:digestive tract development; IEP:RGD.
GO; GO:2000775; P:histone H3-S10 phosphorylation involved in chromosome condensation; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0000278; P:mitotic cell cycle; IEP:RGD.
GO; GO:0007080; P:mitotic metaphase plate congression; IEA:Ensembl.
GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IMP:RGD.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD.
GO; GO:0001556; P:oocyte maturation; IMP:RGD.
GO; GO:0051987; P:positive regulation of attachment of spindle microtubules to kinetochore; IEA:Ensembl.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IDA:RGD.
GO; GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0033129; P:positive regulation of histone phosphorylation; IMP:RGD.
GO; GO:1905448; P:positive regulation of mitochondrial ATP synthesis coupled electron transport; IEA:Ensembl.
GO; GO:0031442; P:positive regulation of mRNA 3'-end processing; IMP:RGD.
GO; GO:0065003; P:protein-containing complex assembly; IDA:RGD.
GO; GO:0051726; P:regulation of cell cycle; IEP:RGD.
GO; GO:0060623; P:regulation of chromosome condensation; IMP:RGD.
GO; GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; IEA:Ensembl.
GO; GO:0046680; P:response to DDT; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
GO; GO:0009636; P:response to toxic substance; IEP:RGD.
GO; GO:0007283; P:spermatogenesis; IEP:RGD.
GO; GO:0042246; P:tissue regeneration; IEP:RGD.
GO; GO:0055015; P:ventricular cardiac muscle cell development; IEP:RGD.
CDD; cd00043; CYCLIN; 2.
InterPro; IPR039361; Cyclin.
InterPro; IPR013763; Cyclin-like.
InterPro; IPR036915; Cyclin-like_sf.
InterPro; IPR004367; Cyclin_C-dom.
InterPro; IPR006671; Cyclin_N.
PANTHER; PTHR10177; PTHR10177; 1.
Pfam; PF02984; Cyclin_C; 1.
Pfam; PF00134; Cyclin_N; 1.
SMART; SM00385; CYCLIN; 2.
SMART; SM01332; Cyclin_C; 1.
SUPFAM; SSF47954; SSF47954; 2.
PROSITE; PS00292; CYCLINS; 1.
2: Evidence at transcript level;
Cell cycle; Cell division; Complete proteome; Cyclin; Cytoplasm;
Cytoskeleton; Mitosis; Nucleus; Phosphoprotein; Reference proteome;
Ubl conjugation.
CHAIN 1 423 G2/mitotic-specific cyclin-B1.
/FTId=PRO_0000080353.
REGION 159 167 Interaction with CDK2. {ECO:0000250}.
REGION 248 251 Interaction with CDK2. {ECO:0000250}.
COMPBIAS 50 82 Lys-rich.
MOD_RES 116 116 Phosphoserine; by CDK1.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 118 118 Phosphoserine.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 123 123 Phosphoserine; by PLK1.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 137 137 Phosphoserine.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 311 311 Phosphothreonine.
{ECO:0000250|UniProtKB:P14635}.
SEQUENCE 423 AA; 47391 MW; 4223CF71F144B279 CRC64;
MALRVTRNTK INTENKAKVS MAGAKRVPVA VAASKPLLRS RTALGDIGNK VSEQSRIPLK
KETKKLGSGT VTVKALPKPV DKVPVCEPEV ELDEPEPEPV MEVKHSPEPI LVDTPSPSPM
ETSGCAPAEE YLCQAFSDVI LAVSDVDADD GGDPNLCSEY VKDIYAYLRQ LEEEQSVRPK
YLLGREVTGN MRAILIDWLI QVQMKFRLLQ ETMYMTVSII DRFMQDSCVP KKMLQLVGVT
AMFIASKYEE MYPPEIGDFA FVTNNTYTKH QIRQMEMKIL RVLNFSLGRP LPLHFLRRAS
KIGEVDVEQH TLAKYLMELS MLDYDMVHFA PSQIAAGAFC LALKILDNGE WTPTLQHYLS
HTEESLLPVM QHLAKNIVMV NRGLTKHMTI KNKYATSKHA KISTLAQLNC TLVQNLSKAV
TKA


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