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G2/mitotic-specific cyclin-B1

 CCNB1_MESAU             Reviewed;         429 AA.
P37882;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
25-OCT-2017, entry version 100.
RecName: Full=G2/mitotic-specific cyclin-B1;
Name=CCNB1;
Mesocricetus auratus (Golden hamster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Mesocricetus.
NCBI_TaxID=10036;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Shiraki T., Yamashita K., Nishitani H., Nishimoto T.;
"Nucleotide sequence of hamster cyclin B1 and B2 cDNA.";
Submitted (JUL-1993) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Essential for the control of the cell cycle at the G2/M
(mitosis) transition.
-!- SUBUNIT: Interacts with the CDC2 protein kinase to form a
serine/threonine kinase holoenzyme complex also known as
maturation promoting factor (MPF). The cyclin subunit imparts
substrate specificity to the complex. Binds HEI10. Interacts with
catalytically active RALBP1 and CDC2 during mitosis to form an
endocytotic complex during interphase. Interacts with CCNF;
interaction is required for nuclear localization. Interacts with
CDK5RAP3. {ECO:0000250|UniProtKB:P14635}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton,
microtubule organizing center, centrosome {ECO:0000250}.
-!- DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is
abruptly destroyed at mitosis.
-!- PTM: Ubiquitinated by the SCF(NIPA) complex during interphase,
leading to its destruction. Not ubiquitinated during G2/M phases
(By similarity). {ECO:0000250}.
-!- PTM: Phosphorylated by PLK1 at Ser-129 on centrosomes during
prophase: phosphorylation by PLK1 does not cause nuclear import.
Phosphorylation at Ser-143 was also reported to be mediated by
PLK1 but Ser-129 seems to be the primary phosphorylation site (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
{ECO:0000305}.
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EMBL; D17293; BAA04126.1; -; mRNA.
RefSeq; NP_001297493.1; NM_001310564.1.
ProteinModelPortal; P37882; -.
SMR; P37882; -.
GeneID; 101836169; -.
CTD; 891; -.
HOVERGEN; HBG061650; -.
OrthoDB; EOG091G0E9B; -.
Proteomes; UP000189706; Genome assembly.
GO; GO:0005813; C:centrosome; ISS:UniProtKB.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
CDD; cd00043; CYCLIN; 2.
Gene3D; 1.10.472.10; -; 2.
InterPro; IPR013763; Cyclin-like.
InterPro; IPR036915; Cyclin-like_sf.
InterPro; IPR004367; Cyclin_C-dom.
InterPro; IPR006671; Cyclin_N.
Pfam; PF02984; Cyclin_C; 1.
Pfam; PF00134; Cyclin_N; 1.
SMART; SM00385; CYCLIN; 2.
SMART; SM01332; Cyclin_C; 1.
SUPFAM; SSF47954; SSF47954; 2.
PROSITE; PS00292; CYCLINS; 1.
2: Evidence at transcript level;
Acetylation; Cell cycle; Cell division; Complete proteome; Cyclin;
Cytoplasm; Cytoskeleton; Mitosis; Nucleus; Phosphoprotein;
Reference proteome; Ubl conjugation.
CHAIN 1 429 G2/mitotic-specific cyclin-B1.
/FTId=PRO_0000080351.
REGION 165 173 Interaction with CDK2. {ECO:0000250}.
REGION 254 257 Interaction with CDK2. {ECO:0000250}.
MOD_RES 73 73 N6-acetyllysine.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 122 122 Phosphoserine; by CDK1.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 124 124 Phosphoserine.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 129 129 Phosphoserine; by PLK1.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 143 143 Phosphoserine.
{ECO:0000250|UniProtKB:P14635}.
MOD_RES 317 317 Phosphothreonine.
{ECO:0000250|UniProtKB:P14635}.
SEQUENCE 429 AA; 47901 MW; FE6FF1016FF06253 CRC64;
MALRVTRNTK LNTENKAKVS MAGAKAVPVT LAAASKPGLR PRTALGDIGN KVSEQAQARL
PLKKELKTSV TGKVSAKIPP PKPLEKVPPV SEPEVELAET HEPEPVMDEK LSPEPILVDN
PSPSPMETSG CAPAEEYLCQ AFSDVILAVS DVDADDGADP NLCSEYVKDI YAYLRQLEEE
QSVRPKYLLG REVTGNMRAI LIDWLIQVQM KFRLLQETMY MTVSIIDRFM QDNCVPKKML
QLVGVTAMFI ASKYEEMYPP EIGDFAFVTN NTYTKHQIRQ MEMKILRVLN FSLGRPLPLH
FLRRTSKIGE VDVEQHTLAK YLMELTLLDY DMVDFAPSQI AAGAFCLALK ILDNGEWTPT
LQHYLSYTEE SLLPVMQHLA KNVVMVNHGL TKHMTIKNKY ATSKHAKIST LAQLNCTLVQ
NLSKAVAKA


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