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GATA binding protein 2

 H2P9F0_PONAB            Unreviewed;       408 AA.
H2P9F0;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
23-MAY-2018, entry version 39.
SubName: Full=GATA binding protein 2 {ECO:0000313|Ensembl:ENSPPYP00000015026};
Name=GATA2 {ECO:0000313|Ensembl:ENSPPYP00000015026};
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000015026, ECO:0000313|Proteomes:UP000001595};
[1] {ECO:0000313|Ensembl:ENSPPYP00000015026, ECO:0000313|Proteomes:UP000001595}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Wilson R.K., Mardis E.;
"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPPYP00000015026}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
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EMBL; ABGA01304456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01304457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_009236699.1; XM_009238424.1.
STRING; 9601.ENSPPYP00000015026; -.
Ensembl; ENSPPYT00000015627; ENSPPYP00000015026; ENSPPYG00000013434.
KEGG; pon:100433496; -.
CTD; 2624; -.
eggNOG; KOG1601; Eukaryota.
eggNOG; COG5641; LUCA.
GeneTree; ENSGT00760000119221; -.
InParanoid; H2P9F0; -.
KO; K17894; -.
OMA; PRWMAHH; -.
OrthoDB; EOG091G0AUR; -.
TreeFam; TF315391; -.
Proteomes; UP000001595; Chromosome 3.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0070742; F:C2H2 zinc finger domain binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IEA:Ensembl.
GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
GO; GO:0035854; P:eosinophil fate commitment; IEA:Ensembl.
GO; GO:0097154; P:GABAergic neuron differentiation; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0070345; P:negative regulation of fat cell proliferation; IEA:Ensembl.
GO; GO:0045650; P:negative regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Ensembl.
GO; GO:0061614; P:pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000977; P:regulation of forebrain neuron differentiation; IEA:Ensembl.
GO; GO:0035065; P:regulation of histone acetylation; IEA:Ensembl.
GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; IEA:Ensembl.
GO; GO:0060872; P:semicircular canal development; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IEA:Ensembl.
Gene3D; 3.30.50.10; -; 2.
InterPro; IPR029522; GATA-2.
InterPro; IPR016374; TF_GATA-2/3.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
PANTHER; PTHR10071:SF149; PTHR10071:SF149; 2.
Pfam; PF00320; GATA; 2.
PIRSF; PIRSF003027; TF_GATA-1/2/3; 2.
PRINTS; PR00619; GATAZNFINGER.
SMART; SM00401; ZnF_GATA; 2.
PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001595};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00094,
ECO:0000256|SAAS:SAAS01008217};
Reference proteome {ECO:0000313|Proteomes:UP000001595};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00094,
ECO:0000256|SAAS:SAAS01008217};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00094,
ECO:0000256|SAAS:SAAS01008217}.
DOMAIN 217 271 GATA-type. {ECO:0000259|PROSITE:PS50114}.
DOMAIN 271 324 GATA-type. {ECO:0000259|PROSITE:PS50114}.
SEQUENCE 408 AA; 43403 MW; 26FFBDA949C392F1 CRC64;
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSHGNPYY
ANPAHARARV SYSPAHGGGS GSSVASLTPT AAHSGSHLFG FPPTPPKEVS PDPSTTGAAS
PASSSAGGSA ARGEDKDGVK YQVSLTESMK MESGSPLRPG LATMGTQPAT HHPIPTYPSY
VPAAAHDYSS GLFHPGGFLG GPASSFTPKQ RSKARSCSEG RECVNCGATA TPLWRRDGTG
HYLCNACGLY HKMNGQNRPL IKPKRRLSAA RRAGTCCANC QTTTTTLWRR NANGDPVCNA
CGLYYKLHNV NRPLTMKKEG IQTRNRKMSN KSKKSKKGAE CFEELSKCMQ EKSSPFSAAA
LAGHMAPVGH LPPFSHSGHI LPTPTPIHPS SSLSFGHPHP SSMVTAMG


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