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GATA-binding factor 2 (GATA-2) (Transcription factor xGATA-2)

 GATA2_XENLA             Reviewed;         452 AA.
P23770;
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
01-NOV-1991, sequence version 1.
12-SEP-2018, entry version 91.
RecName: Full=GATA-binding factor 2;
Short=GATA-2;
AltName: Full=Transcription factor xGATA-2;
Name=gata2;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
STAGE.
TISSUE=Neurula;
PubMed=1961730; DOI=10.1073/pnas.88.23.10642;
Zon L.I., Mather C., Burgess S., Bolce M.E., Harland R.M., Orkin S.H.;
"Expression of GATA-binding proteins during embryonic development in
Xenopus laevis.";
Proc. Natl. Acad. Sci. U.S.A. 88:10642-10646(1991).
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Expressed in the developing ventral blood
island, and in the embryonic nervous system.
{ECO:0000269|PubMed:1961730}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expressed at a low level maternally, and abundantly expressed at
stage 11 (mid-gastrula) and thereafter.
{ECO:0000269|PubMed:1961730}.
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EMBL; M76564; AAA49723.1; -; mRNA.
PIR; C41602; C41602.
UniGene; Xl.792; -.
ProteinModelPortal; P23770; -.
SMR; P23770; -.
PRIDE; P23770; -.
HOVERGEN; HBG051705; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0030097; P:hemopoiesis; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00202; ZnF_GATA; 2.
Gene3D; 3.30.50.10; -; 2.
InterPro; IPR029522; GATA-2.
InterPro; IPR016374; TF_GATA-2/3.
InterPro; IPR039355; Transcription_factor_GATA.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
PANTHER; PTHR10071; PTHR10071; 1.
PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1.
Pfam; PF00320; GATA; 2.
PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
PRINTS; PR00619; GATAZNFINGER.
SMART; SM00401; ZnF_GATA; 2.
PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
2: Evidence at transcript level;
Activator; DNA-binding; Metal-binding; Nucleus; Repeat; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 452 GATA-binding factor 2.
/FTId=PRO_0000083407.
ZN_FING 267 291 GATA-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00094}.
ZN_FING 321 345 GATA-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00094}.
SEQUENCE 452 AA; 48940 MW; 97F4992C8FD71F7A CRC64;
MEVATDQPRW MAHHAVLNGQ HPDSHHPGLA HNYMEPTQLL PPDEVDVFFN HLDSQGNPYY
ANSAHARARV SYSQAHARLT GSQMCRPHLL HSPGLPWLES GKTALSAAHH HNPWTVSPFG
KAPLHPAARG GSLYPGTGSS ACPSSSHSSP HLFGFPPTPP KDVSPDPGPA SPPSSSRLED
KDSIKYQMSL SEGMKMEGGS PLRSSLAPMG TQCSTHHPIP TYPSYVPAAH DYSSGLFHPG
SLLGGPASSF TPKQRSKSRS CSEGRECVNC GATATPLWRR DGTGHYLCNA CGLYHKMNGQ
NRPLIKPKRR LSAARRAGTC CANCQTSTTT LWRRNANGDP VCNACGLYYK LHNVNRPLTM
KKEGIQTRNR KMSNKSKKNK KGSECFEELS RCMQEKSSPF SAAALASHMA PMGHLAPFSH
SGHILQTPTP IHPSSSLSFG HPHHSSMVTA MG


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