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GDP/GTP exchange factor VAV3 (Vav guanine nucleotide exchange factor 3)

 Q8UUX6_CHICK            Unreviewed;       846 AA.
Q8UUX6;
01-MAR-2002, integrated into UniProtKB/TrEMBL.
01-MAR-2002, sequence version 1.
05-DEC-2018, entry version 141.
SubName: Full=GDP/GTP exchange factor VAV3 {ECO:0000313|EMBL:AAL06249.1};
SubName: Full=Vav guanine nucleotide exchange factor 3 {ECO:0000313|Ensembl:ENSGALP00000054725};
Name=VAV3 {ECO:0000313|EMBL:AAL06249.1,
ECO:0000313|Ensembl:ENSGALP00000054725};
ORFNames=RCJMB04_7l6 {ECO:0000313|EMBL:CAH65203.1};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031 {ECO:0000313|EMBL:AAL06249.1};
[1] {ECO:0000313|EMBL:AAL06249.1}
NUCLEOTIDE SEQUENCE.
PubMed=11805146; DOI=10.1084/jem.20011571;
Inabe K., Ishiai M., Scharenberg A.M., Freshney N., Downward J.,
Kurosaki T.;
"Vav3 modulates B cell receptor responses by regulating
phosphoinositide 3-kinase activation.";
J. Exp. Med. 195:189-200(2002).
[2] {ECO:0000313|Ensembl:ENSGALP00000054725, ECO:0000313|Proteomes:UP000000539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000054725,
ECO:0000313|Proteomes:UP000000539};
PubMed=15592404; DOI=10.1038/nature03154;
International Chicken Genome Sequencing Consortium;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
Mardis E.R., Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide
unique perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[3] {ECO:0000313|EMBL:CAH65203.1}
NUCLEOTIDE SEQUENCE.
STRAIN=CB {ECO:0000313|EMBL:CAH65203.1};
TISSUE=Bursa {ECO:0000313|EMBL:CAH65203.1};
PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.M.;
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
function analysis.";
Genome Biol. 6:R6.1-R6.9(2005).
[4] {ECO:0000313|Ensembl:ENSGALP00000054725}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000054725};
Ensembl;
Submitted (OCT-2016) to UniProtKB.
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EMBL; AADN04000104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY046915; AAL06249.1; -; mRNA.
EMBL; AJ851569; CAH65203.1; -; mRNA.
RefSeq; NP_996745.1; NM_206863.2.
UniGene; Gga.2876; -.
IntAct; Q8UUX6; 1.
MINT; Q8UUX6; -.
Ensembl; ENSGALT00000081334; ENSGALP00000054725; ENSGALG00000039327.
GeneID; 373939; -.
KEGG; gga:373939; -.
CTD; 10451; -.
eggNOG; KOG2996; Eukaryota.
eggNOG; ENOG410XPH6; LUCA.
GeneTree; ENSGT00940000155252; -.
HOGENOM; HOG000234364; -.
HOVERGEN; HBG018066; -.
KO; K05730; -.
Reactome; R-GGA-114604; GPVI-mediated activation cascade.
Reactome; R-GGA-193648; NRAGE signals death through JNK.
Reactome; R-GGA-194840; Rho GTPase cycle.
Reactome; R-GGA-2029482; Regulation of actin dynamics for phagocytic cup formation.
Reactome; R-GGA-2424491; DAP12 signaling.
Reactome; R-GGA-2871796; FCERI mediated MAPK activation.
Reactome; R-GGA-2871809; FCERI mediated Ca+2 mobilization.
Reactome; R-GGA-3928665; EPH-ephrin mediated repulsion of cells.
Reactome; R-GGA-416482; G alpha (12/13) signalling events.
Reactome; R-GGA-4420097; VEGFA-VEGFR2 Pathway.
Reactome; R-GGA-5218920; VEGFR2 mediated vascular permeability.
Proteomes; UP000000539; Chromosome 8.
Bgee; ENSGALG00000001915; Expressed in 10 organ(s), highest expression level in spleen.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IEA:Ensembl.
GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0030890; P:positive regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0045785; P:positive regulation of cell adhesion; IEA:Ensembl.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl.
GO; GO:0008361; P:regulation of cell size; IEA:Ensembl.
GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl.
GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:Ensembl.
GO; GO:0006906; P:vesicle fusion; IEA:Ensembl.
CDD; cd00029; C1; 1.
CDD; cd00014; CH; 1.
CDD; cd01223; PH_Vav; 1.
CDD; cd00160; RhoGEF; 1.
CDD; cd10407; SH2_Vav3; 1.
CDD; cd11978; SH3_VAV3_2; 1.
Gene3D; 1.10.418.10; -; 1.
Gene3D; 1.20.900.10; -; 1.
Gene3D; 2.30.29.30; -; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR022613; CAMSAP_CH.
InterPro; IPR001715; CH-domain.
InterPro; IPR036872; CH_dom_sf.
InterPro; IPR035899; DBL_dom_sf.
InterPro; IPR000219; DH-domain.
InterPro; IPR001331; GDS_CDC24_CS.
InterPro; IPR002219; PE/DAG-bd.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR037832; PH_Vav.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
InterPro; IPR003096; SM22_calponin.
InterPro; IPR035881; VAV3_SH2.
InterPro; IPR035734; VAV3_SH3_2.
Pfam; PF00130; C1_1; 1.
Pfam; PF11971; CAMSAP_CH; 1.
Pfam; PF00169; PH; 1.
Pfam; PF00621; RhoGEF; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF07653; SH3_2; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
PRINTS; PR00888; SM22CALPONIN.
SMART; SM00109; C1; 1.
SMART; SM00033; CH; 1.
SMART; SM00233; PH; 1.
SMART; SM00325; RhoGEF; 1.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF47576; SSF47576; 1.
SUPFAM; SSF48065; SSF48065; 1.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50021; CH; 1.
PROSITE; PS00741; DH_1; 1.
PROSITE; PS50010; DH_2; 1.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
PROSITE; PS00479; ZF_DAG_PE_1; 1.
PROSITE; PS50081; ZF_DAG_PE_2; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000539};
Metal-binding {ECO:0000256|SAAS:SAAS00515414};
Reference proteome {ECO:0000313|Proteomes:UP000000539};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}; Zinc {ECO:0000256|SAAS:SAAS00515409}.
DOMAIN 1 119 Calponin-homology (CH).
{ECO:0000259|PROSITE:PS50021}.
DOMAIN 192 371 DH. {ECO:0000259|PROSITE:PS50010}.
DOMAIN 400 502 PH. {ECO:0000259|PROSITE:PS50003}.
DOMAIN 513 562 Phorbol-ester/DAG-type.
{ECO:0000259|PROSITE:PS50081}.
DOMAIN 591 659 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 671 765 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 787 846 SH3. {ECO:0000259|PROSITE:PS50002}.
COILED 292 312 {ECO:0000256|SAM:Coils}.
SEQUENCE 846 AA; 97816 MW; C47EE949D873821B CRC64;
MEPWKQCGQW LISCKVLPPN HRVTWETAQV FDLAQTLRDG VLLCQLLNNL RSHSINLKEI
NLRPQMSQFL CLKNIRTFLS ACCEIFGMKK SELFEAFDLF DVRDFGKVIE TLSKLSRTPI
AIGTGIRPFP TEESVDDEDV YKCLPDLIDE TGVDEDEELY DCVYGEDEGG EVYEDLMKDE
AAQQPKHTEN DVRSCCLAEI KQTEEKYTET LESIEKFFMV PLKRFMSASE FETVFINIPD
LVKIHRSLTQ DISDSIINKN DQNLYQIFIN YKERLVIYGQ YCSQVETAIS CLDNISKTKE
DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTTDPME KANLKLALDA
MKDLAQYVNE VKRDNETLRE IRQFQLSIEN LNHSLLQYGR PQGDGEIRIT TLDKRARQDR
HIFLFDLAVI VCKRRGDNYE MKEIIDLQKY KITNNPTTDK ENKKWSYGFY LIHIQGQNGL
EVYCKTKDLK KKWLEQFQMA LSNIRPDYAD TSFHEFKMHT FSRVTSCKVC QMLLRGTFYQ
GYLCSKCGAG AHKECLGRLD NCGRANSGEH GNLKHEKRTN GIRRNSRHVD PGLPRMQVIR
NYKGIPQPTP QDGPPLHIQI GDTIELITGD VHSLFWQGRN LTTGELGFFP SDAVKPSPCV
PKPVDYSSQL WFAGAMERLQ AESELINRVN STYLVRHRTK ESGEYAISIK YNNEVKHIKI
FTRDGYFHIT ENRKFINLME LVDYYKHHSL KEGFRSLDTT LQFPYKESEN SVGQRGNRAG
GNLLSPKVIG IAIARYDFCA RDMRELSLLK GDVVKIYTKM SANGWWRGEV NGRVGWFPST
YVEEDE


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