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GH20948

 B4J496_DROGR            Unreviewed;       893 AA.
B4J496;
23-SEP-2008, integrated into UniProtKB/TrEMBL.
23-SEP-2008, sequence version 1.
25-OCT-2017, entry version 68.
SubName: Full=GH20948 {ECO:0000313|EMBL:EDW00576.1};
Name=Dgri\GH20948 {ECO:0000313|EMBL:EDW00576.1};
ORFNames=Dgri_GH20948 {ECO:0000313|EMBL:EDW00576.1},
GH20948 {ECO:0000313|FlyBase:FBgn0128410};
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Hawaiian Drosophila.
NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
[1] {ECO:0000313|EMBL:EDW00576.1, ECO:0000313|Proteomes:UP000001070}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
PubMed=17994087; DOI=10.1038/nature06341;
Drosophila 12 Genomes Consortium;
Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
"Evolution of genes and genomes on the Drosophila phylogeny.";
Nature 450:203-218(2007).
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
ProRule:PRU00407, ECO:0000256|SAAS:SAAS00586772}.
-!- SIMILARITY: Belongs to the nuclear hormone receptor family.
{ECO:0000256|SAAS:SAAS00595733}.
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EMBL; CH916367; EDW00576.1; -; Genomic_DNA.
RefSeq; XP_001985709.1; XM_001985673.1.
STRING; 7222.FBpp0154854; -.
EnsemblMetazoa; FBtr0156362; FBpp0154854; FBgn0128410.
GeneID; 6560137; -.
KEGG; dgr:Dgri_GH20948; -.
FlyBase; FBgn0128410; Dgri\GH20948.
eggNOG; KOG3575; Eukaryota.
eggNOG; ENOG410XRZC; LUCA.
InParanoid; B4J496; -.
KO; K14034; -.
OMA; KRIMSQP; -.
OrthoDB; EOG091G0KTD; -.
PhylomeDB; B4J496; -.
Proteomes; UP000001070; Unassembled WGS sequence.
GO; GO:0008232; C:activator ecdysone receptor complex; IEA:EnsemblMetazoa.
GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
GO; GO:0030425; C:dendrite; IEA:EnsemblMetazoa.
GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa.
GO; GO:0008231; C:repressor ecdysone receptor complex; IEA:EnsemblMetazoa.
GO; GO:0001047; F:core promoter binding; IEA:EnsemblMetazoa.
GO; GO:0035100; F:ecdysone binding; IEA:EnsemblMetazoa.
GO; GO:0004884; F:ecdysteroid hormone receptor activity; IEA:EnsemblMetazoa.
GO; GO:0046982; F:protein heterodimerization activity; IEA:EnsemblMetazoa.
GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblMetazoa.
GO; GO:0005102; F:receptor binding; IEA:EnsemblMetazoa.
GO; GO:0070491; F:repressing transcription factor binding; IEA:EnsemblMetazoa.
GO; GO:0001225; F:RNA polymerase II transcription coactivator binding; IEA:EnsemblMetazoa.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IEA:EnsemblMetazoa.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:EnsemblMetazoa.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006914; P:autophagy; IEA:EnsemblMetazoa.
GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
GO; GO:0048738; P:cardiac muscle tissue development; IEA:EnsemblMetazoa.
GO; GO:0010002; P:cardioblast differentiation; IEA:EnsemblMetazoa.
GO; GO:0007155; P:cell adhesion; IEA:EnsemblMetazoa.
GO; GO:0008362; P:chitin-based embryonic cuticle biosynthetic process; IEA:EnsemblMetazoa.
GO; GO:0042632; P:cholesterol homeostasis; IEA:EnsemblMetazoa.
GO; GO:0048813; P:dendrite morphogenesis; IEA:EnsemblMetazoa.
GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
GO; GO:0035053; P:dorsal vessel heart proper cell fate commitment; IEA:EnsemblMetazoa.
GO; GO:0018990; P:ecdysis, chitin-based cuticle; IEA:EnsemblMetazoa.
GO; GO:0008544; P:epidermis development; IEA:EnsemblMetazoa.
GO; GO:0007390; P:germ-band shortening; IEA:EnsemblMetazoa.
GO; GO:0035188; P:hatching; IEA:EnsemblMetazoa.
GO; GO:0008258; P:head involution; IEA:EnsemblMetazoa.
GO; GO:0007488; P:histoblast morphogenesis; IEA:EnsemblMetazoa.
GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IEA:EnsemblMetazoa.
GO; GO:0035193; P:larval central nervous system remodeling; IEA:EnsemblMetazoa.
GO; GO:0035180; P:larval wandering behavior; IEA:EnsemblMetazoa.
GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
GO; GO:0007517; P:muscle organ development; IEA:EnsemblMetazoa.
GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
GO; GO:0044130; P:negative regulation of growth of symbiont in host; IEA:EnsemblMetazoa.
GO; GO:0007406; P:negative regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
GO; GO:0016322; P:neuron remodeling; IEA:EnsemblMetazoa.
GO; GO:0007422; P:peripheral nervous system development; IEA:EnsemblMetazoa.
GO; GO:0006911; P:phagocytosis, engulfment; IEA:EnsemblMetazoa.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:EnsemblMetazoa.
GO; GO:0045938; P:positive regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
GO; GO:0035073; P:pupariation; IEA:EnsemblMetazoa.
GO; GO:0010506; P:regulation of autophagy; IEA:EnsemblMetazoa.
GO; GO:0043457; P:regulation of cellular respiration; IEA:EnsemblMetazoa.
GO; GO:0010906; P:regulation of glucose metabolic process; IEA:EnsemblMetazoa.
GO; GO:0035206; P:regulation of hemocyte proliferation; IEA:EnsemblMetazoa.
GO; GO:0035297; P:regulation of Malpighian tubule diameter; IEA:EnsemblMetazoa.
GO; GO:1904799; P:regulation of neuron remodeling; IEA:EnsemblMetazoa.
GO; GO:0007468; P:regulation of rhodopsin gene expression; IEA:EnsemblMetazoa.
GO; GO:0042220; P:response to cocaine; IEA:EnsemblMetazoa.
GO; GO:0035071; P:salivary gland cell autophagic cell death; IEA:EnsemblMetazoa.
GO; GO:0007291; P:sperm individualization; IEA:EnsemblMetazoa.
Gene3D; 1.10.565.10; -; 2.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR003069; Ecdystd_rcpt.
InterPro; IPR035500; NHR_like_domain.
InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
InterPro; IPR001723; Nuclear_hrmn_rcpt.
InterPro; IPR001628; Znf_hrmn_rcpt.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF00104; Hormone_recep; 1.
Pfam; PF00105; zf-C4; 1.
PRINTS; PR01283; ECDYSTEROIDR.
PRINTS; PR00398; STRDHORMONER.
PRINTS; PR00047; STROIDFINGER.
SMART; SM00430; HOLI; 1.
SMART; SM00399; ZnF_C4; 1.
SUPFAM; SSF48508; SSF48508; 1.
PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000001070};
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517091};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517125};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517080};
Reference proteome {ECO:0000313|Proteomes:UP000001070};
Transcription {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517167};
Transcription regulation {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517167};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517125};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00407,
ECO:0000256|SAAS:SAAS00517125}.
DOMAIN 296 371 Nuclear receptor.
{ECO:0000259|PROSITE:PS51030}.
DNA_BIND 296 371 Nuclear receptor. {ECO:0000256|PROSITE-
ProRule:PRU00407}.
SEQUENCE 893 AA; 94577 MW; A19B0D107ABDCA79 CRC64;
MKRRWSNNGG FLRIQEESSS EVTSSSNGLV LSSGINMSPS SLDSHDYGEP EMWLCGNDAG
GYGNANGNTL GHGNTHTTQQ QQQQQQQQQQ QQSVITLAMQ GCSSTLPAQT TIIPINNNNN
NNNNNNNNNN SNGYVPGATN LGSLTNGHMG SLVSSMQQLQ NGHSHSLINS TTPNMQQNGL
NGAATNNGNA NNNNNNSMAL NMHHHTNGNS NGHGVGVGVG VGVGLVGGGG GGGVLGAMGG
PMGMQAMQHT PRSDSANSIS SGRDDLSPSS SLNGYSVNEG CDAKKSKKGP APRVQEELCL
VCGDRASGYH YNALTCEGCK GFFRRSVTKN AHYCCKFGRA CEMDMYMRRK CQECRLKKCL
AVGMRPECVV PENQCAMKRR EKKAQKEKDK VTSSPSSQHG GAGGGGGGGG GGGIAGGGAC
ANSVGLHGTH DYVKKEILDL MTCEPPQHAT IPLLPDDILA ECQARNIPPL TFNQLAVIYK
LIWYQDGYEQ PSEEDLKRIM SQPDEHESQT DVSFRHITEI TILTVQLIVE FAKGLPAFTK
IPQEDQITLL KACSSEVMML RMARRYDHTS DSIYFANNRS YTRDSYKMAG MADNIEDLLH
FCRQMFAMKV DNVEYALLTA IVIFSDRPGL EKAQLVEAIQ SYYIDTLRIY ILNRHCGNSM
SLVFYAKLLS ILTELRTLGN QNAEMCFSLK LKNRKLPKFL EEIWDVHAVP PSVQLHLQAQ
QDEHDRILRA ERMRGAVGGA IAAGLDADSA STSSQAALAA AAQQQQHHQQ QQHQQLHTLP
SHTAGAGAGG GGAGSVSAVS TSSGYIGGGG AMGPNTAAAS SSTSITAAVP ASSTTPSTVA
NGSVGAGGVG GAGGGVGGAG GRNADVSMYA NTQTAMALMG VPLKTEHSTT SSA


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