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GLI family zinc finger 2a (GLI-Kruppel family member GLI2a)

 B0S6T1_DANRE            Unreviewed;      1439 AA.
B0S6T1;
08-APR-2008, integrated into UniProtKB/TrEMBL.
08-APR-2008, sequence version 1.
05-DEC-2018, entry version 81.
SubName: Full=GLI family zinc finger 2a {ECO:0000313|Ensembl:ENSDARP00000010693};
SubName: Full=GLI-Kruppel family member GLI2a {ECO:0000313|EMBL:AAI63542.1};
Name=gli2a {ECO:0000313|EMBL:AAI63542.1,
ECO:0000313|Ensembl:ENSDARP00000010693,
ECO:0000313|ZFIN:ZDB-GENE-990706-8};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000010693, ECO:0000313|Proteomes:UP000000437};
[1] {ECO:0000313|EMBL:AAI63542.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSDARP00000010693, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000010693,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
Saunders D., Wallis J., Babbage A., Hammond S.,
Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the
human genome.";
Nature 496:498-503(2013).
[3] {ECO:0000313|Ensembl:ENSDARP00000010693}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000010693};
Ensembl;
Submitted (AUG-2013) to UniProtKB.
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EMBL; BX548071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CU013535; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC163542; AAI63542.1; -; mRNA.
UniGene; Dr.8091; -.
STRING; 7955.ENSDARP00000010693; -.
Ensembl; ENSDART00000024555; ENSDARP00000010693; ENSDARG00000025641.
ZFIN; ZDB-GENE-990706-8; gli2a.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00940000159213; -.
HOGENOM; HOG000290688; -.
HOVERGEN; HBG005844; -.
OMA; VVQYIKS; -.
OrthoDB; EOG091G01XS; -.
TreeFam; TF350216; -.
Reactome; R-DRE-5610787; Hedgehog 'off' state.
Reactome; R-DRE-5632684; Hedgehog 'on' state.
Proteomes; UP000000437; Chromosome 9.
Bgee; ENSDARG00000025641; Expressed in 48 organ(s), highest expression level in multi-cellular organism.
GO; GO:0097730; C:non-motile cilium; IDA:ZFIN.
GO; GO:0005634; C:nucleus; IDA:ZFIN.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IGI:ZFIN.
GO; GO:0021984; P:adenohypophysis development; IMP:ZFIN.
GO; GO:0048855; P:adenohypophysis morphogenesis; IMP:ZFIN.
GO; GO:0007411; P:axon guidance; IMP:ZFIN.
GO; GO:0008015; P:blood circulation; IMP:ZFIN.
GO; GO:0007420; P:brain development; IMP:ZFIN.
GO; GO:0021953; P:central nervous system neuron differentiation; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IMP:ZFIN.
GO; GO:0031018; P:endocrine pancreas development; IMP:ZFIN.
GO; GO:0021508; P:floor plate formation; IMP:ZFIN.
GO; GO:0032835; P:glomerulus development; IMP:ZFIN.
GO; GO:0008045; P:motor neuron axon guidance; IMP:ZFIN.
GO; GO:0042694; P:muscle cell fate specification; IMP:ZFIN.
GO; GO:0007517; P:muscle organ development; IMP:ZFIN.
GO; GO:0007399; P:nervous system development; IMP:ZFIN.
GO; GO:0021532; P:neural tube patterning; IMP:ZFIN.
GO; GO:0042476; P:odontogenesis; IMP:ZFIN.
GO; GO:0021634; P:optic nerve formation; IMP:ZFIN.
GO; GO:0021983; P:pituitary gland development; IMP:ZFIN.
GO; GO:0048618; P:post-embryonic foregut morphogenesis; IMP:ZFIN.
GO; GO:0048793; P:pronephros development; IMP:ZFIN.
GO; GO:0050767; P:regulation of neurogenesis; IMP:ZFIN.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IMP:ZFIN.
GO; GO:0007224; P:smoothened signaling pathway; IDA:ZFIN.
GO; GO:0021523; P:somatic motor neuron differentiation; IMP:ZFIN.
GO; GO:0001756; P:somitogenesis; IMP:ZFIN.
GO; GO:0055002; P:striated muscle cell development; IMP:ZFIN.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF00096; zf-C2H2; 4.
SMART; SM00355; ZnF_C2H2; 5.
SUPFAM; SSF57667; SSF57667; 3.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000437};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
DOMAIN 440 467 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 468 497 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 498 528 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 529 559 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
SEQUENCE 1439 AA; 156735 MW; 9A103E2E17BE202B CRC64;
METTSPTSTE KKELKPSVLD GSSFTDLPKK PSPTTASRAP HLFSTFHTPI PIDMRHHEGR
YHYEPHPLHP MHGPHGLAGS PVISDISLIR LSPHAAATGE SPFNPPHPYV NPHMEHYLRS
VHSSPTLSMI SAARGLSPAE LTHEHLKERS LFGLPPPPPG ANPSEYYHLI ASHRSPYGDL
LMQTGAAAAH LPDYMSPVDM SRFPSPRLTP RVSRKRALSI SPVSDASIDL QTMIRTSPNS
LVAYINNSRS SSAASSSYGH LSVGAISPSF TFPHPITPVA YHQLLSQQRG LNAFGHTPPL
LQPSPALSSR QQTLVAAAAL NNTTSSSTSS STADTSTESS QNAGGDPAVS STVNPMIFKR
SKVKTEAEGP HPISPGSQDH LELREELDKD ECKQEPEAVY ETNCHWEGCA KEYDTQDQLV
HHISNDHIHG EKKEFVCRWV ECSREQKPFK AQYMLVVHMR RHTGEKPHKC TFEGCSKAYS
RLENLKTHLR SHTGEKPYVC EHEGCNKAFS NASDRAKHQN RTHSNEKPYV CKIPGCTKRY
TDPSSLRKHV KTVHGPEAHV TKKQRGDAPP KPHPPKGNGE NEAHTKHVRG RTDGSGEANS
TTRGVEDCQH VKTIKTENTV MYQSSPGGQS SCSSEPSPLG SATNNDSGVE MAMHSGGSLG
DLSALDDTPV VDSTGSPGTS AGVGLQLRKN RAGLLQLEHI KKEKLKTVRD SCSWANAPPQ
VRNTKLPPIP SIDSLLDAPN IGTQMSVPPT QHLGDLSSYE MTMLNQLHER RDSSTSTMSS
AYISRRSSGI SPCYSSRRSS EASQFGVRNN NVSSADSYDP ISTDLSRRSS EASQCGGTGG
LPSLLNLTPA QHYSLKAKYA AATGGAPPTP LPNMDRMSLK TRMAMYNDSQ DSSAHLHHAQ
GVVNSRRCSD TGYGAPGIMP HEVPANLPRR ASDPVRRTTL DPLSLPRVQR FNSISNMNLS
RLPAYDRRAF NMQNNTWSDG SLHRHPFSQR PPSISENILM ENMATDGGDQ QGDDLVLPDD
MVQYLRSQNG NSNHDSGISV NGGHALEFHG NMTSQQQQFY GQRRMGMASI NGSHVEPVPE
QIADPQGMNK NNMPVQWNEV SSGSADAVSR VPKQQQQQLR GNLTVVQQKQ NFGSYQGFGS
NQQIVPMSQN LASLQQAYPQ RNIQRMNTVQ QYRQSISNPC QNIGEQVNRQ DLSYNSNQRL
ICNSMGPPNG RVVQNQELQN YRSNLMHMNN INQQNYVPLT QTAIQNAGRG LIQPRPPSEP
KPLNRQHSGS GMVQPNGCSL SNVNSSEASP KRPGEVGQHS NGNGTMYYSG EIHMLDNGID
YGSPMSPCTN QAPVASVSTM ASPGVNQVTS TVDSTQSLDH TQIDFDAMLD DGDHSSLMSG
TLSPGLLQSI SQNSSRLTTP RNSVTLASVP AGIGNMAIGD MSSMLTALAE ESKFLNMMA


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