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GLI family zinc finger 3 (Fragment)

 D2GYG0_AILME            Unreviewed;      1586 AA.
D2GYG0;
09-FEB-2010, integrated into UniProtKB/TrEMBL.
09-FEB-2010, sequence version 1.
30-AUG-2017, entry version 54.
SubName: Full=GLI family zinc finger 3 {ECO:0000313|Ensembl:ENSAMEP00000008907};
Flags: Fragment;
Name=GLI3 {ECO:0000313|Ensembl:ENSAMEP00000008907};
ORFNames=PANDA_002047 {ECO:0000313|EMBL:EFB30146.1};
Ailuropoda melanoleuca (Giant panda).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
Ailuropoda.
NCBI_TaxID=9646;
[1] {ECO:0000313|EMBL:EFB30146.1, ECO:0000313|Ensembl:ENSAMEP00000008907}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=20010809; DOI=10.1038/nature08696;
Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
Wang J., Wang J.;
"The sequence and de novo assembly of the giant panda genome.";
Nature 463:311-317(2010).
[2] {ECO:0000313|Ensembl:ENSAMEP00000008907}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
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EMBL; ACTA01122352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01130352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01138352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01146351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ACTA01154350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GL192380; EFB30146.1; -; Genomic_DNA.
RefSeq; XP_002914184.1; XM_002914138.3.
STRING; 9646.ENSAMEP00000008907; -.
Ensembl; ENSAMET00000009287; ENSAMEP00000008907; ENSAMEG00000008405.
GeneID; 100463969; -.
KEGG; aml:100463969; -.
CTD; 2737; -.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00760000118771; -.
HOGENOM; HOG000290688; -.
KO; K06230; -.
OMA; MHNKRSK; -.
OrthoDB; EOG091G01XS; -.
TreeFam; TF350216; -.
Proteomes; UP000008912; Unassembled WGS sequence.
GO; GO:0005930; C:axoneme; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0016592; C:mediator complex; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0017053; C:transcriptional repressor complex; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0060873; P:anterior semicircular canal development; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0060840; P:artery development; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
GO; GO:0061005; P:cell differentiation involved in kidney development; IEA:Ensembl.
GO; GO:0048589; P:developmental growth; IEA:Ensembl.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0021861; P:forebrain radial glial cell differentiation; IEA:Ensembl.
GO; GO:0060364; P:frontal suture morphogenesis; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0060366; P:lambdoid suture morphogenesis; IEA:Ensembl.
GO; GO:0022018; P:lateral ganglionic eminence cell proliferation; IEA:Ensembl.
GO; GO:0060875; P:lateral semicircular canal development; IEA:Ensembl.
GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0060594; P:mammary gland specification; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0001656; P:metanephros development; IEA:Ensembl.
GO; GO:0046639; P:negative regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0021631; P:optic nerve morphogenesis; IEA:Ensembl.
GO; GO:0060021; P:palate development; IEA:Ensembl.
GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
GO; GO:1903010; P:regulation of bone development; IEA:Ensembl.
GO; GO:0060367; P:sagittal suture morphogenesis; IEA:Ensembl.
GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Ensembl.
GO; GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IEA:Ensembl.
GO; GO:0070242; P:thymocyte apoptotic process; IEA:Ensembl.
GO; GO:0043586; P:tongue development; IEA:Ensembl.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR032851; GLI3.
InterPro; IPR013087; Znf_C2H2_type.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
PANTHER; PTHR19818:SF110; PTHR19818:SF110; 1.
SMART; SM00355; ZnF_C2H2; 5.
SUPFAM; SSF57667; SSF57667; 3.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000008912};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
Reference proteome {ECO:0000313|Proteomes:UP000008912};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
DOMAIN 479 511 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 517 544 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 545 574 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 575 605 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 606 636 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
NON_TER 1586 1586 {ECO:0000313|EMBL:EFB30146.1}.
SEQUENCE 1586 AA; 169464 MW; 8031B3EA66F603F3 CRC64;
MEAQSHSSTT TEKKKVENSI VKCSARTDVS EKAVASSTTS NEDESPGQTY HRERRNAVTM
QPQSVQGLGK ISEEPSTSSE ERASLIKKEI HGSLPHLAEP SVPYRGAVFA MDPRNGYMEP
HYHPSHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHVPS ALSSSPTYSD LPFIRISPHR
NPAAASEPPF SPPHPYINPY MDYIRSLHSP SLSVISAARG LSPTDAPHAG VSPAEYYHQM
ALLAGQRSPY ADIIPSAATA GAGAIHMEYL HAMDSTRFPS PRLSARPSRK RTLSISPLSD
HSFDLQTMIR TSPNSLVTIL NNSRSSSSAS GSYGHLSASA ISPALSFTYP SAPVSLHMHQ
QILSRQQSLG SAFGHSPPLI HPAPTFPTQR PIPGIPTVLN PVQVSSGPSE SSQNKPTSES
AVSSTGDLMH NKRSKIKPDE DLPSPGPRGQ QEQPEGTTLV KEEGDKDESK QEPEVIYETN
CHWEGCTREF DTQEQLVHHI NNDHIHGEKK EFVCRWLDCS REQKPFKAQY MLVVHMRRHT
GEKPHKCTFE GCTKAYSRLE NLKTHLRSHT GEKPYVCEHE GCNKAFSNAS DRAKHQNRTH
SNEKPYVCKI PGCTKRYTDP SSLRKHVKTV HGPEAHVTKK QRGDIHPRPP PPRDSGSHSQ
SRSPGRQTQG ALGEQKDLSN TTSKREECLQ VKAVKAEKPM TSQPSPGGQS SCSSQQSPIS
NYSNSGLELP LTDGGGVGDL GAIDETPIMD STISTATTAL ALQARRNPAG TRWMEHVKLE
RLKQVNGMLP RLNPILPPKA PAVSPLIGNG TQPGTSCSLG GPMTLLPNRS DLSGVDITVL
NTLSRRDSST STISSAYLSS RRSSGISPCF SSRRSSEASQ AEGRPQNVSV ADSYDPISTD
ASRRSSEASQ GDGLPSLLSL TPAQQYRLKA KYAAATGGPP PTPLPNMERM SLKTRMALLG
DAREPAGALP PVHPPRRCSD GGAHSYGRRP LLPTDALGNG VRRASDPVRT VSESLSLPRV
QRFTSLHSFN PPALPPSLEK RNLVLQNYTR PEGGQPRHFP PSPCPPSIAE NVTLESLTMD
ADVSLNDEDF LPDDVVQYLN SQNQAGYEQP FQSAVSDDGK VPHGPGLGNG HGDFDPPGLP
DSHAGHAGQP YRPLEQPCPE ASKPDLPIQW NEVSSGSADL CSSKLKCGQR STAQQARAFG
LYGNVGVHPQ NPLRNGAGPA GGYPTLAEHG SGGPEHLASH SSGPGTNGNA FHEQPYKAQP
YGNCLSRQPG APGLDGACGA GVQAAKLKST AVQGNGGQPD FGLSVVPDES AGSAVNGMAP
PDLVGQGYLA PQLLNDGMHH QGAGRAGQQM LGQVSATSHV NIYQGPESGL PGPACLGSQP
SSLAAARGYQ PCAGYGGGRR QAVLRGGLAL QQGQLSDTSQ TCRVNGVKLE TQGQPHPLCS
NPQSYSGQFY DQTVGFSQQD VKTGSFSVSE ANCLLQGPGA EHSELLSPGA NQVTSTVDSL
DSHDLEGVQI DFDAIIDDGD HASLMSGALS PSIIQNLSHS SSRLTTPRAS LPLPALSVST
TNMAIGDMSS LLTSLAEESK FLAVMQ


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