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GLI family zinc finger 3 (Transcriptional activator GLI3)

 H2QUH1_PANTR            Unreviewed;      1580 AA.
H2QUH1;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
05-JUL-2017, entry version 38.
SubName: Full=GLI family zinc finger 3 {ECO:0000313|EMBL:JAA01207.1};
SubName: Full=Transcriptional activator GLI3 {ECO:0000313|Ensembl:ENSPTRP00000032656};
Name=GLI3 {ECO:0000313|EMBL:JAA01207.1,
ECO:0000313|Ensembl:ENSPTRP00000032656};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000032656, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000032656, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136134; DOI=10.1038/nature04101;
Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
Rozen S., Wilson R.K., Page D.C.;
"Conservation of Y-linked genes during human evolution revealed by
comparative sequencing in chimpanzee.";
Nature 437:100-103(2005).
[3] {ECO:0000313|Ensembl:ENSPTRP00000032656}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[4] {ECO:0000313|EMBL:JAA01207.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA01207.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA18558.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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EMBL; AC146165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC189000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC191392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GABC01010131; JAA01207.1; -; mRNA.
EMBL; GABF01003587; JAA18558.1; -; mRNA.
RefSeq; XP_009451216.1; XM_009452941.2.
UniGene; Ptr.6521; -.
Ensembl; ENSPTRT00000035323; ENSPTRP00000032656; ENSPTRG00000019117.
GeneID; 463369; -.
CTD; 2737; -.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00760000118771; -.
OMA; MHNKRSK; -.
OrthoDB; EOG091G01XS; -.
TreeFam; TF350216; -.
Proteomes; UP000002277; Chromosome 7.
Bgee; ENSPTRG00000019117; -.
GO; GO:0005930; C:axoneme; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0016592; C:mediator complex; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0017053; C:transcriptional repressor complex; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0035035; F:histone acetyltransferase binding; IEA:Ensembl.
GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0060873; P:anterior semicircular canal development; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0060840; P:artery development; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0048593; P:camera-type eye morphogenesis; IEA:Ensembl.
GO; GO:0061005; P:cell differentiation involved in kidney development; IEA:Ensembl.
GO; GO:0048589; P:developmental growth; IEA:Ensembl.
GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0021861; P:forebrain radial glial cell differentiation; IEA:Ensembl.
GO; GO:0060364; P:frontal suture morphogenesis; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0060366; P:lambdoid suture morphogenesis; IEA:Ensembl.
GO; GO:0022018; P:lateral ganglionic eminence cell proliferation; IEA:Ensembl.
GO; GO:0060875; P:lateral semicircular canal development; IEA:Ensembl.
GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0060594; P:mammary gland specification; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IEA:Ensembl.
GO; GO:0001656; P:metanephros development; IEA:Ensembl.
GO; GO:0046639; P:negative regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0045060; P:negative thymic T cell selection; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0021631; P:optic nerve morphogenesis; IEA:Ensembl.
GO; GO:0060021; P:palate development; IEA:Ensembl.
GO; GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0016485; P:protein processing; IEA:Ensembl.
GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
GO; GO:1903010; P:regulation of bone development; IEA:Ensembl.
GO; GO:0060367; P:sagittal suture morphogenesis; IEA:Ensembl.
GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Ensembl.
GO; GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IEA:Ensembl.
GO; GO:0070242; P:thymocyte apoptotic process; IEA:Ensembl.
GO; GO:0043586; P:tongue development; IEA:Ensembl.
InterPro; IPR032851; GLI3.
InterPro; IPR013087; Znf_C2H2_type.
PANTHER; PTHR19818:SF110; PTHR19818:SF110; 1.
SMART; SM00355; ZnF_C2H2; 5.
SUPFAM; SSF57667; SSF57667; 3.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
DOMAIN 480 512 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 518 545 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 546 575 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 576 606 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
DOMAIN 607 637 C2H2-type. {ECO:0000259|PROSITE:PS50157}.
SEQUENCE 1580 AA; 169869 MW; 307480E05B9E53DE CRC64;
MEAQSHSSTT TEKKKVENSI VKCSTRTDVS EKAVASSTTS NEDESPGQTY HRERRNAITM
QPQNVQGLSK VSEEPSTSSD ERASLIKKEI HGSLPHVAEP SVPYRGTVFA MDPRNGYMEP
HYHPPHLFPA FHPPVPIDAR HHEGRYHYDP SPIPPLHMTS ALSSSPTYPD LPFIRISPHR
NPAAASESPF SPPHPYINPY MDYIRSLHSS PSLSMISATR GLSPTDAPHA GVSPAEYYHQ
MALLTGQRSP YADIIPSAAT AGTGAIHMEY LHAMDSTRFP SPRLSARPSR KRTLSISPLS
DHSFDLQTMI RTSPNSLVTI LNNSRSSSSA SGSYGHLSAS AISPALSFTY SSAPVSLHMH
QQILSRQQSL GSAFGHSPPL IHPAPTFPTQ RPIPGIPTVL NPVQVSSGPS ESSQNKPTSE
SAVSSTGDPM HNKRSKIKPD EDLPSPGARG QQEQPEGTTL VKEEGDKDES KQEPEVIYET
NCHWEGCARE FDTQEQLVHH INNDHIHGEK KEFVCRWLDC SREQKPFKAQ YMLVVHMRRH
TGEKPHKCTF EGCTKAYSRL ENLKTHLRSH TGEKPYVCEH EGCNKAFSNA SDRAKHQNRT
HSNEKPYVCK IPGCTKRYTD PSSLRKHVKT VHGPEAHVTK KQRGDIHPRP PPPRDSGSHS
QSRSPGRPTQ GALGEQQDLS NTTSKREECL QVKTVKAEKP MTSQPSPGGQ SSCSSQQSPI
SNYSNSGLEL PLTDGGSIGD LSAIDETPIM DSTISTATTA LALQARRNPA GTKWMEHVKL
ERLKQVNGMF PRLNPILPPK APAVSPLIGN GTQSNNTCSL GGPMTLLPGR SDLSGVDVTM
LNMLNRRDSS ASTISSAYLS SRRSSGISPC FSSRRSSEAS QAEGRPQNVS VADSYDPIST
DASRRSSEAS QSDGLPSLLS LTPAQQYRLK AKYAAATGGP PPTPLPNMER MSLKTRLALL
GDALEPGVAL PPVHAPRRCS DGGAHGYGRR HLQPHDAPGH GVRRASDPVR TGSEGLALPR
VPRFSSLSSC NPPAMATSAE KRSLVLQNYT RPEGGQSRNF HSSPCPPSIT ENVTLESLTM
DADANLNDED FLPDDVVQYL NSQNQAGYEQ HFPSALPDDS KVPHGPGDFD APGLPDSHAG
QQFHALEQPC PEGSKTDLPI QWNEVSSGSA DLSSSKLKCG PRPAVPQTRA FGFCNGMVVH
PQNPLRSGPA GGYQTLGENS NPYGGPEHLM LHNSPGSGTS GNAFHEQPCK APQYGNCLNR
QPVAPGALDG ACGAGIQASK LKSTPMQGSG GQLNFGLPVA PNESAGSMVN GMQNQDPVGQ
GYLAHQLLGD SMQHPGAGRP GQQMLGQISA TSHINIYQGP ESCLPGAHGM GSQPSSLAVV
RGYQPCASFG GSRRQAMPRD SLALQSGQLS DTSQTCRVNG IKMEMKGQPH PLCSNLQNYS
GQFYDQTVGF SQQDTKAGSF SISDASCLLQ GTSAKNSELL SPGANQVTST VDSLDSHDLE
GVQIDFDAII DDGDHSSLMS GALSPSIIQN LSYSSSRLTT PRASLPFPAL SMSTTNMAIG
DMSSLLTSLA EESKFLAVMQ


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