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GLI-Kruppel family member (Zinc finger protein GLI2)

 A5A9W5_MOUSE            Unreviewed;        85 AA.
A5A9W5;
12-JUN-2007, integrated into UniProtKB/TrEMBL.
12-JUN-2007, sequence version 1.
05-DEC-2018, entry version 84.
SubName: Full=GLI-Kruppel family member {ECO:0000313|EMBL:CAK12557.1};
SubName: Full=Zinc finger protein GLI2 {ECO:0000313|Ensembl:ENSMUSP00000125059};
Name=Gli2 {ECO:0000313|Ensembl:ENSMUSP00000125059,
ECO:0000313|MGI:MGI:95728};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:CAK12557.1};
[1] {ECO:0000313|EMBL:CAK12557.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:CAK18609.1}, and
C57BL6/J {ECO:0000313|EMBL:CAK12557.1};
Speek M., Njunkova O., Pata I., Valdre E., Kogerman P.;
"A potential role of alternative splicing in the regulation of the
transcriptional activity of human GLI2 in gonadal tissues.";
BMC Mol. Biol. 7:13-13(2006).
[2] {ECO:0000313|Ensembl:ENSMUSP00000125059, ECO:0000313|Proteomes:UP000000589}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125059,
ECO:0000313|Proteomes:UP000000589};
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[3] {ECO:0000313|Ensembl:ENSMUSP00000125059}
IDENTIFICATION.
STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000125059};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
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EMBL; AC109271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC122287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC132589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AM261670; CAK12557.1; -; mRNA.
EMBL; AM262741; CAK18609.1; -; mRNA.
UniGene; Mm.273292; -.
Ensembl; ENSMUST00000159839; ENSMUSP00000125661; ENSMUSG00000048402.
Ensembl; ENSMUST00000162552; ENSMUSP00000125059; ENSMUSG00000048402.
MGI; MGI:95728; Gli2.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00940000159213; -.
HOVERGEN; HBG099023; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000048402; Expressed in 311 organ(s), highest expression level in limb bud.
GO; GO:0005930; C:axoneme; IEA:Ensembl.
GO; GO:0097542; C:ciliary tip; IEA:Ensembl.
GO; GO:0016020; C:membrane; IEA:Ensembl.
GO; GO:0031514; C:motile cilium; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
GO; GO:0001077; F:proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
GO; GO:0021696; P:cerebellar cortex morphogenesis; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
GO; GO:0048589; P:developmental growth; IEA:Ensembl.
GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0021508; P:floor plate formation; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0007442; P:hindgut morphogenesis; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0060603; P:mammary gland duct morphogenesis; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0060032; P:notochord regression; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
GO; GO:0060513; P:prostatic bud formation; IEA:Ensembl.
GO; GO:0009954; P:proximal/distal pattern formation; IEA:Ensembl.
GO; GO:0008589; P:regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0060831; P:smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IEA:Ensembl.
GO; GO:0021938; P:smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation; IEA:Ensembl.
GO; GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Ensembl.
GO; GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IEA:Ensembl.
GO; GO:0021965; P:spinal cord ventral commissure morphogenesis; IEA:Ensembl.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000589};
Reference proteome {ECO:0000313|Proteomes:UP000000589}.
SEQUENCE 85 AA; 9053 MW; A964AA619AA44106 CRC64;
METSAPAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAA VAAHGVPQQL LPAFHAPLPI
DMRHQEGRYH YDPHSVHSVH GITIL


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