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GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase) (Guanosine monophosphate reductase)

 A0A0A8WY71_9DELT        Unreviewed;       352 AA.
A0A0A8WY71;
04-MAR-2015, integrated into UniProtKB/TrEMBL.
04-MAR-2015, sequence version 1.
28-MAR-2018, entry version 19.
RecName: Full=GMP reductase {ECO:0000256|HAMAP-Rule:MF_00596};
EC=1.7.1.7 {ECO:0000256|HAMAP-Rule:MF_00596};
AltName: Full=Guanosine 5'-monophosphate oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00596};
Short=Guanosine monophosphate reductase {ECO:0000256|HAMAP-Rule:MF_00596};
Name=guaC {ECO:0000256|HAMAP-Rule:MF_00596,
ECO:0000313|EMBL:GAM10921.1};
ORFNames=OR1_03221 {ECO:0000313|EMBL:GAM10921.1};
Geobacter sp. OR-1.
Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
Geobacteraceae; Geobacter.
NCBI_TaxID=1266765 {ECO:0000313|EMBL:GAM10921.1, ECO:0000313|Proteomes:UP000030972};
[1] {ECO:0000313|EMBL:GAM10921.1, ECO:0000313|Proteomes:UP000030972}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=OR-1 {ECO:0000313|EMBL:GAM10921.1,
ECO:0000313|Proteomes:UP000030972};
PubMed=23668621; DOI=10.1021/es400231x;
Ohtsuka T., Yamaguchi N., Makino T., Sakurai K., Kimura K., Kudo K.,
Homma E., Dong DT., Amachi S.;
"Arsenic dissolution from Japanese paddy soil by a dissimilatory
arsenate-reducing bacterium Geobacter sp. OR-1.";
Environ. Sci. Technol. 47:6263-6271(2013).
[2] {ECO:0000313|EMBL:GAM10921.1, ECO:0000313|Proteomes:UP000030972}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=OR-1 {ECO:0000313|EMBL:GAM10921.1,
ECO:0000313|Proteomes:UP000030972};
Ehara A., Suzuki H., Amachi S.;
"Draft Genome Sequence of Geobacter sp. Strain OR-1, an Arsenate-
Respiring Bacterium Isolated from Japanese Paddy Soil.";
Genome Announc. 3:e01478-14(2015).
-!- FUNCTION: Catalyzes the irreversible NADPH-dependent deamination
of GMP to IMP. It functions in the conversion of nucleobase,
nucleoside and nucleotide derivatives of G to A nucleotides, and
in maintaining the intracellular balance of A and G nucleotides.
{ECO:0000256|HAMAP-Rule:MF_00596, ECO:0000256|RuleBase:RU003929,
ECO:0000256|SAAS:SAAS00825629}.
-!- CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH(3) + NADP(+) =
guanosine 5'-phosphate + NADPH. {ECO:0000256|HAMAP-Rule:MF_00596,
ECO:0000256|RuleBase:RU003929, ECO:0000256|SAAS:SAAS00825631}.
-!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00596}.
-!- SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 1
subfamily. {ECO:0000256|HAMAP-Rule:MF_00596}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:GAM10921.1}.
-----------------------------------------------------------------------
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EMBL; BAZF01000017; GAM10921.1; -; Genomic_DNA.
RefSeq; WP_041972859.1; NZ_BAZF01000017.1.
EnsemblBacteria; GAM10921; GAM10921; OR1_03221.
Proteomes; UP000030972; Unassembled WGS sequence.
GO; GO:1902560; C:GMP reductase complex; IEA:UniProtKB-EC.
GO; GO:0003920; F:GMP reductase activity; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006163; P:purine nucleotide metabolic process; IEA:UniProtKB-UniRule.
CDD; cd00381; IMPDH; 1.
Gene3D; 3.20.20.70; -; 1.
HAMAP; MF_00596; GMP_reduct_type1; 1.
InterPro; IPR013785; Aldolase_TIM.
InterPro; IPR005993; GMPR.
InterPro; IPR015875; IMP_DH/GMP_Rdtase_CS.
InterPro; IPR001093; IMP_DH_GMPRt.
Pfam; PF00478; IMPDH; 1.
PIRSF; PIRSF000235; GMP_reductase; 1.
TIGRFAMs; TIGR01305; GMP_reduct_1; 1.
PROSITE; PS00487; IMP_DH_GMP_RED; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000030972};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00596,
ECO:0000256|PIRSR:PIRSR000235-3, ECO:0000256|RuleBase:RU003929};
NADP {ECO:0000256|HAMAP-Rule:MF_00596, ECO:0000256|RuleBase:RU003929,
ECO:0000256|SAAS:SAAS00825633};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00596};
Potassium {ECO:0000256|HAMAP-Rule:MF_00596,
ECO:0000256|PIRSR:PIRSR000235-3, ECO:0000256|RuleBase:RU003929};
Reference proteome {ECO:0000313|Proteomes:UP000030972}.
DOMAIN 9 336 IMPDH. {ECO:0000259|Pfam:PF00478}.
NP_BIND 108 131 NADP. {ECO:0000256|HAMAP-Rule:MF_00596}.
NP_BIND 216 239 NADP; ribose moiety. {ECO:0000256|HAMAP-
Rule:MF_00596}.
ACT_SITE 186 186 Thioimidate intermediate.
{ECO:0000256|HAMAP-Rule:MF_00596,
ECO:0000256|PIRSR:PIRSR000235-1}.
METAL 181 181 Potassium; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_00596,
ECO:0000256|PIRSR:PIRSR000235-3}.
METAL 183 183 Potassium; via carbonyl oxygen.
{ECO:0000256|HAMAP-Rule:MF_00596,
ECO:0000256|PIRSR:PIRSR000235-3}.
SEQUENCE 352 AA; 37692 MW; B48E16F51CC5570F CRC64;
MRVETDMKLG FKDVLIRPKR SNLKSRSQVD LARSYTFLHS RKEWSGIPVI ASNMDTIGTF
EVAGVLARHG LLTAIHKHYT PQEWDSFLNS CGSPVSANIM VTSGTSAEDF AKLVSIMGSH
QALDFICIDV ANGYTETFVE FVLKVREAFP DKTIVAGNVV TGEMVEELLL SGADIVKVGI
GPGSVCTTRL KAGVGYPQLS AVIECADAAH GLGGRIISDG GCTCPGDVAK AFGAGADFVM
LGGMFAGHDE CGGELAERDG RSYKIFYGMS SATAMSRHSG GVPRYRASEG KTVEVPYRGP
IEETVKDILG GVRSACTYVG AGALKELTKR TTFIRVLEQE NRFFSDPSPI TP


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