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GRB2 isoform 3 (GRB2 isoform 4) (GRB2 isoform 6) (Growth factor receptor-bound protein 2)

 G2HGD2_PANTR            Unreviewed;       217 AA.
G2HGD2; A0A2J8KBE0;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
12-SEP-2018, entry version 63.
SubName: Full=GRB2 isoform 3 {ECO:0000313|EMBL:PNI32343.1};
SubName: Full=GRB2 isoform 4 {ECO:0000313|EMBL:PNI32344.1};
SubName: Full=GRB2 isoform 6 {ECO:0000313|EMBL:PNI32346.1};
SubName: Full=Growth factor receptor-bound protein 2 {ECO:0000313|EMBL:BAK62790.1, ECO:0000313|Ensembl:ENSPTRP00000016382};
Name=GRB2 {ECO:0000313|EMBL:JAA03233.1,
ECO:0000313|Ensembl:ENSPTRP00000016382, ECO:0000313|VGNC:VGNC:14183};
ORFNames=CK820_G0039891 {ECO:0000313|EMBL:PNI32343.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|EMBL:BAK62790.1};
[1] {ECO:0000313|Ensembl:ENSPTRP00000016382, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|EMBL:BAK62790.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Testis {ECO:0000313|EMBL:BAK62790.1};
PubMed=21484476; DOI=10.1007/s10142-011-0220-9;
Kim R.N., Kim D.W., Choi S.H., Chae S.H., Nam S.H., Kim D.W., Kim A.,
Kang A., Park K.H., Lee Y.S., Hirai M., Suzuki Y., Sugano S.,
Hashimoto K., Kim D.S., Park H.S.;
"Major chimpanzee-specific structural changes in sperm development-
associated genes.";
Funct. Integr. Genomics 11:507-517(2011).
[3] {ECO:0000313|Ensembl:ENSPTRP00000016382}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[4] {ECO:0000313|EMBL:JAA03233.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03233.1},
Skeletal muscle {ECO:0000313|EMBL:JAA40077.1},
Skin {ECO:0000313|EMBL:JAA30201.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA16033.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:PNI32343.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI32343.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI32343.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AACZ04070071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04070072; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AK305796; BAK62790.1; -; mRNA.
EMBL; GABC01008105; JAA03233.1; -; mRNA.
EMBL; GABC01008104; JAA03234.1; -; mRNA.
EMBL; GABF01006112; JAA16033.1; -; mRNA.
EMBL; GABF01006111; JAA16034.1; -; mRNA.
EMBL; GABF01006110; JAA16035.1; -; mRNA.
EMBL; GABF01006109; JAA16036.1; -; mRNA.
EMBL; GABF01006108; JAA16037.1; -; mRNA.
EMBL; GABF01006107; JAA16038.1; -; mRNA.
EMBL; GABD01002899; JAA30201.1; -; mRNA.
EMBL; GABD01002898; JAA30202.1; -; mRNA.
EMBL; GABD01002897; JAA30203.1; -; mRNA.
EMBL; GABE01004662; JAA40077.1; -; mRNA.
EMBL; GABE01004661; JAA40078.1; -; mRNA.
EMBL; NBAG03000379; PNI32343.1; -; Genomic_DNA.
EMBL; NBAG03000379; PNI32344.1; -; Genomic_DNA.
EMBL; NBAG03000379; PNI32346.1; -; Genomic_DNA.
RefSeq; NP_001233546.1; NM_001246617.1.
SMR; G2HGD2; -.
STRING; 9598.ENSPTRP00000016382; -.
Ensembl; ENSPTRT00000017683; ENSPTRP00000016382; ENSPTRG00000009642.
GeneID; 737245; -.
KEGG; ptr:737245; -.
CTD; 2885; -.
VGNC; VGNC:14183; GRB2.
eggNOG; KOG3601; Eukaryota.
eggNOG; ENOG410XR1G; LUCA.
GeneTree; ENSGT00820000126999; -.
KO; K04364; -.
OMA; HWWHGEI; -.
OrthoDB; EOG091G0HWS; -.
TreeFam; TF354288; -.
Proteomes; UP000002277; Chromosome 17.
Bgee; ENSPTRG00000009642; Expressed in 6 organ(s), highest expression level in cerebellum.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0008180; C:COP9 signalosome; IEA:Ensembl.
GO; GO:0005768; C:endosome; IEA:Ensembl.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IBA:GO_Central.
GO; GO:0070436; C:Grb2-EGFR complex; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0005154; F:epidermal growth factor receptor binding; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0043560; F:insulin receptor substrate binding; IEA:Ensembl.
GO; GO:0005168; F:neurotrophin TRKA receptor binding; IEA:Ensembl.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
GO; GO:0005070; F:SH3/SH2 adaptor activity; IEA:Ensembl.
GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
GO; GO:0048646; P:anatomical structure formation involved in morphogenesis; IEA:Ensembl.
GO; GO:0060670; P:branching involved in labyrinthine layer morphogenesis; IEA:Ensembl.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0016477; P:cell migration; IBA:GO_Central.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0045087; P:innate immune response; IBA:GO_Central.
GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0038083; P:peptidyl-tyrosine autophosphorylation; IBA:GO_Central.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0007265; P:Ras protein signal transduction; IEA:InterPro.
GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IBA:GO_Central.
GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
CDD; cd11949; SH3_GRB2_C; 1.
CDD; cd11946; SH3_GRB2_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR030219; Grb2.
InterPro; IPR035643; GRB2_C_SH3.
InterPro; IPR035641; GRB2_N_SH3.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
PANTHER; PTHR24418:SF290; PTHR24418:SF290; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 2.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 2.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Receptor {ECO:0000313|EMBL:BAK62790.1};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643}.
DOMAIN 1 58 SH3. {ECO:0000259|PROSITE:PS50002}.
DOMAIN 60 152 SH2. {ECO:0000259|PROSITE:PS50001}.
DOMAIN 156 215 SH3. {ECO:0000259|PROSITE:PS50002}.
SEQUENCE 217 AA; 25206 MW; 83A4B0BA1B248DC4 CRC64;
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL
WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG
DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV


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