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GS homeobox 2 (Genetic-screened homeobox 2) (Homeobox protein GSH-2)

 GSX2_MOUSE              Reviewed;         305 AA.
P31316;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 2.
12-SEP-2018, entry version 136.
RecName: Full=GS homeobox 2;
AltName: Full=Genetic-screened homeobox 2;
AltName: Full=Homeobox protein GSH-2;
Name=Gsx2; Synonyms=Gsh-2, Gsh2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
STRAIN=NIH Swiss;
PubMed=7619729; DOI=10.1016/0925-4773(94)00334-J;
Hsieh-Li H.M., Witte D.P., Szucsik J.C., Weinstein M., Li H.,
Potter S.S.;
"Gsh-2, a murine homeobox gene expressed in the developing brain.";
Mech. Dev. 50:177-186(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 203-262.
PubMed=1683707; DOI=10.1073/pnas.88.23.10706;
Singh G., Kaur S., Stock J.L., Jenkins N.A., Gilbert D.J.,
Copeland N.G., Potter S.S.;
"Identification of 10 murine homeobox genes.";
Proc. Natl. Acad. Sci. U.S.A. 88:10706-10710(1991).
[3]
FUNCTION, AND DEVELOPMENTAL STAGE.
PubMed=19709628; DOI=10.1016/j.neuron.2009.07.015;
Waclaw R.R., Wang B., Pei Z., Ehrman L.A., Campbell K.;
"Distinct temporal requirements for the homeobox gene Gsx2 in
specifying striatal and olfactory bulb neuronal fates.";
Neuron 63:451-465(2009).
-!- FUNCTION: During telencephalic development, causes ventralization
of pallial progenitors and, depending on the developmental stage,
specifies different neuronal fates. At early stages, necessary and
sufficient to correctly specify the ventral lateral ganglionic
eminence (LGE) and its major derivatives, the striatal projection
neurons. At later stages, may specify LGE progenitors toward
dorsal LGE fates, including olfactory bulb interneurons
(PubMed:19709628). Transcription factor that binds 5'-CNAATTAG-3'
DNA sequence (PubMed:7619729). {ECO:0000269|PubMed:19709628,
ECO:0000269|PubMed:7619729}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- DEVELOPMENTAL STAGE: At 10.0 dpc, expressed in a band of primitive
neuroepithelial cells in the neural tube, mesencephalon and
telencephalon. At 11.5-13.5 dpc, expression is symmetrical, but
tightly limited in areas of the forebrain, midbrain and hindbrain
(PubMed:7619729). At 11 dpc, in the developping telencephalon,
expressed at high levels in cells throughout the presumptive
lateral ganglionic eminence (LGE), with an apparent ventral-to-
dorsal gradient in expressing cell numbers. Positive cells are
also scattered somewhat uniformly throughout the adjacent medial
ganglionic eminence. At 12.5 dpc onward, exhibits a clear graded
pattern of expression, with low levels found in cells located
ventrally and the highest levels confined to those in the most
dorsal portion of the LGE (at protein level) (PubMed:19709628).
Expression decreases from 14.5 dpc on and becomes undetectable at
16.5 dpc (PubMed:7619729). {ECO:0000269|PubMed:19709628,
ECO:0000269|PubMed:7619729}.
-!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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EMBL; S79041; AAB34947.1; -; mRNA.
CCDS; CCDS19350.1; -.
PIR; B37290; B37290.
RefSeq; NP_573555.1; NM_133256.2.
UniGene; Mm.218752; -.
ProteinModelPortal; P31316; -.
SMR; P31316; -.
BioGrid; 200086; 1.
STRING; 10090.ENSMUSP00000036625; -.
PaxDb; P31316; -.
PRIDE; P31316; -.
DNASU; 14843; -.
Ensembl; ENSMUST00000040477; ENSMUSP00000036625; ENSMUSG00000035946.
GeneID; 14843; -.
KEGG; mmu:14843; -.
UCSC; uc008xtx.1; mouse.
CTD; 170825; -.
MGI; MGI:95843; Gsx2.
eggNOG; KOG0489; Eukaryota.
eggNOG; ENOG410ZTBY; LUCA.
GeneTree; ENSGT00910000144005; -.
HOGENOM; HOG000010106; -.
HOVERGEN; HBG003555; -.
InParanoid; P31316; -.
KO; K09310; -.
OMA; FCVCPLC; -.
OrthoDB; EOG091G0HAO; -.
PhylomeDB; P31316; -.
TreeFam; TF315938; -.
PRO; PR:P31316; -.
Proteomes; UP000000589; Chromosome 5.
Bgee; ENSMUSG00000035946; Expressed in 39 organ(s), highest expression level in kidney interstitium.
CleanEx; MM_GSX2; -.
ExpressionAtlas; P31316; baseline and differential.
Genevisible; P31316; MM.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0007420; P:brain development; IGI:MGI.
GO; GO:0007417; P:central nervous system development; IMP:MGI.
GO; GO:0021798; P:forebrain dorsal/ventral pattern formation; IMP:MGI.
GO; GO:0048853; P:forebrain morphogenesis; IMP:MGI.
GO; GO:0021575; P:hindbrain morphogenesis; IMP:MGI.
GO; GO:0048663; P:neuron fate commitment; IGI:MGI.
GO; GO:0048665; P:neuron fate specification; IMP:MGI.
GO; GO:0021889; P:olfactory bulb interneuron differentiation; IMP:MGI.
GO; GO:0007389; P:pattern specification process; IMP:MGI.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:MGI.
GO; GO:0048714; P:positive regulation of oligodendrocyte differentiation; IMP:MGI.
GO; GO:0030334; P:regulation of cell migration; IMP:MGI.
GO; GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; IMP:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0021527; P:spinal cord association neuron differentiation; IGI:MGI.
GO; GO:0021544; P:subpallium development; IGI:MGI.
GO; GO:0060163; P:subpallium neuron fate commitment; IMP:MGI.
GO; GO:0021978; P:telencephalon regionalization; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
Pfam; PF00046; Homeobox; 1.
PRINTS; PR00024; HOMEOBOX.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; DNA-binding; Homeobox;
Nucleus; Reference proteome; Transcription; Transcription regulation.
CHAIN 1 305 GS homeobox 2.
/FTId=PRO_0000048897.
DNA_BIND 203 262 Homeobox. {ECO:0000255|PROSITE-
ProRule:PRU00108}.
COMPBIAS 124 130 Poly-His.
COMPBIAS 134 139 Poly-His.
COMPBIAS 147 163 Poly-Ala.
SEQUENCE 305 AA; 32167 MW; 51E7F2DB76E32608 CRC64;
MSRSFYVDSL IIKDSSRPAP SLPESHPGPD FFIPLGMPSP LVMSVSGPGC PSRKSGAFCV
CPLCVTSHLH SSRPPAGAGG GATGTAGAAV AGGGVAGGTG ALPLLKSQFS PAPGDAQFCP
RVSHAHHHHH PPQHHHHHHQ PQQPGSAAAA AAAAAAAAAA AAALGHPQHH APVCAATTYN
MSDPRRFHCL SMGGSDTSQV PNGKRMRTAF TSTQLLELER EFSSNMYLSR LRRIEIATYL
NLSEKQVKIW FQNRRVKHKK EGKGASRNNH TSCKCVGSQA HYARSEDEDS LSPASANEDK
EISPL


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