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Galactokinase (EC 2.7.1.6) (Galactose kinase)

 GALK1_HUMAN             Reviewed;         392 AA.
P51570; B2RC07; B4E1G6;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
25-OCT-2017, entry version 179.
RecName: Full=Galactokinase;
EC=2.7.1.6;
AltName: Full=Galactose kinase;
Name=GALK1; Synonyms=GALK;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT II GALACTOSEMIA
MET-32.
PubMed=7670469; DOI=10.1038/ng0795-307;
Stambolian D., Ai Y., Sidjanin D., Nesburn K., Sathe G., Rosenberg M.,
Bergsma D.J.;
"Cloning of the galactokinase cDNA and identification of mutations in
two families with cataracts.";
Nat. Genet. 10:307-312(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8908517; DOI=10.1101/gr.6.10.980;
Bergsma D.J., Ai Y., Skach W.R., Nesburn K., Anoia E., van Horn S.,
Stambolian D.;
"Fine structure of the human galactokinase GALK1 gene.";
Genome Res. 6:980-985(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Lung;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16625196; DOI=10.1038/nature04689;
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
"DNA sequence of human chromosome 17 and analysis of rearrangement in
the human lineage.";
Nature 440:1045-1049(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
PROTEIN SEQUENCE OF 6-17; 22-37; 70-97; 205-239; 257-267; 288-296 AND
343-388, AND IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Fetal brain cortex;
Lubec G., Chen W.-Q., Sun Y.;
Submitted (DEC-2008) to UniProtKB.
[9]
CHARACTERIZATION.
PubMed=7542884; DOI=10.1006/bbrc.1995.2023;
Ai Y., Basu M., Bergsma D.J., Stambolian D.;
"Comparison of the enzymatic activities of human galactokinase GALK1
and a related human galactokinase protein GK2.";
Biochem. Biophys. Res. Commun. 212:687-691(1995).
[10]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-230, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[12]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[13]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 2-392 IN COMPLEX WITH
D-GALACTOSE AND ATP ANALOG, SUBUNIT, AND SUBSTRATE-BINDING SITES.
PubMed=15590630; DOI=10.1074/jbc.M412916200;
Thoden J.B., Timson D.J., Reece R.J., Holden H.M.;
"Molecular structure of human galactokinase: implications for type II
galactosemia.";
J. Biol. Chem. 280:9662-9670(2005).
[14]
VARIANT GALCT2 THR-28.
PubMed=10521295; DOI=10.1086/302611;
Kalaydjieva L., Perez-Lezaun A., Angelicheva D., Onengut S., Dye D.,
Bosshard N.U., Jordanova A., Savov A., Yanakiev P., Kremensky I.,
Radeva B., Hallmayer J., Markov A., Nedkova V., Tournev I., Aneva L.,
Gitzelmann R.;
"A founder mutation in the GK1 gene is responsible for galactokinase
deficiency in Roma (Gypsies).";
Am. J. Hum. Genet. 65:1299-1307(1999).
[15]
VARIANTS GALCT2 THR-28; ARG-36; TYR-44; SER-346 AND SER-349.
PubMed=10790206;
DOI=10.1002/(SICI)1098-1004(200005)15:5<447::AID-HUMU6>3.3.CO;2-D;
Kolosha V., Anoia E., de Cespedes C., Gitzelmann R., Shih L.,
Casco T., Saborio M., Trejos R., Buist N., Tedesco T., Skach W.,
Mitelmann O., Ledee D., Huang K., Stambolian D.;
"Novel mutations in 13 probands with galactokinase deficiency.";
Hum. Mutat. 15:447-453(2000).
[16]
VARIANT GALCT2 VAL-198.
PubMed=11231902; DOI=10.1086/319512;
Okano Y., Asada M., Fujimoto A., Ohtake A., Murayama K., Hsiao K.-J.,
Choeh K., Yang Y., Cao Q., Reichardt J.K.V., Niihira S., Imamura T.,
Yamano T.;
"A genetic factor for age-related cataract: identification and
characterization of a novel galactokinase variant, 'Osaka,' in
Asians.";
Am. J. Hum. Genet. 68:1036-1042(2001).
[17]
VARIANTS GALCT2 CYS-68; MET-288 AND PRO-384.
PubMed=11139256;
DOI=10.1002/1098-1004(2001)17:1<77::AID-HUMU20>3.3.CO;2-8;
Hunter M., Angelicheva D., Levy H.L., Pueschel S.M., Kalaydjieva L.;
"Novel mutations in the GALK1 gene in patients with galactokinase
deficiency.";
Hum. Mutat. 17:77-78(2001).
[18]
CHARACTERIZATION OF VARIANTS GALCT2 THR-28; MET-32; ARG-36; TYR-44;
CYS-68; VAL-198; MET-288; SER-346; SER-349 AND PRO-384.
PubMed=12694189; DOI=10.1046/j.1432-1033.2003.03538.x;
Timson D.J., Reece R.J.;
"Functional analysis of disease-causing mutations in human
galactokinase.";
Eur. J. Biochem. 270:1767-1774(2003).
[19]
VARIANTS MET-184; ASP-274 AND ALA-338.
PubMed=12942049;
Maraini G., Hejtmancik J.F., Shiels A., Mackay D.S., Aldigeri R.,
Jiao X.D., Williams S.L., Sperduto R.D., Reed G.;
"Galactokinase gene mutations and age-related cataract. Lack of
association in an Italian population.";
Mol. Vis. 9:397-400(2003).
[20]
VARIANTS GALCT2 MET-32 AND GLN-239.
PubMed=15024738; DOI=10.1002/humu.9223;
Sangiuolo F., Magnani M., Stambolian D., Novelli G.;
"Biochemical characterization of two GALK1 mutations in patients with
galactokinase deficiency.";
Hum. Mutat. 23:396-396(2004).
-!- FUNCTION: Major enzyme for galactose metabolism.
-!- CATALYTIC ACTIVITY: ATP + alpha-D-galactose = ADP + alpha-D-
galactose 1-phosphate.
-!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
-!- SUBUNIT: Homodimer. {ECO:0000305|PubMed:15590630}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P51570-1; Sequence=Displayed;
Name=2;
IsoId=P51570-2; Sequence=VSP_055079;
Note=No experimental confirmation available.;
-!- DISEASE: Galactosemia II (GALCT2) [MIM:230200]: Autosomal
recessive deficiency characterized by congenital cataracts during
infancy and presenile cataracts in the adult population. The
cataracts are secondary to accumulation of galactitol in the
lenses. {ECO:0000269|PubMed:10521295, ECO:0000269|PubMed:10790206,
ECO:0000269|PubMed:11139256, ECO:0000269|PubMed:11231902,
ECO:0000269|PubMed:12694189, ECO:0000269|PubMed:15024738}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
{ECO:0000305}.
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EMBL; U26401; AAA96147.1; -; mRNA.
EMBL; L76927; AAB51607.1; -; Genomic_DNA.
EMBL; AK303832; BAG64778.1; -; mRNA.
EMBL; AK314890; BAG37404.1; -; mRNA.
EMBL; BT007005; AAP35651.1; -; mRNA.
EMBL; AC087749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471099; EAW89316.1; -; Genomic_DNA.
EMBL; BC001166; AAH01166.1; -; mRNA.
CCDS; CCDS11728.1; -. [P51570-1]
RefSeq; NP_000145.1; NM_000154.1. [P51570-1]
UniGene; Hs.407966; -.
PDB; 1WUU; X-ray; 2.50 A; A/B/C/D=2-392.
PDB; 1YH7; Model; -; A=1-392.
PDBsum; 1WUU; -.
PDBsum; 1YH7; -.
ProteinModelPortal; P51570; -.
SMR; P51570; -.
BioGrid; 108857; 17.
IntAct; P51570; 17.
MINT; MINT-4999410; -.
STRING; 9606.ENSP00000225614; -.
BindingDB; P51570; -.
ChEMBL; CHEMBL1293257; -.
DrugBank; DB04395; Phosphoaminophosphonic Acid-Adenylate Ester.
iPTMnet; P51570; -.
PhosphoSitePlus; P51570; -.
BioMuta; GALK1; -.
DMDM; 1730187; -.
OGP; P51570; -.
REPRODUCTION-2DPAGE; IPI00019383; -.
EPD; P51570; -.
PaxDb; P51570; -.
PeptideAtlas; P51570; -.
PRIDE; P51570; -.
DNASU; 2584; -.
Ensembl; ENST00000225614; ENSP00000225614; ENSG00000108479. [P51570-1]
Ensembl; ENST00000588479; ENSP00000465930; ENSG00000108479. [P51570-1]
GeneID; 2584; -.
KEGG; hsa:2584; -.
CTD; 2584; -.
DisGeNET; 2584; -.
EuPathDB; HostDB:ENSG00000108479.11; -.
GeneCards; GALK1; -.
HGNC; HGNC:4118; GALK1.
HPA; HPA007094; -.
HPA; HPA016960; -.
MalaCards; GALK1; -.
MIM; 230200; phenotype.
MIM; 604313; gene.
neXtProt; NX_P51570; -.
OpenTargets; ENSG00000108479; -.
Orphanet; 79237; Galactokinase deficiency.
PharmGKB; PA28533; -.
eggNOG; KOG0631; Eukaryota.
eggNOG; COG0153; LUCA.
GeneTree; ENSGT00530000063433; -.
HOGENOM; HOG000241100; -.
HOVERGEN; HBG051695; -.
InParanoid; P51570; -.
KO; K00849; -.
OMA; THQDYKG; -.
OrthoDB; EOG091G06HT; -.
PhylomeDB; P51570; -.
TreeFam; TF354326; -.
BRENDA; 2.7.1.6; 2681.
Reactome; R-HSA-70370; Galactose catabolism.
SABIO-RK; P51570; -.
UniPathway; UPA00214; -.
EvolutionaryTrace; P51570; -.
GenomeRNAi; 2584; -.
PRO; PR:P51570; -.
Proteomes; UP000005640; Chromosome 17.
Bgee; ENSG00000108479; -.
CleanEx; HS_GALK1; -.
ExpressionAtlas; P51570; baseline and differential.
Genevisible; P51570; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0016020; C:membrane; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; IDA:UniProtKB.
GO; GO:0004335; F:galactokinase activity; IDA:UniProtKB.
GO; GO:0005534; F:galactose binding; IDA:UniProtKB.
GO; GO:0019402; P:galactitol metabolic process; IEA:Ensembl.
GO; GO:0019388; P:galactose catabolic process; TAS:Reactome.
GO; GO:0006012; P:galactose metabolic process; IMP:UniProtKB.
GO; GO:0061623; P:glycolytic process from galactose; IEA:Ensembl.
Gene3D; 3.30.230.10; -; 1.
Gene3D; 3.30.70.890; -; 1.
InterPro; IPR000705; Galactokinase.
InterPro; IPR019741; Galactokinase_CS.
InterPro; IPR019539; GalKase_gal-bd.
InterPro; IPR013750; GHMP_kinase_C_dom.
InterPro; IPR036554; GHMP_kinase_C_sf.
InterPro; IPR006204; GHMP_kinase_N_dom.
InterPro; IPR006203; GHMP_knse_ATP-bd_CS.
InterPro; IPR006206; Mevalonate/galactokinase.
InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
PANTHER; PTHR10457:SF6; PTHR10457:SF6; 1.
Pfam; PF10509; GalKase_gal_bdg; 1.
Pfam; PF08544; GHMP_kinases_C; 1.
Pfam; PF00288; GHMP_kinases_N; 1.
PIRSF; PIRSF000530; Galactokinase; 1.
PRINTS; PR00473; GALCTOKINASE.
SUPFAM; SSF54211; SSF54211; 1.
SUPFAM; SSF55060; SSF55060; 1.
TIGRFAMs; TIGR00131; gal_kin; 1.
PROSITE; PS00106; GALACTOKINASE; 1.
PROSITE; PS00627; GHMP_KINASES_ATP; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; ATP-binding;
Carbohydrate metabolism; Cataract; Complete proteome;
Direct protein sequencing; Disease mutation; Galactose metabolism;
Kinase; Nucleotide-binding; Phosphoprotein; Polymorphism;
Reference proteome; Transferase.
CHAIN 1 392 Galactokinase.
/FTId=PRO_0000184645.
NP_BIND 134 144 ATP.
REGION 43 46 Substrate binding.
REGION 183 186 Substrate binding.
ACT_SITE 186 186 Proton acceptor. {ECO:0000250}.
BINDING 236 236 Substrate.
SITE 37 37 Transition state stabilizer.
{ECO:0000305}.
MOD_RES 230 230 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
VAR_SEQ 1 1 M -> MCAPPRGAPPEHPAPTGLCRSSCAELQARVM (in
isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_055079.
VARIANT 28 28 P -> T (in GALCT2; founder Romani
mutation; dbSNP:rs104894572).
{ECO:0000269|PubMed:10521295,
ECO:0000269|PubMed:10790206,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_008514.
VARIANT 32 32 V -> M (in GALCT2; dbSNP:rs104894576).
{ECO:0000269|PubMed:12694189,
ECO:0000269|PubMed:15024738,
ECO:0000269|PubMed:7670469}.
/FTId=VAR_002547.
VARIANT 36 36 G -> R (in GALCT2).
{ECO:0000269|PubMed:10790206,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_023486.
VARIANT 44 44 H -> Y (in GALCT2).
{ECO:0000269|PubMed:10790206,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_023487.
VARIANT 68 68 R -> C (in GALCT2).
{ECO:0000269|PubMed:11139256,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_023488.
VARIANT 184 184 I -> M (in dbSNP:rs773416476).
{ECO:0000269|PubMed:12942049}.
/FTId=VAR_023489.
VARIANT 198 198 A -> V (in GALCT2; mild deficiency;
Osaka; dbSNP:rs80084721).
{ECO:0000269|PubMed:11231902,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_015746.
VARIANT 239 239 R -> Q (in GALCT2; dbSNP:rs575139300).
{ECO:0000269|PubMed:15024738}.
/FTId=VAR_023490.
VARIANT 274 274 G -> D (in dbSNP:rs547925860).
{ECO:0000269|PubMed:12942049}.
/FTId=VAR_023491.
VARIANT 288 288 T -> M (in GALCT2; dbSNP:rs759284637).
{ECO:0000269|PubMed:11139256,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_023492.
VARIANT 338 338 V -> A. {ECO:0000269|PubMed:12942049}.
/FTId=VAR_023493.
VARIANT 346 346 G -> S (in GALCT2; dbSNP:rs375690568).
{ECO:0000269|PubMed:10790206,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_023494.
VARIANT 349 349 G -> S (in GALCT2; dbSNP:rs754967473).
{ECO:0000269|PubMed:10790206,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_023495.
VARIANT 384 384 A -> P (in GALCT2).
{ECO:0000269|PubMed:11139256,
ECO:0000269|PubMed:12694189}.
/FTId=VAR_023496.
HELIX 9 24 {ECO:0000244|PDB:1WUU}.
STRAND 29 41 {ECO:0000244|PDB:1WUU}.
HELIX 46 48 {ECO:0000244|PDB:1WUU}.
STRAND 51 68 {ECO:0000244|PDB:1WUU}.
STRAND 72 77 {ECO:0000244|PDB:1WUU}.
STRAND 80 82 {ECO:0000244|PDB:1WUU}.
STRAND 86 91 {ECO:0000244|PDB:1WUU}.
HELIX 105 107 {ECO:0000244|PDB:1WUU}.
HELIX 108 116 {ECO:0000244|PDB:1WUU}.
STRAND 118 120 {ECO:0000244|PDB:1WUU}.
STRAND 124 131 {ECO:0000244|PDB:1WUU}.
STRAND 137 139 {ECO:0000244|PDB:1WUU}.
HELIX 141 156 {ECO:0000244|PDB:1WUU}.
HELIX 163 176 {ECO:0000244|PDB:1WUU}.
HELIX 185 192 {ECO:0000244|PDB:1WUU}.
STRAND 197 202 {ECO:0000244|PDB:1WUU}.
TURN 203 205 {ECO:0000244|PDB:1WUU}.
STRAND 208 212 {ECO:0000244|PDB:1WUU}.
STRAND 216 228 {ECO:0000244|PDB:1WUU}.
TURN 233 235 {ECO:0000244|PDB:1WUU}.
HELIX 236 249 {ECO:0000244|PDB:1WUU}.
HELIX 260 263 {ECO:0000244|PDB:1WUU}.
HELIX 266 269 {ECO:0000244|PDB:1WUU}.
HELIX 272 296 {ECO:0000244|PDB:1WUU}.
HELIX 300 316 {ECO:0000244|PDB:1WUU}.
HELIX 323 333 {ECO:0000244|PDB:1WUU}.
STRAND 338 343 {ECO:0000244|PDB:1WUU}.
STRAND 348 357 {ECO:0000244|PDB:1WUU}.
HELIX 358 360 {ECO:0000244|PDB:1WUU}.
HELIX 361 371 {ECO:0000244|PDB:1WUU}.
STRAND 377 381 {ECO:0000244|PDB:1WUU}.
STRAND 387 389 {ECO:0000244|PDB:1WUU}.
SEQUENCE 392 AA; 42272 MW; 8D7CFF8FDB0E4718 CRC64;
MAALRQPQVA ELLAEARRAF REEFGAEPEL AVSAPGRVNL IGEHTDYNQG LVLPMALELM
TVLVGSPRKD GLVSLLTTSE GADEPQRLQF PLPTAQRSLE PGTPRWANYV KGVIQYYPAA
PLPGFSAVVV SSVPLGGGLS SSASLEVATY TFLQQLCPDS GTIAARAQVC QQAEHSFAGM
PCGIMDQFIS LMGQKGHALL IDCRSLETSL VPLSDPKLAV LITNSNVRHS LASSEYPVRR
RQCEEVARAL GKESLREVQL EELEAARDLV SKEGFRRARH VVGEIRRTAQ AAAALRRGDY
RAFGRLMVES HRSLRDDYEV SCPELDQLVE AALAVPGVYG SRMTGGGFGG CTVTLLEASA
APHAMRHIQE HYGGTATFYL SQAADGAKVL CL


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