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Galectin-3 (Gal-3) (35 kDa lectin) (CBP30) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (IgE-binding protein) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)

 LEG3_CRILO              Reviewed;         245 AA.
P47953;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
25-OCT-2017, entry version 94.
RecName: Full=Galectin-3;
Short=Gal-3;
AltName: Full=35 kDa lectin;
AltName: Full=CBP30;
AltName: Full=Carbohydrate-binding protein 35;
Short=CBP 35;
AltName: Full=Galactose-specific lectin 3;
AltName: Full=IgE-binding protein;
AltName: Full=Laminin-binding protein;
AltName: Full=Lectin L-29;
AltName: Full=Mac-2 antigen;
Name=LGALS3;
Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese
hamster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10030;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Kidney;
PubMed=8027086;
Mehul B., Bawumia S., Martin S.R., Hughes R.C.;
"Structure of baby hamster kidney carbohydrate-binding protein CBP30,
an S-type animal lectin.";
J. Biol. Chem. 269:18250-18258(1994).
-!- FUNCTION: Galactose-specific lectin which binds IgE. May mediate
with the alpha-3, beta-1 integrin the stimulation by CSPG4 of
endothelial cells migration. Together with DMBT1, required for
terminal differentiation of columnar epithelial cells during early
embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor.
Involved in acute inflammatory responses including neutrophil
activation and adhesion, chemoattraction of monocytes macrophages,
opsonization of apoptotic neutrophils, and activation of mast
cells (By similarity). {ECO:0000250}.
-!- SUBUNIT: Probably forms homo- or heterodimers. Interacts with
DMBT1 (By similarity). Interacts with CD6 and ALCAM. Forms a
complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP,
LYPD3, CYHR1 and UACA (By similarity).
{ECO:0000250|UniProtKB:P08699, ECO:0000250|UniProtKB:P16110,
ECO:0000250|UniProtKB:P17931}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}. Secreted {ECO:0000250}. Note=Secreted by a non-
classical secretory pathway and associates with the cell surface.
{ECO:0000250}.
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EMBL; X78879; CAA55479.1; -; mRNA.
ProteinModelPortal; P47953; -.
SMR; P47953; -.
PRIDE; P47953; -.
HOVERGEN; HBG006255; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0019863; F:IgE binding; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
CDD; cd00070; GLECT; 1.
InterPro; IPR013320; ConA-like_dom.
InterPro; IPR015534; Galectin_3.
InterPro; IPR001079; Galectin_CRD.
PANTHER; PTHR11346:SF26; PTHR11346:SF26; 1.
Pfam; PF00337; Gal-bind_lectin; 1.
SMART; SM00908; Gal-bind_lectin; 1.
SMART; SM00276; GLECT; 1.
SUPFAM; SSF49899; SSF49899; 1.
PROSITE; PS51304; GALECTIN; 1.
2: Evidence at transcript level;
Acetylation; Cytoplasm; Differentiation; Disulfide bond;
IgE-binding protein; Immunity; Innate immunity; Lectin;
mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Repeat;
Secreted; Spliceosome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P38486}.
CHAIN 2 245 Galectin-3.
/FTId=PRO_0000076929.
REPEAT 35 43 1.
REPEAT 44 52 2.
REPEAT 53 61 3.
REPEAT 62 70 4.
REPEAT 71 78 5; approximate.
REPEAT 79 88 6; approximate.
REPEAT 89 99 7; approximate.
DOMAIN 113 243 Galectin. {ECO:0000255|PROSITE-
ProRule:PRU00639}.
REGION 35 99 7 X 9 AA tandem repeats of Y-P-G-X(3)-P-
[GS]-A.
REGION 176 182 Beta-galactoside binding. {ECO:0000250}.
MOTIF 221 236 Nuclear export signal. {ECO:0000250}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P38486}.
MOD_RES 6 6 Phosphoserine; by CK1.
{ECO:0000250|UniProtKB:P38486}.
MOD_RES 183 183 Phosphoserine.
{ECO:0000250|UniProtKB:P17931}.
DISULFID 168 168 Interchain. {ECO:0000250}.
SEQUENCE 245 AA; 25739 MW; 9469B9AA146EEF76 CRC64;
MADGFSLNDA LAGSGNPNPQ GWPGAWGNQP GAGGYPGASY PGAYPGQAPP GAYPGQAPPG
AYPGPTAPGA YPGPAPGAYP GQPGASGAYP SAPGAYPAAG PYGAPTGALT VPYKLPLAGG
VMPRMLITIM GTVKPNANRI ILNFLRGNDI AFHFNPRFNE NNRRVIVCNT KQDNNWGREE
RQSAFPFESG RPFKIQVLVE ADHFKVAVND AHLLQYNHRM KNLREINQME ISGDITLTSA
APTMI


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