Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1)

 GBRB1_RAT               Reviewed;         474 AA.
P15431;
01-APR-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1990, sequence version 1.
22-NOV-2017, entry version 158.
RecName: Full=Gamma-aminobutyric acid receptor subunit beta-1;
AltName: Full=GABA(A) receptor subunit beta-1;
Flags: Precursor;
Name=Gabrb1; Synonyms=Gabrb-1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=2548852;
Ymer S., Schofield P.R., Draguhn A., Werner P., Koehler M.,
Seeburg P.H.;
"GABAA receptor beta subunit heterogeneity: functional expression of
cloned cDNAs.";
EMBO J. 8:1665-1670(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
PubMed=1977069; DOI=10.1016/0169-328X(90)90017-8;
Malherbe P., Draguhn A., Multhaup G., Beyreuther K., Mohler H.;
"GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs
displays potentiation by benzodiazepine receptor ligands.";
Brain Res. Mol. Brain Res. 8:199-208(1990).
[3]
FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
PubMed=18281286; DOI=10.1074/jbc.M709993200;
Saras A., Gisselmann G., Vogt-Eisele A.K., Erlkamp K.S., Kletke O.,
Pusch H., Hatt H.;
"Histamine action on vertebrate GABAA receptors: direct channel gating
and potentiation of GABA responses.";
J. Biol. Chem. 283:10470-10475(2008).
-!- FUNCTION: Component of the heteropentameric receptor for GABA, the
major inhibitory neurotransmitter in the vertebrate brain.
Functions also as histamine receptor and mediates cellular
responses to histamine. Functions as receptor for diazepines and
various anesthetics, such as pentobarbital; these are bound at a
separate allosteric effector binding site. Functions as ligand-
gated chloride channel. {ECO:0000269|PubMed:18281286,
ECO:0000269|PubMed:1977069}.
-!- SUBUNIT: Binds UBQLN1. Interacts with KCTD8, KCTD12 and KCTD16;
this interaction determines the pharmacology and kinetics of the
receptor response, the KCTD proteins markedly accelerating the
GABA-B response, although to different extents (By similarity).
Heteropentamer, formed by a combination of alpha, beta, gamma,
delta and rho chains. {ECO:0000250, ECO:0000269|PubMed:18281286}.
-!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
membrane {ECO:0000269|PubMed:18281286}; Multi-pass membrane
protein {ECO:0000269|PubMed:18281286}. Cell membrane
{ECO:0000269|PubMed:18281286}; Multi-pass membrane protein
{ECO:0000269|PubMed:18281286}.
-!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
GABRB1 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X15466; CAA33493.1; -; mRNA.
PIR; S04464; B60039.
RefSeq; NP_037088.1; NM_012956.1.
UniGene; Rn.207157; -.
ProteinModelPortal; P15431; -.
SMR; P15431; -.
IntAct; P15431; 2.
MINT; MINT-219840; -.
STRING; 10116.ENSRNOP00000003170; -.
ChEMBL; CHEMBL1907607; -.
TCDB; 1.A.9.5.1; the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.
iPTMnet; P15431; -.
PhosphoSitePlus; P15431; -.
PRIDE; P15431; -.
Ensembl; ENSRNOT00000003170; ENSRNOP00000003170; ENSRNOG00000002327.
GeneID; 25450; -.
KEGG; rno:25450; -.
UCSC; RGD:2649; rat.
CTD; 2560; -.
RGD; 2649; Gabrb1.
GeneTree; ENSGT00760000118821; -.
HOGENOM; HOG000231335; -.
HOVERGEN; HBG051707; -.
InParanoid; P15431; -.
KO; K05181; -.
OMA; NAGYWIF; -.
OrthoDB; EOG091G0805; -.
PhylomeDB; P15431; -.
TreeFam; TF315453; -.
Reactome; R-RNO-977441; GABA A receptor activation.
PRO; PR:P15431; -.
Proteomes; UP000002494; Chromosome 14.
Bgee; ENSRNOG00000002327; -.
Genevisible; P15431; RN.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0030425; C:dendrite; IDA:RGD.
GO; GO:1902711; C:GABA-A receptor complex; IMP:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; IMP:UniProtKB.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0005635; C:nuclear envelope; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0043235; C:receptor complex; IDA:RGD.
GO; GO:0005253; F:anion channel activity; IDA:RGD.
GO; GO:0050811; F:GABA receptor binding; IPI:RGD.
GO; GO:0004890; F:GABA-A receptor activity; IDA:RGD.
GO; GO:0022851; F:GABA-gated chloride ion channel activity; ISS:UniProtKB.
GO; GO:0015276; F:ligand-gated ion channel activity; IMP:UniProtKB.
GO; GO:0071420; P:cellular response to histamine; IDA:UniProtKB.
GO; GO:0021954; P:central nervous system neuron development; IEP:RGD.
GO; GO:1902476; P:chloride transmembrane transport; ISO:RGD.
GO; GO:0006821; P:chloride transport; TAS:RGD.
GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; ISS:UniProtKB.
GO; GO:0006811; P:ion transport; IMP:UniProtKB.
GO; GO:0042698; P:ovulation cycle; IEP:RGD.
GO; GO:0032570; P:response to progesterone; IEP:RGD.
GO; GO:0009636; P:response to toxic substance; IDA:RGD.
Gene3D; 1.20.58.390; -; 1.
Gene3D; 2.70.170.10; -; 1.
InterPro; IPR006028; GABAA/Glycine_rcpt.
InterPro; IPR002289; GABAAb_rcpt.
InterPro; IPR006202; Neur_chan_lig-bd.
InterPro; IPR036734; Neur_chan_lig-bd_sf.
InterPro; IPR006201; Neur_channel.
InterPro; IPR036719; Neuro-gated_channel_TM_sf.
InterPro; IPR006029; Neurotrans-gated_channel_TM.
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
PANTHER; PTHR18945; PTHR18945; 1.
Pfam; PF02931; Neur_chan_LBD; 1.
Pfam; PF02932; Neur_chan_memb; 1.
PRINTS; PR01160; GABAARBETA.
PRINTS; PR00253; GABAARECEPTR.
PRINTS; PR00252; NRIONCHANNEL.
SUPFAM; SSF63712; SSF63712; 1.
SUPFAM; SSF90112; SSF90112; 1.
TIGRFAMs; TIGR00860; LIC; 1.
PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
1: Evidence at protein level;
Cell junction; Cell membrane; Chloride; Chloride channel;
Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
Ion transport; Ligand-gated ion channel; Membrane;
Postsynaptic cell membrane; Receptor; Reference proteome; Signal;
Synapse; Transmembrane; Transmembrane helix; Transport.
SIGNAL 1 25 {ECO:0000255}.
CHAIN 26 474 Gamma-aminobutyric acid receptor subunit
beta-1.
/FTId=PRO_0000000458.
TOPO_DOM 26 245 Extracellular. {ECO:0000305}.
TRANSMEM 246 267 Helical. {ECO:0000305}.
TRANSMEM 271 293 Helical. {ECO:0000305}.
TRANSMEM 305 327 Helical. {ECO:0000305}.
TOPO_DOM 328 451 Cytoplasmic. {ECO:0000305}.
TRANSMEM 452 473 Helical. {ECO:0000305}.
REGION 120 122 Agonist binding. {ECO:0000250}.
REGION 180 182 Agonist binding. {ECO:0000250}.
REGION 290 311 Allosteric effector binding.
{ECO:0000250}.
BINDING 225 225 Agonist. {ECO:0000250}.
CARBOHYD 33 33 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 105 105 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 174 174 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 161 175 {ECO:0000250}.
CONFLICT 420 420 R -> Q (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
CONFLICT 428 428 R -> P (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
SEQUENCE 474 AA; 54072 MW; 986277FDBD66377A CRC64;
MWTVQNRESL GLLSFPVMVA MVCCAHSSNE PSNMSYVKET VDRLLKGYDI RLRPDFGGPP
VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS GIPLNLTLDN RVADQLWVPD
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE
SYGYTTDDIE FYWNGGEGAV TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK
RNIGYFILQT YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE KNKLEMNKVQ
VDAHGNILLS TLEIRNETSG SEVLTGVSDP KATMYSYDSA SIQYRKPLSS REGFGRGLDR
HGVPGKGRIR RRASQLKVKI PDLTDVNSID KWSRMFFPIT FSLFNVVYWL YYVH


Related products :

Catalog number Product name Quantity
18-003-43131 Gamma-aminobutyric-acid receptor subunit beta-2 - GABA(A) receptor subunit beta-2 Polyclonal 0.05 mg Aff Pur
18-003-42644 Gamma-aminobutyric-acid receptor subunit beta-2 - GABA(A) receptor Polyclonal 0.1 mg Protein A
18-662-20047 Gamma-aminobutyric-acid receptor subunit beta-1 - GABA(A) receptor Polyclonal 0.1 ml
18-003-42952 Gamma-aminobutyric-acid receptor beta-1 subunit - GABA(A) receptor Polyclonal 0.1 mg Protein A
18-662-20048 Gamma-aminobutyric-acid receptor subunit beta-2 - GABA(A) receptor Polyclonal 0.1 ml
18-662-20049 Gamma-aminobutyric-acid receptor subunit beta-3 - GABA(A) receptor Polyclonal 0.1 ml
E2151m ELISA kit GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Mouse,Mus musculus 96T
U2151m CLIA kit GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Mouse,Mus musculus 96T
E2151r ELISA kit GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Rat,Rattus norvegicus 96T
U2151r CLIA kit GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Rat,Rattus norvegicus 96T
U2151r CLIA GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Rat,Rattus norvegicus 96T
E2151m ELISA GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Mouse,Mus musculus 96T
E2151r ELISA GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Rat,Rattus norvegicus 96T
U2151m CLIA GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,Gabbr1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,Mouse,Mus musculus 96T
18-662-20062 Gamma-aminobutyric acid type B receptor. subunit 2 - GABA-B receptor 2; GABA-B-R2; Gb2; GABABR2; G-protein coupled receptor 51 Polyclonal 0.1 ml
18-001-30022 Gamma-aminobutyric acid type B receptor. subunit 2 - GABA-B receptor 2; GABA-B-R2; Gb2; GABABR2; G-protein coupled receptor 51 Polyclonal 0.1 mg
U2151h CLIA GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,GABBR1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,GPRC3A,Homo sapiens,Human 96T
U2151h CLIA kit GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,GABBR1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,GPRC3A,Homo sapiens,Human 96T
E2151h ELISA kit GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,GABBR1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,GPRC3A,Homo sapiens,Human 96T
E2151h ELISA GABA-B receptor 1,GABABR1,GABA-BR1,GABA-B-R1,GABBR1,Gamma-aminobutyric acid type B receptor subunit 1,Gb1,GPRC3A,Homo sapiens,Human 96T
18-003-43894 Gamma-aminobutyric acid receptor subunit gamma-2 - GABA(A) receptor subunit gamma-2 Polyclonal 0.1 mg Protein A
18-003-42956 Gamma-aminobutyric-acid receptor pi subunit - GABA(A) receptor Polyclonal 0.1 mg Protein A
18-003-42955 Gamma-aminobutyric-acid receptor pi subunit - GABA(A) receptor Polyclonal 0.1 mg Protein A
18-003-42957 Gamma-aminobutyric-acid receptor pi subunit - GABA(A) receptor Polyclonal 0.1 mg Protein A
18-003-42956 Gamma-aminobutyric-acid receptor pi subunit - GABA(A) receptor Polyclonal 0.05 mg Aff Pur


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur