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Gamma-aminobutyric acid receptor-associated protein-like 1 (Early estrogen-regulated protein) (GABA(A) receptor-associated protein-like 1) (Glandular epithelial cell protein 1) (GEC-1)

 GBRL1_HUMAN             Reviewed;         117 AA.
Q9H0R8; B4E0Y7; Q6FIE6;
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
22-NOV-2017, entry version 157.
RecName: Full=Gamma-aminobutyric acid receptor-associated protein-like 1;
AltName: Full=Early estrogen-regulated protein;
AltName: Full=GABA(A) receptor-associated protein-like 1;
AltName: Full=Glandular epithelial cell protein 1;
Short=GEC-1;
Flags: Precursor;
Name=GABARAPL1; Synonyms=GEC1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Placenta;
PubMed=11374880; DOI=10.1006/bbrc.2001.4908;
Vernier-Magnin S., Muller S., Sallot M., Radom J., Musard J.-F.,
Adami P., Dulieu P., Remy-Martin J.-P., Jouvenot M., Fraichard A.;
"A novel early estrogen-regulated gene gec1 encodes a protein related
to GABARAP.";
Biochem. Biophys. Res. Commun. 284:118-125(2001).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
PubMed=11414770; DOI=10.1006/geno.2001.6555;
Xin Y., Yu L., Chen Z., Zheng L., Fu Q., Jiang J., Zhang P., Gong R.,
Zhao S.;
"Cloning, expression patterns, and chromosome localization of three
human and two mouse homologues of GABA(A) receptor-associated
protein.";
Genomics 74:408-413(2001).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Liu C., Yu L.;
"Alternative splicing pattern analysis of human Atg8 family
proteins.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=11230166; DOI=10.1101/gr.GR1547R;
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and
analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Thymus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Colon;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
FUNCTION, AND INTERACTION WITH OPRK1.
PubMed=16431922; DOI=10.1074/jbc.M509805200;
Chen C., Li J.-G., Chen Y., Huang P., Wang Y., Liu-Chen L.-Y.;
"GEC1 interacts with the kappa opioid receptor and enhances expression
of the receptor.";
J. Biol. Chem. 281:7983-7993(2006).
[11]
INTERACTION WITH SQSTM1, AND SUBCELLULAR LOCATION.
PubMed=17580304; DOI=10.1074/jbc.M702824200;
Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H.,
Overvatn A., Bjorkoy G., Johansen T.;
"p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of
ubiquitinated protein aggregates by autophagy.";
J. Biol. Chem. 282:24131-24145(2007).
[12]
FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC CLEAVAGE, LIPIDATION AT
GLY-116, AND MUTAGENESIS OF GLY-116.
PubMed=20404487; DOI=10.4161/auto.6.4.11819;
Chakrama F.Z., Seguin-Py S., Le Grand J.N., Fraichard A.,
Delage-Mourroux R., Despouy G., Perez V., Jouvenot M.,
Boyer-Guittaut M.;
"GABARAPL1 (GEC1) associates with autophagic vesicles.";
Autophagy 6:495-505(2010).
[13]
INTERACTION WITH TECPR2.
PubMed=20562859; DOI=10.1038/nature09204;
Behrends C., Sowa M.E., Gygi S.P., Harper J.W.;
"Network organization of the human autophagy system.";
Nature 466:68-76(2010).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[15]
INTERACTION WITH MAPK15.
PubMed=22948227; DOI=10.4161/auto.21857;
Colecchia D., Strambi A., Sanzone S., Iavarone C., Rossi M.,
Dall'Armi C., Piccioni F., Verrotti di Pianella A., Chiariello M.;
"MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP
proteins.";
Autophagy 8:1724-1740(2012).
[16]
INTERACTION WITH ATG13; RB1CC1 AND ULK1.
PubMed=23043107; DOI=10.1074/jbc.M112.378109;
Alemu E.A., Lamark T., Torgersen K.M., Birgisdottir A.B., Larsen K.B.,
Jain A., Olsvik H., Overvatn A., Kirkin V., Johansen T.;
"ATG8 family proteins act as scaffolds for assembly of the ULK
complex: sequence requirements for LC3-interacting region (LIR)
motifs.";
J. Biol. Chem. 287:39275-39290(2012).
[17]
INTERACTION WITH TBC1D5.
PubMed=22354992; DOI=10.1128/MCB.06717-11;
Popovic D., Akutsu M., Novak I., Harper J.W., Behrends C., Dikic I.;
"Rab GTPase-activating proteins in autophagy: regulation of endocytic
and autophagy pathways by direct binding to human ATG8 modifiers.";
Mol. Cell. Biol. 32:1733-1744(2012).
[18]
INTERACTION WITH TP53INP1 AND TP53INP2.
PubMed=22470510; DOI=10.1371/journal.pone.0034034;
Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A.,
Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U.,
Palacin M., Johansen T., Zorzano A.;
"DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding
dual regulators of autophagy and transcription.";
PLoS ONE 7:E34034-E34034(2012).
[19]
DECONJUGATION BY LEGIONELLA RAVZ.
PubMed=23112293; DOI=10.1126/science.1227026;
Choy A., Dancourt J., Mugo B., O'Connor T.J., Isberg R.R., Melia T.J.,
Roy C.R.;
"The Legionella effector RavZ inhibits host autophagy through
irreversible Atg8 deconjugation.";
Science 338:1072-1076(2012).
[20]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=23690988; DOI=10.1371/journal.pone.0063133;
Le Grand J.N., Bon K., Fraichard A., Zhang J., Jouvenot M.,
Risold P.Y., Boyer-Guittaut M., Delage-Mourroux R.;
"Specific distribution of the autophagic protein GABARAPL1/GEC1 in the
developing and adult mouse brain and identification of neuronal
populations expressing GABARAPL1/GEC1.";
PLoS ONE 8:E63133-E63133(2013).
[21]
INTERACTION WITH TRIM5.
PubMed=25127057; DOI=10.1016/j.devcel.2014.06.013;
Mandell M.A., Jain A., Arko-Mensah J., Chauhan S., Kimura T.,
Dinkins C., Silvestri G., Munch J., Kirchhoff F., Simonsen A., Wei Y.,
Levine B., Johansen T., Deretic V.;
"TRIM proteins regulate autophagy and can target autophagic substrates
by direct recognition.";
Dev. Cell 30:394-409(2014).
[22]
INTERACTION WITH WDFY3.
PubMed=24668264; DOI=10.1002/embr.201338003;
Lystad A.H., Ichimura Y., Takagi K., Yang Y., Pankiv S., Kanegae Y.,
Kageyama S., Suzuki M., Saito I., Mizushima T., Komatsu M.,
Simonsen A.;
"Structural determinants in GABARAP required for the selective binding
and recruitment of ALFY to LC3B-positive structures.";
EMBO Rep. 15:557-565(2014).
[23]
INTERACTION WITH MEFV AND TRIM21.
PubMed=26347139; DOI=10.1083/jcb.201503023;
Kimura T., Jain A., Choi S.W., Mandell M.A., Schroder K., Johansen T.,
Deretic V.;
"TRIM-mediated precision autophagy targets cytoplasmic regulators of
innate immunity.";
J. Cell Biol. 210:973-989(2015).
[24]
X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 3-111.
Structural genomics consortium (SGC);
"Crystal structure of human gamma-aminobutyric acid receptor-
associated protein-like 1 (GABARAP1).";
Submitted (SEP-2007) to the PDB data bank.
-!- FUNCTION: Ubiquitin-like modifier that increases cell-surface
expression of kappa-type opioid receptor through facilitating
anterograde intracellular trafficking of the receptor. Involved in
formation of autophagosomal vacuoles. Whereas LC3s are involved in
elongation of the phagophore membrane, the GABARAP/GATE-16
subfamily is essential for a later stage in autophagosome
maturation. {ECO:0000269|PubMed:16431922,
ECO:0000269|PubMed:20404487}.
-!- SUBUNIT: Interacts with GABRG2 and beta-tubulin (By similarity).
Interacts with ATG13, OPRK1, RB1CC1 and ULK1. Interacts with
TP53INP1 and TP53INP2. Directly interacts with SQSTM1. Interacts
with ATG3, ATG7 and MAP15. Interacts with TECPR2. Interacts with
TBC1D5 (PubMed:22354992). Interacts with TRIM5 (PubMed:25127057).
Interacts with MEFV and TRIM21 (PubMed:26347139). Interacts with
WDFY3 (PubMed:24668264). {ECO:0000250,
ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:17580304,
ECO:0000269|PubMed:20562859, ECO:0000269|PubMed:22354992,
ECO:0000269|PubMed:22470510, ECO:0000269|PubMed:22948227,
ECO:0000269|PubMed:23043107, ECO:0000269|PubMed:24668264,
ECO:0000269|PubMed:25127057, ECO:0000269|PubMed:26347139}.
-!- INTERACTION:
Q8IVF2-2:AHNAK2; NbExp=3; IntAct=EBI-746969, EBI-10217765;
O75143:ATG13; NbExp=2; IntAct=EBI-746969, EBI-2798775;
Q2TAZ0:ATG2A; NbExp=3; IntAct=EBI-746969, EBI-2514077;
Q9NT62:ATG3; NbExp=3; IntAct=EBI-746969, EBI-988094;
Q8WYN0:ATG4A; NbExp=5; IntAct=EBI-746969, EBI-3044060;
Q9Y4P1:ATG4B; NbExp=9; IntAct=EBI-746969, EBI-712014;
O95352:ATG7; NbExp=6; IntAct=EBI-746969, EBI-987834;
Q9Z2F7:Bnip3l (xeno); NbExp=4; IntAct=EBI-746969, EBI-1774669;
Q13137:CALCOCO2; NbExp=6; IntAct=EBI-746969, EBI-739580;
Q14677:CLINT1; NbExp=2; IntAct=EBI-746969, EBI-1171113;
Q9NRI5-2:DISC1; NbExp=4; IntAct=EBI-746969, EBI-11988027;
Q8WXU2:DNAAF4; NbExp=2; IntAct=EBI-746969, EBI-2946907;
Q8TF40:FNIP1; NbExp=2; IntAct=EBI-746969, EBI-2946919;
Q9BQS8:FYCO1; NbExp=2; IntAct=EBI-746969, EBI-2869338;
P40939:HADHA; NbExp=4; IntAct=EBI-746969, EBI-356720;
P55084:HADHB; NbExp=4; IntAct=EBI-746969, EBI-356635;
O00410:IPO5; NbExp=4; IntAct=EBI-746969, EBI-356424;
Q86V97:KBTBD6; NbExp=4; IntAct=EBI-746969, EBI-2514778;
Q8WVZ9:KBTBD7; NbExp=6; IntAct=EBI-746969, EBI-473695;
P60409:KRTAP10-7; NbExp=3; IntAct=EBI-746969, EBI-10172290;
P60411:KRTAP10-9; NbExp=3; IntAct=EBI-746969, EBI-10172052;
Q9BQD3:KXD1; NbExp=3; IntAct=EBI-746969, EBI-739657;
Q14596:NBR1; NbExp=4; IntAct=EBI-746969, EBI-742698;
Q8NI08:NCOA7; NbExp=2; IntAct=EBI-746969, EBI-80799;
P46934:NEDD4; NbExp=6; IntAct=EBI-746969, EBI-726944;
Q8TD19:NEK9; NbExp=6; IntAct=EBI-746969, EBI-1044009;
O75323:NIPSNAP2; NbExp=6; IntAct=EBI-746969, EBI-307133;
Q92636:NSMAF; NbExp=6; IntAct=EBI-746969, EBI-2947053;
P41145:OPRK1; NbExp=5; IntAct=EBI-746969, EBI-925028;
P10644:PRKAR1A; NbExp=2; IntAct=EBI-746969, EBI-476431;
Q9Y3P9:RABGAP1; NbExp=2; IntAct=EBI-746969, EBI-1057545;
Q8WWW0:RASSF5; NbExp=2; IntAct=EBI-746969, EBI-367390;
Q14257:RCN2; NbExp=3; IntAct=EBI-746969, EBI-356710;
Q86VR2:RETREG3; NbExp=6; IntAct=EBI-746969, EBI-10192441;
Q14151:SAFB2; NbExp=2; IntAct=EBI-746969, EBI-352869;
Q8IZE3:SCYL3; NbExp=3; IntAct=EBI-746969, EBI-1380680;
Q13501:SQSTM1; NbExp=16; IntAct=EBI-746969, EBI-307104;
O95210:STBD1; NbExp=7; IntAct=EBI-746969, EBI-2947137;
Q13188:STK3; NbExp=2; IntAct=EBI-746969, EBI-992580;
Q13043:STK4; NbExp=2; IntAct=EBI-746969, EBI-367376;
Q8TC07:TBC1D15; NbExp=2; IntAct=EBI-746969, EBI-1048247;
Q9UPU7:TBC1D2B; NbExp=5; IntAct=EBI-746969, EBI-2947180;
B9A6K1:TBC1D5; NbExp=3; IntAct=EBI-746969, EBI-10217641;
Q92609:TBC1D5; NbExp=4; IntAct=EBI-746969, EBI-742381;
O15040:TECPR2; NbExp=2; IntAct=EBI-746969, EBI-2946991;
Q15025:TNIP1; NbExp=5; IntAct=EBI-746969, EBI-357849;
Q96A56:TP53INP1; NbExp=4; IntAct=EBI-746969, EBI-9986117;
Q9GZZ9:UBA5; NbExp=2; IntAct=EBI-746969, EBI-747805;
O75385:ULK1; NbExp=2; IntAct=EBI-746969, EBI-908831;
Q8IZQ1:WDFY3; NbExp=3; IntAct=EBI-746969, EBI-1569256;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasmic vesicle
membrane; Lipid-anchor. Endoplasmic reticulum {ECO:0000250}. Golgi
apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9H0R8-1; Sequence=Displayed;
Name=2;
IsoId=Q9H0R8-2; Sequence=VSP_044422;
-!- TISSUE SPECIFICITY: Ubiquitous. Expressed at very high levels in
the brain, heart, peripheral blood leukocytes, liver, kidney,
placenta and skeletal muscle. Expressed at very low levels in
thymus and small intestine. In the brain, expression is
particularly intense in motoneurons in the embryo and in neurons
involved in somatomotor and neuroendocrine functions in the adult,
particularly in the substantia nigra pars compacta.
{ECO:0000269|PubMed:11374880, ECO:0000269|PubMed:11414770,
ECO:0000269|PubMed:23690988}.
-!- PTM: The precursor molecule is cleaved by ATG4B to form the
cytosolic form, GABARAPL1-I. This is activated by APG7L/ATG7,
transferred to ATG3 and conjugated to phospholipid to form the
membrane-bound form, GABARAPL1-II (By similarity). ATG4B also
mediates the delipidation required for GABARAPL1 recycling when
autophagosomes fuse with lysosomes (PubMed:20404487).
{ECO:0000250, ECO:0000269|PubMed:20404487}.
-!- PTM: The Legionella effector RavZ is a deconjugating enzyme that
produces an ATG8 product that would be resistant to reconjugation
by the host machinery due to the cleavage of the reactive C-
terminal glycine. {ECO:0000269|PubMed:20404487}.
-!- SIMILARITY: Belongs to the ATG8 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF287012; AAK55962.1; -; mRNA.
EMBL; AF087847; AAK20399.1; -; mRNA.
EMBL; JN663881; AEZ06294.1; -; mRNA.
EMBL; AL136676; CAB66611.1; -; mRNA.
EMBL; AK303581; BAG64599.1; -; mRNA.
EMBL; CR533480; CAG38511.1; -; mRNA.
EMBL; AC115676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471094; EAW96164.1; -; Genomic_DNA.
EMBL; BC009309; AAH09309.1; -; mRNA.
EMBL; BC028315; AAH28315.1; -; mRNA.
CCDS; CCDS8620.1; -. [Q9H0R8-1]
RefSeq; NP_113600.1; NM_031412.2. [Q9H0R8-1]
RefSeq; XP_005253401.1; XM_005253344.4. [Q9H0R8-2]
UniGene; Hs.524250; -.
PDB; 2L8J; NMR; -; A=2-115.
PDB; 2R2Q; X-ray; 1.65 A; A/B=3-111.
PDB; 5DPT; X-ray; 2.90 A; A/B=2-117.
PDB; 5LXH; X-ray; 1.58 A; A/B/C=1-117.
PDB; 5LXI; X-ray; 1.44 A; B/D=1-117.
PDBsum; 2L8J; -.
PDBsum; 2R2Q; -.
PDBsum; 5DPT; -.
PDBsum; 5LXH; -.
PDBsum; 5LXI; -.
ProteinModelPortal; Q9H0R8; -.
SMR; Q9H0R8; -.
BioGrid; 117223; 78.
DIP; DIP-35597N; -.
ELM; Q9H0R8; -.
IntAct; Q9H0R8; 532.
MINT; MINT-1456875; -.
STRING; 9606.ENSP00000266458; -.
iPTMnet; Q9H0R8; -.
PhosphoSitePlus; Q9H0R8; -.
BioMuta; GABARAPL1; -.
DMDM; 44887973; -.
EPD; Q9H0R8; -.
MaxQB; Q9H0R8; -.
PaxDb; Q9H0R8; -.
PeptideAtlas; Q9H0R8; -.
PRIDE; Q9H0R8; -.
DNASU; 23710; -.
Ensembl; ENST00000266458; ENSP00000266458; ENSG00000139112. [Q9H0R8-1]
Ensembl; ENST00000421801; ENSP00000411256; ENSG00000139112. [Q9H0R8-2]
Ensembl; ENST00000543602; ENSP00000445857; ENSG00000139112. [Q9H0R8-2]
Ensembl; ENST00000545887; ENSP00000444186; ENSG00000139112. [Q9H0R8-1]
GeneID; 23710; -.
KEGG; hsa:23710; -.
UCSC; uc001qxs.4; human. [Q9H0R8-1]
CTD; 23710; -.
DisGeNET; 23710; -.
EuPathDB; HostDB:ENSG00000139112.10; -.
GeneCards; GABARAPL1; -.
H-InvDB; HIX0036758; -.
HGNC; HGNC:4068; GABARAPL1.
HPA; HPA051386; -.
HPA; HPA065883; -.
MIM; 607420; gene.
neXtProt; NX_Q9H0R8; -.
OpenTargets; ENSG00000139112; -.
PharmGKB; PA28481; -.
eggNOG; KOG1654; Eukaryota.
eggNOG; ENOG4111JAT; LUCA.
GeneTree; ENSGT00390000012937; -.
HOGENOM; HOG000232034; -.
HOVERGEN; HBG051706; -.
InParanoid; Q9H0R8; -.
KO; K08341; -.
OMA; MTYANEN; -.
OrthoDB; EOG091G10QX; -.
PhylomeDB; Q9H0R8; -.
TreeFam; TF314556; -.
Reactome; R-HSA-1632852; Macroautophagy.
SIGNOR; Q9H0R8; -.
ChiTaRS; GABARAPL1; human.
EvolutionaryTrace; Q9H0R8; -.
GenomeRNAi; 23710; -.
PMAP-CutDB; Q9H0R8; -.
PRO; PR:Q9H0R8; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000139112; -.
CleanEx; HS_GABARAPL1; -.
ExpressionAtlas; Q9H0R8; baseline and differential.
Genevisible; Q9H0R8; HS.
GO; GO:0005776; C:autophagosome; IDA:MGI.
GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
GO; GO:0044297; C:cell body; IEA:Ensembl.
GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0032839; C:dendrite cytoplasm; IEA:Ensembl.
GO; GO:0032590; C:dendrite membrane; IEA:Ensembl.
GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO; GO:0005622; C:intracellular; IDA:LIFEdb.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0048487; F:beta-tubulin binding; ISS:UniProtKB.
GO; GO:0050811; F:GABA receptor binding; ISS:UniProtKB.
GO; GO:0030957; F:Tat protein binding; IPI:UniProtKB.
GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.
GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
GO; GO:0097352; P:autophagosome maturation; TAS:Reactome.
GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
GO; GO:0006995; P:cellular response to nitrogen starvation; IBA:GO_Central.
GO; GO:0016236; P:macroautophagy; TAS:Reactome.
CDD; cd01611; GABARAP; 1.
InterPro; IPR004241; Atg8-like.
InterPro; IPR029071; Ubiquitin-like_domsf.
PANTHER; PTHR10969; PTHR10969; 1.
Pfam; PF02991; Atg8; 1.
SUPFAM; SSF54236; SSF54236; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Autophagy; Complete proteome;
Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endoplasmic reticulum;
Golgi apparatus; Lipoprotein; Membrane; Microtubule;
Reference proteome.
CHAIN 1 116 Gamma-aminobutyric acid receptor-
associated protein-like 1.
/FTId=PRO_0000212369.
PROPEP 117 117 Removed in mature form.
/FTId=PRO_0000420208.
REGION 1 22 Interaction with beta-tubulin.
{ECO:0000250}.
REGION 36 68 Interaction with GABRG2. {ECO:0000250}.
SITE 115 116 Cleavage; by RavZ.
SITE 116 117 Cleavage; by ATG4B.
LIPID 116 116 Phosphatidylethanolamine amidated
glycine. {ECO:0000305|PubMed:20404487}.
VAR_SEQ 97 117 DNHEEDYFLYVAYSDESVYGK -> VMVLVAQYWMPSSAVW
HPLALVLDALITHLRSGAEGVIYPDPLTYGSVRL (in
isoform 2). {ECO:0000303|PubMed:14702039,
ECO:0000303|Ref.3}.
/FTId=VSP_044422.
MUTAGEN 116 116 G->A: No processing of precursor.
{ECO:0000269|PubMed:20404487}.
HELIX 4 8 {ECO:0000244|PDB:5LXI}.
HELIX 11 24 {ECO:0000244|PDB:5LXI}.
STRAND 28 35 {ECO:0000244|PDB:5LXI}.
STRAND 48 52 {ECO:0000244|PDB:5LXI}.
HELIX 57 68 {ECO:0000244|PDB:5LXI}.
STRAND 77 80 {ECO:0000244|PDB:5LXI}.
STRAND 87 90 {ECO:0000244|PDB:5DPT}.
HELIX 91 98 {ECO:0000244|PDB:5LXI}.
STRAND 105 113 {ECO:0000244|PDB:5LXI}.
SEQUENCE 117 AA; 14044 MW; 7F56E345255F564B CRC64;
MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF
YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK


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