Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Gamma-secretase subunit pen-2 (Presenilin enhancer protein 2)

 PEN2_CAEEL              Reviewed;         101 AA.
Q9U357;
26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
18-JUL-2018, entry version 120.
RecName: Full=Gamma-secretase subunit pen-2;
AltName: Full=Presenilin enhancer protein 2;
Name=pen-2; ORFNames=T28D6.9;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
TISSUE SPECIFICITY.
PubMed=12110170; DOI=10.1016/S1534-5807(02)00189-2;
Francis R., McGrath G., Zhang J., Ruddy D.A., Sym M., Apfeld J.,
Nicoll M., Maxwell M., Hai B., Ellis M.C., Parks A.L., Xu W., Li J.,
Gurney M., Myers R.L., Himes C.S., Hiebsch R., Ruble C., Nye J.S.,
Curtis D.;
"aph-1 and pen-2 are required for Notch pathway signaling, gamma-
secretase cleavage of betaAPP, and presenilin protein accumulation.";
Dev. Cell 3:85-97(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
-!- FUNCTION: Essential subunit of the gamma-secretase complex, an
endoprotease complex that catalyzes the intramembrane cleavage of
integral membrane proteins such as Notch (glp-1 or lin-12). It may
represent a stabilizing cofactor for the presenilin homodimer that
promotes the formation of a stable complex.
{ECO:0000269|PubMed:12110170}.
-!- SUBUNIT: Component of the gamma-secretase complex, a complex
probably composed of the presenilin homodimer (sel-12, hop-1 or
spe-4), nicastrin (aph-2), aph-1 and pen-2. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000269|PubMed:12110170}; Multi-pass membrane protein
{ECO:0000269|PubMed:12110170}. Golgi apparatus membrane
{ECO:0000269|PubMed:12110170}; Multi-pass membrane protein
{ECO:0000269|PubMed:12110170}. Note=Predominantly located in the
endoplasmic reticulum and Golgi region.
-!- TISSUE SPECIFICITY: Expressed from 100-cell stage in most somatic
tissues, including neurons, muscle, intestine and developing
vulva. Little or not expressed in early embryos.
{ECO:0000269|PubMed:12110170}.
-!- SIMILARITY: Belongs to the PEN-2 family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; Z81134; CAB54316.1; -; Genomic_DNA.
PIR; T25417; T25417.
RefSeq; NP_499459.1; NM_067058.4.
UniGene; Cel.9963; -.
ProteinModelPortal; Q9U357; -.
SMR; Q9U357; -.
BioGrid; 41747; 1.
DIP; DIP-26665N; -.
IntAct; Q9U357; 1.
STRING; 6239.T28D6.9; -.
PaxDb; Q9U357; -.
EnsemblMetazoa; T28D6.9; T28D6.9; WBGene00003975.
GeneID; 176565; -.
KEGG; cel:CELE_T28D6.9; -.
UCSC; T28D6.9; c. elegans.
CTD; 251430; -.
WormBase; T28D6.9; CE24023; WBGene00003975; pen-2.
eggNOG; KOG3402; Eukaryota.
eggNOG; ENOG4111W09; LUCA.
GeneTree; ENSGT00390000016319; -.
HOGENOM; HOG000006914; -.
InParanoid; Q9U357; -.
KO; K06170; -.
OMA; WFFQEAF; -.
OrthoDB; EOG091G0X8A; -.
PhylomeDB; Q9U357; -.
Reactome; R-CEL-1251985; Nuclear signaling by ERBB4.
SignaLink; Q9U357; -.
PRO; PR:Q9U357; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00003975; -.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0070765; C:gamma-secretase complex; ISS:WormBase.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IDA:WormBase.
GO; GO:0045165; P:cell fate commitment; IGI:WormBase.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0048598; P:embryonic morphogenesis; IMP:WormBase.
GO; GO:0007281; P:germ cell development; IGI:WormBase.
GO; GO:0007220; P:Notch receptor processing; IBA:GO_Central.
GO; GO:0007219; P:Notch signaling pathway; IMP:WormBase.
GO; GO:0060465; P:pharynx development; IMP:WormBase.
InterPro; IPR019379; Gamma_Secretase_Asp_P_PEN2.
PANTHER; PTHR16318; PTHR16318; 1.
Pfam; PF10251; PEN-2; 1.
2: Evidence at transcript level;
Complete proteome; Endoplasmic reticulum; Golgi apparatus; Membrane;
Notch signaling pathway; Reference proteome; Transmembrane;
Transmembrane helix.
CHAIN 1 101 Gamma-secretase subunit pen-2.
/FTId=PRO_0000190903.
TOPO_DOM 1 17 Lumenal. {ECO:0000255}.
TRANSMEM 18 38 Helical. {ECO:0000255}.
TOPO_DOM 39 57 Cytoplasmic. {ECO:0000255}.
TRANSMEM 58 78 Helical. {ECO:0000255}.
TOPO_DOM 79 101 Lumenal. {ECO:0000255}.
SEQUENCE 101 AA; 11943 MW; 4DE2725C569CDB4B CRC64;
MDISKLTDVK KVDLCKKYFL IGACFLPLVW IVNTFWFFSD AFCKPINAHR RQIRKYVIAS
IVGSIFWIIV LSAWEIFFQH YRAQGLVWTD FLTFVFPTGR V


Related products :

Catalog number Product name Quantity
EIAAB30549 Bos taurus,Bovine,Gamma-secretase subunit PEN-2,PEN2,Presenilin enhancer protein 2,PSENEN
EIAAB30550 Gamma-secretase subunit PEN-2,Mouse,Mus musculus,Pen2,Presenilin enhancer protein 2,Psenen
EIAAB30548 Gamma-secretase subunit PEN-2,Homo sapiens,Human,MDS033,PEN2,Presenilin enhancer protein 2,PSENEN
EIAAB30547 Gamma-secretase subunit PEN-2,Liver regeneration-related protein LRRGT00140,Presenilin enhancer protein 2,Psenen,Rat,Rattus norvegicus
E0406h ELISA kit APH1A,APH-1a,Aph-1alpha,CGI-78,Gamma-secretase subunit APH-1A,Homo sapiens,Human,Presenilin-stabilization factor,PSF,UNQ579_PRO1141 96T
U0406h CLIA APH1A,APH-1a,Aph-1alpha,CGI-78,Gamma-secretase subunit APH-1A,Homo sapiens,Human,Presenilin-stabilization factor,PSF,UNQ579_PRO1141 96T
E0406h ELISA APH1A,APH-1a,Aph-1alpha,CGI-78,Gamma-secretase subunit APH-1A,Homo sapiens,Human,Presenilin-stabilization factor,PSF,UNQ579_PRO1141 96T
Aph1b-101AP Presenilin stabilization factor-like Gamma Secretase subunit APH-1P Polyclonal anbtibody Host: Rabbit Affinity purifed 200ul
Aph1b-101AP Presenilin stabilization factor-like Gamma Secretase subunit APH-1P WB control: PC-Aph1b Host: Rabbit Affinity purifed 100-150ul
Aph1b-101AP Presenilin stabilization factor-like Gamma Secretase subunit APH-1P Antigenic peptide: P-Aph1b Host: Rabbit Affinity purifed 100ul
18-783-75578 RABBIT ANTI HUMAN PEN2 (C-TERMINAL) - PRESENILIN ENHANCER PROTEIN 2; Presenilin enhancer protein 2 Polyclonal 0.1 mg
18-783-75579 RABBIT ANTI HUMAN PEN2 (N-TERMINAL) - PRESENILIN ENHANCER PROTEIN 2; Presenilin enhancer protein 2 Polyclonal 0.1 mg
Aph1b-101AP Presenilin stabilization factor-like Gamma Secretase subunit APH-1P FITC-conjugates: Aph1b-FITC Host: Rabbit Affinity purifed 200ul
Aph1b-101AP Presenilin stabilization factor-like Gamma Secretase subunit APH-1P Biotin Conjugates: Aph1b-Biotin Host: Rabbit Affinity purifed 200ul
4203 a gamma-secretase subunit 0.5 mg
4203 a gamma-secretase subunit 0.1 mg
EM384 Gamma-secretase subunit APH-1A Elisa Kit 96T
EH887 Gamma-secretase subunit APH-1A Elisa Kit 96T
SF3A1_HUMAN Rat ELISA Kit FOR Gamma-secretase subunit PEN-2 96T
F167B_MOUSE Rat ELISA Kit FOR Gamma-secretase subunit PEN-2 96T
E0169d Rat ELISA Kit FOR Gamma-secretase subunit PEN-2 96T
CSB-EL018848RA Rat Gamma-secretase subunit PEN-2(PSENEN) ELISA kit 96T
PEN2_BOVIN Bovine ELISA Kit FOR Gamma-secretase subunit PEN-2 96T
CSB-EL018848MO Mouse Gamma-secretase subunit PEN-2(PSENEN) ELISA kit 96T
CSB-EL018848RA Rat Gamma-secretase subunit PEN-2(PSENEN) ELISA kit SpeciesRat 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur