Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Ganglioside-induced differentiation-associated protein 1 (GDAP1)

 GDAP1_MOUSE             Reviewed;         358 AA.
O88741; Q8C7Q5; Q9CTN2;
07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
28-FEB-2018, entry version 134.
RecName: Full=Ganglioside-induced differentiation-associated protein 1;
Short=GDAP1;
Name=Gdap1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND INDUCTION.
STRAIN=ICR; TISSUE=Brain;
PubMed=10217254; DOI=10.1046/j.1471-4159.1999.0721781.x;
Liu H., Nakagawa T., Kanematsu T., Uchida T., Tsuji S.;
"Isolation of 10 differentially expressed cDNAs in differentiated
Neuro2a cells induced through controlled expression of the GD3
synthase gene.";
J. Neurochem. 72:1781-1790(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J; TISSUE=Brain, Spinal cord, and Spinal ganglion;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEIN SEQUENCE OF 162-172; 215-225 AND 292-310, AND IDENTIFICATION
BY MASS SPECTROMETRY.
STRAIN=C57BL/6J; TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
[5]
TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=16172208; DOI=10.1083/jcb.200507087;
Niemann A., Ruegg M., La Padula V., Schenone A., Suter U.;
"Ganglioside-induced differentiation associated protein 1 is a
regulator of the mitochondrial network: new implications for Charcot-
Marie-Tooth disease.";
J. Cell Biol. 170:1067-1078(2005).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Regulates the mitochondrial network by promoting
mitochondrial fission. {ECO:0000250, ECO:0000269|PubMed:16172208}.
-!- SUBUNIT: Homodimer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
{ECO:0000250|UniProtKB:Q8TB36}; Multi-pass membrane protein
{ECO:0000250|UniProtKB:Q8TB36}. Cytoplasm
{ECO:0000269|PubMed:16172208}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O88741-1; Sequence=Displayed;
Name=2;
IsoId=O88741-2; Sequence=VSP_008791, VSP_008792;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in brain, spinal cord, muscles and
intestinal villi. In the central nervous system expressed most
prominently in the cortex, cerebellum, thalamus, olfactory bulb,
and spinal cord. Expressed also in sciatic nerves and in dorsal
root ganglia. {ECO:0000269|PubMed:16172208}.
-!- DEVELOPMENTAL STAGE: First expressed at embryonic stage E13.
Levels then increase gradually to reach maximum levels at
adulthood.
-!- INDUCTION: Increased expression during neural differentiation.
{ECO:0000269|PubMed:10217254}.
-!- PTM: Ubiquitinated by PRKN during mitophagy, leading to its
degradation and enhancement of mitophagy. Deubiquitinated by
USP30. {ECO:0000250|UniProtKB:Q8TB36}.
-!- SIMILARITY: Belongs to the GST superfamily. {ECO:0000305}.
-!- CAUTION: While belonging to the GST superfamily, it lacks
glutathione transferase activity. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; Y17850; CAA76893.1; -; mRNA.
EMBL; AK020988; BAB32270.1; -; mRNA.
EMBL; AK045460; BAC32380.1; -; mRNA.
EMBL; AK049655; BAC33861.1; -; mRNA.
EMBL; AK083814; BAC39027.1; -; mRNA.
EMBL; BC048177; AAH48177.1; -; mRNA.
EMBL; BC051135; AAH51135.1; -; mRNA.
CCDS; CCDS14834.1; -. [O88741-1]
RefSeq; NP_034397.1; NM_010267.3. [O88741-1]
UniGene; Mm.18218; -.
ProteinModelPortal; O88741; -.
IntAct; O88741; 2.
MINT; O88741; -.
STRING; 10090.ENSMUSP00000026879; -.
iPTMnet; O88741; -.
PhosphoSitePlus; O88741; -.
MaxQB; O88741; -.
PaxDb; O88741; -.
PeptideAtlas; O88741; -.
PRIDE; O88741; -.
Ensembl; ENSMUST00000026879; ENSMUSP00000026879; ENSMUSG00000025777. [O88741-1]
GeneID; 14545; -.
KEGG; mmu:14545; -.
UCSC; uc007akb.2; mouse. [O88741-2]
UCSC; uc007akc.2; mouse. [O88741-1]
CTD; 54332; -.
MGI; MGI:1338002; Gdap1.
eggNOG; KOG4420; Eukaryota.
eggNOG; ENOG410YE2J; LUCA.
GeneTree; ENSGT00510000046788; -.
HOGENOM; HOG000231002; -.
HOVERGEN; HBG051717; -.
InParanoid; O88741; -.
KO; K22077; -.
OMA; GHQPWLC; -.
OrthoDB; EOG091G0BAC; -.
PhylomeDB; O88741; -.
TreeFam; TF327072; -.
PRO; PR:O88741; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000025777; -.
ExpressionAtlas; O88741; baseline and differential.
Genevisible; O88741; MM.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; ISO:MGI.
GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
GO; GO:0071305; P:cellular response to vitamin D; IEA:Ensembl.
GO; GO:0006749; P:glutathione metabolic process; IBA:GO_Central.
GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
GO; GO:0008053; P:mitochondrial fusion; ISO:MGI.
GO; GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB.
GO; GO:0032526; P:response to retinoic acid; IDA:MGI.
InterPro; IPR034336; GDAP1.
InterPro; IPR010987; Glutathione-S-Trfase_C-like.
InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
InterPro; IPR004045; Glutathione_S-Trfase_N.
InterPro; IPR036249; Thioredoxin-like_sf.
PANTHER; PTHR44188; PTHR44188; 1.
Pfam; PF13417; GST_N_3; 1.
SUPFAM; SSF47616; SSF47616; 1.
SUPFAM; SSF52833; SSF52833; 1.
PROSITE; PS50405; GST_CTER; 1.
PROSITE; PS50404; GST_NTER; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Coiled coil; Complete proteome;
Cytoplasm; Direct protein sequencing; Isopeptide bond; Membrane;
Mitochondrion; Mitochondrion outer membrane; Reference proteome;
Transmembrane; Transmembrane helix; Ubl conjugation.
CHAIN 1 358 Ganglioside-induced differentiation-
associated protein 1.
/FTId=PRO_0000186039.
TRANSMEM 292 312 Helical. {ECO:0000255}.
TRANSMEM 320 340 Helical. {ECO:0000255}.
DOMAIN 24 105 GST N-terminal.
DOMAIN 153 309 GST C-terminal.
REGION 320 358 Required for mitochondrial localization.
{ECO:0000250}.
MOD_RES 203 203 N6-acetyllysine; alternate.
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 50 50 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 172 172 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 173 173 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 188 188 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 190 190 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 203 203 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin);
alternate.
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 206 206 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 207 207 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
CROSSLNK 214 214 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in ubiquitin).
{ECO:0000250|UniProtKB:Q8TB36}.
VAR_SEQ 163 163 Q -> M (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_008791.
VAR_SEQ 164 358 Missing (in isoform 2).
{ECO:0000303|PubMed:16141072}.
/FTId=VSP_008792.
SEQUENCE 358 AA; 41311 MW; 7B533CB34138891F CRC64;
MARRQDEARA GVPLRVEGPP DKEVHLILYH WTHSFSSQKV RLVIAEKALK CEEHDVSLPL
SEHNEPWFMR LNSAGEVPVL VHGENIICEA TQIIDYLEQT FLDERTPRLM PDEGSMYYPR
VQHYRELLDS LPMDAYTHGC ILHPELTVDS MIPAYATTRI RSQIGNTESE LKKLAEENPD
LQEAYIAKQK RLKSKLLDHD NVKYLKKILD ELEKVLDQVE TELQRRNEET PEEGNQPWLC
GESFTLADVS LAVTLHRLKF LGFARRNWGH GKRPNLETYY ERVLKRKTFN KVLGHVNNIL
ISAVLPTAFR VAKKRAPKVL GSTLVVGLLV GMGYFAFMLF RRRLGSMILA LRPRPNYF


Related products :

Catalog number Product name Quantity
GDAP2 GDAP1 Gene ganglioside-induced differentiation-associated protein 1
201-20-2219 GDAP1{ganglioside-induced differentiation-associated protein 1}rabbit.pAb 0.2ml
CSB-EL009338MO Mouse Ganglioside-induced differentiation-associated protein 1(GDAP1) ELISA kit 96T
CSB-EL009338HU Human Ganglioside-induced differentiation-associated protein 1(GDAP1) ELISA kit 96T
CSB-EL009338HU Human Ganglioside-induced differentiation-associated protein 1(GDAP1) ELISA kit SpeciesHuman 96T
CSB-EL009338MO Mouse Ganglioside-induced differentiation-associated protein 1(GDAP1) ELISA kit SpeciesMouse 96T
GDAP1_MOUSE ELISA Kit FOR Ganglioside-induced differentiation-associated protein 1; organism: Mouse; gene name: Gdap1 96T
CSB-EL009338MO Mouse ganglioside-induced differentiation-associated protein 1 (GDAP1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
CSB-EL009338HU Human ganglioside-induced differentiation-associated protein 1 (GDAP1) ELISA kit, Species Human, Sample Type serum, plasma 96T
E1036c Rat ELISA Kit FOR Ganglioside-induced differentiation-associated-protein 2 96T
E1291b Bovine ELISA Kit FOR Ganglioside-induced differentiation-associated protein 1 96T
201-20-2220 GDAP1L1{ganglioside-induced differentiation-associated protein 1-like 1}rabbit.pAb 0.2ml
GDB2 GDAP1L1 Gene ganglioside-induced differentiation-associated protein 1-like 1
GDB3 GDAP2 Gene ganglioside induced differentiation associated protein 2
CSB-EL009340RA Rat Ganglioside-induced differentiation-associated protein 2(GDAP2) ELISA kit 96T
CSB-EL009339MO Mouse Ganglioside-induced differentiation-associated protein 1-like 1(GDAP1L1) ELISA kit 96T
CSB-EL009340RA Rat Ganglioside-induced differentiation-associated protein 2(GDAP2) ELISA kit SpeciesRat 96T
CSB-EL009340MO Mouse Ganglioside-induced differentiation-associated protein 2(GDAP2) ELISA kit 96T
CSB-EL009340BO Bovine Ganglioside-induced differentiation-associated protein 2(GDAP2) ELISA kit 96T
CSB-EL009339HU Human Ganglioside-induced differentiation-associated protein 1-like 1(GDAP1L1) ELISA kit 96T
CSB-EL009340HU Human Ganglioside-induced differentiation-associated protein 2(GDAP2) ELISA kit 96T
CSB-EL009340BO Bovine Ganglioside-induced differentiation-associated protein 2(GDAP2) ELISA kit SpeciesBovine 96T
CSB-EL009339HU Human Ganglioside-induced differentiation-associated protein 1-like 1(GDAP1L1) ELISA kit SpeciesHuman 96T
GS-0840a ganglioside-induced differentiation-associated protein 1 primary antibody, Host: Rabbit 200ul
CSB-EL009339MO Mouse Ganglioside-induced differentiation-associated protein 1-like 1(GDAP1L1) ELISA kit SpeciesMouse 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur