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Gap junction protein

 Q80Z93_CRIGR            Unreviewed;       382 AA.
Q80Z93;
01-JUN-2003, integrated into UniProtKB/TrEMBL.
01-JUN-2003, sequence version 1.
12-SEP-2018, entry version 94.
RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
ORFNames=H671_2g5891 {ECO:0000313|EMBL:ERE84530.1},
I79_018067 {ECO:0000313|EMBL:EGW04497.1};
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029 {ECO:0000313|EMBL:AAO61858.1};
[1] {ECO:0000313|EMBL:AAO61858.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Lung {ECO:0000313|EMBL:AAO61858.1};
PubMed=16194882; DOI=10.1080/15419060500242877;
Cruciani V., Heintz K.M., Husoy T., Hovig E., Warren D.J.,
Mikalsen S.O.;
"The detection of hamster connexins: a comparison of expression
profiles with wild-type mouse and the cancer-prone min mouse.";
Cell Commun. Adhes. 11:155-171(2004).
[2] {ECO:0000313|Proteomes:UP000001075}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
PubMed=21804562; DOI=10.1038/nbt.1932;
Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
Quake S.R., Famili I., Palsson B.O., Wang J.;
"The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
line.";
Nat. Biotechnol. 29:735-741(2011).
[3] {ECO:0000313|EMBL:EGW04497.1}
NUCLEOTIDE SEQUENCE.
Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
Koh W., Fan C.H., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
Quake S.R., Famili I., Palsson B.O., Wang J.;
"The genomic sequence of the Chinese hamster ovary CHO-K1 cell line.";
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Proteomes:UP000030759}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17A/GY {ECO:0000313|Proteomes:UP000030759};
PubMed=23929341; DOI=10.1038/nbt.2645;
Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B.,
Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D.,
Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A.,
Goesmann A., Helk B., Mott J.E., Puhler A., Borth N.;
"Chinese hamster genome sequenced from sorted chromosomes.";
Nat. Biotechnol. 31:694-695(2013).
[5] {ECO:0000313|EMBL:ERE84530.1}
NUCLEOTIDE SEQUENCE.
STRAIN=17A/GY {ECO:0000313|EMBL:ERE84530.1};
Brinkrolf K., Rupp O., Laux H., Kollin F., Ernst W., Linke B.,
Kofler R., Romand S., Hesse F., Budach W.E., Galosy S., Muller D.,
Noll T., Wienberg J., Jostock T., Leonard M., Grillari J., Tauch A.,
Goesmann A., Helk B., Mott J.E., Puehler A., Borth N.;
"Chinese hamster genome sequenced from sorted chromosomes.";
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: One gap junction consists of a cluster of closely packed
pairs of transmembrane channels, the connexons, through which
materials of low MW diffuse from one cell to a neighboring cell.
{ECO:0000256|RuleBase:RU000630}.
-!- SUBUNIT: A connexon is composed of a hexamer of connexins.
{ECO:0000256|RuleBase:RU000630, ECO:0000256|SAAS:SAAS00674186}.
-!- SUBCELLULAR LOCATION: Cell junction, gap junction
{ECO:0000256|SAAS:SAAS00547633}. Cell membrane
{ECO:0000256|RuleBase:RU000630, ECO:0000256|SAAS:SAAS00674192};
Multi-pass membrane protein {ECO:0000256|RuleBase:RU000630,
ECO:0000256|SAAS:SAAS00674192}.
-!- SIMILARITY: Belongs to the connexin family.
{ECO:0000256|RuleBase:RU000630, ECO:0000256|SAAS:SAAS00674180}.
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EMBL; AY206456; AAO61858.1; -; mRNA.
EMBL; JH001202; EGW04497.1; -; Genomic_DNA.
EMBL; KE667904; ERE84530.1; -; Genomic_DNA.
RefSeq; NP_001231004.1; NM_001244075.1.
SMR; Q80Z93; -.
PRIDE; Q80Z93; -.
GeneID; 100689077; -.
KEGG; cge:100689077; -.
CTD; 2697; -.
HOVERGEN; HBG009576; -.
KO; K07372; -.
Proteomes; UP000001075; Unassembled WGS sequence.
Proteomes; UP000030759; Unassembled WGS sequence.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0005922; C:connexin complex; IEA:InterPro.
GO; GO:0043292; C:contractile fiber; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005916; C:fascia adherens; IEA:Ensembl.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005882; C:intermediate filament; IEA:Ensembl.
GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0048487; F:beta-tubulin binding; IEA:Ensembl.
GO; GO:1903763; F:gap junction channel activity involved in cell communication by electrical coupling; IEA:Ensembl.
GO; GO:0015075; F:ion transmembrane transporter activity; IEA:Ensembl.
GO; GO:1990782; F:protein tyrosine kinase binding; IEA:Ensembl.
GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
GO; GO:0007512; P:adult heart development; IEA:Ensembl.
GO; GO:0003294; P:atrial ventricular junction remodeling; IEA:Ensembl.
GO; GO:0048514; P:blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0061337; P:cardiac conduction; IEA:Ensembl.
GO; GO:0010643; P:cell communication by chemical coupling; IEA:Ensembl.
GO; GO:0045216; P:cell-cell junction organization; IEA:Ensembl.
GO; GO:0007267; P:cell-cell signaling; IEA:Ensembl.
GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0002070; P:epithelial cell maturation; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
GO; GO:0060156; P:milk ejection reflex; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:0045844; P:positive regulation of striated muscle tissue development; IEA:Ensembl.
GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl.
GO; GO:0046850; P:regulation of bone remodeling; IEA:Ensembl.
GO; GO:0060373; P:regulation of ventricular cardiac muscle cell membrane depolarization; IEA:Ensembl.
GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; IEA:Ensembl.
GO; GO:0043403; P:skeletal muscle tissue regeneration; IEA:Ensembl.
Gene3D; 1.20.1440.80; -; 1.
Gene3D; 1.20.5.1130; -; 1.
InterPro; IPR035091; Alpha_helix_dom_sf.
InterPro; IPR000500; Connexin.
InterPro; IPR002261; Connexin43.
InterPro; IPR013124; Connexin43_C.
InterPro; IPR034634; Connexin_C.
InterPro; IPR019570; Connexin_CCC.
InterPro; IPR017990; Connexin_CS.
InterPro; IPR013092; Connexin_N.
InterPro; IPR038359; Connexin_N_sf.
PANTHER; PTHR11984; PTHR11984; 1.
PANTHER; PTHR11984:SF33; PTHR11984:SF33; 1.
Pfam; PF00029; Connexin; 1.
Pfam; PF03508; Connexin43; 1.
PRINTS; PR00206; CONNEXIN.
PRINTS; PR01132; CONNEXINA1.
SMART; SM00037; CNX; 1.
SMART; SM01089; Connexin_CCC; 1.
SUPFAM; SSF118220; SSF118220; 1.
PROSITE; PS00407; CONNEXINS_1; 1.
PROSITE; PS00408; CONNEXINS_2; 1.
2: Evidence at transcript level;
Cell junction {ECO:0000256|RuleBase:RU000630,
ECO:0000256|SAAS:SAAS00547643};
Cell membrane {ECO:0000256|SAAS:SAAS00025279};
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000001075};
Gap junction {ECO:0000256|RuleBase:RU000630,
ECO:0000256|SAAS:SAAS00547643};
Membrane {ECO:0000256|SAAS:SAAS00025246,
ECO:0000256|SAAS:SAAS00025279, ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000001075};
Transmembrane {ECO:0000256|SAAS:SAAS00025246,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00025246,
ECO:0000256|SAM:Phobius}.
TRANSMEM 20 41 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 77 99 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 154 176 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 208 233 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 43 76 CNX. {ECO:0000259|SMART:SM00037}.
DOMAIN 165 231 Connexin_CCC.
{ECO:0000259|SMART:SM01089}.
COILED 99 119 {ECO:0000256|SAM:Coils}.
SEQUENCE 382 AA; 43021 MW; 019C7D40C2F06335 CRC64;
MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG
CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG
ANVDMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSVFEVAFL LIQWYIYGFS
LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV
KGRSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN
YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNAKKMAAG HELQPLAIVD
QRPSSRASSR ASSRPRPDDL EI


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