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Gastricsin (EC 3.4.23.3) (Pepsinogen C)

 PEPC_CAVPO              Reviewed;         394 AA.
Q64411;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-NOV-2017, entry version 107.
RecName: Full=Gastricsin;
EC=3.4.23.3;
AltName: Full=Pepsinogen C;
Flags: Precursor;
Name=PGC;
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
Hystricomorpha; Caviidae; Cavia.
NCBI_TaxID=10141;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1644829;
Kageyama T., Ichinose M., Tsukada S., Miki K., Kurokawa K., Koiwai O.,
Tanji M., Yakabe E., Athauda S.B., Takahashi K.;
"Gastric procathepsin E and progastricsin from guinea pig.
Purification, molecular cloning of cDNAs, and characterization of
enzymatic properties, with special reference to procathepsin E.";
J. Biol. Chem. 267:16450-16459(1992).
-!- FUNCTION: Hydrolyzes a variety of proteins.
-!- CATALYTIC ACTIVITY: More restricted specificity than pepsin A, but
shows preferential cleavage at Tyr-|-Xaa bonds. High activity on
hemoglobin.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the peptidase A1 family. {ECO:0000305}.
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EMBL; M88652; AAA37053.1; -; mRNA.
PIR; B43356; B43356.
RefSeq; NP_001166470.1; NM_001172999.1.
ProteinModelPortal; Q64411; -.
SMR; Q64411; -.
STRING; 10141.ENSCPOP00000006477; -.
MEROPS; A01.003; -.
Ensembl; ENSCPOT00000007255; ENSCPOP00000006477; ENSCPOG00000007183.
GeneID; 100135598; -.
CTD; 5225; -.
eggNOG; KOG1339; Eukaryota.
eggNOG; ENOG410XNV7; LUCA.
GeneTree; ENSGT00760000118929; -.
HOGENOM; HOG000197681; -.
HOVERGEN; HBG000482; -.
InParanoid; Q64411; -.
OMA; HARFNPS; -.
OrthoDB; EOG091G0JP7; -.
TreeFam; TF314990; -.
Proteomes; UP000005447; Unassembled WGS sequence.
Bgee; ENSCPOG00000007183; -.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
GO; GO:0002803; P:positive regulation of antibacterial peptide production; IEA:Ensembl.
Gene3D; 2.40.70.10; -; 2.
InterPro; IPR001461; Aspartic_peptidase_A1.
InterPro; IPR001969; Aspartic_peptidase_AS.
InterPro; IPR012848; Aspartic_peptidase_N.
InterPro; IPR033735; Gastricsin.
InterPro; IPR033121; PEPTIDASE_A1.
InterPro; IPR021109; Peptidase_aspartic_dom_sf.
PANTHER; PTHR13683; PTHR13683; 1.
PANTHER; PTHR13683:SF292; PTHR13683:SF292; 1.
Pfam; PF07966; A1_Propeptide; 1.
Pfam; PF00026; Asp; 1.
PRINTS; PR00792; PEPSIN.
SUPFAM; SSF50630; SSF50630; 1.
PROSITE; PS00141; ASP_PROTEASE; 2.
PROSITE; PS51767; PEPTIDASE_A1; 1.
2: Evidence at transcript level;
Aspartyl protease; Complete proteome; Digestion; Disulfide bond;
Hydrolase; Protease; Reference proteome; Secreted; Signal; Zymogen.
SIGNAL 1 16 {ECO:0000255}.
PROPEP 17 65 Activation peptide.
/FTId=PRO_0000026054.
CHAIN 66 394 Gastricsin.
/FTId=PRO_0000026055.
DOMAIN 79 391 Peptidase A1. {ECO:0000255|PROSITE-
ProRule:PRU01103}.
ACT_SITE 97 97 {ECO:0000255|PROSITE-ProRule:PRU10094}.
ACT_SITE 283 283 {ECO:0000255|PROSITE-ProRule:PRU10094}.
DISULFID 110 115 {ECO:0000250}.
DISULFID 273 277 {ECO:0000250}.
DISULFID 316 349 {ECO:0000250}.
SEQUENCE 394 AA; 42996 MW; 114F08E105D49865 CRC64;
MKWMVVVLLC LPLLEATQIK VPLKKIKSIR EVLREKGLLG DFLKNHKPQH ARKFFRNRLA
KTGDFSVLYE PMSYMDAAYF GQISLGTPPQ SFQVLFDTGS SNLWVPSVYC SSLACTTHTR
FNPRDSSTYV ATDQSFSLEY GTGSLTGVFG YDTMTIQDIQ VPKQEFGLSE TEPGSDFVYA
EFDGILGLGY PGLSEGGATT AMQGLLREGA LSQSLFSVYL GSQQGSDEGQ LILGGVDESL
YTGDIYWTPV TQELYWQIGI EGFLIDGSAS GWCSRGCQGI VDTGTSLLTV PSDYLSTLVQ
AIGAEENEYG EYFVSCSSIQ DLPTLTFVIS GVEFPLSPSA YILSGENYCM VGLESTYVSP
GGGEPVWILG DVFLRSYYSV YDLANNRVGF ATAA


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