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Gastrin/cholecystokinin-like peptide (Antral peptide)

 ANTR_LITCT              Reviewed;         102 AA.
P80111;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
15-JUL-1999, sequence version 2.
12-SEP-2018, entry version 66.
RecName: Full=Gastrin/cholecystokinin-like peptide;
AltName: Full=Antral peptide;
Flags: Precursor;
Name=GAST;
Lithobates catesbeiana (American bullfrog) (Rana catesbeiana).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Rana;
Aquarana.
NCBI_TaxID=8400;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
PubMed=9075736; DOI=10.1210/endo.138.4.5084;
Rourke I.J., Rehfeld J.F., Moeller M., Johnson A.H.;
"Characterization of the cholecystokinin and gastrin genes from the
bullfrog, Rana catesbeiana: evolutionary conservation of primary and
secondary sites of gene expression.";
Endocrinology 138:1719-1727(1997).
[2]
PROTEIN SEQUENCE OF 46-92, SULFATION AT TYR-86, AND AMIDATION AT
PHE-92.
TISSUE=Gastric mucosa;
PubMed=1633800; DOI=10.1111/j.1432-1033.1992.tb17065.x;
Johnsen A.H., Rehfeld J.F.;
"Identification of cholecystokinin/gastrin peptides in frog and
turtle. Evidence that cholecystokinin is phylogenetically older than
gastrin.";
Eur. J. Biochem. 207:419-428(1992).
-!- FUNCTION: May control digestion processes.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed in antrum, duodenum, colon,
pancreas, brain and testis. No expression found in kidney, lung,
liver, skin or distal two-thirds of small intestine. In the brain,
strongly expressed in the pituitary gland with moderate expression
in the neural lobe, brain stem and hypothalamus.
-!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
{ECO:0000305}.
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EMBL; Y08399; CAA69676.1; -; Genomic_DNA.
EMBL; Y08400; CAA69676.1; JOINED; Genomic_DNA.
EMBL; Y08397; CAA69675.1; -; mRNA.
PIR; S24142; S24142.
HOVERGEN; HBG098151; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
InterPro; IPR039236; GAST.
InterPro; IPR001651; Gastrin/CCK.
InterPro; IPR013152; Gastrin/cholecystokinin_CS.
PANTHER; PTHR19309; PTHR19309; 1.
Pfam; PF00918; Gastrin; 1.
PROSITE; PS00259; GASTRIN; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Digestion;
Direct protein sequencing; Hormone; Secreted; Signal; Sulfation.
SIGNAL 1 20 {ECO:0000255}.
PROPEP 21 45 {ECO:0000269|PubMed:1633800}.
/FTId=PRO_0000010659.
PEPTIDE 46 92 Gastrin/cholecystokinin-like peptide.
/FTId=PRO_0000010660.
PROPEP 96 102
/FTId=PRO_0000010661.
MOD_RES 86 86 Sulfotyrosine.
{ECO:0000269|PubMed:1633800}.
MOD_RES 92 92 Phenylalanine amide.
{ECO:0000269|PubMed:1633800}.
SEQUENCE 102 AA; 11551 MW; 6FCBEB01538A0C93 CRC64;
MDKKVCVSIL LAMLAIAALC RPMTELESAR HGAQRKNSIS DVSRRDLLAS LTHEQKQLIM
SQLLPELLSE LSNAEDHLHP MRDRDYAGWM DFGRRSSEVT ES


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