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Gastrin [Cleaved into: Big gastrin (Gastrin-34) (G34); Gastrin]

 GAST_RAT                Reviewed;         104 AA.
P04563;
13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 2.
28-FEB-2018, entry version 135.
RecName: Full=Gastrin;
Contains:
RecName: Full=Big gastrin;
AltName: Full=Gastrin-34;
Short=G34;
Contains:
RecName: Full=Gastrin;
Flags: Precursor;
Name=Gast; Synonyms=Gas;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Gastric antrum;
PubMed=3453895; DOI=10.1210/mend-1-4-306;
Fuller P.J., Stone D.L., Brand S.J.;
"Molecular cloning and sequencing of a rat preprogastrin complementary
deoxyribonucleic acid.";
Mol. Endocrinol. 1:306-311(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 56-92.
PubMed=6897117; DOI=10.1016/0196-9781(82)90172-3;
Schaffer M.H., Agarwal K.L., Noyes B.E.;
"Rat gastrin's amino acid sequence determined from the nucleotide
sequence of the mRNA.";
Peptides 3:693-696(1982).
[3]
PROTEOLYTIC PROCESSING, PHOSPHORYLATION AT SER-96, SULFATION AT TYR-87
AND TYR-103, AND AMIDATION AT PHE-92.
PubMed=1701434;
Varro A., Nemeth J., Bridson J., Lee C., Moore S., Dockray G.J.;
"Processing of the gastrin precursor. Modulation of phosphorylated,
sulfated, and amidated products.";
J. Biol. Chem. 265:21476-21481(1990).
-!- FUNCTION: Gastrin stimulates the stomach mucosa to produce and
secrete hydrochloric acid and the pancreas to secrete its
digestive enzymes. It also stimulates smooth muscle contraction
and increases blood circulation and water secretion in the stomach
and intestine.
-!- SUBCELLULAR LOCATION: Secreted.
-!- PTM: Sulfation on Tyr-87 enhances proteolytic processing, and
blocks peptide degradation. Levels of sulfation differ between
proteolytically-cleaved gastrins and between tissues (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
{ECO:0000305}.
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EMBL; M38653; AAA41919.1; -; mRNA.
EMBL; M25459; AAA41195.1; -; mRNA.
PIR; A40910; A40910.
RefSeq; NP_036981.1; NM_012849.1.
RefSeq; XP_017452526.1; XM_017597037.1.
UniGene; Rn.9754; -.
STRING; 10116.ENSRNOP00000019863; -.
iPTMnet; P04563; -.
PhosphoSitePlus; P04563; -.
PaxDb; P04563; -.
PRIDE; P04563; -.
Ensembl; ENSRNOT00000019863; ENSRNOP00000019863; ENSRNOG00000014740.
GeneID; 25320; -.
KEGG; rno:25320; -.
UCSC; RGD:2662; rat.
CTD; 2520; -.
RGD; 2662; Gast.
eggNOG; ENOG410J1ZA; Eukaryota.
eggNOG; ENOG4111D7Y; LUCA.
GeneTree; ENSGT00390000014792; -.
HOGENOM; HOG000073533; -.
HOVERGEN; HBG097593; -.
InParanoid; P04563; -.
KO; K13768; -.
OMA; KKQGPWM; -.
OrthoDB; EOG091G147Z; -.
PhylomeDB; P04563; -.
TreeFam; TF336994; -.
Reactome; R-RNO-416476; G alpha (q) signalling events.
Reactome; R-RNO-881907; Gastrin-CREB signalling pathway via PKC and MAPK.
PRO; PR:P04563; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000014740; -.
Genevisible; P04563; RN.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005179; F:hormone activity; IDA:RGD.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:RGD.
GO; GO:0032094; P:response to food; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; IDA:RGD.
InterPro; IPR001651; Gastrin.
InterPro; IPR013152; Gastrin/cholecystokinin_CS.
Pfam; PF00918; Gastrin; 1.
PROSITE; PS00259; GASTRIN; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Hormone; Phosphoprotein; Reference proteome; Secreted; Signal;
Sulfation.
SIGNAL 1 21 {ECO:0000305}.
PROPEP 22 58
/FTId=PRO_0000010648.
PEPTIDE 59 92 Big gastrin.
/FTId=PRO_0000010649.
PEPTIDE 76 92 Gastrin.
/FTId=PRO_0000010650.
PROPEP 96 104
/FTId=PRO_0000010651.
MOD_RES 87 87 Sulfotyrosine.
{ECO:0000269|PubMed:1701434}.
MOD_RES 92 92 Phenylalanine amide.
{ECO:0000269|PubMed:1701434}.
MOD_RES 96 96 Phosphoserine.
{ECO:0000269|PubMed:1701434}.
MOD_RES 103 103 Sulfotyrosine.
{ECO:0000269|PubMed:1701434}.
SEQUENCE 104 AA; 11832 MW; 973FD06276BF1E21 CRC64;
MPRLCVCMLV LVLALATFSE ASWKPRSQLQ DASSGPRTNG ALEQHQLEKL GPASHHRRQL
GPQGPQHFIA DLSKKQRPPM EEEEEAYGWM DFGRRSAEEE DQYN


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