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Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-(18-27)) (GRP-10)]

 GRP_BOVIN               Reviewed;         134 AA.
Q863C3; A6QQP2; Q7M2Y8;
27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
23-OCT-2007, sequence version 3.
12-SEP-2018, entry version 85.
RecName: Full=Gastrin-releasing peptide;
Short=GRP;
Contains:
RecName: Full=Neuromedin-C;
AltName: Full=GRP-(18-27);
AltName: Full=GRP-10;
Flags: Precursor;
Name=GRP;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Kidney;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 9-134.
TISSUE=Endometrium;
Budipitojo T., Sasaki T., Cruzana M.B.C., Kitamura N., Yamada J.;
"Molecular cloning of cDNA encoding an endometrial gastrin-releasing
peptide (GRP) of cow.";
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
[3]
PROTEIN SEQUENCE OF 41-50, AMIDATION AT MET-50, SUBCELLULAR LOCATION,
AND TISSUE SPECIFICITY.
TISSUE=Adrenal medulla;
PubMed=2755876; DOI=10.1016/0196-9781(89)90043-0;
Lemaire S., Trifaro J.-M., Chouinard L., Cecyre D., Dessureault J.,
Mercier P., Dumont M.;
"Structural identification, subcellular localization and secretion of
bovine adrenomedullary neuromedin C [GRP-(18-27)].";
Peptides 10:355-360(1989).
-!- FUNCTION: Stimulates the release of gastrin and other
gastrointestinal hormones (By similarity). Contributes to the
perception of prurient stimuli and to the transmission of itch
signals in the spinal cord that promote scratching behavior.
Contributes primarily to nonhistaminergic itch sensation.
Contributes to long-term fear memory, but not normal spatial
memory. Contributes to the regulation of food intake (By
similarity). {ECO:0000250|UniProtKB:P63153,
ECO:0000250|UniProtKB:Q8R1I2}.
-!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle lumen
{ECO:0000269|PubMed:2755876}. Secreted
{ECO:0000305|PubMed:2755876}.
-!- TISSUE SPECIFICITY: Detected in adrenal medulla (at protein
level). {ECO:0000269|PubMed:2755876}.
-!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAP13050.1; Type=Frameshift; Positions=24, 116; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; BC149933; AAI49934.1; -; mRNA.
EMBL; AY255852; AAP13050.1; ALT_FRAME; mRNA.
PIR; A60647; A60647.
RefSeq; NP_001094709.1; NM_001101239.1.
UniGene; Bt.59634; -.
STRING; 9913.ENSBTAP00000006297; -.
PaxDb; Q863C3; -.
PRIDE; Q863C3; -.
Ensembl; ENSBTAT00000006297; ENSBTAP00000006297; ENSBTAG00000004796.
GeneID; 615323; -.
KEGG; bta:615323; -.
CTD; 2922; -.
VGNC; VGNC:29664; GRP.
eggNOG; ENOG410IZ53; Eukaryota.
eggNOG; ENOG4111D8H; LUCA.
GeneTree; ENSGT00390000017865; -.
HOGENOM; HOG000112821; -.
HOVERGEN; HBG005912; -.
InParanoid; Q863C3; -.
KO; K05224; -.
OMA; YIRWEEA; -.
OrthoDB; EOG091G0VOZ; -.
TreeFam; TF336391; -.
Reactome; R-BTA-375276; Peptide ligand-binding receptors.
Reactome; R-BTA-381771; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
Reactome; R-BTA-416476; G alpha (q) signalling events.
Proteomes; UP000009136; Chromosome 24.
Bgee; ENSBTAG00000004796; Expressed in 7 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0034774; C:secretory granule lumen; IDA:UniProtKB.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:Ensembl.
GO; GO:0048565; P:digestive tract development; NAS:AgBase.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:Ensembl.
GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
GO; GO:1900738; P:positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0036343; P:psychomotor behavior; IEA:Ensembl.
GO; GO:0043207; P:response to external biotic stimulus; IEA:Ensembl.
GO; GO:0035176; P:social behavior; IEA:Ensembl.
InterPro; IPR000874; Bombesin.
InterPro; IPR015674; Gastrin-RP.
PANTHER; PTHR16866:SF2; PTHR16866:SF2; 1.
Pfam; PF02044; Bombesin; 1.
PROSITE; PS00257; BOMBESIN; 1.
1: Evidence at protein level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Cytoplasmic vesicle; Direct protein sequencing; Reference proteome;
Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
PEPTIDE 24 50 Gastrin-releasing peptide.
/FTId=PRO_0000003030.
PEPTIDE 41 50 Neuromedin-C.
{ECO:0000269|PubMed:2755876}.
/FTId=PRO_0000003031.
PROPEP 54 134
/FTId=PRO_0000003032.
MOD_RES 50 50 Methionine amide.
{ECO:0000269|PubMed:2755876}.
CONFLICT 17 17 L -> P (in Ref. 2; AAP13050).
{ECO:0000305}.
CONFLICT 22 23 WA -> SG (in Ref. 2; AAP13050).
{ECO:0000305}.
CONFLICT 31 31 G -> A (in Ref. 2; AAP13050).
{ECO:0000305}.
CONFLICT 64 64 E -> ES (in Ref. 2; AAP13050).
{ECO:0000305}.
CONFLICT 93 98 ARGHQM -> PEPTRL (in Ref. 2; AAP13050).
{ECO:0000305}.
CONFLICT 124 129 PQHEGR -> SQREGG (in Ref. 2; AAP13050).
{ECO:0000305}.
CONFLICT 134 134 N -> Y (in Ref. 2; AAP13050).
{ECO:0000305}.
SEQUENCE 134 AA; 14934 MW; 581CA992A778C961 CRC64;
MRGREVPLVL LALVLCLAPR GWAAPVTAGR GGALAKMYTR GNHWAVGHLM GKKSVAESPQ
LHEEESLKEQ LREYAQWEEA TRNLLSLLQA KGARGHQMPP WEPLSIHQPA WDSEDVSNFK
DTGPQHEGRN PQLN


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