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Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10)]

 GRP_HUMAN               Reviewed;         148 AA.
P07492; P07491; P81553; Q14454; Q53YA0; Q9BSY7;
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 2.
20-JUN-2018, entry version 165.
RecName: Full=Gastrin-releasing peptide;
Short=GRP;
Contains:
RecName: Full=Neuromedin-C;
AltName: Full=GRP-10;
Flags: Precursor;
Name=GRP;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF
70-148 (ISOFORM 2), AND VARIANT SER-4.
PubMed=3001723; DOI=10.1073/pnas.83.1.19;
Spindel E.R., Zilberberg M.D., Habener J.F., Chin W.W.;
"Two prohormones for gastrin-releasing peptide are encoded by two
mRNAs differing by 19 nucleotides.";
Proc. Natl. Acad. Sci. U.S.A. 83:19-23(1986).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT MET-50, AND SUBCELLULAR
LOCATION.
PubMed=3211139; DOI=10.1128/MCB.8.8.3129;
Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G.,
van Wyke Coelingh K., Lebacq J.A., Battey J.F.;
"Posttranslational processing of endogenous and of baculovirus-
expressed human gastrin-releasing peptide precursor.";
Mol. Cell. Biol. 8:3129-3135(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
PubMed=3003116;
Sausville E.A., Lebacq-Verheyden A.-M., Spindel E.R., Cuttitta F.,
Gazdar A.F., Battey J.F.;
"Expression of the gastrin-releasing peptide gene in human small cell
lung cancer. Evidence for alternative processing resulting in three
distinct mRNAs.";
J. Biol. Chem. 261:2451-2457(1986).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor
vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16177791; DOI=10.1038/nature03983;
Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
"DNA sequence and analysis of human chromosome 18.";
Nature 437:551-555(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
STRUCTURE BY NMR OF 41-50.
DOI=10.1039/C5RA12753J;
Adrover M., Sanchis P., Vilanova B., Pauwels K., Martorell G.,
Perez J.J.;
"Conformational ensembles of neuromedin C reveal a progressive coil-
helix transition within a binding-induced folding mechanism.";
RSC Adv. 5:83074-83088(2015).
-!- FUNCTION: Stimulates the release of gastrin and other
gastrointestinal hormones (By similarity). Contributes to the
perception of prurient stimuli and to the transmission of itch
signals in the spinal cord that promote scratching behavior.
Contributes primarily to nonhistaminergic itch sensation.
Contributes to long-term fear memory, but not normal spatial
memory. Contributes to the regulation of food intake (By
similarity). {ECO:0000250|UniProtKB:P63153,
ECO:0000250|UniProtKB:Q8R1I2}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3211139}.
Cytoplasmic vesicle, secretory vesicle lumen
{ECO:0000250|UniProtKB:Q863C3}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P07492-1; Sequence=Displayed;
Name=2;
IsoId=P07492-2; Sequence=VSP_000549;
Name=3;
IsoId=P07492-3; Sequence=VSP_000550;
-!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA52612.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Wikipedia; Note=Gastrin-releasing peptide
entry;
URL="https://en.wikipedia.org/wiki/Gastrin_releasing_peptide";
-----------------------------------------------------------------------
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EMBL; K02054; AAA52613.1; -; mRNA.
EMBL; M12550; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; M12512; AAA52612.1; ALT_SEQ; Genomic_DNA.
EMBL; M12511; AAA52612.1; JOINED; Genomic_DNA.
EMBL; M12512; AAA52611.1; -; Genomic_DNA.
EMBL; M12511; AAA52611.1; JOINED; Genomic_DNA.
EMBL; BT006803; AAP35449.1; -; mRNA.
EMBL; AC067859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471096; EAW63091.1; -; Genomic_DNA.
EMBL; BC004488; AAH04488.1; -; mRNA.
CCDS; CCDS11971.1; -. [P07492-1]
CCDS; CCDS45877.1; -. [P07492-3]
CCDS; CCDS45878.1; -. [P07492-2]
PIR; A26182; A26182.
PIR; B26182; B26182.
RefSeq; NP_001012530.1; NM_001012512.2. [P07492-3]
RefSeq; NP_001012531.1; NM_001012513.2. [P07492-2]
RefSeq; NP_002082.2; NM_002091.4. [P07492-1]
UniGene; Hs.153444; -.
PDB; 2N0B; NMR; -; A=41-50.
PDB; 2N0C; NMR; -; A=41-50.
PDB; 2N0D; NMR; -; A=41-50.
PDB; 2N0E; NMR; -; A=41-50.
PDB; 2N0F; NMR; -; A=41-50.
PDB; 2N0G; NMR; -; A=41-50.
PDB; 2N0H; NMR; -; A=41-50.
PDBsum; 2N0B; -.
PDBsum; 2N0C; -.
PDBsum; 2N0D; -.
PDBsum; 2N0E; -.
PDBsum; 2N0F; -.
PDBsum; 2N0G; -.
PDBsum; 2N0H; -.
ProteinModelPortal; P07492; -.
SMR; P07492; -.
BioGrid; 109179; 13.
IntAct; P07492; 1.
STRING; 9606.ENSP00000256857; -.
iPTMnet; P07492; -.
PhosphoSitePlus; P07492; -.
BioMuta; GRP; -.
DMDM; 308153451; -.
PaxDb; P07492; -.
PeptideAtlas; P07492; -.
PRIDE; P07492; -.
ProteomicsDB; 52008; -.
ProteomicsDB; 52009; -. [P07492-2]
ProteomicsDB; 52010; -. [P07492-3]
DNASU; 2922; -.
Ensembl; ENST00000256857; ENSP00000256857; ENSG00000134443. [P07492-1]
Ensembl; ENST00000420468; ENSP00000389696; ENSG00000134443. [P07492-3]
Ensembl; ENST00000529320; ENSP00000434101; ENSG00000134443. [P07492-2]
GeneID; 2922; -.
KEGG; hsa:2922; -.
UCSC; uc002lhu.4; human. [P07492-1]
CTD; 2922; -.
DisGeNET; 2922; -.
EuPathDB; HostDB:ENSG00000134443.9; -.
GeneCards; GRP; -.
HGNC; HGNC:4605; GRP.
MIM; 137260; gene.
neXtProt; NX_P07492; -.
OpenTargets; ENSG00000134443; -.
PharmGKB; PA28999; -.
eggNOG; ENOG410IZ53; Eukaryota.
eggNOG; ENOG4111D8H; LUCA.
GeneTree; ENSGT00390000017865; -.
HOGENOM; HOG000112821; -.
HOVERGEN; HBG005912; -.
InParanoid; P07492; -.
KO; K05224; -.
OMA; YIRWEEA; -.
OrthoDB; EOG091G0VOZ; -.
PhylomeDB; P07492; -.
TreeFam; TF336391; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-381771; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
Reactome; R-HSA-416476; G alpha (q) signalling events.
SIGNOR; P07492; -.
GeneWiki; Gastrin-releasing_peptide; -.
GenomeRNAi; 2922; -.
PMAP-CutDB; Q53YA0; -.
PRO; PR:P07492; -.
Proteomes; UP000005640; Chromosome 18.
Bgee; ENSG00000134443; -.
CleanEx; HS_GRP; -.
ExpressionAtlas; P07492; baseline and differential.
Genevisible; P07492; HS.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0034774; C:secretory granule lumen; ISS:UniProtKB.
GO; GO:0005184; F:neuropeptide hormone activity; IDA:MGI.
GO; GO:0005102; F:signaling receptor binding; NAS:ProtInc.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
GO; GO:1900738; P:positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0036343; P:psychomotor behavior; IEA:Ensembl.
GO; GO:0043207; P:response to external biotic stimulus; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; NAS:ProtInc.
GO; GO:0035176; P:social behavior; IEA:Ensembl.
InterPro; IPR000874; Bombesin.
InterPro; IPR015674; Gastrin-RP.
PANTHER; PTHR16866:SF2; PTHR16866:SF2; 1.
Pfam; PF02044; Bombesin; 1.
PROSITE; PS00257; BOMBESIN; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Amidation;
Cleavage on pair of basic residues; Complete proteome;
Cytoplasmic vesicle; Polymorphism; Reference proteome; Secreted;
Signal.
SIGNAL 1 23
PEPTIDE 24 50 Gastrin-releasing peptide.
/FTId=PRO_0000003035.
PEPTIDE 41 50 Neuromedin-C.
/FTId=PRO_0000003036.
PROPEP 54 148
/FTId=PRO_0000003037.
MOD_RES 50 50 Methionine amide.
{ECO:0000269|PubMed:3211139}.
VAR_SEQ 122 148 VGSKGKVGRLSAPGSQREGRNPQLNQQ -> LVDSLLQVLN
VKEGTPS (in isoform 2).
{ECO:0000303|PubMed:3001723}.
/FTId=VSP_000549.
VAR_SEQ 128 134 Missing (in isoform 3). {ECO:0000305}.
/FTId=VSP_000550.
VARIANT 4 4 R -> S (in dbSNP:rs1062557).
{ECO:0000269|PubMed:3001723}.
/FTId=VAR_027834.
HELIX 45 48 {ECO:0000244|PDB:2N0E}.
SEQUENCE 148 AA; 16213 MW; 6A9ED9E2748255BD CRC64;
MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS
VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK
DVGSKGKVGR LSAPGSQREG RNPQLNQQ


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