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Gastrin-releasing peptide (GRP) [Cleaved into: Neuromedin-C (GRP-10)]

 GRP_RAT                 Reviewed;         147 AA.
P24393; G3V871;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
07-JUN-2017, sequence version 2.
23-MAY-2018, entry version 103.
RecName: Full=Gastrin-releasing peptide;
Short=GRP;
Contains:
RecName: Full=Neuromedin-C;
AltName: Full=GRP-10;
Flags: Precursor;
Name=Grp;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=2843761; DOI=10.1210/mend-2-6-556;
Lebacq-Verheyden A.-M., Krystal G., Sartor O., Way J., Battey J.F.;
"The rat prepro gastrin releasing peptide gene is transcribed from two
initiation sites in the brain.";
Mol. Endocrinol. 2:556-563(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15057822; DOI=10.1038/nature02426;
Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
Collins F.S.;
"Genome sequence of the Brown Norway rat yields insights into
mammalian evolution.";
Nature 428:493-521(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway {ECO:0000312|EMBL:EDM14697.1};
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
FUNCTION.
PubMed=17208656; DOI=10.1016/j.brainresbull.2006.10.007;
Fekete E.M., Bagi E.E., Toth K., Lenard L.;
"Neuromedin C microinjected into the amygdala inhibits feeding.";
Brain Res. Bull. 71:386-392(2007).
-!- FUNCTION: Stimulates the release of gastrin and other
gastrointestinal hormones (By similarity). Contributes to the
perception of prurient stimuli and to the transmission of itch
signals in the spinal cord that promote scratching behavior.
Contributes primarily to nonhistaminergic itch sensation.
Contributes to long-term fear memory, but not normal spatial
memory (By similarity). Contributes to the regulation of food
intake (PubMed:17208656). {ECO:0000250|UniProtKB:P63153,
ECO:0000250|UniProtKB:Q8R1I2, ECO:0000269|PubMed:17208656}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}.
Cytoplasmic vesicle, secretory vesicle lumen
{ECO:0000250|UniProtKB:Q863C3}.
-!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin
family. {ECO:0000305}.
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EMBL; M31176; AAA41197.1; -; mRNA.
EMBL; AABR07032332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH473971; EDM14697.1; -; Genomic_DNA.
EMBL; CH473971; EDM14698.1; -; Genomic_DNA.
PIR; A40922; A40922.
RefSeq; NP_598254.2; NM_133570.5.
UniGene; Rn.10930; -.
SMR; P24393; -.
STRING; 10116.ENSRNOP00000022845; -.
PhosphoSitePlus; P24393; -.
PaxDb; P24393; -.
Ensembl; ENSRNOT00000022845; ENSRNOP00000022845; ENSRNOG00000016999.
GeneID; 171101; -.
KEGG; rno:171101; -.
UCSC; RGD:621740; rat.
CTD; 2922; -.
RGD; 621740; Grp.
eggNOG; ENOG410IZ53; Eukaryota.
eggNOG; ENOG4111D8H; LUCA.
GeneTree; ENSGT00390000017865; -.
HOGENOM; HOG000112821; -.
HOVERGEN; HBG005912; -.
InParanoid; P24393; -.
KO; K05224; -.
OMA; YIRWEEA; -.
OrthoDB; EOG091G0VOZ; -.
PhylomeDB; P24393; -.
TreeFam; TF336391; -.
Reactome; R-RNO-375276; Peptide ligand-binding receptors.
Reactome; R-RNO-381771; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
Reactome; R-RNO-416476; G alpha (q) signalling events.
PRO; PR:P24393; -.
Proteomes; UP000002494; Chromosome 18.
Bgee; ENSRNOG00000016999; -.
GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
GO; GO:0034774; C:secretory granule lumen; ISS:UniProtKB.
GO; GO:0005184; F:neuropeptide hormone activity; IEA:Ensembl.
GO; GO:0007218; P:neuropeptide signaling pathway; IMP:RGD.
GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
GO; GO:1900738; P:positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0036343; P:psychomotor behavior; IEA:Ensembl.
GO; GO:0043207; P:response to external biotic stimulus; IEA:Ensembl.
GO; GO:0035176; P:social behavior; IEA:Ensembl.
InterPro; IPR000874; Bombesin.
InterPro; IPR015674; Gastrin-RP.
PANTHER; PTHR16866:SF2; PTHR16866:SF2; 1.
Pfam; PF02044; Bombesin; 1.
PROSITE; PS00257; BOMBESIN; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Complete proteome;
Cytoplasmic vesicle; Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000250}.
PEPTIDE 24 52 Gastrin-releasing peptide.
/FTId=PRO_0000003039.
PEPTIDE 43 52 Neuromedin-C.
/FTId=PRO_0000003040.
PROPEP 56 147 {ECO:0000250}.
/FTId=PRO_0000003041.
MOD_RES 52 52 Methionine amide.
{ECO:0000250|UniProtKB:P63153}.
CONFLICT 95 96 AG -> SR (in Ref. 1; AAA41197).
SEQUENCE 147 AA; 15702 MW; 54AF30AEF24E56B0 CRC64;
MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH LMGKKSTDEL
PPLYAADRDG LKEQLRGYIR WEEAARNLLG LLEAAGNRSH QPPQDQPLGS LQPTWDPEDG
SYFSDAQNAK LVDSLLQVLK GKEGTAS


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