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Gastrin-releasing peptide receptor (GRP-R) (GRP-preferring bombesin receptor)

 GRPR_HUMAN              Reviewed;         384 AA.
P30550; B2R910;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 1.
05-DEC-2018, entry version 160.
RecName: Full=Gastrin-releasing peptide receptor;
Short=GRP-R;
AltName: Full=GRP-preferring bombesin receptor;
Name=GRPR;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
TISSUE=Lung;
PubMed=1655761;
Corjay M.H., Dobrzanski D.J., Way J.M., Viallet J., Shapira H.,
Worland P., Sausville E.A., Battey J.F.;
"Two distinct bombesin receptor subtypes are expressed and functional
in human lung carcinoma cells.";
J. Biol. Chem. 266:18771-18779(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
PubMed=11245983; DOI=10.1016/S0378-1119(00)00596-5;
Xiao D., Wang J., Hampton L.L., Weber H.C.;
"The human gastrin-releasing peptide receptor gene structure, its
tissue expression and promoter.";
Gene 264:95-103(2001).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Receptor for gastrin-releasing peptide (GRP)
(PubMed:1655761). Signals via association with G proteins that
activate a phosphatidylinositol-calcium second messenger system,
resulting in Akt phosphorylation. Contributes to the regulation of
food intake. Contributes to the perception of prurient stimuli and
transmission of itch signals in the spinal cord that promote
scratching behavior, but does not play a role in the perception of
pain. Contributes primarily to nonhistaminergic itch sensation.
Contributes to long-term fear memory, but not normal spatial
memory (By similarity). {ECO:0000250|UniProtKB:P21729,
ECO:0000269|PubMed:1655761}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1655761};
Multi-pass membrane protein {ECO:0000255}.
-!- TISSUE SPECIFICITY: Highly expressed in pancreas. Also expressed
in stomach, adrenal cortex and brain.
{ECO:0000269|PubMed:11245983}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-----------------------------------------------------------------------
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EMBL; M73481; AAA88050.1; -; mRNA.
EMBL; AF293323; AAL96377.1; -; Genomic_DNA.
EMBL; AF293321; AAL96377.1; JOINED; Genomic_DNA.
EMBL; AF293322; AAL96377.1; JOINED; Genomic_DNA.
EMBL; AK313588; BAG36357.1; -; mRNA.
EMBL; CH471074; EAW98909.1; -; Genomic_DNA.
EMBL; BC074733; AAH74733.1; -; mRNA.
CCDS; CCDS14174.1; -.
PIR; A41007; A41007.
RefSeq; NP_005305.1; NM_005314.2.
UniGene; Hs.567282; -.
ProteinModelPortal; P30550; -.
SMR; P30550; -.
BioGrid; 109181; 63.
STRING; 9606.ENSP00000369643; -.
BindingDB; P30550; -.
ChEMBL; CHEMBL4959; -.
GuidetoPHARMACOLOGY; 39; -.
iPTMnet; P30550; -.
PhosphoSitePlus; P30550; -.
BioMuta; GRPR; -.
DMDM; 232185; -.
EPD; P30550; -.
PaxDb; P30550; -.
PeptideAtlas; P30550; -.
PRIDE; P30550; -.
ProteomicsDB; 54720; -.
Ensembl; ENST00000380289; ENSP00000369643; ENSG00000126010.
GeneID; 2925; -.
KEGG; hsa:2925; -.
CTD; 2925; -.
DisGeNET; 2925; -.
EuPathDB; HostDB:ENSG00000126010.5; -.
GeneCards; GRPR; -.
HGNC; HGNC:4609; GRPR.
HPA; HPA069604; -.
MIM; 305670; gene.
neXtProt; NX_P30550; -.
OpenTargets; ENSG00000126010; -.
PharmGKB; PA29002; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00940000153205; -.
HOGENOM; HOG000230781; -.
HOVERGEN; HBG004898; -.
InParanoid; P30550; -.
KO; K04169; -.
OMA; NICHEGY; -.
OrthoDB; EOG091G085Y; -.
PhylomeDB; P30550; -.
TreeFam; TF331292; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-416476; G alpha (q) signalling events.
SIGNOR; P30550; -.
ChiTaRS; GRPR; human.
GeneWiki; Gastrin-releasing_peptide_receptor; -.
GenomeRNAi; 2925; -.
PRO; PR:P30550; -.
Proteomes; UP000005640; Chromosome X.
Bgee; ENSG00000126010; Expressed in 48 organ(s), highest expression level in body of pancreas.
CleanEx; HS_GRPR; -.
ExpressionAtlas; P30550; baseline and differential.
Genevisible; P30550; HS.
GO; GO:0005887; C:integral component of plasma membrane; IMP:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0008528; F:G protein-coupled peptide receptor activity; IDA:UniProtKB.
GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
GO; GO:0042923; F:neuropeptide binding; IEA:Ensembl.
GO; GO:0008188; F:neuropeptide receptor activity; ISS:UniProtKB.
GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
GO; GO:0007611; P:learning or memory; IEA:Ensembl.
GO; GO:0061744; P:motor behavior; ISS:UniProtKB.
GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
GO; GO:0036343; P:psychomotor behavior; IEA:Ensembl.
GO; GO:0042127; P:regulation of cell proliferation; IEA:Ensembl.
GO; GO:0043207; P:response to external biotic stimulus; IEA:Ensembl.
GO; GO:0035176; P:social behavior; ISS:UniProtKB.
CDD; cd15124; 7tmA_GRPR; 1.
InterPro; IPR001556; Bombsn_rcpt-like.
InterPro; IPR001966; Gastrin_pep_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00358; BOMBESINR.
PRINTS; PR00640; GASTRINRELPR.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
Palmitate; Phosphoprotein; Receptor; Reference proteome; Transducer;
Transmembrane; Transmembrane helix.
CHAIN 1 384 Gastrin-releasing peptide receptor.
/FTId=PRO_0000069662.
TOPO_DOM 1 38 Extracellular. {ECO:0000255}.
TRANSMEM 39 62 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 63 76 Cytoplasmic. {ECO:0000255}.
TRANSMEM 77 96 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 97 114 Extracellular. {ECO:0000255}.
TRANSMEM 115 136 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 137 152 Cytoplasmic. {ECO:0000255}.
TRANSMEM 153 174 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 175 208 Extracellular. {ECO:0000255}.
TRANSMEM 209 234 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 235 264 Cytoplasmic. {ECO:0000255}.
TRANSMEM 265 285 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 286 298 Extracellular. {ECO:0000255}.
TRANSMEM 299 325 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 326 384 Cytoplasmic. {ECO:0000255}.
MOD_RES 350 350 Phosphoserine.
{ECO:0000250|UniProtKB:O54799}.
LIPID 339 339 S-palmitoyl cysteine. {ECO:0000250}.
CARBOHYD 20 20 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 113 196 {ECO:0000255|PROSITE-ProRule:PRU00521}.
SEQUENCE 384 AA; 43199 MW; 70A75F11D9C82F19 CRC64;
MALNDCFLLN LEVDHFMHCN ISSHSADLPV NDDWSHPGIL YVIPAVYGVI ILIGLIGNIT
LIKIFCTVKS MRNVPNLFIS SLALGDLLLL ITCAPVDASR YLADRWLFGR IGCKLIPFIQ
LTSVGVSVFT LTALSADRYK AIVRPMDIQA SHALMKICLK AAFIWIISML LAIPEAVFSD
LHPFHEESTN QTFISCAPYP HSNELHPKIH SMASFLVFYV IPLSIISVYY YFIAKNLIQS
AYNLPVEGNI HVKKQIESRK RLAKTVLVFV GLFAFCWLPN HVIYLYRSYH YSEVDTSMLH
FVTSICARLL AFTNSCVNPF ALYLLSKSFR KQFNTQLLCC QPGLIIRSHS TGRSTTCMTS
LKSTNPSVAT FSLINGNICH ERYV


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