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General negative regulator of transcription subunit 1 (Cell division cycle protein 39)

 NOT1_YEAST              Reviewed;        2108 AA.
P25655; D6VR93;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
05-OCT-2010, sequence version 3.
30-AUG-2017, entry version 163.
RecName: Full=General negative regulator of transcription subunit 1;
AltName: Full=Cell division cycle protein 39;
Name=CDC39; Synonyms=NOT1, ROS1; OrderedLocusNames=YCR093W;
ORFNames=YCR1151, YCR93W;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
STRAIN=KY803;
PubMed=8428577;
Collart M.A., Struhl K.;
"CDC39, an essential nuclear protein that negatively regulates
transcription and differentially affects the constitutive and
inducible HIS3 promoters.";
EMBO J. 12:177-186(1993).
[2]
ERRATUM.
Collart M.A., Struhl K.;
EMBO J. 12:2990-2990(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=1574125; DOI=10.1038/357038a0;
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M.,
Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W.,
Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H.,
Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V.,
Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A.,
de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H.,
Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K.,
Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B.,
Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A.,
Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y.,
Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R.,
Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G.,
Tzermia M., Urrestarazu L.A., Valle G., Vetter I.,
van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H.,
Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C.,
Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.;
"The complete DNA sequence of yeast chromosome III.";
Nature 357:38-46(1992).
[4]
SEQUENCE REVISION TO 1298.
Valles G., Volckaerts G.;
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
[5]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[6]
CHARACTERIZATION.
PubMed=7926748; DOI=10.1101/gad.8.5.525;
Collart M.A., Struhl K.;
"NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative
regulator of transcription that differentially affects TATA-element
utilization.";
Genes Dev. 8:525-537(1994).
[7]
IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, AND FUNCTION OF THE
CCR4-NOT CORE COMPLEX IN TRANSCRIPTIONAL REGULATION.
PubMed=9463387; DOI=10.1093/emboj/17.4.1096;
Liu H.Y., Badarinarayana V., Audino D.C., Rappsilber J., Mann M.,
Denis C.L.;
"The NOT proteins are part of the CCR4 transcriptional complex and
affect gene expression both positively and negatively.";
EMBO J. 17:1096-1106(1998).
[8]
INTERACTION WITH CCR4; POP2; NOT2; NOT4 AND NOT5.
PubMed=10490603; DOI=10.1128/MCB.19.10.6642;
Bai Y., Salvadore C., Chiang Y.C., Collart M.A., Liu H.Y., Denis C.L.;
"The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and
functionally separated from NOT2, NOT4, and NOT5.";
Mol. Cell. Biol. 19:6642-6651(1999).
[9]
IDENTIFICATION IN THE CCR4-NOT CORE COMPLEX, AND INTERACTION WITH
CAF40 AND CAF130.
PubMed=11733989; DOI=10.1006/jmbi.2001.5162;
Chen J., Rappsilber J., Chiang Y.C., Russell P., Mann M., Denis C.L.;
"Purification and characterization of the 1.0 MDa CCR4-NOT complex
identifies two novel components of the complex.";
J. Mol. Biol. 314:683-694(2001).
[10]
SUBCELLULAR LOCATION.
PubMed=11889048; DOI=10.1093/emboj/21.6.1427;
Tucker M., Staples R.R., Valencia-Sanchez M.A., Muhlrad D., Parker R.;
"Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase
complex in Saccharomyces cerevisiae.";
EMBO J. 21:1427-1436(2002).
[11]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2102, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=YAL6B;
PubMed=15665377; DOI=10.1074/mcp.M400219-MCP200;
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,
Mann M., Jensen O.N.;
"Quantitative phosphoproteomics applied to the yeast pheromone
signaling pathway.";
Mol. Cell. Proteomics 4:310-327(2005).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2102, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18407956; DOI=10.1074/mcp.M700468-MCP200;
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth
phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
-!- FUNCTION: Acts as component of the CCR4-NOT core complex, which in
the nucleus seems to be a general transcription factor, and in the
cytoplasm the major mRNA deadenylase involved in mRNA turnover.
The NOT protein subcomplex negatively regulates the basal and
activated transcription of many genes. Preferentially affects TC-
type TATA element-dependent transcription. Could directly or
indirectly inhibit component(s) of the general transcription
machinery. {ECO:0000269|PubMed:9463387}.
-!- SUBUNIT: Forms a NOT protein complex that comprises NOT1, NOT2,
NOT3, NOT4 and NOT5. Subunit of the 1.0 MDa CCR4-NOT core complex
that contains CCR4, CAF1, NOT1, NOT2, NOT3, NOT4, NOT5, CAF40 and
CAF130. In the complex interacts with CCR4, POP2, NOT2, NOT4 and
NOT5. The core complex probably is part of a less characterized
1.9 MDa CCR4-NOT complex. {ECO:0000269|PubMed:10490603,
ECO:0000269|PubMed:11733989, ECO:0000269|PubMed:9463387}.
-!- INTERACTION:
P53280:CAF130; NbExp=6; IntAct=EBI-12139, EBI-23322;
P53829:CAF40; NbExp=9; IntAct=EBI-12139, EBI-28306;
P31384:CCR4; NbExp=7; IntAct=EBI-12139, EBI-4396;
P34909:MOT2; NbExp=4; IntAct=EBI-12139, EBI-12174;
P06102:NOT3; NbExp=3; IntAct=EBI-12139, EBI-12165;
P39008:POP2; NbExp=9; IntAct=EBI-12139, EBI-13629;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11889048}.
Nucleus {ECO:0000269|PubMed:11889048}.
-!- MISCELLANEOUS: Present with 4300 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the CNOT1 family. {ECO:0000305}.
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EMBL; X70151; CAA49721.1; -; Genomic_DNA.
EMBL; X59720; CAA42248.2; -; Genomic_DNA.
EMBL; BK006937; DAA07562.1; -; Genomic_DNA.
PIR; S28417; S28417.
RefSeq; NP_010017.2; NM_001178799.1.
PDB; 4B89; X-ray; 1.50 A; A=755-1000.
PDB; 4B8A; X-ray; 2.40 A; A=755-1000.
PDB; 4B8B; X-ray; 2.80 A; A/B=151-753.
PDB; 4B8C; X-ray; 3.41 A; B/G/H/I=755-1000.
PDB; 4CV5; X-ray; 3.81 A; A/C=1071-1282.
PDBsum; 4B89; -.
PDBsum; 4B8A; -.
PDBsum; 4B8B; -.
PDBsum; 4B8C; -.
PDBsum; 4CV5; -.
ProteinModelPortal; P25655; -.
SMR; P25655; -.
BioGrid; 31065; 348.
DIP; DIP-1202N; -.
IntAct; P25655; 41.
MINT; MINT-383459; -.
STRING; 4932.YCR093W; -.
iPTMnet; P25655; -.
MaxQB; P25655; -.
PRIDE; P25655; -.
EnsemblFungi; CAA42248; CAA42248; CAA42248.
EnsemblFungi; YCR093W; YCR093W; YCR093W.
GeneID; 850455; -.
KEGG; sce:YCR093W; -.
EuPathDB; FungiDB:YCR093W; -.
SGD; S000000689; CDC39.
GeneTree; ENSGT00390000014869; -.
HOGENOM; HOG000057131; -.
InParanoid; P25655; -.
KO; K12604; -.
OMA; PNVFAND; -.
OrthoDB; EOG092C00SU; -.
BioCyc; YEAST:G3O-29387-MONOMER; -.
PRO; PR:P25655; -.
Proteomes; UP000002311; Chromosome III.
GO; GO:0030015; C:CCR4-NOT core complex; IPI:SGD.
GO; GO:0005737; C:cytoplasm; IDA:SGD.
GO; GO:0005634; C:nucleus; IDA:SGD.
GO; GO:0000932; C:P-body; IBA:GO_Central.
GO; GO:0001671; F:ATPase activator activity; IDA:SGD.
GO; GO:0032947; F:protein complex scaffold activity; IBA:GO_Central.
GO; GO:0010607; P:negative regulation of cytoplasmic mRNA processing body assembly; IDA:SGD.
GO; GO:0017148; P:negative regulation of translation; IBA:GO_Central.
GO; GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IDA:SGD.
GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IDA:SGD.
GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IDA:SGD.
GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
GO; GO:0051726; P:regulation of cell cycle; IMP:SGD.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IPI:SGD.
GO; GO:0000749; P:response to pheromone involved in conjugation with cellular fusion; IMP:SGD.
GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IMP:SGD.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR007196; CCR4-Not_Not1_C.
InterPro; IPR024557; CCR4-Not_Not1su_DUF3819.
InterPro; IPR032191; CNOT1_CAF1_bind.
InterPro; IPR032194; CNOT1_HEAT.
InterPro; IPR032195; CNOT1_HEAT_N.
InterPro; IPR032193; CNOT1_TTP_bind.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
Pfam; PF16415; CNOT1_CAF1_bind; 1.
Pfam; PF16418; CNOT1_HEAT; 1.
Pfam; PF16419; CNOT1_HEAT_N; 1.
Pfam; PF16417; CNOT1_TTP_bind; 1.
Pfam; PF12842; DUF3819; 1.
Pfam; PF04054; Not1; 1.
1: Evidence at protein level;
3D-structure; Activator; Coiled coil; Complete proteome; Cytoplasm;
Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
Transcription regulation.
CHAIN 1 2108 General negative regulator of
transcription subunit 1.
/FTId=PRO_0000096955.
COILED 795 813 {ECO:0000255}.
COILED 1021 1046 {ECO:0000255}.
COMPBIAS 1009 1046 Gln-rich.
COMPBIAS 1300 1329 Gln-rich.
MOD_RES 2102 2102 Phosphothreonine.
{ECO:0000244|PubMed:15665377,
ECO:0000244|PubMed:18407956}.
CONFLICT 526 526 T -> A (in Ref. 1; CAA49721).
{ECO:0000305}.
CONFLICT 569 569 A -> R (in Ref. 1; CAA49721).
{ECO:0000305}.
HELIX 194 197 {ECO:0000244|PDB:4B8B}.
HELIX 198 200 {ECO:0000244|PDB:4B8B}.
HELIX 201 207 {ECO:0000244|PDB:4B8B}.
HELIX 234 245 {ECO:0000244|PDB:4B8B}.
HELIX 249 251 {ECO:0000244|PDB:4B8B}.
HELIX 254 263 {ECO:0000244|PDB:4B8B}.
HELIX 275 285 {ECO:0000244|PDB:4B8B}.
HELIX 288 296 {ECO:0000244|PDB:4B8B}.
HELIX 301 312 {ECO:0000244|PDB:4B8B}.
TURN 316 319 {ECO:0000244|PDB:4B8B}.
HELIX 323 325 {ECO:0000244|PDB:4B8B}.
STRAND 334 336 {ECO:0000244|PDB:4B8B}.
HELIX 343 345 {ECO:0000244|PDB:4B8B}.
HELIX 347 358 {ECO:0000244|PDB:4B8B}.
TURN 359 362 {ECO:0000244|PDB:4B8B}.
HELIX 367 382 {ECO:0000244|PDB:4B8B}.
HELIX 384 393 {ECO:0000244|PDB:4B8B}.
HELIX 395 402 {ECO:0000244|PDB:4B8B}.
HELIX 405 421 {ECO:0000244|PDB:4B8B}.
HELIX 424 426 {ECO:0000244|PDB:4B8B}.
HELIX 427 433 {ECO:0000244|PDB:4B8B}.
HELIX 437 450 {ECO:0000244|PDB:4B8B}.
HELIX 457 464 {ECO:0000244|PDB:4B8B}.
HELIX 468 474 {ECO:0000244|PDB:4B8B}.
HELIX 479 482 {ECO:0000244|PDB:4B8B}.
HELIX 484 490 {ECO:0000244|PDB:4B8B}.
HELIX 495 502 {ECO:0000244|PDB:4B8B}.
TURN 505 507 {ECO:0000244|PDB:4B8B}.
HELIX 508 520 {ECO:0000244|PDB:4B8B}.
TURN 530 532 {ECO:0000244|PDB:4B8B}.
HELIX 536 547 {ECO:0000244|PDB:4B8B}.
HELIX 553 569 {ECO:0000244|PDB:4B8B}.
HELIX 571 573 {ECO:0000244|PDB:4B8B}.
TURN 574 577 {ECO:0000244|PDB:4B8B}.
HELIX 581 585 {ECO:0000244|PDB:4B8B}.
STRAND 589 591 {ECO:0000244|PDB:4B8B}.
HELIX 595 609 {ECO:0000244|PDB:4B8B}.
HELIX 615 626 {ECO:0000244|PDB:4B8B}.
HELIX 631 647 {ECO:0000244|PDB:4B8B}.
HELIX 648 653 {ECO:0000244|PDB:4B8B}.
HELIX 656 671 {ECO:0000244|PDB:4B8B}.
HELIX 677 691 {ECO:0000244|PDB:4B8B}.
HELIX 698 709 {ECO:0000244|PDB:4B8B}.
HELIX 710 716 {ECO:0000244|PDB:4B8B}.
HELIX 718 727 {ECO:0000244|PDB:4B8B}.
HELIX 729 733 {ECO:0000244|PDB:4B8B}.
HELIX 735 743 {ECO:0000244|PDB:4B8B}.
STRAND 765 767 {ECO:0000244|PDB:4B8C}.
HELIX 783 795 {ECO:0000244|PDB:4B89}.
TURN 798 800 {ECO:0000244|PDB:4B89}.
HELIX 801 811 {ECO:0000244|PDB:4B89}.
HELIX 814 816 {ECO:0000244|PDB:4B89}.
HELIX 817 827 {ECO:0000244|PDB:4B89}.
TURN 828 831 {ECO:0000244|PDB:4B89}.
HELIX 833 835 {ECO:0000244|PDB:4B89}.
HELIX 836 846 {ECO:0000244|PDB:4B89}.
HELIX 849 867 {ECO:0000244|PDB:4B89}.
HELIX 872 874 {ECO:0000244|PDB:4B89}.
HELIX 877 890 {ECO:0000244|PDB:4B89}.
HELIX 892 894 {ECO:0000244|PDB:4B89}.
TURN 900 902 {ECO:0000244|PDB:4B89}.
HELIX 905 914 {ECO:0000244|PDB:4B89}.
HELIX 918 929 {ECO:0000244|PDB:4B89}.
HELIX 930 932 {ECO:0000244|PDB:4B89}.
STRAND 936 939 {ECO:0000244|PDB:4B89}.
HELIX 943 958 {ECO:0000244|PDB:4B89}.
HELIX 963 975 {ECO:0000244|PDB:4B89}.
HELIX 980 982 {ECO:0000244|PDB:4B89}.
SEQUENCE 2108 AA; 240279 MW; 5B2AE15BCF95E009 CRC64;
MLSATYRDLN TASNLETSKE KQAAQIVIAQ ISLLFTTLNN DNFESVEREI RHILDRSSVD
IYIKVWERLL TLSSRDILQA GKFLLQENLL HRLLLEFAKD LPKKSTDLIE LLKERTFNNQ
EFQKQTGITL SLFIDLFDKS ANKDIIESLD RSSQINDFKT IKMNHTNYLR NFFLQTTPET
LESNLRDLLH SLEGESLNDL LALLLSEILS PGSQNLQNDP TRSWLTPPMV LDATNRGNVI
ARSISSLQAN QINWNRVFNL MSTKYFLSAP LMPTTASLSC LFAALHDGPV IDEFFSCDWK
VIFKLDLAIQ LHKWSVQNGC FDLLNAEGTR KVSETIPNTK QSLLYLLSIA SLNLELFLQR
EELSDGPMLA YFQECFFEDF NYAPEYLILA LVKEMKRFVL LIENRTVIDE ILITLLIQVH
NKSPSSFKDV ISTITDDSKI VDAAKIIINS DDAPIANFLK SLLDTGRLDT VINKLPFNEA
FKILPCARQI GWEGFDTFLK TKVSPSNVDV VLESLEVQTK MTDTNTPFRS LKTFDLFAFH
SLIEVLNKCP LDVLQLQRFE SLEFSLLIAF PRLINFGFGH DEAILANGDI AGINNDIEKE
MQNYLQKMYS GELAIKDVIE LLRRLRDSDL PRDQEVFTCI THAVIAESTF FQDYPLDALA
TTSVLFGSMI LFQLLRGFVL DVAFRIIMRF AKEPPESKMF KFAVQAIYAF RIRLAEYPQY
CKDLLRDVPA LKSQAQVYQS IVEAATLANA PKERSRPVQE MIPLKFFAVD EVSCQINQEG
APKDVVEKVL FVLNNVTLAN LNNKVDELKK SLTPNYFSWF STYLVTQRAK TEPNYHDLYS
KVIVAMGSGL LHQFMVNVTL RQLFVLLSTK DEQAIDKKHL KNLASWLGCI TLALNKPIKH
KNIAFREMLI EAYKENRLEI VVPFVTKILQ RASESKIFKP PNPWTVGILK LLIELNEKAN
WKLSLTFEVE VLLKSFNLTT KSLKPSNFIN TPEVIETLSG ALGSITLEQQ QTEQQRQIIL
MQQHQQQMLI YQQRQQQQQQ RQQQQQHHIS ANTIADQQAA FGGEGSISHD NPFNNLLGST
IFVTHPDLKR VFQMALAKSV REILLEVVEK SSGIAVVTTT KIILKDFATE VDESKLKTAA
IIMVRHLAQS LARATSIEPL KEGIRSTMQS LAPNLMSLSS SPAEELDTAI NENIGIALVL
IEKASMDKST QDLADQLMQA IAIRRYHKER RADQPFITQN TNPYSLSLPE PLGLKNTGVT
PQQFRVYEEF GKNIPNLDVI PFAGLPAHAP PMTQNVGLTQ PQQQQAQMPT QILTSEQIRA
QQQQQQLQKS RLNQPSQSAQ PPGVNVPNPQ GGIAAVQSDL EQNQRVLVHL MDILVSQIKE
NATKNNLAEL GDQNQIKTII FQILTFIAKS AQKDQLALKV SQAVVNSLFA TSESPLCREV
LSLLLEKLCS LSLVARKDVV WWLVYALDSR KFNVPVIRSL LEVNLIDATE LDNVLVTAMK
NKMENSTEFA MKLIQNTVLS DDPILMRMDF IKTLEHLASS EDENVKKFIK EFEDTKIMPV
RKGTKTTRTE KLYLVFTEWV KLLQRVENND VITTVFIKQL VEKGVISDTD NLLTFVKSSL
ELSVSSFKES DPTDEVFIAI DALGSLIIKL LILQGFKDDT RRDYINAIFS VIVLVFAKDH
SQEGTTFNER PYFRLFSNIL YEWATIRTHN FVRISDSSTR QELIEFDSVF YNTFSGYLHA
LQPFAFPGFS FAWVTLLSHR MLLPIMLRLP NKIGWEKLML LIIDLFKFLD QYTSKHAVSD
AVSVVYKGTL RVILGISNDM PSFLIENHYE LMNNLPPTYF QLKNVILSAI PKNMTVPNPY
DVDLNMEDIP ACKELPEVFF DPVIDLHSLK KPVDNYLRIP SNSLLRTILS AIYKDTYDIK
KGVGYDFLSV DSKLIRAIVL HVGIEAGIEY KRTSSNAVFN TKSSYYTLLF NLIQNGSIEM
KYQIILSIVE QLRYPNIHTY WFSFVLMNMF KSDEWNDQKL EVQEIILRNF LKRIIVNKPH
TWGVSVFFTQ LINNNDINLL DLPFVQSVPE IKLILQQLVK YSKKYTTSEQ DDQSATINRR
QTPLQSNA


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EIAAB06420 Anapc6,Anaphase-promoting complex subunit 6,APC6,Cdc16,Cell division cycle protein 16 homolog,Cyclosome subunit 6,Mouse,Mus musculus
CCBL1 CCAR1 Gene cell division cycle and apoptosis regulator 1
U1771m CLIA Anapc8,Anaphase-promoting complex subunit 8,APC8,Cdc23,Cell division cycle protein 23 homolog,Cyclosome subunit 8,Mouse,Mus musculus 96T
U1771b CLIA ANAPC8,Anaphase-promoting complex subunit 8,APC8,Bos taurus,Bovine,CDC23,Cell division cycle protein 23 homolog,Cyclosome subunit 8 96T
E1771b ELISA kit ANAPC8,Anaphase-promoting complex subunit 8,APC8,Bos taurus,Bovine,CDC23,Cell division cycle protein 23 homolog,Cyclosome subunit 8 96T
E1771m ELISA kit Anapc8,Anaphase-promoting complex subunit 8,APC8,Cdc23,Cell division cycle protein 23 homolog,Cyclosome subunit 8,Mouse,Mus musculus 96T
E1771m ELISA Anapc8,Anaphase-promoting complex subunit 8,APC8,Cdc23,Cell division cycle protein 23 homolog,Cyclosome subunit 8,Mouse,Mus musculus 96T
E1771b ELISA ANAPC8,Anaphase-promoting complex subunit 8,APC8,Bos taurus,Bovine,CDC23,Cell division cycle protein 23 homolog,Cyclosome subunit 8 96T
E1771h ELISA ANAPC8,Anaphase-promoting complex subunit 8,APC8,CDC23,Cell division cycle protein 23 homolog,Cyclosome subunit 8,Homo sapiens,Human 96T
E1771h ELISA kit ANAPC8,Anaphase-promoting complex subunit 8,APC8,CDC23,Cell division cycle protein 23 homolog,Cyclosome subunit 8,Homo sapiens,Human 96T
U1771h CLIA ANAPC8,Anaphase-promoting complex subunit 8,APC8,CDC23,Cell division cycle protein 23 homolog,Cyclosome subunit 8,Homo sapiens,Human 96T
EIAAB42050 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,GTF2H4,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42045 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,GTF2H3,Homo sapiens,Human,TFIIH basal transcription facto
27-305 In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. CHEK2 is a cell cycle checkpoint regulator and putative tumor 0.05 mg


 

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