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General transcription factor IIF subunit 2 (EC 3.6.4.12) (Transcription initiation factor IIF subunit beta)

 H2ML17_ORYLA            Unreviewed;       266 AA.
H2ML17;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
20-JUN-2018, entry version 34.
RecName: Full=General transcription factor IIF subunit 2 {ECO:0000256|PIRNR:PIRNR015849};
EC=3.6.4.12 {ECO:0000256|PIRNR:PIRNR015849};
AltName: Full=Transcription initiation factor IIF subunit beta {ECO:0000256|PIRNR:PIRNR015849};
Oryzias latipes (Japanese rice fish) (Japanese killifish).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
Oryziinae; Oryzias.
NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000019388, ECO:0000313|Proteomes:UP000001038};
[1] {ECO:0000313|Ensembl:ENSORLP00000019388, ECO:0000313|Proteomes:UP000001038}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019388,
ECO:0000313|Proteomes:UP000001038};
PubMed=17554307; DOI=10.1038/nature05846;
Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B.,
Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D.,
Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A.,
Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K.,
Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F.,
Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H.,
Morishita S., Kohara Y.;
"The medaka draft genome and insights into vertebrate genome
evolution.";
Nature 447:714-719(2007).
[2] {ECO:0000313|Ensembl:ENSORLP00000019388}
IDENTIFICATION.
STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000019388};
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- FUNCTION: TFIIF is a general transcription initiation factor that
binds to RNA polymerase II and helps to recruit it to the
initiation complex in collaboration with TFIIB. It promotes
transcription elongation. This subunit shows ATP-dependent DNA-
helicase activity. {ECO:0000256|PIRNR:PIRNR015849}.
-!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
{ECO:0000256|PIRNR:PIRNR015849}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR015849}.
-!- SIMILARITY: Belongs to the TFIIF beta subunit family.
{ECO:0000256|PIRNR:PIRNR015849}.
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EMBL; BAAF04013301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BAAF04013302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BAAF04013303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BAAF04013304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BAAF04013305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BAAF04013306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BAAF04013307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BAAF04013308; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 8090.ENSORLP00000019388; -.
Ensembl; ENSORLT00000019389; ENSORLP00000019388; ENSORLG00000015486.
eggNOG; KOG2905; Eukaryota.
eggNOG; COG5090; LUCA.
GeneTree; ENSGT00390000016051; -.
InParanoid; H2ML17; -.
OMA; KGVWLVK; -.
OrthoDB; EOG091G0IN2; -.
TreeFam; TF314290; -.
Proteomes; UP000001038; Chromosome 21.
GO; GO:0005674; C:transcription factor TFIIF complex; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006367; P:transcription initiation from RNA polymerase II promoter; IEA:UniProtKB-UniRule.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR003196; TFIIF_beta.
InterPro; IPR011039; TFIIF_interaction.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
PANTHER; PTHR10445; PTHR10445; 1.
Pfam; PF02270; TFIIF_beta; 1.
PIRSF; PIRSF015849; TFIIF-beta; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF50916; SSF50916; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|PIRNR:PIRNR015849};
Complete proteome {ECO:0000313|Proteomes:UP000001038};
DNA-binding {ECO:0000256|PIRNR:PIRNR015849};
Helicase {ECO:0000256|PIRNR:PIRNR015849};
Hydrolase {ECO:0000256|PIRNR:PIRNR015849};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR015849};
Nucleus {ECO:0000256|PIRNR:PIRNR015849};
Reference proteome {ECO:0000313|Proteomes:UP000001038};
Transcription {ECO:0000256|PIRNR:PIRNR015849};
Transcription regulation {ECO:0000256|PIRNR:PIRNR015849}.
SEQUENCE 266 AA; 30040 MW; 826D79F664CDCB8C CRC64;
MSNKVEVNLT GVRQSKGVWL VKVPKYLSQQ WDKATEKGEV GKITIGKKQG KTEVCFSLSE
ELAALGSAEE KDASVQVPRD HPFTMQTVGG QTMAVFSQSD TGQSLIQGGG KEAASGPERH
GISLEGTVVH RAECRPNVSE DYMKIKRLQS ESVKPQRLSQ QLDRAITTVF KPVANHDFNV
EFEKKKKSEG KMVRAERQVV MDMLFSAFEK HQYYSFKDLV DITKQPVTYL KEIVREIGVC
NRKGAHKSSW ELKPEYQHYR ADDEEE


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