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General vesicular transport factor p115

 USO1_DROME              Reviewed;         836 AA.
Q9W3N6; Q9NFR8;
12-APR-2017, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 2.
27-SEP-2017, entry version 144.
RecName: Full=General vesicular transport factor p115 {ECO:0000305};
Name=p115 {ECO:0000312|FlyBase:FBgn0040087};
ORFNames=CG1422 {ECO:0000312|FlyBase:FBgn0040087};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
[1] {ECO:0000312|EMBL:CAB72935.1}
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND DEVELOPMENTAL
STAGE.
PubMed=11514618; DOI=10.1091/mbc.12.8.2308;
Kondylis V., Goulding S.E., Dunne J.C., Rabouille C.;
"Biogenesis of Golgi stacks in imaginal discs of Drosophila
melanogaster.";
Mol. Biol. Cell 12:2308-2327(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[3] {ECO:0000312|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000312|EMBL:AAL13980.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley {ECO:0000312|EMBL:AAL13980.1};
TISSUE=Embryo {ECO:0000312|EMBL:AAL13980.1};
PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M.,
George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H.,
Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
[5] {ECO:0000305}
FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
PHENOTYPE.
PubMed=12876273; DOI=10.1083/jcb.200301136;
Kondylis V., Rabouille C.;
"A novel role for dp115 in the organization of tER sites in
Drosophila.";
J. Cell Biol. 162:185-198(2003).
-!- FUNCTION: Essential for maintaining the architecture of the Golgi
stacks and for normal organization of the transitional endoplasmic
reticulum (tER). Required for both the formation of the Golgi
stacks and the maintenance of the individual cisternae.
{ECO:0000269|PubMed:12876273}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12876273}.
Golgi apparatus, Golgi stack {ECO:0000269|PubMed:11514618,
ECO:0000269|PubMed:12876273}. Golgi apparatus, Golgi stack
membrane {ECO:0000269|PubMed:11514618,
ECO:0000269|PubMed:12876273}; Peripheral membrane protein
{ECO:0000269|PubMed:11514618, ECO:0000269|PubMed:12876273}.
Endoplasmic reticulum {ECO:0000269|PubMed:11514618,
ECO:0000269|PubMed:12876273}. Endoplasmic reticulum membrane
{ECO:0000269|PubMed:12876273}; Peripheral membrane protein
{ECO:0000269|PubMed:12876273}. Note=Associates with the tER
membrane (PubMed:12876273). Localizes in developing Golgi stacks
(PubMed:11514618). {ECO:0000269|PubMed:11514618,
ECO:0000269|PubMed:12876273}.
-!- DEVELOPMENTAL STAGE: Detected in embryos and larvae (at protein
level) (PubMed:12876273). Expressed in larval imaginal disks (at
protein level) (PubMed:11514618). {ECO:0000269|PubMed:11514618,
ECO:0000269|PubMed:12876273}.
-!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in a loss of
Golgi stacks and affects the organization of the transitional ER
(tER) sites. Golgi stacks break down and form clusters of vesicles
and tubules. The Golgi stacks that are present have an adherent
morphology, including a decrease in stack diameter and total
cisternae (stacked and single). The tER sites lose their
organization and become dispersed throughout the cytoplasm.
However, the efficiency of anterograde intracellular transport is
not affected. {ECO:0000269|PubMed:12876273}.
-!- SIMILARITY: Belongs to the VDP/USO1/EDE1 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAB72935.1; Type=Frameshift; Positions=741, 753; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AJ272048; CAB72935.1; ALT_FRAME; mRNA.
EMBL; AE014298; AAF46286.2; -; Genomic_DNA.
EMBL; AE014298; AHN59463.1; -; Genomic_DNA.
EMBL; AY058751; AAL13980.1; -; mRNA.
RefSeq; NP_001284992.1; NM_001298063.1.
RefSeq; NP_572417.1; NM_132189.3.
UniGene; Dm.4686; -.
ProteinModelPortal; Q9W3N6; -.
SMR; Q9W3N6; -.
IntAct; Q9W3N6; 44.
MINT; MINT-278744; -.
STRING; 7227.FBpp0071045; -.
PaxDb; Q9W3N6; -.
PRIDE; Q9NFR8; -.
EnsemblMetazoa; FBtr0071089; FBpp0071045; FBgn0040087.
EnsemblMetazoa; FBtr0340162; FBpp0309148; FBgn0040087.
GeneID; 31698; -.
KEGG; dme:Dmel_CG1422; -.
UCSC; CG1422-RA; d. melanogaster.
CTD; 31698; -.
FlyBase; FBgn0040087; p115.
eggNOG; KOG0946; Eukaryota.
eggNOG; ENOG410XRCG; LUCA.
GeneTree; ENSGT00390000017018; -.
OMA; QQFFKEG; -.
OrthoDB; EOG091G046H; -.
Reactome; R-DME-204005; COPII (Coat Protein 2) Mediated Vesicle Transport.
Reactome; R-DME-6807878; COPI-mediated anterograde transport.
GenomeRNAi; 31698; -.
Proteomes; UP000000803; Chromosome X.
Bgee; FBgn0040087; -.
ExpressionAtlas; Q9W3N6; differential.
GO; GO:0005783; C:endoplasmic reticulum; IDA:FlyBase.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IBA:GO_Central.
GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
GO; GO:0005795; C:Golgi stack; IDA:FlyBase.
GO; GO:0008565; F:protein transporter activity; IBA:GO_Central.
GO; GO:0006888; P:ER to Golgi vesicle-mediated transport; IBA:GO_Central.
GO; GO:0007030; P:Golgi organization; IMP:FlyBase.
GO; GO:0048211; P:Golgi vesicle docking; IBA:GO_Central.
GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
GO; GO:0061025; P:membrane fusion; IBA:GO_Central.
GO; GO:0051726; P:regulation of cell cycle; IDA:FlyBase.
GO; GO:0045056; P:transcytosis; IBA:GO_Central.
GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:InterPro.
Gene3D; 1.25.10.10; -; 1.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR000225; Armadillo.
InterPro; IPR006955; Uso1_p115_C.
InterPro; IPR006953; Vesicle_Uso1_P115_head.
Pfam; PF04871; Uso1_p115_C; 1.
Pfam; PF04869; Uso1_p115_head; 1.
SMART; SM00185; ARM; 2.
SUPFAM; SSF48371; SSF48371; 1.
PROSITE; PS50176; ARM_REPEAT; 1.
1: Evidence at protein level;
Coiled coil; Complete proteome; Cytoplasm; Endoplasmic reticulum;
Golgi apparatus; Membrane; Reference proteome; Repeat.
CHAIN 1 836 General vesicular transport factor p115.
{ECO:0000305}.
/FTId=PRO_0000439489.
REPEAT 24 64 ARM 1. {ECO:0000250|UniProtKB:P41541}.
REPEAT 65 124 ARM 2. {ECO:0000250|UniProtKB:P41541}.
REPEAT 126 166 ARM 3. {ECO:0000250|UniProtKB:P41541}.
REPEAT 169 210 ARM 4. {ECO:0000250|UniProtKB:P41541}.
REPEAT 211 256 ARM 5. {ECO:0000250|UniProtKB:P41541}.
REPEAT 316 359 ARM 7. {ECO:0000250|UniProtKB:P41541}.
REPEAT 368 413 ARM 8. {ECO:0000250|UniProtKB:P41541}.
REPEAT 424 463 ARM 9. {ECO:0000250|UniProtKB:P41541}.
REPEAT 477 518 ARM 10. {ECO:0000250|UniProtKB:P41541}.
REPEAT 523 577 ARM 11. {ECO:0000250|UniProtKB:P41541}.
REPEAT 579 636 ARM 12. {ECO:0000250|UniProtKB:P41541}.
COILED 663 707 {ECO:0000255}.
COILED 744 806 {ECO:0000255}.
CONFLICT 455 455 N -> D (in Ref. 1; CAB72935).
{ECO:0000305}.
CONFLICT 508 508 A -> P (in Ref. 1; CAB72935).
{ECO:0000305}.
SEQUENCE 836 AA; 92069 MW; E802308CB3219334 CRC64;
MEFLKSGIKT VLGSTEPGQQ PSAAETVEKL VDRVYSSTLL EDRRDACRAL KALSRKYRIE
VGAQGMPPLV QVLQNDGQDA EIISYALDTL CNVVTSEEFD EEADNPTVSV NVGEQFTEMF
IKTPEHVTLV MGYLDEYDFR VRRAAIQLIT SLISNKTREL QDLILVSPMG VSKLMDLLTD
SREVIRNDVL LLLIELTKGN SNIQKIVAFE NAFDRLFEIV REEGCSDGGI VVEDCLILLL
NLLKNNSSNQ QFFKEGSYIQ RLSPMFELSQ DAEEVGWSPQ KVSNFHCLLQ VVRALVTPSN
QQQVVAACQR VMQKSRLLHA LCEILMSSGV PADILTETIN AVAEVVRGDR DNQDELGRVM
APSSPPRPAI VVLLMSMINE KQLLALRCAV LYCFECFLYR NADGQRAVVQ TLLPSSASDV
SALSTGQLLC TGLFSTDALA NWFSAVALMH SLVENVALKE ELLRVLLATP GGQKPITLLE
QCTNLMQQER YRLQSKVGLL MLLSLWLAHC PGAVKALLET QGTMAYLTAQ LCSNEHDERE
FLVQGMCAFL MGLCIQFNDN SLPGQKREDI SQLIIKRIGQ ESFCSKLAEV SRHEAYSRAC
KQAQIRAKSA GELLLDFEYC KLYKGLEALI AKLVSGFDVD GIELTELTLS SEASALVSQY
KGIIRGMDAQ IQALQQSSKE LEQENAELKE KLGEEQSLKA QLLDQNTLLK AQLGASTGQV
QSAQGAEATP PNEEELNAAR YQANMYFAEN IRLTKELETL RQQLSAEKQS ADAAQDSLAA
MQKDQEDLLE LLADQEAKLT RYEEAGSTNT LPTSNVAPSV PAAGGGSPIP SGTASR


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