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Genome polyprotein

 A0A1S5WLE2_9PICO        Unreviewed;      2182 AA.
A0A1S5WLE2;
10-MAY-2017, integrated into UniProtKB/TrEMBL.
10-MAY-2017, sequence version 1.
23-MAY-2018, entry version 8.
RecName: Full=Genome polyprotein {ECO:0000256|SAAS:SAAS00958788};
Human parechovirus 4.
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Picornavirales; Picornaviridae; Parechovirus.
NCBI_TaxID=362784 {ECO:0000313|EMBL:AQQ13079.1};
[1] {ECO:0000313|EMBL:AQQ13079.1}
NUCLEOTIDE SEQUENCE.
STRAIN=FI121301 {ECO:0000313|EMBL:AQQ13079.1};
PubMed=28081453; DOI=10.1016/j.jcv.2017.01.001;
Kolehmainen P., Siponen A., Smura T., Kallio-Kokko H., Vapalahti O.,
Jaaskelainen A., Tauriainen S.;
"Intertypic recombination of human parechovirus 4 isolated from
infants with sepsis-like disease.";
J. Clin. Virol. 88:1-7(2017).
-!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
{ECO:0000256|SAAS:SAAS00711622}.
-!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
+ RNA(n+1). {ECO:0000256|SAAS:SAAS00383097}.
-!- CATALYTIC ACTIVITY: Selective cleavage of Gln-|-Gly bond in the
poliovirus polyprotein. In other picornavirus reactions Glu may be
substituted for Gln, and Ser or Thr for Gly.
{ECO:0000256|SAAS:SAAS00711755}.
-!- SUBCELLULAR LOCATION: Host cytoplasmic vesicle membrane
{ECO:0000256|SAAS:SAAS00711512}; Peripheral membrane protein
{ECO:0000256|SAAS:SAAS00711512}; Cytoplasmic side
{ECO:0000256|SAAS:SAAS00711512}. Virion
{ECO:0000256|SAAS:SAAS01033941}.
-!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
{ECO:0000256|SAAS:SAAS00727971}.
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EMBL; KY404171; AQQ13079.1; -; Genomic_RNA.
GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
GO; GO:0019015; C:viral genome; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
CDD; cd00205; rhv_like; 2.
Gene3D; 2.60.120.20; -; 3.
InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001676; Picornavirus_capsid.
InterPro; IPR033703; Rhv-like.
InterPro; IPR001205; RNA-dir_pol_C.
InterPro; IPR007094; RNA-dir_pol_PSvirus.
InterPro; IPR029053; Viral_coat.
InterPro; IPR009419; VPP_parechovir_P3A.
InterPro; IPR009407; VPP_parechovir_P3B.
Pfam; PF06344; Parecho_VpG; 1.
Pfam; PF00548; Peptidase_C3; 1.
Pfam; PF06363; Picorna_P3A; 1.
Pfam; PF00680; RdRP_1; 1.
Pfam; PF00073; Rhv; 1.
Pfam; PF00910; RNA_helicase; 1.
PRINTS; PR00918; CALICVIRUSNS.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PROSITE; PS51218; SF3_HELICASE_2; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|SAAS:SAAS01033926};
Capsid protein {ECO:0000256|SAAS:SAAS00958801};
Helicase {ECO:0000256|SAAS:SAAS01033926};
Host cytoplasm {ECO:0000256|SAAS:SAAS00711571};
Host cytoplasmic vesicle {ECO:0000256|SAAS:SAAS00711589};
Host membrane {ECO:0000256|SAAS:SAAS00795395};
Host-virus interaction {ECO:0000256|SAAS:SAAS00711583};
Hydrolase {ECO:0000256|SAAS:SAAS01033926,
ECO:0000256|SAAS:SAAS01035925};
Ion channel {ECO:0000256|SAAS:SAAS00711569};
Ion transport {ECO:0000256|SAAS:SAAS00711569};
Membrane {ECO:0000256|SAAS:SAAS00795395};
Nucleotide-binding {ECO:0000256|SAAS:SAAS01033926};
Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00510600};
Protease {ECO:0000256|SAAS:SAAS01035925};
RNA-binding {ECO:0000256|SAAS:SAAS00711776};
RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00510600};
Thiol protease {ECO:0000256|SAAS:SAAS01035925};
Transferase {ECO:0000256|SAAS:SAAS00510600};
Transport {ECO:0000256|SAAS:SAAS00711569};
Viral attachment to host cell {ECO:0000256|SAAS:SAAS00711583};
Viral ion channel {ECO:0000256|SAAS:SAAS00711569};
Viral RNA replication {ECO:0000256|SAAS:SAAS00664279};
Virion {ECO:0000256|SAAS:SAAS00711583, ECO:0000256|SAAS:SAAS00958801};
Virus entry into host cell {ECO:0000256|SAAS:SAAS00711583}.
DOMAIN 1159 1320 SF3 helicase.
{ECO:0000259|PROSITE:PS51218}.
DOMAIN 1947 2061 RdRp catalytic.
{ECO:0000259|PROSITE:PS50507}.
SEQUENCE 2182 AA; 245788 MW; C4803D6ED7503FFB CRC64;
METIKGIADM ATGITKTIDS TVNTVNEAIT NPSNAAGGDM LTKVADDASN VLGPNCFATT
STPENKDVVQ ATTTVNTTNL TQHPSAPTMP FTPDFRNVDM FHSMAYDVTT GDKNPSKLIR
LKTEYWERTY ARQHLIVDVE LPHAFWDNTN KPAYGQSRYF AAVRCGFHFQ VQVNVNQGTA
GSALVVYEPK PAVTHSDKME FGAFTNLPHV LMNLAETTQA DLCIPYVSDT NYVKTDSSDL
GRLRVYVWAP LTIPSGATST VDVTVLGSLL QLDFQNPRVY NTQVDIYDNN NDRAKQIRKK
KWLTMSTKYK WTRNKIDIAE GPGAMNMANV LSTTGAQSVA LVGERAFYDP RTAGSKSRFD
DLVKIAQLFS VMCDSTTPSA SSGIDDKGYF EWKATATPQT VIHRNVVKLN QFPNLNMFVN
SYSYFRGSLI IRLSVYASTF NRGRLRMGFF PNFTTNTTSE IDNSIYTICD IGSDNSFEIT
IPYTFSTWMR KTNGHALGLF QIEVLNRLTY NSSSPSSVHC IVQGRLGNDA KFFCPAGSLV
TFQNSWGSQM DLTDPLCVED DCTEDCKQTI SPDELGLTSA QDDGPLGGEK PNYFLNFRAV
NVDIFTVSHT KVDNIFGRAW FAYDHTYRDE GTWRQALDFP KKGHGALTQL FAYYSGELNI
HVLFLSETGF LRVAHTYDSD TNRSDFFSSN GVITVPAGEQ MTLSIPFYSS KPLRTIRDSA
ALGYVMCKPF MSGTTGGKIE IYLSLRCPNL FFPLPAPKPA TSRALRGDMA NFSDQSPYDQ
QPQGQVMKLA YLDRGFYKHY GIIVGESVYQ LDSDDIFKTA LTGKARFTKT KLTPDWVVEE
ECELDYFRVK YLESSVNSEH IFSVDHNCET IAKDIFGTHT LSQHQAIGLI GTILLTAGLM
STIKTPVNAT TIKEFFNHAV DGDEQGLSLL VQKCTTFFSS AATEILDNDL VKFIVKILVR
ILCYMVLYCH KPNILTTACL STLLIMDVTS SSVLSPSCKA LMQCLMDGDV KRLAEVVAES
MSNTDDEEIK EQICDTVKYT KSILSNQGPF KGFNEVSTAF RHIDWWIHTL LKIKDMVLSV
FKPSMESKAI QWLERNKEHV CAILDYASDI IVESKDQTKM KSQEFYQKYT DCLAKFKPIM
AICFRSCHNS ISNTVYRLFQ ELARIPSRIS TQNDLIRVEP IGVWIQGEPG QGKSFLTHTL
SRQLQKSCML NGVYTNPTAS EFMDGYDNQD IHLIDDLGQT RKEKDIEMLC NCISSVPFIV
PMAHLEEKGK FYTSKLVIAT TNKSDFSSTV LQDSGALKRR FPYIMHIRAA KAYSKAGKLN
VSQAMSTMVT GECWEVSKNG RDWETLKLKD LVQKITEDYQ ERQKNYNCWK KQLENQTLDD
LDDAVSYIKH NFPDAIPYID EYLNIEMSTL IEQMEAFIEP RPSVFKCFAT KVASQTQKAA
KEVVDWFSSK IKSMLSFVER NKAWLTVVSA VTSAISILLL VTKIFKKEDS KDERAYNPTL
PISKSKGAFP VTQREFKNEA PYDGQLEHII SQMAYITGST TGHLTHCAGY QHDEIILHGH
SIKYLEQEED LTLHYKNKVF PIENPSVTQV TLGGKPMDLA ILKCKLPFRF KKNSKYYTNK
IGTESMLIWM TEQGIITKEV QRVHHSGGIK TREGTESTKT ISYTVKSCKG MCGGLLISKV
EGNFKILGMH IAGNGEMGVA IPFNFLKNDM SDQGIVTEIA PIQPMYINTK TQIHKSPVYG
AVEVKMGPAV LSKLDPRLEE PVECLIKKSA AKYRVNKFQV NNELWQGVKA CVKSKFREIF
GINGIVDMKT AILGTSHVNS MDLSTSAGYS FVKSGYKKKD LICLEPFSVS PMLEKLVQDK
FHALLKGSQI TTIFNTCLKD ELRKLDKISA GKTRCIEACE VDYCIVYRMI MMEIYDKIYQ
TPCYYSGLAV GINPYKDWHF MINALNDFNY EMDYSQYDGS LSSMLLWEAV EVLAYCHDSP
DLVMQLHKPV IDSDHVVFNE RWLIHGGMPS GSPCTTVLNS LCNLMMCIYT TNLISPGIDC
LPIVYGDDVI LSLDKEIDPE RLQGVMADSF GAEVTGSRKD EPPSLKPRME VEFLKRKPGY
FPESTFIVGK LDTENMIQHL MWMKNFSTFK QQLQSYLMEL CLHGKDTYLH YIKILDPYLK
EWNITVDEYD VVIAKLMPMV FD


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