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Genome polyprotein

 Q5CAR0_9PICO            Unreviewed;      2177 AA.
Q5CAR0;
12-APR-2005, integrated into UniProtKB/TrEMBL.
12-APR-2005, sequence version 1.
23-MAY-2018, entry version 95.
RecName: Full=Genome polyprotein {ECO:0000256|SAAS:SAAS00958788};
Human parechovirus 3.
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Picornavirales; Picornaviridae; Parechovirus.
NCBI_TaxID=195055 {ECO:0000313|EMBL:CAI64373.1, ECO:0000313|Proteomes:UP000102597};
[1] {ECO:0000313|EMBL:CAI64373.1, ECO:0000313|Proteomes:UP000102597}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Can82853-01 {ECO:0000313|EMBL:CAI64373.1};
PubMed=16254961; DOI=10.1002/jmv.20493;
Abed Y., Boivin G.;
"Molecular characterization of a Canadian human parechovirus (HPeV)-3
isolate and its relationship to other HPeVs.";
J. Med. Virol. 77:566-570(2005).
[2] {ECO:0000313|EMBL:CAI64373.1, ECO:0000313|Proteomes:UP000102597}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Can82853-01 {ECO:0000313|EMBL:CAI64373.1};
PubMed=16707054;
Abed Y., Boivin G.;
"Human Parechovirus Infections in Canada.";
Emerg. Infect. Dis. 12:969-975(2006).
[3] {ECO:0000313|EMBL:CAI64373.1, ECO:0000313|Proteomes:UP000102597}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Can82853-01 {ECO:0000313|EMBL:CAI64373.1};
PubMed=17442804; DOI=10.1128/JCM.02432-06;
Abed Y., Wolf D., Dagan R., Boivin G.;
"Development of a serological assay based on a synthetic peptide
selected from the VP0 capsid protein for detection of human
parechoviruses.";
J. Clin. Microbiol. 45:2037-2039(2007).
-!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
{ECO:0000256|SAAS:SAAS00711622}.
-!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
+ RNA(n+1). {ECO:0000256|SAAS:SAAS00383097}.
-!- CATALYTIC ACTIVITY: Selective cleavage of Gln-|-Gly bond in the
poliovirus polyprotein. In other picornavirus reactions Glu may be
substituted for Gln, and Ser or Thr for Gly.
{ECO:0000256|SAAS:SAAS00711755}.
-!- SUBCELLULAR LOCATION: Host cytoplasmic vesicle membrane
{ECO:0000256|SAAS:SAAS00711512}; Peripheral membrane protein
{ECO:0000256|SAAS:SAAS00711512}; Cytoplasmic side
{ECO:0000256|SAAS:SAAS00711512}. Virion
{ECO:0000256|SAAS:SAAS01033941}.
-!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
{ECO:0000256|SAAS:SAAS00727971}.
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EMBL; AJ889918; CAI64373.1; -; Genomic_RNA.
ProteinModelPortal; Q5CAR0; -.
Proteomes; UP000102597; Genome.
GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
GO; GO:0019015; C:viral genome; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
CDD; cd00205; rhv_like; 2.
Gene3D; 2.60.120.20; -; 4.
InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001676; Picornavirus_capsid.
InterPro; IPR033703; Rhv-like.
InterPro; IPR001205; RNA-dir_pol_C.
InterPro; IPR007094; RNA-dir_pol_PSvirus.
InterPro; IPR029053; Viral_coat.
InterPro; IPR009419; VPP_parechovir_P3A.
InterPro; IPR009407; VPP_parechovir_P3B.
Pfam; PF06344; Parecho_VpG; 1.
Pfam; PF00548; Peptidase_C3; 1.
Pfam; PF06363; Picorna_P3A; 1.
Pfam; PF00680; RdRP_1; 1.
Pfam; PF00073; Rhv; 1.
Pfam; PF00910; RNA_helicase; 1.
PRINTS; PR00918; CALICVIRUSNS.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PROSITE; PS51218; SF3_HELICASE_2; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|SAAS:SAAS01033926};
Capsid protein {ECO:0000256|SAAS:SAAS00958801};
Complete proteome {ECO:0000313|Proteomes:UP000102597};
Helicase {ECO:0000256|SAAS:SAAS01033926};
Host cytoplasm {ECO:0000256|SAAS:SAAS00711571};
Host cytoplasmic vesicle {ECO:0000256|SAAS:SAAS00711589};
Host membrane {ECO:0000256|SAAS:SAAS00795395};
Host-virus interaction {ECO:0000256|SAAS:SAAS00711583};
Hydrolase {ECO:0000256|SAAS:SAAS01033926,
ECO:0000256|SAAS:SAAS01035925};
Ion channel {ECO:0000256|SAAS:SAAS00711569};
Ion transport {ECO:0000256|SAAS:SAAS00711569};
Membrane {ECO:0000256|SAAS:SAAS00795395};
Nucleotide-binding {ECO:0000256|SAAS:SAAS01033926};
Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00510600};
Protease {ECO:0000256|SAAS:SAAS01035925};
RNA-binding {ECO:0000256|SAAS:SAAS00711776};
RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00510600};
Thiol protease {ECO:0000256|SAAS:SAAS01035925};
Transferase {ECO:0000256|SAAS:SAAS00510600};
Transport {ECO:0000256|SAAS:SAAS00711569};
Viral attachment to host cell {ECO:0000256|SAAS:SAAS00711583};
Viral ion channel {ECO:0000256|SAAS:SAAS00711569};
Viral RNA replication {ECO:0000256|SAAS:SAAS00664279};
Virion {ECO:0000256|SAAS:SAAS00711583, ECO:0000256|SAAS:SAAS00958801};
Virus entry into host cell {ECO:0000256|SAAS:SAAS00711583}.
DOMAIN 1154 1315 SF3 helicase.
{ECO:0000259|PROSITE:PS51218}.
DOMAIN 1942 2056 RdRp catalytic.
{ECO:0000259|PROSITE:PS50507}.
SEQUENCE 2177 AA; 246020 MW; 653969D7E4D9D26F CRC64;
MESIKDLVNV ATGAMDTLSL SNVETEANNI ISGNEVGGEI ITKVADDASN LLGPNSFATT
AQPENKDVVQ ATTTVNTTNL TQHPSAPTIP FTPDFRNVDN FHSMAYDITT GDKNPSKLIR
LDTTSWQTSY TRQYKITTVE LPKSFWDDTR KPAYGQAKYF AAVRCGFHFQ VQVNVNQGTA
GSALVVYEPK PVIDSRQYLE FGSLTNLPHV LMNLAETTQA DLCIPYVADT NYVKTDSSDL
GQLRVYVWTP LSVPTGASNE VDVTVMGSLL QLDFQNPRPY GEDVEIYDNG PNKANANRFN
KRKFLTASTK YKWTRTKVDI AEGPGTMNMA NVLSTTGAQS VALVGERAFY DPRTAGSKSR
FDDMIKIAQL FSVMSDNTTP SSSSGIDKYG YFDWAATVAP QNMVHRNVVT LDQFPNLNLF
MNTYSYFRGS LIIRLSIYAS TFNRGRLRMG FFPNCTHDTQ LELDNAIYTI CDIGSDNSFE
LTIPYSFSTW MRKTHGHQLG LFQVEVLNRL TYNSSSPNKV HCIVQGRLGD DAKFFCPTGS
LVSFQNSWGS QMDLTDPLCI EDNMENCKQS ISPNELGLTS AQDDGPLGNE KPNYFLNFRT
MNVDIFTVSH TKVDNIFGRA WYVTSHDFNN GDTWRQKLTF PKEGHGMLSQ FFAYFTGEIN
IHILYMAEQG FLRVAHTYDT EDNRKTFLSS NGVITIPAGE QMTLSVPFYS NKPLRTVRHD
SALGFLMCRP MMHGTTRTTA EVYISLRCPN FFFPVPAPKP TGSRAAALYD ESPYVPTDNR
KMQLAYLDRG FYKHYGIIVG DSVYQLDSDD IFKTALTGKA RFTRTKLTPD WVIEEECELD
YFRVKYLESS VNSEHIFSVD HNCETIAKDI FGTHTLNQHQ AIGLVGTILL TAGLMSTIKT
PVNATTIKEF FNHALEGDEQ GLSLLVQKCT TFFSSAATEI LDNDLVKFIV KILVRILCYM
VLYCHKPNIL TTACLSTLLI MDVTSSSVLS PSCKALMQCL MDGDVKKLAE VVAESMSNTD
DEEIKEQICD TVKYTKSILS NQGPFKGFNE VSTAFRHIDW WIHTLLKIKD MVLSVFKPSM
ESKAIQWLER NKEHVCAILD YASDIIVESK DQTKMKSQEF YQKYTDCLSK FKPIMAICFR
SCHNSISNTV YRLFQELARI PSRISTQNDL IRVEPIGIWI QGEPGQGKSF LTHTLSRQLQ
KSCKLNGVYT NPTASEFMDG YDNQDIHLID DLGQTRKEKD IEMLCNCISS VPFIVPMAHL
EEKGKFYTSK LVIATTNKSD FSSTVLQDSG ALKRRFPYIM HIRAAKAYSK AGKLNVSQAM
STMATGECWE VSKNGRDWET LKLKDLVQKI TEDYQERQKN YNCWKQQLEN QTLDDLDDAV
SYIKHNFPDA IPYIDEYLNI EMSTLIEQME AFIEPRPSVF KCFATKVANQ TRKAAKEVVE
WFSSKIKLML SFVERNKAWL TVASAVTSAI SILLLVTKIF KKEDSKDERA YNPTLPVAKP
KGTFPVSQRE FKNEAPYDGQ LEHIISQMAY ITGSTTGHLT HCAGYQHDEI ILHGHSIKYL
EQEEDLTLHY KNKVFPIENP SVTQVTLGGK PMDLAILKCK LPFRFKKNSK YYTNKIGTES
MLIWMTEQGI ITKEVKRVHH SGGIKTREGT ESTKTISYTV KSCKGMCGGL LISKVEGNFK
ILGMHIAGNG EMGVAIPFNF LKNDMSDQGI VTEITPLQPM YINTRTQIHK SPVYGAVEVK
MGPAVLSKSD PRLEEPVECL IKKSAAKYRV NKFQVNNELW QGVKACVKSK FREIFGINGI
VDMKTAILGT SHVNSMDLST SAGYSFVKSG YKKKDLICLE PFSVSPMLEK LVQDKFHALL
KGNQITTIFN TCLKDELRKL DKISTGKTRC IEACEVDYCI VYRMIMMEIY DKIYQTPCYY
SGLAVGINPY KDWHFMINAL NDYNYEMDYS QYDGSLSSML LWEAVEVLAY CHDSPDLVIQ
LHKPVIDSDH VVFNERWLIH GGMPSGSPCT TVLNSLCNLM MCIYTTNLIS PGIDCLPIVY
GDDVILSLDR EIDPEKLQGI MADSFGAEVT GSRKDEPPSL KPRLEVEFLK RKPGYFPEST
FIVGKLDTEN MIQHLMWMKN FSTFKQQLQS YLMELCLHGK DTYLYYIKIL DPYLKEWNII
VDDYDVVIAK LMPMVFD


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