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Genome polyprotein

 Q66338_9ENTO            Unreviewed;      2185 AA.
Q66338;
01-NOV-1996, integrated into UniProtKB/TrEMBL.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 127.
RecName: Full=Genome polyprotein {ECO:0000256|SAAS:SAAS00711595};
Coxsackievirus B3.
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Picornavirales; Picornaviridae; Enterovirus; Enterovirus B.
NCBI_TaxID=12072 {ECO:0000313|EMBL:AAB59927.1, ECO:0000313|Proteomes:UP000110494};
[1] {ECO:0000313|EMBL:AAB59927.1, ECO:0000313|Proteomes:UP000110494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=3027968; DOI=10.1016/0042-6822(87)90435-1;
Lindberg A.M., Staalhandske P.O.K., Pettersson U.;
"Genome of coxsackievirus B3.";
Virology 156:50-63(1987).
[2] {ECO:0000313|EMBL:AAB59927.1, ECO:0000313|Proteomes:UP000110494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=2157045;
Klump W.M., Bergmann I., Mueller B.C., Ameis D., Kandolf R.;
"Complete nucleotide sequence of infectious Coxsackievirus B3 cDNA:
two initial 5' uridine residues are regained during plus-strand RNA
synthesis.";
J. Virol. 64:1573-1583(1990).
[3] {ECO:0000313|EMBL:AAB59927.1, ECO:0000313|Proteomes:UP000110494}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tracy S., Chapman N.M., Tu Z.;
"Coxsackievirus-B3 from an infectious cDNA copy of the genome is
cardiovirulent in mice.";
Arch. Virol. 122:398-409(1992).
[4] {ECO:0000313|EMBL:AAV34213.1, ECO:0000313|Proteomes:UP000161976}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=20 {ECO:0000313|EMBL:AAV34213.1};
PubMed=1310000; DOI=10.1007/BF01317202;
Tracy S., Chapman N.M., Tu Z.;
"Coxsackievirus B3 from an infectious cDNA copy of the genome is
cardiovirulent in mice.";
Arch. Virol. 122:399-409(1992).
[5] {ECO:0000313|EMBL:AAV34213.1}
NUCLEOTIDE SEQUENCE.
STRAIN=20 {ECO:0000313|EMBL:AAV34213.1};
Tracy S., Chapman N.M., Tu Z.;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
-!- CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.
{ECO:0000256|SAAS:SAAS00817576}.
-!- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate
+ RNA(n+1). {ECO:0000256|SAAS:SAAS00383097}.
-!- CATALYTIC ACTIVITY: Selective cleavage of Gln-|-Gly bond in the
poliovirus polyprotein. In other picornavirus reactions Glu may be
substituted for Gln, and Ser or Thr for Gly.
{ECO:0000256|SAAS:SAAS00711755}.
-!- SUBCELLULAR LOCATION: Host cytoplasmic vesicle membrane
{ECO:0000256|SAAS:SAAS00711512}; Peripheral membrane protein
{ECO:0000256|SAAS:SAAS00711512}; Cytoplasmic side
{ECO:0000256|SAAS:SAAS00711512}.
-!- SUBCELLULAR LOCATION: Virion {ECO:0000256|SAAS:SAAS00803776}.
-!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
{ECO:0000256|SAAS:SAAS00782306}.
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EMBL; M88483; AAB59927.1; -; mRNA.
EMBL; AY752946; AAV34213.1; -; Genomic_RNA.
Proteomes; UP000110494; Genome.
Proteomes; UP000161976; Genome.
GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW.
GO; GO:0018144; P:RNA-protein covalent cross-linking; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
CDD; cd00205; rhv_like; 3.
Gene3D; 4.10.80.10; -; 1.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR014838; P3A.
InterPro; IPR036203; P3A_soluble_dom.
InterPro; IPR000081; Peptidase_C3.
InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR003138; Pico_P1A.
InterPro; IPR036988; Pico_P1A_sf.
InterPro; IPR002527; Pico_P2B.
InterPro; IPR001676; Picornavirus_capsid.
InterPro; IPR033703; Rhv-like.
InterPro; IPR001205; RNA-dir_pol_C.
InterPro; IPR007094; RNA-dir_pol_PSvirus.
Pfam; PF08727; P3A; 1.
Pfam; PF00548; Peptidase_C3; 1.
Pfam; PF02226; Pico_P1A; 1.
Pfam; PF00947; Pico_P2A; 1.
Pfam; PF01552; Pico_P2B; 1.
Pfam; PF00680; RdRP_1; 1.
Pfam; PF00073; Rhv; 3.
Pfam; PF00910; RNA_helicase; 1.
ProDom; PD001306; Peptidase_C3; 1.
ProDom; PD649346; Pico_P2B; 1.
SMART; SM00382; AAA; 1.
SUPFAM; SSF50494; SSF50494; 2.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF89043; SSF89043; 1.
PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PROSITE; PS51218; SF3_HELICASE_2; 1.
2: Evidence at transcript level;
ATP-binding {ECO:0000256|SAAS:SAAS00124676};
Capsid protein {ECO:0000256|SAAS:SAAS00803779};
Complete proteome {ECO:0000313|Proteomes:UP000110494,
ECO:0000313|Proteomes:UP000161976};
Helicase {ECO:0000256|SAAS:SAAS00124676};
Host cytoplasm {ECO:0000256|SAAS:SAAS00711571};
Host cytoplasmic vesicle {ECO:0000256|SAAS:SAAS00711589};
Host membrane {ECO:0000256|SAAS:SAAS00795395};
Host-virus interaction {ECO:0000256|SAAS:SAAS00711583};
Hydrolase {ECO:0000256|SAAS:SAAS00124676,
ECO:0000256|SAAS:SAAS00482329};
Ion channel {ECO:0000256|SAAS:SAAS00711569};
Ion transport {ECO:0000256|SAAS:SAAS00711569};
Membrane {ECO:0000256|SAAS:SAAS00795395};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00124676};
Nucleotidyltransferase {ECO:0000256|SAAS:SAAS00510600};
Protease {ECO:0000256|SAAS:SAAS00482329};
RNA-binding {ECO:0000256|SAAS:SAAS00711776};
RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS00510600};
Thiol protease {ECO:0000256|SAAS:SAAS00482329};
Transferase {ECO:0000256|SAAS:SAAS00510600};
Transport {ECO:0000256|SAAS:SAAS00711569};
Viral attachment to host cell {ECO:0000256|SAAS:SAAS00711583};
Viral ion channel {ECO:0000256|SAAS:SAAS00711569};
Viral RNA replication {ECO:0000256|SAAS:SAAS00664279};
Virion {ECO:0000256|SAAS:SAAS00711583, ECO:0000256|SAAS:SAAS00803779};
Virus entry into host cell {ECO:0000256|SAAS:SAAS00711583}.
DOMAIN 1205 1361 SF3 helicase.
{ECO:0000259|PROSITE:PS51218}.
DOMAIN 1950 2066 RdRp catalytic.
{ECO:0000259|PROSITE:PS50507}.
SEQUENCE 2185 AA; 243560 MW; 0E804BFF517F63A6 CRC64;
MGAQVSTQKT GAHETRLNAS GNSIIHYTNI NYYKDAASNS ANRQDFTQDP GKFTEPVKDI
MIKSLPALNS PTVEECGYSD RVRSITLGNS TITTQECANV VVGYGVWPDY LKDSEATAED
QPTQPDVATC RFYTLDSVQW QKTSPGWWWK LPDALSNLGL FGQNMQYHYL GRTGYTVHVQ
CNASKFHQGC LLVVCVPEAE MGCATLDNTP SSAELLGGDS AKEFADKPVA SGSNKLVQRV
VYNAGMGVGV GNLTIFPHQW INLRTNNSAT IVMPYTNSVP MDNMFRHNNV TLMVIPFVPL
DYCPGSTTYV PITVTIAPMC AEYNGLRLAG HQGLPTMNTP GSCQFLTSDD FQSPSAMPQY
DVTPEMRIPG EVKNLMEIAE VDSVVPVQNV GEKVNSMEAY QIPVRSNEGS GTQVFGFPLQ
PGYSSVFSRT LLGEILNYYT HWSGSIKLTF MFCGSAMATG KFLLAYSPPG AGAPTKRVDA
MLGTHVVWDV GLQSSCVLCI PWISQTHYRF VASDEYTAGG FITCWYQTNI VVPADAQSSC
YIMCFVSACN DFSVRLLKDT PFISQQNFFQ GPVEDAITAA IGRVADTVGT GPTNSEAIPA
LTAAETGHTS QVVPGDTMQT RHVKNYHSRS ESTIENFLCR SACVYFTEYK NSGAKRYAEW
VLTPRQAAQL RRKLEFFTYV RFDLELTFVI TSTQQPSTTQ NQDAQILTHQ IMYVPPGGPV
PDKVDSYVWQ TSTNPSVFWT EGNAPPRMSI PFLSIGNAYS NFYDGWSEFS RNGVYGINTL
NNMGTLYARH VNAGSTGPIK STIRIYFKPK HVKAWIPRPP RLCQYEKAKN VNFRPSGVTT
TRQSITTMTN TGAFGQQSGA VYVGNYRVVN RHLATSADWQ NCVWESYNRD LLVSTTTTHG
CDIIARCQCT TGVYFCASKN KHYPISFEGP GLVEVQESEY YPRRYQSHVL LAAGFSEPGD
CGGILRCEHG VIGIVTMGGE GVVGFADIRD LLWLEDDAME QGVKDYVEQL GNALGSGFTN
QICEQVNLLK ESLVGQDSIL EKSLKALVKI ISALVIVVRN HDDLITVTAT LALIGCTSSP
WRWLKQKVSQ YYGIPMAERQ NNSWLKKFTE MTNACKGMEW IAVKIQKFIE WLKVKILPEV
REKHEFLNRL KQLPLLESQI ATIEQSAPSQ SDQEQLFSNV QYFAHYCRKY APLYAAEAKR
VFSLEKKMSN YIQFKSKCRI EPVCLLLHGS PGAGKSVATN LIGRSLAEKL NSSVYSLPPD
PDHFDGYKQQ AVVIMDDLCQ NPDGKDVSLF CQMVSSVDFV PPMAALEEKG ILFTSPFVLA
STNAGSINAP TVSDSRALAR RFHFDMNIEV ISMYSQNGKI NMPMSVKTCD DECCPVNFKK
CCPLVCGKAI QFIDRRTQVR YSLDMLVTEM FREYNHRHSV GTTLEALFQG PPVYREIKIS
VAPETPPPPA IADLLKSVDS EAVREYCKEK GWLVPEINST LQIEKHVSRA FICLQALTTF
VSVAGIIYII YKLFAGFQGA YTGVPNQKPR VPTLRQAKVQ GPAFEFAVAM MKRNSSRVKT
EYGEFTMLGI YDRWAVLPRH AKPGPTILMN DQEVGVLDAK ELVDKDGTNL ELTLLKLNRN
EKFRDIRGFL AKEEVEVNEA VLAINTSKFP NMYIPVGQVT EYGFLNLGGT PTKRMLMYNF
PTRAGQCGGV LMSTGKVLGI HVGGNGHQGF SAALLKHYFN DEQGEIEFIE SSKDAGFPVI
NTPSKTKLEP SVFHQVFEGN KEPAVLRSGD PRLKANFEEA IFSKYIGNVN THVDEYMLEA
VDHYAGQLAT LDISTEPMKL EDAVYGTEGL EALDLTTSAG YPYVALGIKK RDILSKKTKD
LTKLKECMDK YGLNLPMVTY VKDELRSIEK VAKGKSRLIE ASSLNDSVAM RQTFGNLYKT
FHLNPGVVTG SAVGCDPDLF WSKIPVMLDG HLIAFDYSGY DASLSPVWFA CLKMLLEKLG
YTHKETNYID YLCNSHHLYR DKHYFVRGGM PSGCSGTSIF NSMINNIIIR TLMLKVYKGI
DLDQFRMIAY GDDVIASYPW PIDASLLAEA GKGYGLIMTP ADKGECFNEV TWTNVTFLKR
YFRADEQYPF LVHPVMPMKD IHESIRWTKD PKNTQDHVRS LCLLAWHNGE HEYEEFIRKI
RSVPVGRCLT LPAFSTLRRK WLDSF


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