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Genome polyprotein [Cleaved into: Protein VP0 (VP4-VP2); Protein VP4 (P1A) (Virion protein 4); Protein VP2 (P1B) (Virion protein 2); Protein VP3 (P1C) (Virion protein 3); Protein VP1-2A (PX); Protein VP1 (P1D) (Virion protein 1); Protein 2A; Protein 2B; Protein 2BC] (Fragment)

 POLG_HAVSC              Reviewed;         839 AA.
P31788;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
10-MAY-2017, entry version 84.
RecName: Full=Genome polyprotein;
Contains:
RecName: Full=Protein VP0;
AltName: Full=VP4-VP2;
Contains:
RecName: Full=Protein VP4;
AltName: Full=P1A;
AltName: Full=Virion protein 4;
Contains:
RecName: Full=Protein VP2;
AltName: Full=P1B;
AltName: Full=Virion protein 2;
Contains:
RecName: Full=Protein VP3;
AltName: Full=P1C;
AltName: Full=Virion protein 3;
Contains:
RecName: Full=Protein VP1-2A;
AltName: Full=PX;
Contains:
RecName: Full=Protein VP1;
AltName: Full=P1D;
AltName: Full=Virion protein 1;
Contains:
RecName: Full=Protein 2A;
Contains:
RecName: Full=Protein 2B;
Contains:
RecName: Full=Protein 2BC;
Flags: Fragment;
Simian hepatitis A virus genotype IV (isolate CY-145) (SHAV) (Simian
hepatitis A virus (isolate Macaca/Philippines/CY-145/1988)).
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage;
Picornavirales; Picornaviridae; Hepatovirus.
NCBI_TaxID=31707;
NCBI_TaxID=9481; Callithrix.
NCBI_TaxID=9536; Cercopithecus hamlyni (Owl-faced monkey) (Hamlyn's monkey).
NCBI_TaxID=9534; Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops).
NCBI_TaxID=9539; Macaca (macaques).
NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC RNA].
PubMed=1649902; DOI=10.1099/0022-1317-72-7-1685;
Nainan O.V., Margolis H.S., Robertson B.H., Balayan M., Brinton M.A.;
"Sequence analysis of a new hepatitis A virus naturally infecting
cynomolgus macaques (Macaca fascicularis).";
J. Gen. Virol. 72:1685-1689(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 764-818.
PubMed=1318940; DOI=10.1099/0022-1317-73-6-1365;
Robertson B.H., Jansen R.W., Khanna B., Totsuka A., Nainan O.V.,
Siegl G., Widell A., Margolis H.S., Isomura S., Ito K., Ishizu T.,
Moritsugu Y., Lemon S.M.;
"Genetic relatedness of hepatitis A virus strains recovered from
different geographical regions.";
J. Gen. Virol. 73:1365-1377(1992).
-!- FUNCTION: Capsid proteins VP1, VP2, and VP3 form a closed capsid
enclosing the viral positive strand RNA genome. All these proteins
contain a beta-sheet structure called beta-barrel jelly roll.
Together they form an icosahedral capsid (T=3) composed of 60
copies of each VP1, VP2, and VP3, with a diameter of approximately
300 Angstroms. VP1 is situated at the 12 fivefold axes, whereas
VP2 and VP3 are located at the quasi-sixfold axes. The capsid
interacts with HAVCR1 to provide virion attachment to target cell
(By similarity). {ECO:0000250}.
-!- FUNCTION: Protein VP0: VP0 precursor is a component of immature
procapsids. The N-terminal domain of VP0, protein VP4, is needed
for the assembly of 12 pentamers into the icosahedral structure.
Unlike other picornaviruses, HAV VP4 does not seem to be
myristoylated and has not been detected in mature virions,
supposedly owing to its small size (By similarity). {ECO:0000250}.
-!- FUNCTION: VP1-2A precursor is a component of immature procapsids
and corresponds to an extended form of the structural protein VP1.
The C-terminal domain of VP1-2A, protein 2A, acts as an assembly
signal that allows multimerization of VP1-2A and formation of
pentamers of VP1-VP2-VP3 trimers. It is proteolytically removed
from the precursor by a host protease and does not seem to be
found in mature particles (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Protein VP2: Virion {ECO:0000250}. Host
cytoplasm {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Protein VP3: Virion {ECO:0000250}. Host
cytoplasm {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Protein VP1: Virion {ECO:0000250}. Host
cytoplasm {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Protein VP1-2A: Virion {ECO:0000250}. Host
cytoplasm {ECO:0000305}.
-!- PTM: Specific enzymatic cleavages by the viral protease in vivo
yield a variety of precursors and mature proteins. Polyprotein
processing intermediates are produced, such as P1-2A which is a
functional precursor of the structural proteins, VP0 which is a
VP4-VP2 precursor, and VP1-2A precursor. The assembly signal 2A is
removed from VP1-2A by a host protease. During virion maturation,
non-infectious particles are rendered infectious following
cleavage of VP0. This maturation cleavage is followed by a
conformational change of the particle (By similarity).
{ECO:0000250}.
-!- MISCELLANEOUS: The need for an intact eIF4G factor for the
initiation of translation results in an inability to shut off host
protein synthesis by a mechanism similar to that of other
picornaviruses. {ECO:0000250}.
-!- SIMILARITY: Belongs to the picornaviridae polyprotein family.
{ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
In vitro, both are used, with a preference for Met-3.
{ECO:0000305}.
-!- CAUTION: Protein VP1 seems to have a heterogeneous C-terminus in
cell culture. It may be reduced by a few amino acids compared to
the sequence shown. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; M59286; AAA45473.1; -; Genomic_RNA.
EMBL; L07732; -; NOT_ANNOTATED_CDS; Genomic_RNA.
PIR; JQ1180; GNNYS2.
ProteinModelPortal; P31788; -.
SMR; P31788; -.
OrthoDB; VOG090000CY; -.
Proteomes; UP000007633; Genome.
GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0044385; C:integral to membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
GO; GO:0005216; F:ion channel activity; IEA:UniProtKB-KW.
GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
GO; GO:0039707; P:pore formation by virus in membrane of host cell; IEA:UniProtKB-KW.
GO; GO:0051259; P:protein oligomerization; IEA:UniProtKB-KW.
GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
CDD; cd00205; rhv_like; 2.
InterPro; IPR024354; Hepatitis_A_VP1-2A.
InterPro; IPR001676; Picornavirus_capsid.
InterPro; IPR033703; Rhv-like.
Pfam; PF12944; HAV_VP; 1.
Pfam; PF00073; Rhv; 2.
3: Inferred from homology;
Capsid protein; Complete proteome;
Eukaryotic host gene expression shutoff by virus;
Eukaryotic host translation shutoff by virus; Host cytoplasm;
Host gene expression shutoff by virus; Host-virus interaction;
Ion channel; Ion transport; Transport; Viral attachment to host cell;
Viral ion channel; Virion; Virus entry into host cell.
CHAIN 1 >839 Genome polyprotein.
/FTId=PRO_0000311031.
CHAIN 1 245 Protein VP0. {ECO:0000255}.
/FTId=PRO_0000311032.
CHAIN 1 23 Protein VP4. {ECO:0000255}.
/FTId=PRO_0000039990.
CHAIN 24 245 Protein VP2. {ECO:0000255}.
/FTId=PRO_0000039991.
CHAIN 246 491 Protein VP3. {ECO:0000255}.
/FTId=PRO_0000039992.
CHAIN 492 835 Protein VP1-2A. {ECO:0000255}.
/FTId=PRO_0000311033.
CHAIN 492 769 Protein VP1. {ECO:0000255}.
/FTId=PRO_0000039993.
CHAIN 770 835 Protein 2A. {ECO:0000255}.
/FTId=PRO_0000039994.
CHAIN 836 >839 Protein 2B. {ECO:0000255}.
/FTId=PRO_0000311034.
CHAIN 836 >839 Protein 2BC. {ECO:0000255}.
/FTId=PRO_0000311035.
TOPO_DOM 1 >839 Cytoplasmic. {ECO:0000255}.
SITE 23 24 Cleavage. {ECO:0000255}.
SITE 245 246 Cleavage; by protease 3C. {ECO:0000255}.
SITE 491 492 Cleavage; by protease 3C. {ECO:0000255}.
SITE 769 770 Cleavage; by host. {ECO:0000255}.
SITE 769 769 Important for VP1 folding and capsid
assembly. {ECO:0000250}.
SITE 835 836 Cleavage; by protease 3C. {ECO:0000250}.
NON_TER 839 839
SEQUENCE 839 AA; 93825 MW; 2CACC4BD1E192DBC CRC64;
MNMARQGLFQ TVGSGLDHIL SLADVEEEQM IQSVDRTAVT GASYFTSVDQ SSVHTAEVGS
HQSEPLKTSV DKPGSKKTQG EKFFLIHSAD WLSTHALFHE VAKLDVVSLL YNEQFAVQGL
LRYHTYARFG IEIQVQINPT PFQQGGLICA MVPGDQGYGS IASLTVYPHG LLNCNINNVV
RIKVPFIYTR GAYHFKDPQY PVWELTIRVW SEFNIGTGTS AYTSLNVLAR FTDLELHGLT
PLSTQMMRNE FRVSTTENVV NLSNYEDARA KMSFALDQEN WRSDPSEGGG IKITHFSTWT
SIPTLAAQFA FNASASVGQQ IKVIPVDPYF YQMTNSNPDQ KYITALASIC QMFCFWRGDL
VFDFQVFPTK YHSGRLQFCF VPGNELIEVT SITLKQATTA PCAVMDITGV QSTLRFRVPW
ISDTPYRVNC YIKSSHQKGE YTAIEKLIVY CYNRLTSPSN VASHVRVNVY LSAINLECFA
PLYHAMDVTS QTGDDSGGFS TTVSTEQNVP DPQVGITTPK DLKGKANKGK MDVSGVQAPV
GAITTIEDPV LAKKVPETFP ELKPGESRHT SDHMSVYKFM GRSHFLCTFT FNANNREYTF
PITLSSTSNP PHGSPSTLRW FFNLFQLYRG PLDLTIIITG ATDVDGMAWF TPVGLAVDTP
WVEKQSALTI DYKTALGAIR FNTRRTGNIQ IRLPWYSYLY AVSGALDGLG DTTDSTFGLV
SIQIANYNHS DEYLSFSCYL SVTEQSEFFF PRAPLNSSAM MTSENMLDRI AGGDLESSVD
DPRTDEDRRF ESHIEKKPYK ELRLEVGKQR FKYAREELSN EILPPPRKLK GLFSQSKIS


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