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Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)

 GGPPS_NEUCR             Reviewed;         433 AA.
P24322; Q7RVC0; Q86ZV1;
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
15-JAN-2008, sequence version 2.
22-NOV-2017, entry version 135.
RecName: Full=Geranylgeranyl pyrophosphate synthase;
Short=GGPP synthase;
Short=GGPPSase;
EC=2.5.1.-;
AltName: Full=(2E,6E)-farnesyl diphosphate synthase;
AltName: Full=Albino-3 protein;
AltName: Full=Dimethylallyltranstransferase;
EC=2.5.1.1;
AltName: Full=Farnesyl diphosphate synthase;
AltName: Full=Farnesyltranstransferase;
EC=2.5.1.29;
AltName: Full=Geranylgeranyl diphosphate synthase;
AltName: Full=Geranyltranstransferase;
EC=2.5.1.10;
Name=al-3; ORFNames=B8P8.010, NCU01427;
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM
1257 / FGSC 987).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae;
Neurospora.
NCBI_TaxID=367110;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=1826006;
Carattoli A., Romano N., Ballario P., Morelli G., Macino G.;
"The Neurospora crassa carotenoid biosynthetic gene (albino 3) reveals
highly conserved regions among prenyltransferases.";
J. Biol. Chem. 266:5854-5859(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=12655011; DOI=10.1093/nar/gkg293;
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V.,
Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J.,
Schulte U.;
"What's in the genome of a filamentous fungus? Analysis of the
Neurospora genome sequence.";
Nucleic Acids Res. 31:1944-1954(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
PubMed=12712197; DOI=10.1038/nature01554;
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S.,
Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-134, AND ALTERNATIVE
INITIATION.
PubMed=7929398;
Vittorioso P., Carattoli A., Londei P., Macino G.;
"Internal translational initiation in the mRNA from the Neurospora
crassa albino-3 gene.";
J. Biol. Chem. 269:26650-26654(1994).
-!- FUNCTION: Catalyzes the trans-addition of the three molecules of
IPP onto DMAPP to form geranylgeranyl pyrophosphate.
-!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
diphosphate = diphosphate + geranyl diphosphate.
-!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
= diphosphate + (2E,6E)-farnesyl diphosphate.
-!- CATALYTIC ACTIVITY: (2E,6E)-farnesyl diphosphate + isopentenyl
diphosphate = diphosphate + geranylgeranyl diphosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
-!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
biosynthesis; farnesyl diphosphate from geranyl diphosphate and
isopentenyl diphosphate: step 1/1.
-!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
and isopentenyl diphosphate: step 1/1.
-!- PATHWAY: Isoprenoid biosynthesis; geranylgeranyl diphosphate
biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate
and isopentenyl diphosphate: step 1/1.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=3;
Name=1;
IsoId=P24322-1; Sequence=Displayed;
Note=Main product.;
Name=2;
IsoId=P24322-2; Sequence=VSP_029974;
Name=3;
IsoId=P24322-3; Sequence=VSP_029973;
-!- INDUCTION: By blue light.
-!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
{ECO:0000305}.
-!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC13867.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAD70868.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; U20940; AAC13867.1; ALT_INIT; Genomic_DNA.
EMBL; BX294018; CAD70868.1; ALT_INIT; Genomic_DNA.
EMBL; CM002240; EAA31459.2; -; Genomic_DNA.
EMBL; S74011; AAP21085.1; -; Genomic_DNA.
PIR; S15662; S15662.
RefSeq; XP_960695.2; XM_955602.3. [P24322-1]
ProteinModelPortal; P24322; -.
SMR; P24322; -.
EnsemblFungi; EAA31459; EAA31459; NCU01427. [P24322-1]
GeneID; 3876842; -.
KEGG; ncr:NCU01427; -.
EuPathDB; FungiDB:NCU01427; -.
HOGENOM; HOG000169461; -.
InParanoid; P24322; -.
KO; K00804; -.
OMA; FYSKAFF; -.
OrthoDB; EOG092C3Q3X; -.
UniPathway; UPA00259; UER00368.
UniPathway; UPA00260; UER00369.
UniPathway; UPA00389; UER00564.
Proteomes; UP000001805; Chromosome 2, Linkage Group V.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:UniProtKB-EC.
GO; GO:0004311; F:farnesyltranstransferase activity; ISS:UniProtKB.
GO; GO:0004337; F:geranyltranstransferase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0016117; P:carotenoid biosynthetic process; IEA:UniProtKB-KW.
GO; GO:0045337; P:farnesyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0033384; P:geranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0033386; P:geranylgeranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0006720; P:isoprenoid metabolic process; ISS:UniProtKB.
Gene3D; 1.10.600.10; -; 1.
InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
InterPro; IPR000092; Polyprenyl_synt.
InterPro; IPR033749; Polyprenyl_synt_CS.
Pfam; PF00348; polyprenyl_synt; 1.
SUPFAM; SSF48576; SSF48576; 1.
PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
2: Evidence at transcript level;
Alternative initiation; Carotenoid biosynthesis; Complete proteome;
Cytoplasm; Isoprene biosynthesis; Magnesium; Metal-binding;
Reference proteome; Transferase.
CHAIN 1 433 Geranylgeranyl pyrophosphate synthase.
/FTId=PRO_0000123966.
METAL 186 186 Magnesium 1. {ECO:0000250}.
METAL 186 186 Magnesium 2. {ECO:0000250}.
METAL 190 190 Magnesium 1. {ECO:0000250}.
METAL 190 190 Magnesium 2. {ECO:0000250}.
METAL 310 310 Magnesium 3. {ECO:0000250}.
BINDING 147 147 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 150 150 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 179 179 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 195 195 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 196 196 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 273 273 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 274 274 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 307 307 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 324 324 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 334 334 Dimethylallyl diphosphate. {ECO:0000250}.
SITE 218 218 Important for determining product chain
length. {ECO:0000250}.
VAR_SEQ 1 98 Missing (in isoform 3). {ECO:0000305}.
/FTId=VSP_029973.
VAR_SEQ 1 88 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_029974.
SEQUENCE 433 AA; 48485 MW; BE6BB03A938BDFA5 CRC64;
MEHVTMAVTS SSPGPAPLSL LSNNDDFIAP FNINTKFPSA IVPPRTSSNQ PISVAIPSNR
ISSAGLAATQ QAQTRKRKAS VAQISLPSML PTSFSPYTMA PQPPQPPPNP DRFATEDFFS
PSRRTWSEEK EKVLTGPYDY LNGHPGKDIR SQMVKAFDAW LDVPSESLEV ITKVISMLHT
ASLLVDDVED NSVLRRGFPV AHSIFGIPQT INTSNYVYFY ALQELQKLKN PKAVSIFSEE
LLNLHRGQGM DLFWRDTLTC PTEDDYLEMV SNKTGGLFRL GIKLMQAESR SPVDCVPLVN
IIGLIFQIAD DYHNLWNREY TANKGMCEDL TEGKFSFPVI HSIRSNPSNM QLLNILKQKT
GDEEVKRYAV AYMESTGSFE YTRKVIKVLV DRARQMTEDI DDGRGKSGGI HKILDRIMLH
QEENVAQKNG KKE


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