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Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)

 GGPPS_BOVIN             Reviewed;         300 AA.
P56966; Q0VC78;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
03-APR-2007, sequence version 2.
07-JUN-2017, entry version 111.
RecName: Full=Geranylgeranyl pyrophosphate synthase;
Short=GGPP synthase;
Short=GGPPSase;
EC=2.5.1.-;
AltName: Full=(2E,6E)-farnesyl diphosphate synthase;
AltName: Full=Dimethylallyltranstransferase;
EC=2.5.1.1;
AltName: Full=Farnesyl diphosphate synthase;
AltName: Full=Farnesyltranstransferase;
EC=2.5.1.29;
AltName: Full=Geranylgeranyl diphosphate synthase;
AltName: Full=Geranyltranstransferase;
EC=2.5.1.10;
Name=GGPS1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Brain cortex;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 3-296, AND PROTEIN SEQUENCE OF 3-16 AND
289-296.
PubMed=10026212; DOI=10.1074/jbc.274.9.5888;
Kuzuguchi T., Morita Y., Sagami I., Sagami H., Ogura K.;
"Human geranylgeranyl diphosphate synthase. cDNA cloning and
expression.";
J. Biol. Chem. 274:5888-5894(1999).
-!- FUNCTION: Catalyzes the trans-addition of the three molecules of
IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important
precursor of carotenoids and geranylated proteins.
-!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
diphosphate = diphosphate + geranyl diphosphate.
-!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
= diphosphate + (2E,6E)-farnesyl diphosphate.
-!- CATALYTIC ACTIVITY: (2E,6E)-farnesyl diphosphate + isopentenyl
diphosphate = diphosphate + geranylgeranyl diphosphate.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
-!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
biosynthesis; farnesyl diphosphate from geranyl diphosphate and
isopentenyl diphosphate: step 1/1.
-!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
and isopentenyl diphosphate: step 1/1.
-!- PATHWAY: Isoprenoid biosynthesis; geranylgeranyl diphosphate
biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate
and isopentenyl diphosphate: step 1/1.
-!- SUBUNIT: Homohexamer; trimer of homodimers. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
-!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
{ECO:0000305}.
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EMBL; BC120313; AAI20314.1; -; mRNA.
RefSeq; NP_001073269.1; NM_001079801.1.
RefSeq; XP_010818738.1; XM_010820436.1.
UniGene; Bt.71777; -.
ProteinModelPortal; P56966; -.
SMR; P56966; -.
STRING; 9913.ENSBTAP00000017376; -.
PaxDb; P56966; -.
PRIDE; P56966; -.
Ensembl; ENSBTAT00000017376; ENSBTAP00000017376; ENSBTAG00000013068.
GeneID; 780882; -.
KEGG; bta:780882; -.
CTD; 9453; -.
eggNOG; KOG0777; Eukaryota.
eggNOG; COG0142; LUCA.
GeneTree; ENSGT00390000010417; -.
HOGENOM; HOG000169461; -.
HOVERGEN; HBG051729; -.
InParanoid; P56966; -.
KO; K00804; -.
OMA; FYSKAFF; -.
OrthoDB; EOG091G0AO6; -.
TreeFam; TF300101; -.
Reactome; R-BTA-191273; Cholesterol biosynthesis.
UniPathway; UPA00259; UER00368.
UniPathway; UPA00260; UER00369.
UniPathway; UPA00389; UER00564.
Proteomes; UP000009136; Chromosome 28.
Bgee; ENSBTAG00000013068; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:UniProtKB-EC.
GO; GO:0004311; F:farnesyltranstransferase activity; IDA:UniProtKB.
GO; GO:0004337; F:geranyltranstransferase activity; IEA:UniProtKB-EC.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0045337; P:farnesyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0033384; P:geranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0033386; P:geranylgeranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0006720; P:isoprenoid metabolic process; IDA:UniProtKB.
Gene3D; 1.10.600.10; -; 1.
InterPro; IPR008949; Isoprenoid_synthase_dom.
InterPro; IPR000092; Polyprenyl_synt.
InterPro; IPR033749; Polyprenyl_synt_CS.
Pfam; PF00348; polyprenyl_synt; 1.
SUPFAM; SSF48576; SSF48576; 1.
PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
Isoprene biosynthesis; Magnesium; Metal-binding; Reference proteome;
Transferase.
CHAIN 1 300 Geranylgeranyl pyrophosphate synthase.
/FTId=PRO_0000123961.
METAL 64 64 Magnesium 1. {ECO:0000250}.
METAL 64 64 Magnesium 2. {ECO:0000250}.
METAL 68 68 Magnesium 1. {ECO:0000250}.
METAL 68 68 Magnesium 2. {ECO:0000250}.
METAL 188 188 Magnesium 3. {ECO:0000250}.
BINDING 25 25 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 28 28 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 57 57 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 73 73 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 74 74 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 151 151 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 152 152 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 185 185 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 202 202 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 212 212 Dimethylallyl diphosphate. {ECO:0000250}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000250|UniProtKB:O95749}.
SEQUENCE 300 AA; 34900 MW; FF6606F42CB9AE81 CRC64;
MEKTQETVQR ILLEPYKYLL QLPGKQVRTK LSQAFNHWLK VPEDKLQIII EVTEMLHNAS
LLIDDIEDNS KLRRGFPVAH SIYGIPSVIN SANYVYFLGL EKVLTLNHPD AVKLFTRQLL
ELHQGQGLDI YWRDNYTCPT EEEYKAMVLQ KTGGLFGLAV GLMQLFSDYK EDLKPLLDTL
GLFFQIRDDY ANLHSKEYSE NKSFCEDLTE GKFSFPTIHA IWSRPESTQV QNILRQRTEN
IDIKKYCVHY LENVGSFEYT RNTLKELESK AYKQIDARGG NPELVALIKH LSKMFKEENE


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