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Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
GGPPS_MUCCL Reviewed; 303 AA.
Q9P885;
12-APR-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
22-NOV-2017, entry version 65.
RecName: Full=Geranylgeranyl pyrophosphate synthase;
Short=GGPP synthase;
Short=GGPPSase;
EC=2.5.1.-;
AltName: Full=(2E,6E)-farnesyl diphosphate synthase;
AltName: Full=Dimethylallyltranstransferase;
EC=2.5.1.1;
AltName: Full=Farnesyl diphosphate synthase;
AltName: Full=Farnesyltranstransferase;
EC=2.5.1.29;
AltName: Full=Geranylgeranyl diphosphate synthase;
AltName: Full=Geranyltranstransferase;
EC=2.5.1.10;
Name=carG {ECO:0000312|EMBL:CAB89115.1};
Mucor circinelloides f. lusitanicus (Mucor racemosus var.
lusitanicus).
Eukaryota; Fungi; Mucoromycota; Mucoromycotina; Mucorales; Mucorineae;
Mucoraceae; Mucor.
NCBI_TaxID=29924;
[1] {ECO:0000305, ECO:0000312|EMBL:CAB89115.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, PATHWAY, AND
INDUCTION.
STRAIN=ATCC 1216b / BCRC 32522 / CBS 277.49 / NRRL 3631;
TISSUE=Mycelium {ECO:0000269|PubMed:12695851};
PubMed=12695851; DOI=10.1007/s00294-003-0376-5;
Velayos A., Papp T., Aguilar-Elena R., Fuentes-Vicente M.,
Eslava A.P., Iturriaga E.A., Alvarez M.I.;
"Expression of the carG gene, encoding geranylgeranyl pyrophosphate
synthase, is up-regulated by blue light in Mucor circinelloides.";
Curr. Genet. 43:112-120(2003).
-!- FUNCTION: Catalyzes the trans-addition of the three molecules of
IPP onto DMAPP to form geranylgeranyl pyrophosphate.
{ECO:0000305}.
-!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
diphosphate = diphosphate + geranyl diphosphate.
{ECO:0000269|PubMed:12695851, ECO:0000305}.
-!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
= diphosphate + (2E,6E)-farnesyl diphosphate.
{ECO:0000269|PubMed:12695851}.
-!- CATALYTIC ACTIVITY: (2E,6E)-farnesyl diphosphate + isopentenyl
diphosphate = diphosphate + geranylgeranyl diphosphate.
{ECO:0000269|PubMed:12695851}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
-!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
biosynthesis; farnesyl diphosphate from geranyl diphosphate and
isopentenyl diphosphate: step 1/1. {ECO:0000269|PubMed:12695851}.
-!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
and isopentenyl diphosphate: step 1/1.
{ECO:0000269|PubMed:12695851}.
-!- PATHWAY: Isoprenoid biosynthesis; geranylgeranyl diphosphate
biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate
and isopentenyl diphosphate: step 1/1.
{ECO:0000269|PubMed:12695851}.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- INDUCTION: By blue light. {ECO:0000269|PubMed:12695851}.
-!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
{ECO:0000305}.
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EMBL; AJ276129; CAB89115.1; -; Genomic_DNA.
ProteinModelPortal; Q9P885; -.
SMR; Q9P885; -.
UniPathway; UPA00259; UER00368.
UniPathway; UPA00260; UER00369.
UniPathway; UPA00389; UER00564.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:UniProtKB-EC.
GO; GO:0004311; F:farnesyltranstransferase activity; IDA:UniProtKB.
GO; GO:0004337; F:geranyltranstransferase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0016117; P:carotenoid biosynthetic process; IDA:UniProtKB.
GO; GO:0045337; P:farnesyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0033384; P:geranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0033386; P:geranylgeranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
GO; GO:0006720; P:isoprenoid metabolic process; IDA:UniProtKB.
Gene3D; 1.10.600.10; -; 1.
InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
InterPro; IPR000092; Polyprenyl_synt.
InterPro; IPR033749; Polyprenyl_synt_CS.
Pfam; PF00348; polyprenyl_synt; 1.
SUPFAM; SSF48576; SSF48576; 1.
PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
1: Evidence at protein level;
Carotenoid biosynthesis; Cytoplasm; Isoprene biosynthesis; Magnesium;
Metal-binding; Transferase.
CHAIN 1 303 Geranylgeranyl pyrophosphate synthase.
/FTId=PRO_0000123967.
METAL 69 69 Magnesium 1. {ECO:0000250}.
METAL 69 69 Magnesium 2. {ECO:0000250}.
METAL 73 73 Magnesium 1. {ECO:0000250}.
METAL 73 73 Magnesium 2. {ECO:0000250}.
METAL 193 193 Magnesium 3. {ECO:0000250}.
BINDING 30 30 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 33 33 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 62 62 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 78 78 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 79 79 Isopentenyl diphosphate. {ECO:0000250}.
BINDING 156 156 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 157 157 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 190 190 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 207 207 Dimethylallyl diphosphate. {ECO:0000250}.
BINDING 217 217 Dimethylallyl diphosphate. {ECO:0000250}.
SEQUENCE 303 AA; 34787 MW; D440757CA7D0E215 CRC64;
MLNSHNRTEE RSTEDIILEP YTYLISQPGK DIRAKLISAF DLWLHVPKDV LCVINKIIGM
LHNASLMIDD VQDDSDLRRG VPVAHHIYGV PQTINTANYV IFLALQEVMK LNIPSMMQVC
TEELINLHRG QGIELYWRDS LTCPTEEEYI DMVNNKTSGL LRLAVRLMQA ASESDIDYTP
LVNIIGIHFQ VRDDYMNLQS TSYTNNKGFC EDLTEGKFSF PIIHAIRKDP SNRQLLNIIS
QKPTSIEVKK YALEVIRKAG SFEYVREFLR QKEAESLKEI KRLGGNPLLE KYIETIRVEA
TND
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Pathways :
WP2211: Geranylgeranyldiphosphate biosynthesis II (plastidic)
WP1708: Terpenoid backbone biosynthesis
WP677: Momilactone biosynthesis
WP1403: AMPK signaling
WP1422: Sphingolipid Metabolism
WP1423: Ganglio Sphingolipid Metabolism
WP1424: Globo Sphingolipid Metabolism
WP1461: Photosynthetic Carbon Reduction
WP1621: Arginine and proline metabolism
WP2199: Seed Development
WP2208: Cardiolipin Biosynthesis
WP2210: Oryzalexin S biosynthesis
WP2248: anthocyanin biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP296: TCA Cycle - biocyc
WP626: Abscisic Acid Biosynthesis
WP668: Octadecanoid Pathway
WP174: Hexaprenyl Diphosphate Biosynthesis
Related Genes :
[RGTB1 At5g12210 MXC9.17] Geranylgeranyl transferase type-2 subunit beta 1 (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta 1) (Rab geranylgeranyl transferase beta subunit 1) (AtRGTB1) (Rab-GGT beta 1)
[RGTB2 At3g12070 T21B14.11] Geranylgeranyl transferase type-2 subunit beta 2 (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta 2) (Rab geranylgeranyl transferase beta subunit 2) (AtRGTB2) (Rab-GGT beta 2)
[GGPS1] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[RABGGTB GGTB] Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)
[Rabggtb] Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)
[Rabggtb Ggtb] Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)
[RABGGTA] Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)
[CHLP At1g74470 F1M20.15] Geranylgeranyl diphosphate reductase, chloroplastic (EC 1.3.1.83) (Geranylgeranyl reductase)
[BTS1 YPL069C] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (BET2 suppressor protein 1) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[spo9 SPBC36.06c] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) (Sporulation-specific protein 9)
[Ggps1] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[GGPS1] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[GGB PGGT1B PGGTI At2g39550 F12L6] Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (AtGGT-IB) (GGTase-I-beta)
[Pggt1b] Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)
[Rabggta Ggta] Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)
[CDC43 CAL1 YGL155W G1864] Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Cell division cycle protein 43) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (RAS proteins geranylgeranyltransferase subunit beta) (Type I protein geranyl-geranyltransferase subunit beta) (PGGT)
[Ggps1] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[al-3 B8P8.010 NCU01427] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[carG] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[PGGT1B] Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)
[paxG] Geranylgeranyl pyrophosphate synthase paxG (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) (Paxilline synthesis protein G)
[BET2 YPR176C P9705.12] Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Type II protein geranyl-geranyltransferase subunit beta) (PGGT) (YPT1/SEC4 proteins geranylgeranyltransferase subunit beta)
[GGS GGPPS] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[BET4 YJL031C J1254] Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (GGTase-II-alpha) (Geranylgeranyl transferase type II subunit alpha) (PGGT) (Type II protein geranyl-geranyltransferase subunit alpha) (YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha)
[GGS-D] Geranylgeranyl pyrophosphate synthase D (GGPP synthase D) (GGPPSase) ((2E,6E)-farnesyl diphosphate synthase D) (Dimethylallyltranstransferase D) (EC 2.5.1.1) (Farnesyl diphosphate synthase D) (Farnesyltranstransferase D) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase D) (Geranyltranstransferase D) (EC 2.5.1.10)
[BTS1 AEL238C] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[GGPPS2 GGPP5 GGPS2 At2g23800 F27L4.2] Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 2 (GGPP synthase 2) (GGPS2) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase 2) (Dimethylallyltranstransferase 2) (EC 2.5.1.1) (Farnesyl diphosphate synthase 2) (Farnesyltranstransferase 2) (EC 2.5.1.29) (Geranyltranstransferase 2) (EC 2.5.1.10)
[ggps1 DDB_G0293588] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[GGPPS1 GGPPS11 GGPS1 At4g36810 C7A10.550] Heterodimeric geranylgeranyl pyrophosphate synthase large subunit 1, chloroplastic (GGPP synthase 1) (GGPS1) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase 1) (Dimethylallyltranstransferase 1) (EC 2.5.1.1) (Farnesyl diphosphate synthase 1) (Farnesyltranstransferase 1) (EC 2.5.1.29) (Geranyltranstransferase 1) (EC 2.5.1.10)
[GGPS1] Geranylgeranyl pyrophosphate synthase, chloroplastic (GGPP synthase) (GGPS) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranyltranstransferase) (EC 2.5.1.10)
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