GENTAUR Molecular Products.

 GGPPS_MUCCL             Reviewed;         303 AA.
 Q9P885;
 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
 01-OCT-2000, sequence version 1.
 18-JUL-2018, entry version 67.
 RecName: Full=Geranylgeranyl pyrophosphate synthase;
          Short=GGPP synthase;
          Short=GGPPSase;
          EC=2.5.1.-;
 AltName: Full=(2E,6E)-farnesyl diphosphate synthase;
 AltName: Full=Dimethylallyltranstransferase;
          EC=2.5.1.1;
 AltName: Full=Farnesyl diphosphate synthase;
 AltName: Full=Farnesyltranstransferase;
          EC=2.5.1.29;
 AltName: Full=Geranylgeranyl diphosphate synthase;
 AltName: Full=Geranyltranstransferase;
          EC=2.5.1.10;
 Name=carG {ECO:0000312|EMBL:CAB89115.1};
 Mucor circinelloides f. lusitanicus (Mucor racemosus var.
 lusitanicus).
 Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
 Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
 NCBI_TaxID=29924;
 [1] {ECO:0000305, ECO:0000312|EMBL:CAB89115.1}
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY, PATHWAY, AND
 INDUCTION.
 STRAIN=ATCC 1216b / BCRC 32522 / CBS 277.49 / NRRL 3631;
 TISSUE=Mycelium {ECO:0000269|PubMed:12695851};
 PubMed=12695851; DOI=10.1007/s00294-003-0376-5;
 Velayos A., Papp T., Aguilar-Elena R., Fuentes-Vicente M.,
 Eslava A.P., Iturriaga E.A., Alvarez M.I.;
 "Expression of the carG gene, encoding geranylgeranyl pyrophosphate
 synthase, is up-regulated by blue light in Mucor circinelloides.";
 Curr. Genet. 43:112-120(2003).
 -!- FUNCTION: Catalyzes the trans-addition of the three molecules of
     IPP onto DMAPP to form geranylgeranyl pyrophosphate.
     {ECO:0000305}.
 -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
     diphosphate = diphosphate + geranyl diphosphate.
     {ECO:0000269|PubMed:12695851, ECO:0000305}.
 -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
     = diphosphate + (2E,6E)-farnesyl diphosphate.
     {ECO:0000269|PubMed:12695851}.
 -!- CATALYTIC ACTIVITY: (2E,6E)-farnesyl diphosphate + isopentenyl
     diphosphate = diphosphate + geranylgeranyl diphosphate.
     {ECO:0000269|PubMed:12695851}.
 -!- COFACTOR:
     Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
     Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
 -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
     biosynthesis; farnesyl diphosphate from geranyl diphosphate and
     isopentenyl diphosphate: step 1/1. {ECO:0000269|PubMed:12695851}.
 -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
     biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
     and isopentenyl diphosphate: step 1/1.
     {ECO:0000269|PubMed:12695851}.
 -!- PATHWAY: Isoprenoid biosynthesis; geranylgeranyl diphosphate
     biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate
     and isopentenyl diphosphate: step 1/1.
     {ECO:0000269|PubMed:12695851}.
 -!- SUBCELLULAR LOCATION: Cytoplasm.
 -!- INDUCTION: By blue light. {ECO:0000269|PubMed:12695851}.
 -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
     {ECO:0000305}.
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 EMBL; AJ276129; CAB89115.1; -; Genomic_DNA.
 ProteinModelPortal; Q9P885; -.
 SMR; Q9P885; -.
 UniPathway; UPA00259; UER00368.
 UniPathway; UPA00260; UER00369.
 UniPathway; UPA00389; UER00564.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:UniProtKB-EC.
 GO; GO:0004311; F:farnesyltranstransferase activity; IDA:UniProtKB.
 GO; GO:0004337; F:geranyltranstransferase activity; IEA:UniProtKB-EC.
 GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO; GO:0016117; P:carotenoid biosynthetic process; IDA:UniProtKB.
 GO; GO:0045337; P:farnesyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO; GO:0033384; P:geranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO; GO:0033386; P:geranylgeranyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO; GO:0006720; P:isoprenoid metabolic process; IDA:UniProtKB.
 Gene3D; 1.10.600.10; -; 1.
 InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
 InterPro; IPR000092; Polyprenyl_synt.
 InterPro; IPR033749; Polyprenyl_synt_CS.
 Pfam; PF00348; polyprenyl_synt; 1.
 SUPFAM; SSF48576; SSF48576; 1.
 PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
 PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
 1: Evidence at protein level;
 Carotenoid biosynthesis; Cytoplasm; Isoprene biosynthesis; Magnesium;
 Metal-binding; Transferase.
 CHAIN         1    303       Geranylgeranyl pyrophosphate synthase.
                              /FTId=PRO_0000123967.
 METAL        69     69       Magnesium 1. {ECO:0000250}.
 METAL        69     69       Magnesium 2. {ECO:0000250}.
 METAL        73     73       Magnesium 1. {ECO:0000250}.
 METAL        73     73       Magnesium 2. {ECO:0000250}.
 METAL       193    193       Magnesium 3. {ECO:0000250}.
 BINDING      30     30       Isopentenyl diphosphate. {ECO:0000250}.
 BINDING      33     33       Isopentenyl diphosphate. {ECO:0000250}.
 BINDING      62     62       Isopentenyl diphosphate. {ECO:0000250}.
 BINDING      78     78       Dimethylallyl diphosphate. {ECO:0000250}.
 BINDING      79     79       Isopentenyl diphosphate. {ECO:0000250}.
 BINDING     156    156       Dimethylallyl diphosphate. {ECO:0000250}.
 BINDING     157    157       Dimethylallyl diphosphate. {ECO:0000250}.
 BINDING     190    190       Dimethylallyl diphosphate. {ECO:0000250}.
 BINDING     207    207       Dimethylallyl diphosphate. {ECO:0000250}.
 BINDING     217    217       Dimethylallyl diphosphate. {ECO:0000250}.
 SEQUENCE   303 AA;  34787 MW;  D440757CA7D0E215 CRC64;
 MLNSHNRTEE RSTEDIILEP YTYLISQPGK DIRAKLISAF DLWLHVPKDV LCVINKIIGM
 LHNASLMIDD VQDDSDLRRG VPVAHHIYGV PQTINTANYV IFLALQEVMK LNIPSMMQVC
 TEELINLHRG QGIELYWRDS LTCPTEEEYI DMVNNKTSGL LRLAVRLMQA ASESDIDYTP
 LVNIIGIHFQ VRDDYMNLQS TSYTNNKGFC EDLTEGKFSF PIIHAIRKDP SNRQLLNIIS
 QKPTSIEVKK YALEVIRKAG SFEYVREFLR QKEAESLKEI KRLGGNPLLE KYIETIRVEA
 TND

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