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Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Cell division cycle protein 43) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (RAS proteins geranylgeranyltransferase subunit beta) (Type I protein geranyl-geranyltransferase subunit beta) (PGGT)

 PGTB1_YEAST             Reviewed;         376 AA.
P18898; D6VTZ6;
01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
01-APR-1993, sequence version 2.
12-SEP-2018, entry version 159.
RecName: Full=Geranylgeranyl transferase type-1 subunit beta;
EC=2.5.1.59;
AltName: Full=Cell division cycle protein 43;
AltName: Full=Geranylgeranyl transferase type I subunit beta;
Short=GGTase-I-beta;
AltName: Full=RAS proteins geranylgeranyltransferase subunit beta;
AltName: Full=Type I protein geranyl-geranyltransferase subunit beta;
Short=PGGT;
Name=CDC43; Synonyms=CAL1; OrderedLocusNames=YGL155W; ORFNames=G1864;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
PRELIMINARY NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2199333; DOI=10.1016/0378-1119(90)90443-U;
Johnson D.I., O'Brien J.M., Jacobs C.W.;
"Isolation and sequence analysis of CDC43, a gene involved in the
control of cell polarity in Saccharomyces cerevisiae.";
Gene 90:93-98(1990).
[2]
SEQUENCE REVISION.
PubMed=2013407; DOI=10.1016/0378-1119(91)90119-V;
Johnson D.I., O'Brien J.M., Jacobs C.W.;
"Isolation and sequence analysis of CDC43, a gene involved in the
control of cell polarity in Saccharomyces cerevisiae.";
Gene 98:149-150(1991).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=A5-8-1A;
PubMed=2061313;
Ohya Y., Goebl M., Goodman L.E., Petersen-Bjoern S., Friesen J.D.,
Tamanoi F., Anraku Y.;
"Yeast CAL1 is a structural and functional homologue to the DPR1 (RAM)
gene involved in ras processing.";
J. Biol. Chem. 266:12356-12360(1991).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8585324; DOI=10.1002/yea.320111409;
James C.M., Indge K.J., Oliver S.G.;
"DNA sequence analysis of a 35 kb segment from Saccharomyces
cerevisiae chromosome VII reveals 19 open reading frames including
RAD54, ACE1/CUP2, PMR1, RCK1, AMS1 and CAL1/CDC43.";
Yeast 11:1413-1419(1995).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169869;
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M.,
Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J.,
Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E.,
Clemente M.L., Coblenz A., Coglievina M., Coissac E., Defoor E.,
Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B.,
Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L.,
Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M.,
Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M.,
Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B.,
Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W.,
Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A.,
Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S.,
Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L.,
Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S.,
Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J.,
Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M.,
Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B.,
Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J.,
Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M.,
van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M.,
Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H.,
Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M.,
Zollner A., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
Nature 387:81-84(1997).
[6]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[7]
FUNCTION.
PubMed=2034682; DOI=10.1073/pnas.88.10.4448;
Finegold A.A., Johnson D.I., Farnsworth C.C., Gelb M.H., Judd S.R.,
Glomset J.A., Tamanoi F.;
"Protein geranylgeranyltransferase of Saccharomyces cerevisiae is
specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43
gene product but not the DPR1 gene product.";
Proc. Natl. Acad. Sci. U.S.A. 88:4448-4452(1991).
[8]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
-!- FUNCTION: Catalyzes the transfer of a geranyl-geranyl moiety from
geranyl-geranyl pyrophosphate to proteins having the C-terminal
sequence Cys-Ile-Ile-Leu or Cys-Val-Leu-Leu. Acts, among other
substrates, on Rho1 and Rho2 and CDC42 proteins. Participates in a
RAS-like C-terminal modification of proteins involved in nuclear
division and bud growth. It is involved in bud positioning and
cell polarity. {ECO:0000269|PubMed:2034682}.
-!- CATALYTIC ACTIVITY: Geranylgeranyl diphosphate + protein-cysteine
= S-geranylgeranyl-protein + diphosphate.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
Note=Binds 1 zinc ion per subunit. {ECO:0000250};
-!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
-!- INTERACTION:
P29703:RAM2; NbExp=3; IntAct=EBI-3961, EBI-14814;
-!- MISCELLANEOUS: Present with 3940 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the protein prenyltransferase subunit beta
family. {ECO:0000305}.
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EMBL; M31114; AAA34481.1; -; Genomic_DNA.
EMBL; M74109; AAA34464.1; -; Genomic_DNA.
EMBL; Z48618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; Z72677; CAA96867.1; -; Genomic_DNA.
EMBL; BK006941; DAA07957.1; -; Genomic_DNA.
PIR; A40875; RGBY43.
RefSeq; NP_011360.1; NM_001181020.1.
ProteinModelPortal; P18898; -.
SMR; P18898; -.
BioGrid; 33099; 226.
ComplexPortal; CPX-1635; Protein geranylgeranyltransferase type I complex.
DIP; DIP-1232N; -.
IntAct; P18898; 1.
MINT; P18898; -.
STRING; 4932.YGL155W; -.
MaxQB; P18898; -.
PaxDb; P18898; -.
PRIDE; P18898; -.
EnsemblFungi; YGL155W; YGL155W; YGL155W.
GeneID; 852722; -.
KEGG; sce:YGL155W; -.
EuPathDB; FungiDB:YGL155W; -.
SGD; S000003123; CDC43.
HOGENOM; HOG000180333; -.
InParanoid; P18898; -.
KO; K11713; -.
OMA; LDDWSGM; -.
OrthoDB; EOG092C2PP2; -.
BioCyc; YEAST:YGL155W-MONOMER; -.
PRO; PR:P18898; -.
Proteomes; UP000002311; Chromosome VII.
GO; GO:0005953; C:CAAX-protein geranylgeranyltransferase complex; IDA:SGD.
GO; GO:0005622; C:intracellular; TAS:SGD.
GO; GO:0004662; F:CAAX-protein geranylgeranyltransferase activity; IDA:SGD.
GO; GO:0004661; F:protein geranylgeranyltransferase activity; IDA:SGD.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0006874; P:cellular calcium ion homeostasis; TAS:SGD.
GO; GO:0030010; P:establishment of cell polarity; TAS:SGD.
GO; GO:0018344; P:protein geranylgeranylation; IDA:SGD.
GO; GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD.
InterPro; IPR001330; PFTB_repeat.
InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
Pfam; PF00432; Prenyltrans; 4.
SUPFAM; SSF48239; SSF48239; 1.
1: Evidence at protein level;
Complete proteome; Metal-binding; Prenyltransferase;
Reference proteome; Repeat; Transferase; Zinc.
CHAIN 1 376 Geranylgeranyl transferase type-1 subunit
beta.
/FTId=PRO_0000119775.
REPEAT 128 179 PFTB 1.
REPEAT 192 231 PFTB 2.
REPEAT 259 301 PFTB 3.
REPEAT 310 353 PFTB 4.
REGION 216 218 Geranylgeranyl diphosphate binding.
{ECO:0000250}.
REGION 280 283 Geranylgeranyl diphosphate binding.
{ECO:0000250}.
REGION 289 292 Geranylgeranyl diphosphate binding.
{ECO:0000250}.
COMPBIAS 138 180 Cys-rich.
METAL 286 286 Zinc; catalytic. {ECO:0000250}.
METAL 288 288 Zinc; catalytic. {ECO:0000250}.
METAL 341 341 Zinc; via tele nitrogen; catalytic.
{ECO:0000250}.
MUTAGEN 328 328 G->S: Defect in nuclear division and bud
formation.
SEQUENCE 376 AA; 42690 MW; B52E56F353B3914E CRC64;
MCQATNGPSR VVTKKHRKFF ERHLQLLPSS HQGHDVNRMA IIFYSISGLS IFDVNVSAKY
GDHLGWMRKH YIKTVLDDTE NTVISGFVGS LVMNIPHATT INLPNTLFAL LSMIMLRDYE
YFETILDKRS LARFVSKCQR PDRGSFVSCL DYKTNCGSSV DSDDLRFCYI AVAILYICGC
RSKEDFDEYI DTEKLLGYIM SQQCYNGAFG AHNEPHSGYT SCALSTLALL SSLEKLSDKF
KEDTITWLLH RQVSSHGCMK FESELNASYD QSDDGGFQGR ENKFADTCYA FWCLNSLHLL
TKDWKMLCQT ELVTNYLLDR TQKTLTGGFS KNDEEDADLY HSCLGSAALA LIEGKFNGEL
CIPQEIFNDF SKRCCF


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