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Ghrelin (Ghrelin and obestatin prepropeptide) (Preproghrelin)

 Q8AV73_CHICK            Unreviewed;       116 AA.
Q8AV73;
01-MAR-2003, integrated into UniProtKB/TrEMBL.
01-MAR-2003, sequence version 1.
18-JUL-2018, entry version 106.
SubName: Full=Appetite-regulating hormone preproprotein {ECO:0000313|Ensembl:ENSGALP00000013685};
SubName: Full=Ghrelin {ECO:0000313|EMBL:BAC24980.1};
SubName: Full=Preproghrelin {ECO:0000313|EMBL:ABE69159.1};
Flags: Precursor;
Name=ghr {ECO:0000313|EMBL:BAC24980.1};
Synonyms=ghre {ECO:0000313|EMBL:BAD27409.1},
GHRL {ECO:0000313|Ensembl:ENSGALP00000013685};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031 {ECO:0000313|EMBL:BAC24980.1};
[1] {ECO:0000313|EMBL:BAC24980.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Stomach {ECO:0000313|EMBL:BAC24980.1};
PubMed=12193558; DOI=10.1210/en.2002-220255;
Kaiya H., Van Der Geyten S., Kojima M., Hosoda H., Kitajima Y.,
Matsumoto M., Geelissen S., Darras V.M., Kangawa K.;
"Chicken ghrelin: purification, cDNA cloning, and biological
activity.";
Endocrinology 143:3454-3463(2002).
[2] {ECO:0000313|EMBL:AAP57945.1}
NUCLEOTIDE SEQUENCE.
PubMed=15623213; DOI=10.1080/00071660400006263;
Nie Q., Zeng H., Lei M., Ishag N.A., Fang M., Sun B., Yang G.,
Zhang X.;
"Genomic organisation of the chicken ghrelin gene and its single
nucleotide polymorphisms detected by denaturing high-performance
liquid chromatography.";
Br. Poult. Sci. 45:611-618(2004).
[3] {ECO:0000313|Ensembl:ENSGALP00000013685, ECO:0000313|Proteomes:UP000000539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000013685,
ECO:0000313|Proteomes:UP000000539};
PubMed=15592404; DOI=10.1038/nature03154;
International Chicken Genome Sequencing Consortium;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
Mardis E.R., Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide
unique perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[4] {ECO:0000313|EMBL:BAD27409.1}
NUCLEOTIDE SEQUENCE.
Tanaka M., Miyazaki T., Oikawa Y., Tanaka S., Nakata S., Nakai N.,
Ohta Y., Tsusima N., Shimada K.;
"Characterization of structure and expression of chicken ghrelin
gene.";
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:ABE69159.1}
NUCLEOTIDE SEQUENCE.
Ran X.Q., Dai X.L., Wang J.F.;
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|EMBL:ACA48580.1}
NUCLEOTIDE SEQUENCE.
Guan W.J., Liu C.Q., Bao A., Ma Y.H.;
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|Ensembl:ENSGALP00000013685}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000013685};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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EMBL; AADN04000009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AY303688; AAP57945.1; -; Genomic_DNA.
EMBL; DQ458767; ABE69159.1; -; Genomic_DNA.
EMBL; EU477526; ACA48580.1; -; Genomic_DNA.
EMBL; AB075215; BAC24980.1; -; mRNA.
EMBL; AB158617; BAD27409.1; -; Genomic_DNA.
RefSeq; XP_015148527.1; XM_015293041.1.
UniGene; Gga.16; -.
STRING; 9031.ENSGALP00000013685; -.
Ensembl; ENSGALT00000013700; ENSGALP00000013685; ENSGALG00000008411.
CTD; 51738; -.
eggNOG; ENOG410IZYV; Eukaryota.
eggNOG; ENOG410ZG1B; LUCA.
GeneTree; ENSGT00390000004064; -.
HOVERGEN; HBG018522; -.
OMA; EIQFNAP; -.
OrthoDB; EOG091G0YG0; -.
TreeFam; TF336219; -.
Reactome; R-GGA-416476; G alpha (q) signalling events.
Reactome; R-GGA-422085; Synthesis, secretion, and deacylation of Ghrelin.
Proteomes; UP000000539; Chromosome 12.
Bgee; ENSGALG00000008411; -.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IDA:AgBase.
GO; GO:0098794; C:postsynapse; IEA:GOC.
GO; GO:0031768; F:ghrelin receptor binding; IMP:AgBase.
GO; GO:0016608; F:growth hormone-releasing hormone activity; IBA:GO_Central.
GO; GO:0030296; F:protein tyrosine kinase activator activity; IEA:Ensembl.
GO; GO:0008154; P:actin polymerization or depolymerization; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0071375; P:cellular response to peptide hormone stimulus; IMP:AgBase.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
GO; GO:0001696; P:gastric acid secretion; IBA:GO_Central.
GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0032099; P:negative regulation of appetite; IDA:AgBase.
GO; GO:0042322; P:negative regulation of circadian sleep/wake cycle, REM sleep; IEA:Ensembl.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0050728; P:negative regulation of inflammatory response; IBA:GO_Central.
GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
GO; GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IEA:Ensembl.
GO; GO:0040013; P:negative regulation of locomotion; IEA:Ensembl.
GO; GO:0042536; P:negative regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl.
GO; GO:0032100; P:positive regulation of appetite; IEA:Ensembl.
GO; GO:0046010; P:positive regulation of circadian sleep/wake cycle, non-REM sleep; IEA:Ensembl.
GO; GO:2000854; P:positive regulation of corticosterone secretion; IDA:AgBase.
GO; GO:0051461; P:positive regulation of corticotropin secretion; IEA:Ensembl.
GO; GO:0051464; P:positive regulation of cortisol secretion; IEA:Ensembl.
GO; GO:0060124; P:positive regulation of growth hormone secretion; IBA:GO_Central.
GO; GO:0061098; P:positive regulation of protein tyrosine kinase activity; IBA:GO_Central.
GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0006939; P:smooth muscle contraction; IMP:AgBase.
InterPro; IPR006737; Motilin_assoc.
InterPro; IPR005441; Preproghrelin.
PANTHER; PTHR14122; PTHR14122; 1.
Pfam; PF04643; Motilin_assoc; 1.
PRINTS; PR01624; GHRELIN.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000000539};
Reference proteome {ECO:0000313|Proteomes:UP000000539};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 116 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5015099022.
DOMAIN 56 114 Motilin_assoc.
{ECO:0000259|Pfam:PF04643}.
COILED 83 103 {ECO:0000256|SAM:Coils}.
SEQUENCE 116 AA; 13227 MW; F5C5FA038F187DE9 CRC64;
MFLRVILLGI LLLSILGTET ALAGSSFLSP TYKNIQQQKD TRKPTARLHR RGTESFWDTD
ETEGEDDNNS VDIKFNVPFE IGVKITEREY QEYGQALEKM LQDILAENAE ETQTKS


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