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 MBOA4_MOUSE             Reviewed;         435 AA.
 P0C7A3; B1Q004; B2RWL6;
 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
 08-APR-2008, sequence version 1.
 16-JAN-2019, entry version 61.
 RecName: Full=Ghrelin O-acyltransferase;
          EC=2.3.1.-;
 AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 4;
          Short=O-acyltransferase domain-containing protein 4;
 Name=Mboat4; Synonyms=Gm171, Goat;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
 SPECIFICITY, AND MUTAGENESIS OF CYS-181; ASN-307 AND HIS-338.
 PubMed=18267071; DOI=10.1016/j.cell.2008.01.017;
 Yang J., Brown M.S., Liang G., Grishin N.V., Goldstein J.L.;
 "Identification of the acyltransferase that octanoylates ghrelin, an
 appetite-stimulating peptide hormone.";
 Cell 132:387-396(2008).
 [2]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
 STRAIN=BALB/cJ;
 PubMed=18443287; DOI=10.1073/pnas.0800708105;
 Gutierrez J.A., Solenberg P.J., Perkins D.R., Willency J.A.,
 Knierman M.D., Jin Z., Witcher D.R., Luo S., Onyia J.E., Hale J.E.;
 "Ghrelin octanoylation mediated by an orphan lipid transferase.";
 Proc. Natl. Acad. Sci. U.S.A. 105:6320-6325(2008).
 [3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=C57BL/6J;
 PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
 Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
 She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
 Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
 Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
 Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
 Lindblad-Toh K., Eichler E.E., Ponting C.P.;
 "Lineage-specific biology revealed by a finished genome assembly of
 the mouse.";
 PLoS Biol. 7:E1000112-E1000112(2009).
 [4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA
 project: the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 -!- FUNCTION: Mediates the octanoylation of ghrelin at 'Ser-3'. Can
     use a variety of fatty acids as substrates including octanoic
     acid, decanoic acid and tetradecanoic acid.
     {ECO:0000269|PubMed:18267071, ECO:0000269|PubMed:18443287}.
 -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
     {ECO:0000269|PubMed:18267071}; Multi-pass membrane protein
     {ECO:0000269|PubMed:18267071}.
 -!- TISSUE SPECIFICITY: Highly expressed in stomach. Lower expression
     in small intestine and colon. Very low expression in testis.
     {ECO:0000269|PubMed:18267071}.
 -!- DISRUPTION PHENOTYPE: Mice display a complete lack of octanoylated
     ghrelin in blood. {ECO:0000269|PubMed:18443287}.
 -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
     {ECO:0000305}.
 -!- SEQUENCE CAUTION:
     Sequence=AAI47845.1; Type=Erroneous initiation; Evidence={ECO:0000305};
     Sequence=AAI47850.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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 EMBL; EU721729; ACD93144.1; -; mRNA.
 EMBL; EU518496; ACB05874.1; -; mRNA.
 EMBL; AC167537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; BC147844; AAI47845.1; ALT_INIT; mRNA.
 EMBL; BC147849; AAI47850.1; ALT_INIT; mRNA.
 CCDS; CCDS52540.1; -.
 RefSeq; NP_001119786.1; NM_001126314.2.
 UniGene; Mm.324008; -.
 STRING; 10090.ENSMUSP00000092988; -.
 ChEMBL; CHEMBL1255134; -.
 iPTMnet; P0C7A3; -.
 PhosphoSitePlus; P0C7A3; -.
 PaxDb; P0C7A3; -.
 PRIDE; P0C7A3; -.
 Ensembl; ENSMUST00000095345; ENSMUSP00000092988; ENSMUSG00000071113.
 GeneID; 234155; -.
 KEGG; mmu:234155; -.
 UCSC; uc012gch.1; mouse.
 CTD; 619373; -.
 MGI; MGI:2685017; Mboat4.
 eggNOG; KOG2704; Eukaryota.
 eggNOG; COG5202; LUCA.
 GeneTree; ENSGT00940000154052; -.
 HOGENOM; HOG000113492; -.
 HOVERGEN; HBG108120; -.
 InParanoid; P0C7A3; -.
 OMA; KWNQSTA; -.
 OrthoDB; 881262at2759; -.
 PhylomeDB; P0C7A3; -.
 TreeFam; TF314906; -.
 Reactome; R-MMU-422085; Synthesis, secretion, and deacylation of Ghrelin.
 PRO; PR:P0C7A3; -.
 Proteomes; UP000000589; Chromosome 8.
 Bgee; ENSMUSG00000071113; Expressed in 108 organ(s), highest expression level in bone marrow.
 Genevisible; P0C7A3; MM.
 GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
 GO; GO:0016412; F:serine O-acyltransferase activity; IDA:UniProtKB.
 GO; GO:0018191; P:peptidyl-serine octanoylation; IDA:UniProtKB.
 InterPro; IPR004299; MBOAT_fam.
 Pfam; PF03062; MBOAT; 1.
 1: Evidence at protein level;
 Acyltransferase; Complete proteome; Endoplasmic reticulum; Membrane;
 Reference proteome; Transferase; Transmembrane; Transmembrane helix.
 CHAIN         1    435       Ghrelin O-acyltransferase.
                              /FTId=PRO_0000329073.
 TRANSMEM      6     26       Helical. {ECO:0000255}.
 TRANSMEM     45     65       Helical. {ECO:0000255}.
 TRANSMEM    163    183       Helical. {ECO:0000255}.
 TRANSMEM    241    261       Helical. {ECO:0000255}.
 TRANSMEM    331    351       Helical. {ECO:0000255}.
 TRANSMEM    377    397       Helical. {ECO:0000255}.
 TRANSMEM    408    428       Helical. {ECO:0000255}.
 ACT_SITE    307    307       {ECO:0000305}.
 ACT_SITE    338    338       {ECO:0000305}.
 MUTAGEN     181    181       C->A: No effect on ability to acylate
                              ghrelin. {ECO:0000269|PubMed:18267071}.
 MUTAGEN     307    307       N->A: Abolished ability to acylate
                              ghrelin. {ECO:0000269|PubMed:18267071}.
 MUTAGEN     338    338       H->A: Abolished ability to acylate
                              ghrelin. {ECO:0000269|PubMed:18267071}.
 CONFLICT     31     31       I -> V (in Ref. 4; AAI47845/AAI47850).
                              {ECO:0000305}.
 CONFLICT     53     53       F -> L (in Ref. 4; AAI47845/AAI47850).
                              {ECO:0000305}.
 SEQUENCE   435 AA;  49879 MW;  C2B7E69E35185620 CRC64;
 MDWLQLFFLH PLSFYQGAAF PFALLFNYLC ILDTFSTRAR YLFLLAGGGV LAFAAMGPYS
 LLIFIPALCA VALVSFLSPQ EVHRLTFFFQ MGWQTLCHLG LHYTEYYLGE PPPVRFYITL
 SSLMLLTQRV TSLSLDICEG KVEAPRRGIR SKSSFSEHLW DALPHFSYLL FFPALLGGSL
 CSFRRFQACV QRSSSLYPSI SFRALTWRGL QILGLECLKV ALRSAVSAGA GLDDCQRLEC
 IYLMWSTAWL FKLTYYSHWI LDDSLLHAAG FGAEAGQGPG EEGYVPDVDI WTLETTHRIS
 LFARQWNRST ALWLRRLVFR KSRRWPLLQT FAFSAWWHGL HPGQVFGFLC WSVMVKADYL
 IHTFANVCIR SWPLRLLYRA LTWAHTQLII AYIMLAVEGR SLSSLCQLCC SYNSLFPVMY
 GLLLFLLAER KDKRN

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