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Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
MBOA4_MOUSE Reviewed; 435 AA.
P0C7A3; B1Q004; B2RWL6;
08-APR-2008, integrated into UniProtKB/Swiss-Prot.
08-APR-2008, sequence version 1.
10-MAY-2017, entry version 57.
RecName: Full=Ghrelin O-acyltransferase;
EC=2.3.1.-;
AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 4;
Short=O-acyltransferase domain-containing protein 4;
Name=Mboat4; Synonyms=Gm171, Goat;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND MUTAGENESIS OF CYS-181; ASN-307 AND HIS-338.
PubMed=18267071; DOI=10.1016/j.cell.2008.01.017;
Yang J., Brown M.S., Liang G., Grishin N.V., Goldstein J.L.;
"Identification of the acyltransferase that octanoylates ghrelin, an
appetite-stimulating peptide hormone.";
Cell 132:387-396(2008).
[2]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=BALB/cJ;
PubMed=18443287; DOI=10.1073/pnas.0800708105;
Gutierrez J.A., Solenberg P.J., Perkins D.R., Willency J.A.,
Knierman M.D., Jin Z., Witcher D.R., Luo S., Onyia J.E., Hale J.E.;
"Ghrelin octanoylation mediated by an orphan lipid transferase.";
Proc. Natl. Acad. Sci. U.S.A. 105:6320-6325(2008).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
Lindblad-Toh K., Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of
the mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Mediates the octanoylation of ghrelin at 'Ser-3'. Can
use a variety of fatty acids as substrates including octanoic
acid, decanoic acid and tetradecanoic acid.
{ECO:0000269|PubMed:18267071, ECO:0000269|PubMed:18443287}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000269|PubMed:18267071}; Multi-pass membrane protein
{ECO:0000269|PubMed:18267071}.
-!- TISSUE SPECIFICITY: Highly expressed in stomach. Lower expression
in small intestine and colon. Very low expression in testis.
{ECO:0000269|PubMed:18267071}.
-!- DISRUPTION PHENOTYPE: Mice display a complete lack of octanoylated
ghrelin in blood. {ECO:0000269|PubMed:18443287}.
-!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAI47845.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=AAI47850.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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EMBL; EU721729; ACD93144.1; -; mRNA.
EMBL; EU518496; ACB05874.1; -; mRNA.
EMBL; AC167537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC147844; AAI47845.1; ALT_INIT; mRNA.
EMBL; BC147849; AAI47850.1; ALT_INIT; mRNA.
CCDS; CCDS52540.1; -.
RefSeq; NP_001119786.1; NM_001126314.2.
UniGene; Mm.324008; -.
STRING; 10090.ENSMUSP00000092988; -.
ChEMBL; CHEMBL1255134; -.
iPTMnet; P0C7A3; -.
PhosphoSitePlus; P0C7A3; -.
PaxDb; P0C7A3; -.
PRIDE; P0C7A3; -.
Ensembl; ENSMUST00000095345; ENSMUSP00000092988; ENSMUSG00000071113.
GeneID; 234155; -.
KEGG; mmu:234155; -.
UCSC; uc012gch.1; mouse.
CTD; 619373; -.
MGI; MGI:2685017; Mboat4.
eggNOG; KOG2704; Eukaryota.
eggNOG; COG5202; LUCA.
GeneTree; ENSGT00550000074565; -.
HOGENOM; HOG000113492; -.
HOVERGEN; HBG108120; -.
InParanoid; P0C7A3; -.
OMA; AFSAWWH; -.
OrthoDB; EOG091G07L0; -.
PhylomeDB; P0C7A3; -.
TreeFam; TF314906; -.
Reactome; R-MMU-422085; Synthesis, secretion, and deacylation of Ghrelin.
PRO; PR:P0C7A3; -.
Proteomes; UP000000589; Chromosome 8.
Bgee; ENSMUSG00000071113; -.
Genevisible; P0C7A3; MM.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IDA:UniProtKB.
GO; GO:0016412; F:serine O-acyltransferase activity; IDA:UniProtKB.
GO; GO:0018191; P:peptidyl-serine octanoylation; IDA:UniProtKB.
InterPro; IPR004299; MBOAT_fam.
Pfam; PF03062; MBOAT; 1.
1: Evidence at protein level;
Acyltransferase; Complete proteome; Endoplasmic reticulum; Membrane;
Reference proteome; Transferase; Transmembrane; Transmembrane helix.
CHAIN 1 435 Ghrelin O-acyltransferase.
/FTId=PRO_0000329073.
TRANSMEM 6 26 Helical. {ECO:0000255}.
TRANSMEM 45 65 Helical. {ECO:0000255}.
TRANSMEM 163 183 Helical. {ECO:0000255}.
TRANSMEM 241 261 Helical. {ECO:0000255}.
TRANSMEM 331 351 Helical. {ECO:0000255}.
TRANSMEM 377 397 Helical. {ECO:0000255}.
TRANSMEM 408 428 Helical. {ECO:0000255}.
ACT_SITE 307 307 {ECO:0000305}.
ACT_SITE 338 338 {ECO:0000305}.
MUTAGEN 181 181 C->A: No effect on ability to acylate
ghrelin. {ECO:0000269|PubMed:18267071}.
MUTAGEN 307 307 N->A: Abolished ability to acylate
ghrelin. {ECO:0000269|PubMed:18267071}.
MUTAGEN 338 338 H->A: Abolished ability to acylate
ghrelin. {ECO:0000269|PubMed:18267071}.
CONFLICT 31 31 I -> V (in Ref. 4; AAI47845/AAI47850).
{ECO:0000305}.
CONFLICT 53 53 F -> L (in Ref. 4; AAI47845/AAI47850).
{ECO:0000305}.
SEQUENCE 435 AA; 49879 MW; C2B7E69E35185620 CRC64;
MDWLQLFFLH PLSFYQGAAF PFALLFNYLC ILDTFSTRAR YLFLLAGGGV LAFAAMGPYS
LLIFIPALCA VALVSFLSPQ EVHRLTFFFQ MGWQTLCHLG LHYTEYYLGE PPPVRFYITL
SSLMLLTQRV TSLSLDICEG KVEAPRRGIR SKSSFSEHLW DALPHFSYLL FFPALLGGSL
CSFRRFQACV QRSSSLYPSI SFRALTWRGL QILGLECLKV ALRSAVSAGA GLDDCQRLEC
IYLMWSTAWL FKLTYYSHWI LDDSLLHAAG FGAEAGQGPG EEGYVPDVDI WTLETTHRIS
LFARQWNRST ALWLRRLVFR KSRRWPLLQT FAFSAWWHGL HPGQVFGFLC WSVMVKADYL
IHTFANVCIR SWPLRLLYRA LTWAHTQLII AYIMLAVEGR SLSSLCQLCC SYNSLFPVMY
GLLLFLLAER KDKRN
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Pathways :
WP1665: Limonene and pinene degradation
WP1714: Tyrosine metabolism
WP1657: Glycerolipid metabolism
WP1689: Porphyrin and chlorophyll metabolism
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1646: Ethylbenzene degradation
WP1686: Phenylalanine metabolism
WP1502: Mitochondrial biogenesis
WP1624: Bacterial secretion system
WP1658: Glycerophospholipid metabolism
WP1668: Lipopolysaccharide biosynthesis
WP1692: Protein export
WP1713: Two-component system
WP2199: Seed Development
WP627: Triacylglycerol Biosynthesis
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
Related Genes :
[GHRL MTLRP UNQ524/PRO1066] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]
[ghrl] Ghrelin [Cleaved into: Ghrelin-23; Ghrelin-24]
[ghrl] Ghrelin (Ghrelin-21)
[ghr ghre GHRL] Ghrelin (Ghrelin and obestatin prepropeptide) (Preproghrelin)
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[Ghrl] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin-23; Obestatin-13]
[Ghrl Mtlrp] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin; Obestatin]
[GHRL MTLRP] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[Ghrl mCG_132953] Ghrelin (Ghrelin, isoform CRA_c) (Preproghrelin)
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[GHRL] Ghrelin [Cleaved into: Ghrelin-27; Ghrelin-28]
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[Ghsr] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[Ghsr] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[Mboat4 Gm171 Goat] Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[MBOAT4 GOAT OACT4 FKSG89] Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[GHRL] Ghrelin and obestatin prepropeptide
[GHRL] Ghrelin and obestatin prepropeptide
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[GHRL] Ghrelin and obestatin prepropeptide (Preproghrelin)
[ghrl] Ghrelin [Cleaved into: Ghrelin-12; Ghrelin-19]
[GHRL] Appetite-regulating hormone (Ghrelin/obestatin prepropeptide)
[GHRL] Ghrelin (Fragment)
[GHRL] Appetite-regulating hormone isoform 1 preproprotein (Appetite-regulating hormone preproprotein) (Ghrelin and obestatin prepropeptide)
[GHRL CR201_G0011253] GHRL isoform 1 (GHRL isoform 3) (GHRL isoform 5) (Ghrelin and obestatin prepropeptide)
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