GENTAUR Molecular Products.

 MBOA4_HUMAN             Reviewed;         435 AA.
 Q96T53; B1Q003;
 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
 08-APR-2008, sequence version 2.
 10-MAY-2017, entry version 88.
 RecName: Full=Ghrelin O-acyltransferase;
          EC=2.3.1.-;
 AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 4;
          Short=O-acyltransferase domain-containing protein 4;
 Name=MBOAT4; Synonyms=GOAT, OACT4; ORFNames=FKSG89;
 Homo sapiens (Human).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Hominidae; Homo.
 NCBI_TaxID=9606;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY,
 MUTAGENESIS OF HIS-338, AND VARIANT ALA-46.
 TISSUE=Thyroid carcinoma;
 PubMed=18443287; DOI=10.1073/pnas.0800708105;
 Gutierrez J.A., Solenberg P.J., Perkins D.R., Willency J.A.,
 Knierman M.D., Jin Z., Witcher D.R., Luo S., Onyia J.E., Hale J.E.;
 "Ghrelin octanoylation mediated by an orphan lipid transferase.";
 Proc. Natl. Acad. Sci. U.S.A. 105:6320-6325(2008).
 [2]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
 Wang Y.-G., Gong L.;
 "Identification of FKSG89, a novel gene located on human chromosome
 8.";
 Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
 [3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=16421571; DOI=10.1038/nature04406;
 Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
 Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
 Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
 Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
 Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
 DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
 Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
 Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
 Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
 Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
 O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
 Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
 Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
 Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
 Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
 Lander E.S.;
 "DNA sequence and analysis of human chromosome 8.";
 Nature 439:331-335(2006).
 -!- FUNCTION: Mediates the octanoylation of ghrelin at 'Ser-3'. Can
     use a variety of fatty acids as substrates including octanoic
     acid, decanoic acid and tetradecanoic acid.
     {ECO:0000269|PubMed:18443287}.
 -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
     {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=2;
     Name=1;
       IsoId=Q96T53-1; Sequence=Displayed;
     Name=2;
       IsoId=Q96T53-2; Sequence=VSP_032958, VSP_032959;
       Note=No experimental confirmation available.;
 -!- TISSUE SPECIFICITY: Expressed predominantly in stomach with
     moderate levels in pancreas and relatively low levels in most
     other tissues. {ECO:0000269|PubMed:18443287}.
 -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
     {ECO:0000305}.
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 EMBL; EU518495; ACB05873.2; -; mRNA.
 EMBL; AF359269; AAK43717.1; -; mRNA.
 EMBL; AC026979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 CCDS; CCDS47835.1; -. [Q96T53-1]
 RefSeq; NP_001094386.1; NM_001100916.1. [Q96T53-1]
 RefSeq; XP_016869215.1; XM_017013726.1. [Q96T53-1]
 UniGene; Hs.627194; -.
 ProteinModelPortal; Q96T53; -.
 STRING; 9606.ENSP00000314196; -.
 BindingDB; Q96T53; -.
 ChEMBL; CHEMBL3588729; -.
 PhosphoSitePlus; Q96T53; -.
 BioMuta; MBOAT4; -.
 DMDM; 182676418; -.
 PaxDb; Q96T53; -.
 PRIDE; Q96T53; -.
 Ensembl; ENST00000320542; ENSP00000314196; ENSG00000177669. [Q96T53-1]
 GeneID; 619373; -.
 KEGG; hsa:619373; -.
 UCSC; uc010lvg.4; human. [Q96T53-1]
 CTD; 619373; -.
 DisGeNET; 619373; -.
 GeneCards; MBOAT4; -.
 H-InvDB; HIX0034281; -.
 HGNC; HGNC:32311; MBOAT4.
 HPA; HPA044509; -.
 MIM; 611940; gene.
 neXtProt; NX_Q96T53; -.
 OpenTargets; ENSG00000177669; -.
 PharmGKB; PA142671233; -.
 eggNOG; KOG2704; Eukaryota.
 eggNOG; COG5202; LUCA.
 GeneTree; ENSGT00550000074565; -.
 HOGENOM; HOG000113492; -.
 HOVERGEN; HBG108120; -.
 InParanoid; Q96T53; -.
 OMA; AFSAWWH; -.
 OrthoDB; EOG091G07L0; -.
 PhylomeDB; Q96T53; -.
 TreeFam; TF314906; -.
 Reactome; R-HSA-422085; Synthesis, secretion, and deacylation of Ghrelin.
 GenomeRNAi; 619373; -.
 PRO; PR:Q96T53; -.
 Proteomes; UP000005640; Chromosome 8.
 Bgee; ENSG00000177669; -.
 CleanEx; HS_MBOAT4; -.
 GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
 GO; GO:0008374; F:O-acyltransferase activity; TAS:Reactome.
 GO; GO:0016412; F:serine O-acyltransferase activity; IDA:UniProtKB.
 GO; GO:0018191; P:peptidyl-serine octanoylation; IDA:UniProtKB.
 InterPro; IPR004299; MBOAT_fam.
 Pfam; PF03062; MBOAT; 1.
 1: Evidence at protein level;
 Acyltransferase; Alternative splicing; Complete proteome;
 Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome;
 Transferase; Transmembrane; Transmembrane helix.
 CHAIN         1    435       Ghrelin O-acyltransferase.
                              /FTId=PRO_0000273024.
 TRANSMEM      6     26       Helical. {ECO:0000255}.
 TRANSMEM     43     63       Helical. {ECO:0000255}.
 TRANSMEM    163    183       Helical. {ECO:0000255}.
 TRANSMEM    241    261       Helical. {ECO:0000255}.
 TRANSMEM    345    365       Helical. {ECO:0000255}.
 TRANSMEM    377    397       Helical. {ECO:0000255}.
 TRANSMEM    407    427       Helical. {ECO:0000255}.
 ACT_SITE    307    307       {ECO:0000250}.
 ACT_SITE    338    338       {ECO:0000305}.
 VAR_SEQ       1    106       Missing (in isoform 2).
                              {ECO:0000303|Ref.2}.
                              /FTId=VSP_032958.
 VAR_SEQ     107    114       YLHEPPSV -> MFFKKLSC (in isoform 2).
                              {ECO:0000303|Ref.2}.
                              /FTId=VSP_032959.
 VARIANT      46     46       T -> A (in dbSNP:rs7813902).
                              {ECO:0000269|PubMed:18443287}.
                              /FTId=VAR_059434.
 VARIANT     231    231       G -> E (in dbSNP:rs16876563).
                              /FTId=VAR_030069.
 MUTAGEN     338    338       H->A: Abolishes ability to acylate
                              ghrelin. {ECO:0000269|PubMed:18443287}.
 SEQUENCE   435 AA;  49716 MW;  0CF97AAE734F24A7 CRC64;
 MEWLWLFFLH PISFYQGAAF PFALLFNYLC IMDSFSTRAR YLFLLTGGGA LAVAAMGSYA
 VLVFTPAVCA VALLCSLAPQ QVHRWTFCFQ MSWQTLCHLG LHYTEYYLHE PPSVRFCITL
 SSLMLLTQRV TSLSLDICEG KVKAASGGFR SRSSLSEHVC KALPYFSYLL FFPALLGGSL
 CSFQRFQARV QGSSALHPRH SFWALSWRGL QILGLECLNV AVSRVVDAGA GLTDCQQFEC
 IYVVWTTAGL FKLTYYSHWI LDDSLLHAAG FGPELGQSPG EEGYVPDADI WTLERTHRIS
 VFSRKWNQST ARWLRRLVFQ HSRAWPLLQT FAFSAWWHGL HPGQVFGFVC WAVMVEADYL
 IHSFANEFIR SWPMRLFYRT LTWAHTQLII AYIMLAVEVR SLSSLWLLCN SYNSVFPMVY
 CILLLLLAKR KHKCN

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