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Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)

 MBOA4_HUMAN             Reviewed;         435 AA.
Q96T53; B1Q003;
23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
08-APR-2008, sequence version 2.
27-SEP-2017, entry version 89.
RecName: Full=Ghrelin O-acyltransferase;
EC=2.3.1.-;
AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 4;
Short=O-acyltransferase domain-containing protein 4;
Name=MBOAT4; Synonyms=GOAT, OACT4; ORFNames=FKSG89;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY,
MUTAGENESIS OF HIS-338, AND VARIANT ALA-46.
TISSUE=Thyroid carcinoma;
PubMed=18443287; DOI=10.1073/pnas.0800708105;
Gutierrez J.A., Solenberg P.J., Perkins D.R., Willency J.A.,
Knierman M.D., Jin Z., Witcher D.R., Luo S., Onyia J.E., Hale J.E.;
"Ghrelin octanoylation mediated by an orphan lipid transferase.";
Proc. Natl. Acad. Sci. U.S.A. 105:6320-6325(2008).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Wang Y.-G., Gong L.;
"Identification of FKSG89, a novel gene located on human chromosome
8.";
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16421571; DOI=10.1038/nature04406;
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
Lander E.S.;
"DNA sequence and analysis of human chromosome 8.";
Nature 439:331-335(2006).
-!- FUNCTION: Mediates the octanoylation of ghrelin at 'Ser-3'. Can
use a variety of fatty acids as substrates including octanoic
acid, decanoic acid and tetradecanoic acid.
{ECO:0000269|PubMed:18443287}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q96T53-1; Sequence=Displayed;
Name=2;
IsoId=Q96T53-2; Sequence=VSP_032958, VSP_032959;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed predominantly in stomach with
moderate levels in pancreas and relatively low levels in most
other tissues. {ECO:0000269|PubMed:18443287}.
-!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
{ECO:0000305}.
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EMBL; EU518495; ACB05873.2; -; mRNA.
EMBL; AF359269; AAK43717.1; -; mRNA.
EMBL; AC026979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS47835.1; -. [Q96T53-1]
RefSeq; NP_001094386.1; NM_001100916.1. [Q96T53-1]
RefSeq; XP_016869215.1; XM_017013726.1. [Q96T53-1]
UniGene; Hs.627194; -.
ProteinModelPortal; Q96T53; -.
STRING; 9606.ENSP00000314196; -.
BindingDB; Q96T53; -.
ChEMBL; CHEMBL3588729; -.
PhosphoSitePlus; Q96T53; -.
BioMuta; MBOAT4; -.
DMDM; 182676418; -.
PaxDb; Q96T53; -.
PRIDE; Q96T53; -.
Ensembl; ENST00000320542; ENSP00000314196; ENSG00000177669. [Q96T53-1]
GeneID; 619373; -.
KEGG; hsa:619373; -.
UCSC; uc010lvg.4; human. [Q96T53-1]
CTD; 619373; -.
DisGeNET; 619373; -.
EuPathDB; HostDB:ENSG00000177669.3; -.
GeneCards; MBOAT4; -.
H-InvDB; HIX0034281; -.
HGNC; HGNC:32311; MBOAT4.
HPA; HPA044509; -.
MIM; 611940; gene.
neXtProt; NX_Q96T53; -.
OpenTargets; ENSG00000177669; -.
PharmGKB; PA142671233; -.
eggNOG; KOG2704; Eukaryota.
eggNOG; COG5202; LUCA.
GeneTree; ENSGT00550000074565; -.
HOGENOM; HOG000113492; -.
HOVERGEN; HBG108120; -.
InParanoid; Q96T53; -.
OMA; AFSAWWH; -.
OrthoDB; EOG091G07L0; -.
PhylomeDB; Q96T53; -.
TreeFam; TF314906; -.
Reactome; R-HSA-422085; Synthesis, secretion, and deacylation of Ghrelin.
GenomeRNAi; 619373; -.
PRO; PR:Q96T53; -.
Proteomes; UP000005640; Chromosome 8.
Bgee; ENSG00000177669; -.
CleanEx; HS_MBOAT4; -.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0008374; F:O-acyltransferase activity; TAS:Reactome.
GO; GO:0016412; F:serine O-acyltransferase activity; IDA:UniProtKB.
GO; GO:0018191; P:peptidyl-serine octanoylation; IDA:UniProtKB.
InterPro; IPR004299; MBOAT_fam.
Pfam; PF03062; MBOAT; 1.
1: Evidence at protein level;
Acyltransferase; Alternative splicing; Complete proteome;
Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome;
Transferase; Transmembrane; Transmembrane helix.
CHAIN 1 435 Ghrelin O-acyltransferase.
/FTId=PRO_0000273024.
TRANSMEM 6 26 Helical. {ECO:0000255}.
TRANSMEM 43 63 Helical. {ECO:0000255}.
TRANSMEM 163 183 Helical. {ECO:0000255}.
TRANSMEM 241 261 Helical. {ECO:0000255}.
TRANSMEM 345 365 Helical. {ECO:0000255}.
TRANSMEM 377 397 Helical. {ECO:0000255}.
TRANSMEM 407 427 Helical. {ECO:0000255}.
ACT_SITE 307 307 {ECO:0000250}.
ACT_SITE 338 338 {ECO:0000305}.
VAR_SEQ 1 106 Missing (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_032958.
VAR_SEQ 107 114 YLHEPPSV -> MFFKKLSC (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_032959.
VARIANT 46 46 T -> A (in dbSNP:rs7813902).
{ECO:0000269|PubMed:18443287}.
/FTId=VAR_059434.
VARIANT 231 231 G -> E (in dbSNP:rs16876563).
/FTId=VAR_030069.
MUTAGEN 338 338 H->A: Abolishes ability to acylate
ghrelin. {ECO:0000269|PubMed:18443287}.
SEQUENCE 435 AA; 49716 MW; 0CF97AAE734F24A7 CRC64;
MEWLWLFFLH PISFYQGAAF PFALLFNYLC IMDSFSTRAR YLFLLTGGGA LAVAAMGSYA
VLVFTPAVCA VALLCSLAPQ QVHRWTFCFQ MSWQTLCHLG LHYTEYYLHE PPSVRFCITL
SSLMLLTQRV TSLSLDICEG KVKAASGGFR SRSSLSEHVC KALPYFSYLL FFPALLGGSL
CSFQRFQARV QGSSALHPRH SFWALSWRGL QILGLECLNV AVSRVVDAGA GLTDCQQFEC
IYVVWTTAGL FKLTYYSHWI LDDSLLHAAG FGPELGQSPG EEGYVPDADI WTLERTHRIS
VFSRKWNQST ARWLRRLVFQ HSRAWPLLQT FAFSAWWHGL HPGQVFGFVC WAVMVEADYL
IHSFANEFIR SWPMRLFYRT LTWAHTQLII AYIMLAVEVR SLSSLWLLCN SYNSVFPMVY
CILLLLLAKR KHKCN


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