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Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
MBOA4_HUMAN Reviewed; 435 AA.
Q96T53; B1Q003;
23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
08-APR-2008, sequence version 2.
28-FEB-2018, entry version 90.
RecName: Full=Ghrelin O-acyltransferase;
EC=2.3.1.-;
AltName: Full=Membrane-bound O-acyltransferase domain-containing protein 4;
Short=O-acyltransferase domain-containing protein 4;
Name=MBOAT4; Synonyms=GOAT, OACT4; ORFNames=FKSG89;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY,
MUTAGENESIS OF HIS-338, AND VARIANT ALA-46.
TISSUE=Thyroid carcinoma;
PubMed=18443287; DOI=10.1073/pnas.0800708105;
Gutierrez J.A., Solenberg P.J., Perkins D.R., Willency J.A.,
Knierman M.D., Jin Z., Witcher D.R., Luo S., Onyia J.E., Hale J.E.;
"Ghrelin octanoylation mediated by an orphan lipid transferase.";
Proc. Natl. Acad. Sci. U.S.A. 105:6320-6325(2008).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Wang Y.-G., Gong L.;
"Identification of FKSG89, a novel gene located on human chromosome
8.";
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16421571; DOI=10.1038/nature04406;
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
Lander E.S.;
"DNA sequence and analysis of human chromosome 8.";
Nature 439:331-335(2006).
-!- FUNCTION: Mediates the octanoylation of ghrelin at 'Ser-3'. Can
use a variety of fatty acids as substrates including octanoic
acid, decanoic acid and tetradecanoic acid.
{ECO:0000269|PubMed:18443287}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q96T53-1; Sequence=Displayed;
Name=2;
IsoId=Q96T53-2; Sequence=VSP_032958, VSP_032959;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed predominantly in stomach with
moderate levels in pancreas and relatively low levels in most
other tissues. {ECO:0000269|PubMed:18443287}.
-!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
{ECO:0000305}.
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EMBL; EU518495; ACB05873.2; -; mRNA.
EMBL; AF359269; AAK43717.1; -; mRNA.
EMBL; AC026979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS47835.1; -. [Q96T53-1]
RefSeq; NP_001094386.1; NM_001100916.1. [Q96T53-1]
RefSeq; XP_016869215.1; XM_017013726.1. [Q96T53-1]
UniGene; Hs.627194; -.
ProteinModelPortal; Q96T53; -.
STRING; 9606.ENSP00000314196; -.
BindingDB; Q96T53; -.
ChEMBL; CHEMBL3588729; -.
PhosphoSitePlus; Q96T53; -.
BioMuta; MBOAT4; -.
DMDM; 182676418; -.
PaxDb; Q96T53; -.
PeptideAtlas; Q96T53; -.
PRIDE; Q96T53; -.
Ensembl; ENST00000320542; ENSP00000314196; ENSG00000177669. [Q96T53-1]
GeneID; 619373; -.
KEGG; hsa:619373; -.
UCSC; uc010lvg.4; human. [Q96T53-1]
CTD; 619373; -.
DisGeNET; 619373; -.
EuPathDB; HostDB:ENSG00000177669.3; -.
GeneCards; MBOAT4; -.
H-InvDB; HIX0034281; -.
HGNC; HGNC:32311; MBOAT4.
HPA; HPA044509; -.
MIM; 611940; gene.
neXtProt; NX_Q96T53; -.
OpenTargets; ENSG00000177669; -.
PharmGKB; PA142671233; -.
eggNOG; KOG2704; Eukaryota.
eggNOG; COG5202; LUCA.
GeneTree; ENSGT00550000074565; -.
HOGENOM; HOG000113492; -.
HOVERGEN; HBG108120; -.
InParanoid; Q96T53; -.
OMA; AFSAWWH; -.
OrthoDB; EOG091G07L0; -.
PhylomeDB; Q96T53; -.
TreeFam; TF314906; -.
Reactome; R-HSA-422085; Synthesis, secretion, and deacylation of Ghrelin.
GenomeRNAi; 619373; -.
PRO; PR:Q96T53; -.
Proteomes; UP000005640; Chromosome 8.
Bgee; ENSG00000177669; -.
CleanEx; HS_MBOAT4; -.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0008374; F:O-acyltransferase activity; TAS:Reactome.
GO; GO:0016412; F:serine O-acyltransferase activity; IDA:UniProtKB.
GO; GO:0018191; P:peptidyl-serine octanoylation; IDA:UniProtKB.
InterPro; IPR004299; MBOAT_fam.
Pfam; PF03062; MBOAT; 1.
1: Evidence at protein level;
Acyltransferase; Alternative splicing; Complete proteome;
Endoplasmic reticulum; Membrane; Polymorphism; Reference proteome;
Transferase; Transmembrane; Transmembrane helix.
CHAIN 1 435 Ghrelin O-acyltransferase.
/FTId=PRO_0000273024.
TRANSMEM 6 26 Helical. {ECO:0000255}.
TRANSMEM 43 63 Helical. {ECO:0000255}.
TRANSMEM 163 183 Helical. {ECO:0000255}.
TRANSMEM 241 261 Helical. {ECO:0000255}.
TRANSMEM 345 365 Helical. {ECO:0000255}.
TRANSMEM 377 397 Helical. {ECO:0000255}.
TRANSMEM 407 427 Helical. {ECO:0000255}.
ACT_SITE 307 307 {ECO:0000250}.
ACT_SITE 338 338 {ECO:0000305}.
VAR_SEQ 1 106 Missing (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_032958.
VAR_SEQ 107 114 YLHEPPSV -> MFFKKLSC (in isoform 2).
{ECO:0000303|Ref.2}.
/FTId=VSP_032959.
VARIANT 46 46 T -> A (in dbSNP:rs7813902).
{ECO:0000269|PubMed:18443287}.
/FTId=VAR_059434.
VARIANT 231 231 G -> E (in dbSNP:rs16876563).
/FTId=VAR_030069.
MUTAGEN 338 338 H->A: Abolishes ability to acylate
ghrelin. {ECO:0000269|PubMed:18443287}.
SEQUENCE 435 AA; 49716 MW; 0CF97AAE734F24A7 CRC64;
MEWLWLFFLH PISFYQGAAF PFALLFNYLC IMDSFSTRAR YLFLLTGGGA LAVAAMGSYA
VLVFTPAVCA VALLCSLAPQ QVHRWTFCFQ MSWQTLCHLG LHYTEYYLHE PPSVRFCITL
SSLMLLTQRV TSLSLDICEG KVKAASGGFR SRSSLSEHVC KALPYFSYLL FFPALLGGSL
CSFQRFQARV QGSSALHPRH SFWALSWRGL QILGLECLNV AVSRVVDAGA GLTDCQQFEC
IYVVWTTAGL FKLTYYSHWI LDDSLLHAAG FGPELGQSPG EEGYVPDADI WTLERTHRIS
VFSRKWNQST ARWLRRLVFQ HSRAWPLLQT FAFSAWWHGL HPGQVFGFVC WAVMVEADYL
IHSFANEFIR SWPMRLFYRT LTWAHTQLII AYIMLAVEVR SLSSLWLLCN SYNSVFPMVY
CILLLLLAKR KHKCN
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Pathways :
WP1665: Limonene and pinene degradation
WP1714: Tyrosine metabolism
WP1657: Glycerolipid metabolism
WP1689: Porphyrin and chlorophyll metabolism
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1646: Ethylbenzene degradation
WP1686: Phenylalanine metabolism
WP1502: Mitochondrial biogenesis
WP1624: Bacterial secretion system
WP1658: Glycerophospholipid metabolism
WP1668: Lipopolysaccharide biosynthesis
WP1692: Protein export
WP1713: Two-component system
WP2199: Seed Development
WP627: Triacylglycerol Biosynthesis
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
Related Genes :
[GHRL MTLRP UNQ524/PRO1066] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin-27; Ghrelin-28 (Ghrelin); Obestatin]
[ghrl] Ghrelin [Cleaved into: Ghrelin-23; Ghrelin-24]
[ghrl] Ghrelin (Ghrelin-21)
[ghr ghre GHRL] Ghrelin (Ghrelin and obestatin prepropeptide) (Preproghrelin)
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[Ghrl] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin-23; Obestatin-13]
[Ghrl Mtlrp] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) (Protein M46) [Cleaved into: Ghrelin; Obestatin]
[GHRL MTLRP] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[Ghrl mCG_132953] Ghrelin (Ghrelin, isoform CRA_c) (Preproghrelin)
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[GHRL] Ghrelin [Cleaved into: Ghrelin-27; Ghrelin-28]
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[GHRL] Appetite-regulating hormone (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Cleaved into: Ghrelin; Obestatin]
[Ghsr] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[Ghsr] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[Mboat4 Gm171 Goat] Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[MBOAT4 GOAT OACT4 FKSG89] Ghrelin O-acyltransferase (EC 2.3.1.-) (Membrane-bound O-acyltransferase domain-containing protein 4) (O-acyltransferase domain-containing protein 4)
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[GHRL] Ghrelin and obestatin prepropeptide
[GHRL] Ghrelin and obestatin prepropeptide
[GHSR] Growth hormone secretagogue receptor type 1 (GHS-R) (GH-releasing peptide receptor) (GHRP) (Ghrelin receptor)
[GHRL] Ghrelin and obestatin prepropeptide (Preproghrelin)
[ghrl] Ghrelin [Cleaved into: Ghrelin-12; Ghrelin-19]
[GHRL] Appetite-regulating hormone (Ghrelin/obestatin prepropeptide)
[GHRL] Ghrelin (Fragment)
[GHRL] Appetite-regulating hormone isoform 1 preproprotein (Appetite-regulating hormone preproprotein) (Ghrelin and obestatin prepropeptide)
[GHRL CR201_G0011253] GHRL isoform 1 (GHRL isoform 3) (GHRL isoform 5) (Ghrelin and obestatin prepropeptide)
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