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Glandular kallikrein-7, submandibular/renal (rGK-7) (EC 3.4.21.35) (Esterase B) (Kallikrein-related protein K1) (Proteinase A) (RSKG-7) (Tissue kallikrein)

 KLK7_RAT                Reviewed;         261 AA.
P36373;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
23-MAY-2018, entry version 124.
RecName: Full=Glandular kallikrein-7, submandibular/renal;
Short=rGK-7;
EC=3.4.21.35;
AltName: Full=Esterase B;
AltName: Full=Kallikrein-related protein K1;
AltName: Full=Proteinase A;
AltName: Full=RSKG-7;
AltName: Full=Tissue kallikrein;
Flags: Precursor;
Name=Klk7; Synonyms=Klk-7;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2849988; DOI=10.1021/bi00419a005;
Chen Y.-P., Chao J., Chao L.;
"Molecular cloning and characterization of two rat renal kallikrein
genes.";
Biochemistry 27:7189-7196(1988).
[2]
PROTEIN SEQUENCE OF 25-75.
TISSUE=Submandibular gland;
PubMed=3482210; DOI=10.1093/oxfordjournals.jbchem.a122185;
Kato H., Nakanishi E., Enjyoji K., Hayashi I., Oh-Ishi S., Iwanaga S.;
"Characterization of serine proteinases isolated from rat submaxillary
gland: with special reference to the degradation of rat kininogens by
these enzymes.";
J. Biochem. 102:1389-1404(1987).
[3]
PROTEIN SEQUENCE OF 25-36.
TISSUE=Submandibular gland;
PubMed=2194829; DOI=10.1016/0014-5793(90)80903-V;
Elmoujahed A., Gutman N., Brillard M., Gauthier F.;
"Substrate specificity of two kallikrein family gene products isolated
from the rat submaxillary gland.";
FEBS Lett. 265:137-140(1990).
[4]
PROTEIN SEQUENCE OF 43-261, AND TISSUE SPECIFICITY.
PubMed=2183721; DOI=10.1016/0003-9861(90)90269-5;
Brady J.M., MacDonald R.J.;
"The expression of two kallikrein gene family members in the rat
kidney.";
Arch. Biochem. Biophys. 278:342-349(1990).
-!- FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds
in kininogen to release Lys-bradykinin. Predominant kallikrein
protein in the kidney.
-!- CATALYTIC ACTIVITY: Preferential cleavage of Arg-|-Xaa bonds in
small molecule substrates. Highly selective action to release
kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of
Met-|-Xaa or Leu-|-Xaa.
-!- TISSUE SPECIFICITY: Kidney and submandibular gland. Not expressed
in liver, pancreas, spleen, parotid, testis, cortex, prostate,
ovary and pituitary. {ECO:0000269|PubMed:2183721}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Kallikrein
subfamily. {ECO:0000255|PROSITE-ProRule:PRU00274}.
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EMBL; M19647; AAA41461.1; -; Genomic_DNA.
PIR; A31136; A31136.
RefSeq; NP_036725.1; NM_012593.1.
UniGene; Rn.207160; -.
ProteinModelPortal; P36373; -.
SMR; P36373; -.
STRING; 10116.ENSRNOP00000066004; -.
MEROPS; S01.406; -.
iPTMnet; P36373; -.
PhosphoSitePlus; P36373; -.
PaxDb; P36373; -.
PRIDE; P36373; -.
GeneID; 24523; -.
KEGG; rno:24523; -.
UCSC; RGD:1306420; rat.
CTD; 3816; -.
RGD; 1306420; Klk7.
eggNOG; KOG3627; Eukaryota.
eggNOG; COG5640; LUCA.
HOGENOM; HOG000251820; -.
HOVERGEN; HBG013304; -.
InParanoid; P36373; -.
KO; K01325; -.
PhylomeDB; P36373; -.
PRO; PR:P36373; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
CDD; cd00190; Tryp_SPc; 1.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Complete proteome; Direct protein sequencing; Disulfide bond;
Glycoprotein; Hydrolase; Protease; Reference proteome;
Serine protease; Signal; Zymogen.
SIGNAL 1 18 {ECO:0000305}.
PROPEP 19 24 Activation peptide.
{ECO:0000305|PubMed:2194829,
ECO:0000305|PubMed:3482210}.
/FTId=PRO_0000028005.
CHAIN 25 261 Glandular kallikrein-7,
submandibular/renal.
/FTId=PRO_0000028006.
DOMAIN 25 258 Peptidase S1. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
ACT_SITE 65 65 Charge relay system.
ACT_SITE 120 120 Charge relay system.
ACT_SITE 213 213 Charge relay system.
CARBOHYD 108 108 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 31 173 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 50 66 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 152 219 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 184 198 {ECO:0000255|PROSITE-ProRule:PRU00274}.
DISULFID 209 234 {ECO:0000255|PROSITE-ProRule:PRU00274}.
CONFLICT 35 35 S -> D (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 46 46 T -> S (in Ref. 2; AA sequence and 4; AA
sequence). {ECO:0000305}.
CONFLICT 115 115 D -> A (in Ref. 4; AA sequence).
{ECO:0000305}.
SEQUENCE 261 AA; 28972 MW; 4FB06C422F25AF16 CRC64;
MWFLILFLDL SLGQIDAAPP GQSRVIGGYK CEKNSQPWQV ALYSFTKYLC GGVLIDPSWV
ITAAHCSSNN YQVWLGRNNL LEDEPFAQHR LVSQSFPHPD YKPFLMRNHT RKPGDDHSND
LMLLHLSQPA DITDGVKVID LPTEEPKVGS TCLASGWGST KPLIWEFPDD LQCVNIHLLS
NEKCIKAYKE KVTDLMLCAG ELEGGKDTCT GDSGGPLLCD GVLQGITSWG SVPCAKTNMP
AIYTKLIKFT SWIKEVMKEN P


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