Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Glucagon [Cleaved into: Glicentin-related polypeptide (GRPP); Glucagon; Glucagon-like peptide 1 (GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)]

 GLUC_HELSU              Reviewed;         204 AA.
O12956; O12955;
15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-JUL-1997, sequence version 1.
25-OCT-2017, entry version 80.
RecName: Full=Glucagon;
Contains:
RecName: Full=Glicentin-related polypeptide;
Short=GRPP;
Contains:
RecName: Full=Glucagon;
Contains:
RecName: Full=Glucagon-like peptide 1;
Short=GLP-1;
Contains:
RecName: Full=Glucagon-like peptide 1(7-37);
Short=GLP-1(7-37);
Contains:
RecName: Full=Glucagon-like peptide 1(7-36);
Short=GLP-1(7-36);
Contains:
RecName: Full=Glucagon-like peptide 2;
Short=GLP-2;
Flags: Precursor;
Name=GCG;
Heloderma suspectum (Gila monster).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Anguimorpha; Neoanguimorpha; Helodermatidae; Heloderma.
NCBI_TaxID=8554;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LPI AND LPII), AND TISSUE
SPECIFICITY.
TISSUE=Intestine, and Pancreas;
PubMed=9020121;
Chen Y.E., Drucker D.J.;
"Tissue-specific expression of unique mRNAs that encode proglucagon-
derived peptides or exendin 4 in the lizard.";
J. Biol. Chem. 272:4108-4115(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 65-81 AND 110-132.
TISSUE=Lung;
PubMed=9545315; DOI=10.1074/jbc.273.16.9778;
Pohl M., Wank S.A.;
"Molecular cloning of the helodermin and exendin-4 cDNAs in the
lizard. Relationship to vasoactive intestinal polypeptide/pituitary
adenylate cyclase activating polypeptide and glucagon-like peptide 1
and evidence against the existence of mammalian homologues.";
J. Biol. Chem. 273:9778-9784(1998).
[3]
REVIEW.
PubMed=12554744; DOI=10.1210/me.2002-0306;
Drucker D.J.;
"Glucagon-like peptides: regulators of cell proliferation,
differentiation, and apoptosis.";
Mol. Endocrinol. 17:161-171(2003).
[4]
REVIEW.
PubMed=12626323; DOI=10.1152/ajpendo.00492.2002;
Jiang G., Zhang B.B.;
"Glucagon and regulation of glucose metabolism.";
Am. J. Physiol. 284:E671-E678(2003).
[5]
REVIEW.
PubMed=10322410; DOI=10.1016/S1043-2760(98)00136-2;
Drucker D.J.;
"Glucagon-like peptide 2.";
Trends Endocrinol. Metab. 10:153-156(1999).
[6]
REVIEW.
PubMed=10605628; DOI=10.1210/edrv.20.6.0385;
Kieffer T.J., Habener J.F.;
"The glucagon-like peptides.";
Endocr. Rev. 20:876-913(1999).
-!- FUNCTION: Glucagon plays a key role in glucose metabolism and
homeostasis. Regulates blood glucose by increasing gluconeogenesis
and decreasing glycolysis.
-!- FUNCTION: GLP-1 is a potent stimulator of glucose-dependent
insulin release. Play important roles on gastric motility and the
suppression of plasma glucagon levels.
-!- FUNCTION: GLP-2 stimulates intestinal growth and up-regulates
villus height in the small intestine, concomitant with increased
crypt cell proliferation and decreased enterocyte apoptosis.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=LPII;
IsoId=O12956-1; Sequence=Displayed;
Name=LPI;
IsoId=O12956-2; Sequence=VSP_001756, VSP_001757;
-!- TISSUE SPECIFICITY: Isoform LPII is expressed in both pancreas and
intestine. Expression of isoform LPI is restricted to the
pancreas. Neither isoform is detected in salivary glands.
{ECO:0000269|PubMed:9020121}.
-!- INDUCTION: Produced in the A cells of the islets of Langerhans in
response to a drop in blood sugar concentration.
-!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U77612; AAB51129.1; -; mRNA.
EMBL; U77611; AAB51128.1; -; mRNA.
ProteinModelPortal; O12956; -.
SMR; O12956; -.
HOVERGEN; HBG003010; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
InterPro; IPR015550; Glucagon.
InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
PANTHER; PTHR11418; PTHR11418; 1.
Pfam; PF00123; Hormone_2; 3.
PRINTS; PR00275; GLUCAGON.
SMART; SM00070; GLUCA; 3.
PROSITE; PS00260; GLUCAGON; 2.
2: Evidence at transcript level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Hormone; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
PEPTIDE 21 50 Glicentin-related polypeptide.
{ECO:0000250}.
/FTId=PRO_0000011410.
PEPTIDE 53 81 Glucagon. {ECO:0000250}.
/FTId=PRO_0000011411.
PROPEP 84 109 {ECO:0000250}.
/FTId=PRO_0000011412.
PEPTIDE 110 146 Glucagon-like peptide 1. {ECO:0000250}.
/FTId=PRO_0000011413.
PEPTIDE 116 146 Glucagon-like peptide 1(7-37).
{ECO:0000250}.
/FTId=PRO_0000011414.
PEPTIDE 116 145 Glucagon-like peptide 1(7-36).
{ECO:0000250}.
/FTId=PRO_0000011415.
PROPEP 149 161 {ECO:0000250}.
/FTId=PRO_0000011416.
PEPTIDE 164 196 Glucagon-like peptide 2. {ECO:0000250}.
/FTId=PRO_0000011417.
PROPEP 197 204 {ECO:0000250}.
/FTId=PRO_0000011418.
SITE 52 53 Cleavage; by PCSK2. {ECO:0000250}.
SITE 83 84 Cleavage; by PCSK1 and PCSK2.
{ECO:0000250}.
SITE 115 116 Cleavage; by PCSK1. {ECO:0000250}.
SITE 148 149 Cleavage; by PCSK1. {ECO:0000250}.
SITE 163 164 Cleavage; by PCSK1. {ECO:0000250}.
MOD_RES 145 145 Arginine amide. {ECO:0000250}.
VAR_SEQ 149 149 D -> E (in isoform LPI).
{ECO:0000303|PubMed:9020121}.
/FTId=VSP_001756.
VAR_SEQ 150 204 Missing (in isoform LPI).
{ECO:0000303|PubMed:9020121}.
/FTId=VSP_001757.
CONFLICT 120 120 R -> T (in Ref. 2; no nucleotide entry).
{ECO:0000305}.
SEQUENCE 204 AA; 23553 MW; B132E3FE46873E72 CRC64;
MTSMYFVAGL LLMIVQGSWQ SPLQETEEKS RSFKASQAEP LDDSRQLNEV KRHSQGTFTS
DYSKYLDTRR AQDFVQWLMN TKRSGQQGVE EREKENLLDQ LSSNGLARHH AEYERHADGR
YTSDISSYLE GQAAKEFIAW LVNGRGRRDF LEEAGTADDI GRRHADGTFT SDYNQLLDDI
ATQEFLKWLI NQKVTQRDLL GEYQ


Related products :

Catalog number Product name Quantity
32-161 Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon 0.1 mg
orb80725 Glucagon protein Glucagon Human Synthetic peptide is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3485 Dalton.The Glucagon is purified by prop 4 mg
297-57101 Glucagon ELISA KIT, Rat Glucagon is known as a hormone secreted from the pancreas and intestines. This kit aims at measurement of rat Glucagon peptide secreted from pancreatic a_cells by competitive f 96 tests
orb80723 Human Glucagon Like Peptide-1 (7-36) protein Glucagon Like Peptide-1 is a single, non-glycosylated, polypeptide chain containing 30 amino acids and having a molecular mass of 3298.7 Dalton. The GLP-1 1 mg
orb80722 Human Glucagon Like Peptide-1 (7-36) protein Glucagon Like Peptide-1 Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 30 amino acids and having a molecu 10
orb81955 Glucagon-Like Peptide 2 protein Glucagon-Like Peptide 2 (GLP2), Human is a purified reagent for bone and calcium metabolism. For research use only. 100
orb80724 Human Glucagon Like Peptide-2 protein Glucagon Like Peptide-2 contains 34 amino acids having a molecular mass of 3922.38 Dalton. For research use only. 1 mg
orb80726 Human Glucagon protein Glucagon Human Recombinant produced in E.coli is a single, non-glycosylated, polypeptide chain containing 29 amino acids and having a molecular mass of 3483 Dalton. The Glucagon 100
A 6102AG.2 Glucagon-like Peptide (GLP) antigen: human Glucagon like Peptide-2 1 mg
A 6104AG.1 Glucagon-like Peptide (GLP) antigen: human Glucagon like Peptide-1 100
A 6102AG.1 Glucagon-like Peptide (GLP) antigen: human Glucagon like Peptide-2 100
A 6104AG.2 Glucagon-like Peptide (GLP) antigen: human Glucagon like Peptide-1 1 mg
orb70678 Glucagon-Like 1 (7-17)-Cys, GLP-1 (7-17) Cys peptide This is Glucagon-Like 1 (7-17)-Cys, GLP-1 (7-17) Cys peptide. For research use only. 1 mg
orb71638 Glucagon-Like 1 (7-37) peptide This is Glucagon-Like 1 (7-37) peptide. For research use only. 1 mg
27-172 The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-d 0.05 mg
orb71637 Human Glucagon-Like I (7-36) peptide This is Human Glucagon-Like I (7-36) peptide. For research use only. 1 mg
orb71635 Pig Glucagon (1-37) Oxyntomodulin peptide This is Pig Glucagon (1-37) Oxyntomodulin peptide. For research use only. 1 mg
orb71636 Human Glucagon-Like 1 peptide This is Human Glucagon-Like 1 peptide. For research use only. 1 mg
orb71177 [Des-Thr5]-Glucagon peptide This is [Des-Thr5]-Glucagon peptide. For research use only. 1 mg
orb71178 [Des-Thr7]-Glucagon peptide This is [Des-Thr7]-Glucagon peptide. For research use only. 1 mg
YK-COM-SO-Glucagon Substrate Buffer 1bottle(26mL)+OPD tablet(2tablets) for Glucagon 1 set
MA1047 Monoclonal Antibodies: Glucagon; reactive species: Human, rat.; Clone: IMD-7; Isotype: IgG1; Specificity: Glucagon 100?g
orb70677 Bovine, Human, Pig Glucagon (19-29) peptide This is Bovine, Human, Pig Glucagon (19-29) peptide. For research use only. 1 mg
orb71174 [Des-His1, Glu9]-Glucagon (1-29) peptide This is [Des-His1, Glu9]-Glucagon (1-29) peptide. For research use only. 1 mg
orb71431 Human Glucagon Like 1 (7-36) Biotin peptide This is Human Glucagon Like 1 (7-36) Biotin peptide. For research use only. 1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur